The Retinoids: Biology, Biochemistry, and Disease

634 Pages·2015·25.554 MB·English

by  Pascal Dollé, Karen Niederreither

The ReTinoids

The ReTinoids
Biology, Biochemistry,
and disease
ediTed By
Pascal Dollé
and
Karen Neiderreither
Copyright © 2015 by Wiley-Blackwell. All rights reserved
Published by John Wiley & Sons, Inc., Hoboken, New Jersey
Published simultaneously in Canada
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Library of Congress Cataloging-in-Publication Data:
Printed in the United States of America
10 9 8 7 6 5 4 3 2 1
Contents
Contributors ix
Preface xiii
Part I: VItamIn a metabolIC and enzymatIC Pathways 1
1
VItamIn a metabolIsm, storage and tIssue
delIVery meChanIsms 3
William S. Blaner and Yang Li
2
assImIlatIon and ConVersIon of dIetary
VItamIn a Into bIoaCtIVe retInoIds 35
Earl H. Harrison and Carlo dela Seña’s
3
IntraCellular storage and metabolIC aCtIVatIon
of retInoIds: lIPId droPlets 57
Joseph L. Napoli and Charles R. Krois
4
eVolutIon of the retInoIC aCId sIgnalIng Pathway 75
Vincent Laudet, Elisabeth Zieger, and Michael Schubert
Part II: bIoChemIstry and Cellular bIology of
retInoIC aCId sIgnalIng 91
5
Control of gene exPressIon by nuClear retInoIC
aCId reCePtors: Post-translatIonal and ePIgenetIC
regulatory meChanIsms 93
Marilyn Carrier and Cécile Rochette-Egly
6
retInoIC aCId reCePtor Coregulators In ePIgenetIC
regulatIon of target genes 117
Li-Na Wei
7
retInoId reCePtors: ProteIn struCture, dna
reCognItIon and struCture–funCtIon relatIonshIPs 131
William Bourguet and Dino Moras
8
how the rar–rxr heterodImer reCognIzes the genome 151
Sylvia Urban, Tao Ye, and Irwin Davidson
v
vi Contents
9
retInoId reCePtor-seleCtIVe modulators: ChemIstry,
3d struCtures and systems bIology 165
Marco-Antonio Mendoza-Parra, William Bourguet,
Angel R. de Lera, and Hinrich Gronemeyer
10
use of retInoId reCePtor lIgands to IdentIfy other
nuClear reCePtor lIgands: retInoId-related moleCules
are lIgands for the small heterodImer Partner (shP)
“orPhan” reCePtor 193
Marcia I. Dawson and Zebin Xia
11
the dual transCrIPtIonal aCtIVIty of retInoIC aCId 273
Noa Noy
12
retInoIds, ePIgenetIC Changes durIng stem Cell
dIfferentIatIon, and Cell lIneage ChoICe 291
Lorraine J. Gudas
Part III: retInoIC aCId sIgnalIng In deVeloPment 307
13
retInoIC aCId sIgnalIng and Central nerVous
system deVeloPment 309
Malcolm Maden
14
the role of retInoIC aCId In lImb deVeloPment 339
Gregg Duester
15
retInoIC aCId sIgnalIng and heart deVeloPment 353
Stéphane Zaffran and Karen Niederreither
16
retInoIC aCId In the deVeloPIng lung
and other foregut derIVatIVes 371
Wellington V. Cardoso and Felicia Chen
17
retInoIC aCId and the Control of meIotIC InItIatIon 383
Josephine Bowles and Peter Koopman
Part IV: retInoIds and PhysIologICal funCtIons 401
18
retInoIds and the VIsual CyCle: new aCtors
for an “old” funCtIon 403
Darwin Babino and Johannes von Lintig
19
retInoId sIgnalIng In the Central nerVous system 421
Peter McCaffery and Wojciech Krężel
20
retInoId turnoVer and CatabolIsm: InfluenCes
of dIet and InflammatIon 449
A. Catharine Ross and Reza Zolfaghari
Contents vii
21
retInoIds and the Immune system 465
J. Rodrigo Mora and Makoto Iwata
22
retInoIC aCId reCePtor sIgnalIng In Post-natal
male germ Cell dIfferentIatIon 485
Manuel Mark and Norbert B. Ghyselinck
Part V: retInoIds, dIsease and theraPy 505
23
ePIdemIology and PreVentIon
of VItamIn a defICIenCy dIsorders 507
Keith P. West, Jr.
24
retInoId Pathway gene mutatIons and the
PathoPhysIology of related VIsual dIseases 529
Yaroslav Tsybovsky and Krzysztof Palczewski
25
retInoIC aCId In aCute myeloId leukemIas 543
Hugues de Thé and Pierre Fenaux
26
adVanCes In the use of retInoIds In CanCer
theraPy and PreVentIon 557
Michael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky
Index 575