University of Groningen Intraoperative fluorescence imaging in cancer Crane, Lucia Marie Albertine

217 Pages·2011·8.89 MB·English

University of Groningen

Intraoperative fluorescence imaging in cancer
Crane, Lucia Marie Albertine
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Download date: 17-03-2023
INTRAOPERATIVE FLUORESCENCE IMAGING IN CANCER
L.M.A. CRANE
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Colofon
Crane, L.M.A.
Intraoperative fl uorescence imaging in cancer
Dissertation University of Groningen, with summary in Dutch
ISBN: 978-90-367-4678-6 (printed version)
ISBN: 978-90-367-4679-3 (electronic version)
© 2010 L.M.A. Crane
All rights reserved. No part of this publication may be reproduced, stored in a retrieval
system, or transmitted in any form or by any means, mechanically, by photocopying,
recording, or otherwise, without the written permission of the author.
Design: Marijke Crane-de Wal
Cover design: Marijke Crane-de Wal & Lucy Crane
Cover picture: Stock.XCHNG
Printing: Ipskamp Drukkers, Enschede
For the printing of this thesis, fi nancial sponsoring of the following institutions and com-
panies is gratefully acknowledged: University of Groningen, University Medical Center
Groningen (UMCG), Groningen University Institute for Drug Exploration (GUIDE),
ChipSoft, Li-COR Biosciences, Caliper LifeSciences
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Intraoperative fl uorescence imaging in cancer
Proefschrift
ter verkrijging van het doctoraat in de
Medische Wetenschappen
aan de Rijksuniversiteit Groningen
op gezag van de
Rector Magnifi cus, dr. F. Zwarts,
in het openbaar te verdedigen op
woensdag 26 januari 2011
om 14.45 uur
door
Lucia Marie Albertine Crane
geboren op 5 oktober 1983
te Groningen
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Promotores: Prof. dr. T. Wiggers
Prof. dr. A.G.J. van der Zee
Copromotor: Dr. G.M. van Dam
Beoordelingscommissie: Prof. dr. P.J. van Diest
Prof. dr. H.W. Nijman
Prof. dr. R.J. Porte
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Paranimfen: Reinier F. Crane
Marleen van Oosten
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All fi gures referred to in the text are printed in full color on pages 193-208.
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TABLE OF CONTENTS
1. Introduction & Rationale 09
Part I: Sentinel lymph node imaging 15
2. Intraoperative multispectral fl uorescence imaging for the detection of
the sentinel lymph node in cervical cancer: a novel concept 17
3. Intraoperative near-infrared fl uorescence imaging for sentinel lymph
node detection in vulvar cancer: fi rst clinical results 31
4. Optical imaging for lymph node surveillance in breast cancer patients:
intraoperative detection as a step-up approach towards tumor-targeted
imaging 43
5. Multispectral real-time fl uorescence imaging for intraoperative detection
of the sentinel lymph node in gynecologic oncology 55
Part II: Tumor-targeted imaging 61
6. Animal models of oesophageal cancer and hypoxia: An overview of ap-
plications, possibilities and limitations 63
7. Intraoperative imaging in ovarian cancer: fact or fi ction? 93
8. Selecting potential targetable biomarkers for imaging purposes in
colorectal cancer using TArget Selection Criteria (TASC): a novel target
identifi cation tool 111
9. Folate receptor-alpha and the eff ect of chemotherapy on expression rates
in ovarian cancer 139
10. Intraoperative tumor-specifi c fl uorescence imaging in ovarian cancer by
folate receptor-alpha targeting: fi rst in-human results 157
11. Summary
Conclusions & Future perspectives 169
12. Nederlandse Samenvatting 177
List of Abbreviations
Contents Supplementary CD 189
Color Figures 193
Dankwoord
Biografi e / Biography 209
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1
INTRODUCTIO&N
LUCIA M.A. CRANE RATIONALE
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