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151 Pages·2012·10.63 MB·English

THE ROLE OF TRANSCRIPTION FACTOR STOX1A
IN TRANSCRIPTIONAL NETWORKS ASSOCIATED
WITH NEURODEGENERATION
Daan van Abel
The studies described in this thesis were carried out at the Department of Clinical
Chemistry, Pathology and Molecular Biology Laboratory (MBL), VU University
Medical Center, Amsterdam, The Netherlands.
Printing of this thesis was kindly supported by:
Alzheimer Nederland (Bunnik)
Internationale Stichting Alzheimer Onderzoek
Clinical Chemistry Department VUMC, Amsterdam, The Netherlands
ISBN:
Layout: Daan van Abel; Cover Design: Bas van Abel
Printing: Ipskamp Drukkers
Copyright © 2012 Daan van Abel. All rights reserved
VRIJE UNIVERSITEIT
THE ROLE OF TRANSCRIPTION FACTOR STOX1A
IN TRANSCRIPTIONAL NETWORKS ASSOCIATED
WITH NEURODEGENERATION
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam,
op gezag van rector magnificus
prof.dr. L.M. Bouter,
in het openbaar te verdedigen
ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde
op woensdag 19 september 2012 om 15.45 uur
in de aula van de universiteit,
de Boelelaan 1105
door
Daan van Abel
geboren te Nijmegen
promotor: prof.dr. C.B.M. Oudejans

copromotor: dr. M. van Dijk
reading committee: dr. N.Ameziane
prof.dr. M.A. Blankenstein
prof.dr. A.J Rozemuller
dr. W. Scheper
prof.dr. J.C van Swieten
dr. R.M.F. Wolthuis

Vaak hebben invalletjes van één regel weinig om het lijf
Van Kooten & De Bie

Contents
Chapter 1 General Introduction 11
Aims and Outline 22
Chapter 2 Direct downregulation of CNTNAP2 by STOX1A is 33
associated with Alzheimer’s disease.
Journal of Alzheimer’s Disease (Accepted), 2012
Chapter 3 SFRS7-mediated splicing of tau exon 10 is directly regulated 55
by STOX1A in glial cells.
PloS ONE, 2011
Chapter 4 Transcription factor STOX1A promotes mitotic entry by 75
binding to the CCNB1 promotor.
PloS ONE, 2012
Chapter 5 STOX1A induces phosphorylation of tau proteins at epitopes 91
hyperphosphorylated in Alzheimer’s disease.
Submitted
Chapter 6 RNA-seq transcriptome analysis of STOX1A induced 105
differential expression in neuronal cells.
In Preparation
Chapter 7 Summarizing Discussion 127
Directions for Future Work 130
Appendices Nederlandse Samenvatting 140
List of Publications 145
Curriculum Vitae 147
Dankwoord 148
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