10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

132 Pages·2006·3.16 MB·English

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a 10th International Conference on
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Malignancies in AIDS and Other Acquired
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Immunodeficiencies:
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Basic, Epidemiologic and Clinical Research
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Presented by the Office of AIDS Malignancy Program and the
Office of International Affairs
October 16–17, 2006
Marriott Bethesda North Hotel and Conference Center, North Bethesda, Maryland
U.S. Department
of HealtH anD
HUman ServiceS
national institutes
of Health
10th International Conference on

Malignancies in AIDS and Other Acquired

Immunodeficiencies:

Basic, Epidemiologic and Clinical Research

Presented by the Office of AIDS Malignancy Program and
the Office of International Affairs

October 16–17, 2006

Marriott Bethesda North Hotel and Conference Center

North Bethesda, Maryland

10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

TABLE OF CONTENTS

Program .............................................................................................................................. 1

Continuing Medical Education................................................................................................ 7

Program Committee ............................................................................................................. 9

ACSR..................................................................................................................................11

Abstracts ............................................................................................................................13

Author Index ......................................................................................................................89

List of Participants...............................................................................................................95

Assessment

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10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

PROGRAM
Monday, October 16
8:00 AM–
Poster Presentations
6:00 PM
8:00 Opening Remarks and Welcome
Kishor Bhatia, PhD, MRCPath
National Cancer Institute, NIH, Bethesda, MD, USA

8:15 P1: Viral Malignancies and an International Perspective
John Ziegler, MD, MSc
University of California, San Francisco, Comprehensive Cancer Center, USA

9:00 AM– KSHV and Kaposi’s Sarcoma (KS)
10:00 AM Moderator: Denise Whitby, PhD

9:00 P2: Modulation of Cell Signaling and Angiogenesis by KSHV
Blossom Damania, PhD
University of North Carolina at Chapel Hill, USA

9:30 P3: AIDS-Associated Kaposi’s Sarcoma (KS) at 25: A Model for the Evaluation
of Targeted Antiangiogenesis Therapy
Susan Krown, MD
Memorial Sloan-Kettering Cancer Center, New York, NY, USA

10:00 AM Break

10:20 AM– Session 1: Kaposi’s Sarcoma–Associated Herpesvirus (KSHV/HHV-8):
12:05 PM Pathogenesis of Disease and Pathogenesis-Based Therapy
Moderators: Robert Yarchoan, MD, and Andrew Grulich, PhD

10:20 Activation of Kaposi’s Sarcoma–Associated Herpesvirus (KSHV) to Lytic Replication by the
Cytotoxic Chemotherapy Drugs Vincristine and Doxorubicin
Kazushi Nakano, MD, National Cancer Institute, Bethesda, MD, USA

10:35 Identification of Novel NFκΒ Inhibitors in Primary Effusion Lymphoma Cells
Ethel Cesarman, MD, PhD, Weill Medical College of Cornell University, New York, NY, USA

10:50 Rapamycin is Efficacious against Primary Effusion Lymphoma (PEL)
Dirk Dittmer, PhD, University of North Carolina at Chapel Hill, USA

11:05 Cyclooxygenase-2 (COX-2) Induced by KSHV Early During In Vitro Infection of Target
Cells Plays a Role in the Maintenance of Latent Viral Gene Expression
Neelam Sharma-Walla, PhD, Rosalind Franklin University of Medicine and Science,
North Chicago, IL, USA

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10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

Session 1, continued

11:20 Intracellular KSHV Load Determines Early Loss of Immune Synapse Components

Laura Adang, PhD, University of Virginia, Charlottesville, USA

11:35 HHV-8 Infects and Replicates in Primary Cultures of Activated B Lymphocytes Through
DC-SIGN
Giovanna Rappocciolo, PhD, University of Pittsburgh, PA, USA

11:50 KSHV-LANA Stabilizes c-Myc by Activating ERK1/2 and Inhibiting GSK-3

Jianyong Liu, MD, PhD, Johns Hopkins School of Medicine, Baltimore, MD, USA

12:05 PM Lunch

1:25 PM– Lymphoma and EBV as a Therapeutic Target
2:30 PM
1:25 Introductory Remarks

Elliott Kieff, MD, PhD

Harvard Medical School, Boston, MA, USA

1:30 P4: InterLymph: An International Collaboration on the Epidemiology of

Non-Hodgkin Lymphoma

Wendy Cozen, DO, MPH
Keck School of Medicine, University of Southern California, Los Angeles, USA

2:00 P5: Pathogenesis of B Cell Lymphomas: Implications in the Context of AIDS
Gianluca Gaidano, MD, PhD
Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

2:30 PM– Session 2: Lymphoma and Epstein-Barr Virus (EBV): New Insights and
3:15 PM Treatments
Moderators: Kevin Howcroft, PhD, and Sam Mbulaiteye, MD

2:30 Elevated Activation-Induced Cytidine Deaminase (AID) Expression Preceding the
Diagnosis of AIDS-Associated Burkitt’s Lymphoma
Marta Epeldegui, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

2:45 Development of a Therapeutic Vaccine for HIV-associated Hodgkin’s Lymphoma

Rajiv Khanna, PhD, Queensland Institute of Medical Research, Brisbane, Australia

3:00 EBV Gene Transcription Kinetics During Viral Reactivation by Bortezomib in Cell Lines and
in a Clinical Setting

Rachel Bagni, MS, NCI-Frederick, MD, USA

3:15 PM Break

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10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

3:30 PM– Session 3: Clinical Management of AIDS-Associated Lymphoma
4:30 PM Moderator: Alexandra Levine, MD, and Richard Ambinder MD, PhD

3:30 Randomized Phase II Trial of Infusional EPOCH Chemotherapy Given Either Concurrently
with or Sequentially Followed by Rituximab in HIV-Associated Lymphoma: AIDS
Malignancy Consortium Trial 034
Joseph Sparano, MD, Montefiore-Einstein Cancer Center, Bronx, NY, USA

3:45 Abbreviated EPOCH-Rituximab Therapy with HAART Suspension Is Highly Effective and
Tolerable in AIDS Related Lymphoma
Kieron Dunleavy, MD, National Cancer Institute, Bethesda, MD, USA

4:00 Dose Modified Oral Chemotherapy for AIDS-Related Non-Hodgkin's Lymphoma (AR-NHL)
in East Africa: Impact on CD4+ count and HIV-1 replication; and Retrospective Look
at Similar Regimen In Pre-HAART Era in the USA
Walter Mwanda, MBChB, MD, University of Nairobi College of Health Sciences and
Kenyatta National Hospital–Case Research Collaboration, Kenya

4:15 Discussion

4:35 PM– Adjourn to Posters
6:00 PM Authors of AB#1–41 please stand by your poster.

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10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

Tuesday, October 17
8:00 AM– Poster Presentations
6:00 PM
8:10 Administrative Remarks
Geraldina Dominguez, PhD

8:15 AM– HPV, Disease and Vaccine
10:15 AM Moderator: Joel Palefsky, MD, FRCP

8:15 P6: HPV Infection and Cancer in Normal and Immunologically Impaired Hosts
Douglas Lowy, MD

National Cancer Institute, NIH, Bethesda, MD, USA

8:45 P7: HPV Infection in HIV-Positive Women

Silvia Franceschi, MD

International Agency for Research on Cancer, Lyon, France

9:15 P8: HPV VLP Vaccine: Clinical Trial Results and Implementation Challenges
Diane Harper, MD, MPH, MS
Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH, USA

9:45 P9: Development of a Broadly Protective HPV Vaccine Based on L2

Richard Roden, PhD

Johns Hopkins School of Medicine, Baltimore, MD, USA

10:15 AM Break

10:35 AM– Session 4: Human Papillomavirus (HPV): Diverse Sites of Infection with
12:00 PM Implications to Treatment and Prevention
Moderators: T-C Wu, MD, PhD, and Elizabeth Read-Connole, PhD

10:35 Human Papillomavirus (HPV) Infection of the Anus Is More Prevalent and Diverse than
Cervical HPV Infection Among HIV-Infected Women in the Study to Understand the
Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study)
Erna Kojic, MD, The Miriam Hospital, Providence, RI, USA

10:50 Six-Month History of Oral Versus Cervical Human Papillomavirus Infection

Gypsyamber D’Souza, PhD, Johns Hopkins University, Baltimore, MD, USA

11:05 Clinical Profile of HIV-Positive Women with Cervical Cancer in India

Aruna Alahari, MD, Tata Memorial Hospital, Mumbai, India

11:20 A High Prevalence of High Risk Human Papillomavirus and Cervical Dysplasia in HIV
Seropositive Women in a Urban South African Cancer Cohort (SACCC)
Cynthia Firnhaber, MD, University of Witwatersrand, Johannesburg, South Africa

11:35 Prevalence of Cervical Dysplasia in HIV-Positive Women in Jos, Nigeria
Patricia Agaba, MD, AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital

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10th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies

Marriott Bethesda North Hotel & Conference Center, North Bethesda, Maryland

October 16–17, 2006

Session 4, continued

11:50 Infrared Coagulator (IRC) for Treatment of High Grade Squamous Intraepithelial
Neoplasia (HSIL) of the Anal Canal in HIV Infected Individuals: A Pilot
Study (AMC 032)
Elizabeth Stier, MD, Boston Medical Center, MA, USA

12:05 Interaction of HPV Pseudovirus with the Murine Female Genital Tract and Identification of
Compounds That Can Potentiate or Inhibit In Vivo Infection
Jeffrey Roberts, PhD, NCI-Frederick, MD, USA

12:20 PM Lunch

1:30 PM– Inflammation, Immunity, and Malignancies
2:30 PM Moderator: Elliott Kieff, MD, PhD

1:30 P10: A Role for the Chemokine Receptor CXCR4 in the Homing of Kaposi’s
Sarcoma–Associated Herpes Virus (KSHV)–Infected Cells
Giovana Tosato, MD
National Cancer Institute, NIH, Bethesda, MD, USA

2:00 P11: Liver and Inflammation
Snorri S.Thorgeirsson, MD, PhD
National Cancer Institute, NIH, Bethesda, MD, USA

2:30 PM Break

2:50 PM– Session 5: Emerging Themes in HIV/AIDS Malignancies
4:30 PM Moderators: Catherine Godfrey, MD, and Mostafa Nokta, MD, PhD

2:50 Conservation of Virally-Encoded MicroRNAs in the Kaposi’s Sarcoma-Associated
Herpesvirus (KSHV) in Primary Effusion Lymphoma Cell Lines and in Patients with
Kaposi’s Sarcoma or Multicentric Castleman’s Disease
Vickie Marshall, MS, NCI-Frederick, MD, USA

3:05 EBV Encoded Micro RNAs in Endemic and HIV-Related Burkitt’s Lymphoma
William Harrington, MD, University of Miami, FL, USA

3:20 Tumor Recognition and Cytolysis by the CD45RA-/CD27- Effector Subset of Human
VGVD2 T Cells
Andrew Hebbeler, PhD, Institute of Human Virology, Baltimore, MD, USA

3:35 Association of Cells with Natural Killer (NK) and NKT Immunophenotype with Incident
Cancers in HIV-Infected Women
Marek Nowicki, PhD, Keck School of Medicine, University of Southern California, Los
Angeles, USA

3:50 Risk of Cancers during Interrupted Antiretroviral Therapy: Malignant Outcomes in the
SMART Study
Donald Abrams, MD, San Francisco General Hospital, University of San Francisco, CA, USA

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