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Ultrasound therapeutic apparatus using a therapeutic ultrasonic PDF

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US005984881A United States Patent [19] [11] Patent Number: 5,984,881 Ishibashi et al. [45] Date of Patent: Nov. 16, 1999 [54] ULTRASOUND THERAPEUTIC APPARATUS 5,111,822 5/1992 Dory . USING A THERAPEUTIC ULTRASONIC 5,143,073 9/1992 Dory . WAVE SOURCE AND AN ULTRASONIC 5,150,712 9/1992 Dory . PROBE 5,391,140 2/1995 Shaetzke et al. ......................... .. 601/4 5,431,621 7/1995 Dory ......................................... .. 601/2 [75] Inventors: Yoshiharu Ishibashi, Tokyo; 5,435,311 7/1995 Umemura et al. ............... .. 128/66003 Katsuhiko Fujimoto, UraWa; Mariko 5,558,092 9/1996 Unger et al ...................... .. 128/66003 Shibata, Yokohama; Takuji Suzuki, FOREIGN PATENT DOCUMENTS Kawasaki; Satoshi Aida, Tokyo, all of Japan 0 162 735 11/1985 European Pat. Off. . 0 170 416 2/1986 European Pat. Off. . [73] Assignee: Kabushiki Kaisha Toshiba, Kawasaki, 0 370 841 3/1990 European Pat. Off. . Japan 0 627 206 12/1994 European Pat. Off. . 42 27 800 3/1993 Germany . 42 29 817 3/1994 Germany . [21] Appl. No.: 08/624,104 43 02 538 4/1994 Germany . 6-59289 8/1994 Japan . [22] Filed: Mar. 29, 1996 [30] Foreign Application Priority Data Primary Examiner—George Manuel Attorney, Agent, or Firm—Oblon, Spivak, McClelland, Mar. 31, 1995 [JP] Japan .................................. .. 7-097474 Maier & Neustadt P C Aug. 9, 1995 [JP] Japan .................................. .. 7-203576 ’ ' ' [51] Int. Cl.6 ..................................................... .. A61H 1/00 [57] ABSTRACT [52] US. Cl. ................................................................. .. 601/2 An ultrasonic therapeutic apparatus consisting of a thera [58] Field of Search ..................... .. 601/2, 3, 4; 600/449, peutic ultrasonic Wave generating source driven by a driver 600/459 circuit to generate therapeutic ultrasonic Waves, an in vivo imaging probe so as to obtain a tissue tomographic image in [56] References Cited the vicinity of the focus of the therapeutic ultrasonic Waves. U'S' PATENT DOCUMENTS The imaging probe is used to receive echoes of the ultrasonic pulses emitted from therapeutic ultrasonic Wave generating Re. 33,590 5/1991 Dory . source. The driving conditions for the therapeutic ultrasonic 4,617,931 10/1986 Dory . Wave generating source is adjusted on the basis of a received 4,620,546 11/1986 Aida et a1- - echo signal. The received echo signal contains information 4,658,828 4/1987 DOTY- about actual intensity of the therapeutic ultrasonic Waves 479427878 7/1990 Dofy ' Within a living body, thus improving the safety and reliabil 4,986,275 1/1991 Ishida et al. . it of thera 5,076,277 12/1991 IWama et al. .................... .. 128/66003 y W‘ 5,080,101 1/1992 Dory . 5,080,102 1/1992 Dory . 6 Claims, 35 Drawing Sheets CONSOLE 40~ ULTRASONIC DIAGNOSTIC C I SECTION I0 FREGUENCY- INFORMATION -\_ 4‘ {a ANALYZER / ROINTE‘TNG I6 '\~ ~ 43 ULTRASONIC 5 |GNAL THERAPY SECTION GENERATOR J 46(II 5) SYSTEM 2 ’ CONTROLER I \ CALCULATING / SECTION \\ 42 // S 5 \ / 4 44 45 \\ // ( 6 \ ’ MEMORY S \ / 9 U.S. Patent Nov. 16,1999 Sheet 1 0f35 5,984,881 CONSOLE WCAONV E I Nuous NH GENERATING +5 14 CIRCUIT \ \ c T MATCHING _ B PULSE ‘_ * CIRCUIT ‘ RF AMP , w GENERATOR 1 SYNCH— 3 “2 RONIZING ‘ > 4 GNAL m {6 TRANS_ GENERATOR 5 T \ MITTING ° \ CIRCUIT E ( Z 2 s 18 8 4 {7 2O 2 \\ // S E \ / > 5 \\ / m \ ,/ PRE-AMP RECEIVING 6 \ / DELAY /g, - _{> CIRCUIT 3 9x 22 2T‘ V B-MODE 8m1QESSlNG ECHO FILTER / & PULSE DOPPLER UNIT DS'C ‘J S 28/ 27 F- CRT I G- * 29w O U.S. Patent Nov. 16,1999 Sheet 2 0f35 5,984,881 CRT RECEIVING \ DELAY SYSTEM CONTROLER 9 CIRCUIT 2o 29~<> ECHO FILTERl 22 21\ f 3}’ HIGH- K 32H FREQUENCY ~ HPF ) \ PROCESSING 03C cmcun 28 N, 3: LOW » LPF FREQUENCY PROCESSING CIRCUIT "32L ~27 PULSE DOPPLER UNIT FIG. 2 F I G. 3 FOCUS U.S. Patent 5,984,881 Nov. 16, 1999 Sheet 3 0f 35 / SECOND SYNC SIGNAL 4 ULTRASONIC PULSE TIME FOR IMAGING "FIRST SYNC SIGNAL TIME ULTRASONIC PULSE FOR INTENSITY \DISTRIBUTION IMAGING F I 6.4 9,4 H I GH- FREQUENCY PULSE GENERATI NG SW-2 RF-AMP 1 CIRCUIT 11111; I34 SW-I 35 C B I C CONTINUOUS WAVE 18 I H IGH GENERATING CIRCUIT I FREQUENCY SYNCH- < SW-I MC RON I Z I NG IGNAL GENERATOR SCOYNSTRTOELEMR TRANSMITTING IRECEIVING CIRCUIT DSC U.S. Patent Nov. 16,1999 Sheet 5 0f35 5,984,881 RECIEVED 51* 5F 523 SIGNAL FR EQUENCY INIAGING EQUALIZER —SPECTRUM ANALYZER 5mm" 54 55 56 I I I IMAGE ECHO ADDING FILTER ggigggggg" CIRCUIT 29 I 2(8 CRT DIGITAL 3885mm F l G. T (DS-C) HARMONIC HARMONIC FUNDMENTAL WAVE BAND WAVE BAND WAVE BAND (240) (3 f0) I SPECTRUM OF RECIEVED SIGNAL 'f\ -\ / SPECTRUM 0F / / _ ' '\< /ECHO FOR INTENSITY DISTRIBUTION - .- / \ \. IMAGING I \ ._ , / 'l \\ / " >/\"’ FRE UENCY / »/“0' " \~ ~_ “\I ? /%'I>R%%B%%‘SE$% / i % : "J IMA§ING fI f2I'=.2-fII 3-fI f (LTMHZ) (3.5MHZ) FIG. 8 U.S. Patent Nov. 16,1999 Sheet 6 0f35 5,984,881 zorrosmhmmol _:___________\ wPQxwH mm ow U.S. Patent Nov. 16,1999 Sheet 7 0f35 5,984,881 555 o5. 6528 WTAIU EEw>z8 4%” V7a2$am05 2582 8 6A5l8l0% :2 5% 29$55%.2 2 :8mo1mm;wQ oE mmmm 8w m2?@2 52 (%8. 8. 88 v, 558%. EU5 222585 wf E£_5N0m 010m cm 5E.5 E w U.S. Patent Nov. 16,1999 Sheet 8 0f35 5,984,881 SHIFT BAND BY BLOOD STREAM SPECTRUM OF RECIEVED SIGNAL FIG. H U.S. Patent Nov. 16,1999 Sheet 9 0f35 5,984,881 5.51.58 SW55 6 EOE: :575N.?22 4 222 5% 2-25225588?2 w N.h_?0_ Qz22Q?02w5...?5 w m 02:33.20 _‘,J AQ.‘“ 2c02.059052.95:: 2E2s5mmEm x 2\2 6% (8

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Nov 16, 1999 WAVE SOURCE AND AN ULTRASONIC 5,159-71? 9/1992 601/2, 3, 4; 600/ 449, peutic ultrasonic Wave generating source driven by a driver.
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