76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page i 100 Questions & Answers About Crohn’s Disease and Ulcerative Colitis: A Lahey Clinic Guide Second Edition Andrew S. Warner, MD Chairman of the Department of Gastroenterology Lahey Clinic Burlington, MA Amy E. Barto, MD Department of Gastroenterology Lahey Clinic Burlington, MA 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page ii World Headquarters Jones and Bartlett Jones and Bartlett Jones and Bartlett Publishers Publishers Canada Publishers International 40 Tall Pine Drive 6339 Ormindale Way Barb House, Barb Mews Sudbury, MA 01776 Mississauga, Ontario L5V 1J2 London W6 7PA 978-443-5000 Canada United Kingdom [email protected] www.jbpub.com Jones and Bartlett’s books and products are available through most bookstores and online booksellers. To contact Jones and Bartlett Publishers directly, call 800-832-0034, fax 978-443-8000, or visit our website, www.jbpub.com. 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Production Credits Executive Publisher: Christopher Davis Editorial Assistant: Sara Cameron Associate Production Editor: Leah Corrigan Senior Marketing Manager: Barb Bartoszek Manufacturing and Inventory Supervisor: Amy Bacus Composition: Glyph International Cover Design: Colleen Lamy Cover Images: © Photos.com, ©Jessica Bilen/ShutterStock, Inc., © Biljana Kumer/ShutterStock, Inc. Printing and Binding: Malloy, Inc. Cover Printing: Malloy, Inc. Library of Congress Cataloging-in-Publication Data Warner, Andrew S. 100 questions & answers about Crohn’s disease and ulcerative colitis : a Lahey Clinic guide / Andrew S. Warner, Amy E. Barto. -- 2nd ed. p. cm. Includes index. ISBN 978-0-7637-7638-1 (alk. paper) 1. Crohn’s disease--Miscellanea. 2. Crohn’s disease--Popular works. 3. Ulcerative colitis--Miscellanea. 4. Ulcerative colitis--Popular works. I. Title. II. Title: 100 questions and answers about Crohn's disease and ulcerative colitis. III. Title: One hundred questions and answers about Crohn’s disease and ulcerative colitis. RC862.E52W37 2010 616.3'44--dc22 2009031500 6048 Printed in the United States of America 13 12 11 10 09 10 9 8 7 6 5 4 3 2 1 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page iii Dedication This book is dedicated to our patients. 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page iv 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page v Contents Preface ix Part 1:The Basics 1 Questions 1–7introduce Crohn’s disease and ulcerative colitis: • What are Crohn’s disease and ulcerative colitis? • How do you know if you have Crohn’s disease or ulcerative colitis? • How common are Crohn’s disease and ulcerative colitis? I seem to know more and more people with it. Part 2:Diagnosis 17 Questions 8–17discuss how Crohn’s disease and ulcerative colitis are diagnosed, as well as the prognosis and other related diseases, such as: • How are Crohn’s disease and ulcerative colitis diagnosed? • Can I ever be cured of IBD, or will I have it for my entire life? • Are Crohn’s disease and ulcerative colitis ever confused with other disorders? Part 3:Medications 43 Questions 18–30explain different types of medications used to treat Crohn’s disease and ulcerative colitis, including: • What is the role of topical therapy in treating proctitis, and is topical therapy used for treating anything else? • What are biologics and who should get them? I’ve heard of infliximab (Remicade). Are there newer biologics available for the treatment of Crohn’s and ulcerative colitis? • Does having Crohn’s disease or ulcerative colitis mean I will be on medication for my entire life? Part 4:Cancer and Dysplasia 77 Questions 31–37discuss the relationship of cancer and dysplasia to Crohn’s disease and ulcerative colitis, such as: • Am I more likely to get colon cancer if I have ulcerative colitis? • What is dysplasia and how is it related to cancer? • Can I do anything to prevent getting colon cancer? 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page vi 100 Q&A ABOUT CROHN’S DISEASE AND ULCERATIVE COLITIS: A LAHEY CLINIC GUIDE Part 5:Complications 87 Questions 38–47review numerous complications that are associated with Crohn’s disease and ulcerative colitis, including: • What is toxic megacolon? • I heard that people with Crohn’s disease can get something called a fistula. Can you tell me what this is? • I have ulcerative colitis and often pass blood with my bowel movements. Is this something I should worry about? Part 6:Surgery 101 Questions 48–54explain different surgery options used to treat this disease, such as: • What types of operations are performed in Crohn’s disease? • What is the role of surgery in ulcerative colitis? • What are some of the other complications found after ileal pouch surgery? Part 7:Diet and Nutrition 119 Questions 55–64include helpful tips on how to best maintain a healthy diet, such as: • How does having Crohn’s disease or ulcerative colitis affect my nutrition? • Since I have to avoid fruits and vegetables due to my Crohn’s disease, what can I do to lose weight? • Is there a specific diet that I should follow if I have Crohn’s disease or ulcerative colitis? Part 8:Extraintestinal Manifestations 139 Questions 65–77discuss the affects Crohn’s disease and ulcerative colitis can have on the rest of your body, including: • How can IBD affect my skin? • My joints are often stiff and sore. Is this related to my IBD? • Am I more likely to get osteoporosis if I have IBD and is there any way to prevent it? Part 9:Sexuality,Reproductive Issues,and Pregnancy 163 Questions 78–92review issues surrounding sexuality, pregnancy, and the disease, like: • Is it safe to have a baby if I have IBD? • Can IBD affect fertility in men? • Should I continue to take my IBD medications during pregnancy and are they safe to use during pregnancy? vi 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page vii 100 Q&A ABOUT CROHNS DISEASE AND ULCERATIVE COLITIS: A LAHEY CLINIC GUIDE Part 10:Lifestyle 183 Questions 93–97discuss the potential affects of Crohn’s disease and ulcerative colitis on your lifestyle, such as: • Does stress affect Crohn’s disease and ulcerative colitis? C o • Do I have to take any precautions if I want to exercise? n t • Can I drink alcohol if I have IBD? e n t s Part 11:IBD in Children and the Elderly 193 Questions 98–99 explain IBD in children and the elderly: • Does IBD occur in children? How is it different than in adults? • Can IBD occur in the elderly? Part 12:The Future ofCrohn’s Disease and Ulcerative Colitis 197 Question 100discusses the future of treatment options and diagnosis methods: • What does the future hold for the diagnosis and treatment of Crohn’s disease and ulcerative colitis? Appendix 199 Glossary 201 Index 215 vii 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page viii 76381_FMxx_FINAL.QXP 8/31/09 7:19 PM Page ix PParretf Oacnee Crohn’s disease and ulcerative colitis are the two most common forms of inflammatory bowel disease (IBD). Believed to be caused by an autoimmune process, Crohn’s disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract, and potentially of many different organ systems throughout the body. Symptoms of inflammatory bowel disease range from mild to severe, and up to three-quarters of patients with Crohn’s disease and one-quarter of patients with ulcerative colitis eventually need surgery. Fortunately, many effective treatments are currently available,with new and potentially even more effective therapies on the horizon. After a successful first edition, 100 Questions & Answers About Crohn’s Disease and Ulcerative Colitis: A Lahey Clinic Guide, Second Edition has been completely revised to contain up-to-date infor- mation on these two diseases. It is intended to be a patient- oriented, practical guide about Crohn’s disease and ulcerative colitis. The questions are taken directly from the thousands we have been asked over the years by our patients with IBD. The answers are a compilation of the latest scientific information along with our own experience in treating inflammatory bowel disease. In essence, this book re-creates a visit to the doctor’s office. It contains all the questions you wished you had asked and many that you never even thought to ask. In addition to our thoughts as physicians, two of our patients (one with Crohn’s dis- ease and one with ulcerative colitis) have also offered helpful hints and invaluable insights about living with IBD from the patient’s perspective. 100 Questions & Answers About Crohn’s Disease and Ulcerative Colitis:A Lahey Clinic Guide,Second Edition covers a wide range of issues. We explore how inflammatory bowel disease is diagnosed and treated, complications of the disease including dysplasia and
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