The Overlap of Affective and Schizophrenic Spectra PDF
Preview The Overlap of Affective and Schizophrenic Spectra
This page intentionally left blank The Overlap of Affective and Schizophrenic Spectra An increasing number ofclinicians and researchers are now favoring an overlap between affective and schizophrenic spectra. In this book, an international team ofexperts discuss aspects ofcomorbidity, genetic models, clinical course, phenomenology and therapies. This is thefirst comprehensive overview ofthis area ofoverlap. Challenging cases presenting clinical and paraclinical features ofboth spectra are surprisingly numerous. Not only the phenomenology but also the course, outcome and treatment ofsuch cases have their own characteristics. Recent research shows that the overlap also involves genetics and biological processes related to psychotic disorders. Within the overlap ofaffective and schizophrenic spectra it is possible to identify some groups ofdisorders having similar clinical and non-clinical features: the “Schizoaffective”group, “Acute and Transient Psychotic Disorder”or “BriefPsychosis,”and other groups found in so-called “Atypical Forms.” Andreas Marnerosis Professor ofPsychiatry in the Department ofPsychiatry and Psychotherapy at the Martin Luther University in Halle-Wittenberg, Germany. He won the Kraeplin Research Prize in 2002 for his work on psychoses, especially schizoaffective and acute briefpsychoses. Hagop Akiskalis Professor ofPsychiatry and Director ofthe International Mood Center at the University ofCalifornia at San Diego. Among his awards are the Anna Monika Prize for research on the depressive spectrum, and the World Psychiatric Association’s Jean Delay Prize for bridging clinical and research perspectives in the bipolar spectrum. The Overlap of Affective and Schizophrenic Spectra Andreas Marneros Department ofPsychiatry and Psychotherapy, Martin Luther University,Halle-Wittenberg,Germany Hagop S. Akiskal International Mood Center, University ofCalifornia at San Diego,USA CAMBRIDGE UNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge CB2 8RU, UK Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521858588 © Cambridge University Press 2007 This publication is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published in print format 2006 ISBN-13 978-0-511-26872-4 eBook (EBL) ISBN-10 0-511-26872-6 eBook (EBL) ISBN-13 978-0-521-85858-8 hardback ISBN-10 0-521-85858-5 hardback Cambridge University Press has no responsibility for the persistence or accuracy of urls for external or third-party internet websites referred to in this publication, and does not guaranteethatanycontentonsuchwebsitesis,orwillremain,accurateorappropriate. Contents List ofcontributors pagevii Preface pagexi 1 The paradigma ofoverlapping affective and schizophrenic spectra: schizoaffective conditions 1 Andreas Marneros 2 The overlapping ofthe spectra: overlapping genes and genetic models 25 John R. Kelsoe 3 The continuum ofpsychosis and its genetic basis 43 T. J. Crow 4 Functional psychoses: molecular-genetic evidence for a continuum 55 Hans H. Stassen, Christian Scharfetter and Jules Angst 5 State- and trait-related deficits in sustained attention in bipolar disorder: are there any overlaps with schizophrenia? 79 Luke Clark 6 The concept ofschizoaffective disorder: utility versus validity and reliability – a transcultural perspective 104 Ahmed Okasha 7 Phenomenological approaches to the schizoaffective spectrum 133 William Coryell 8 Clinical course ofschizoaffective disorders 145 Maria Reinares, Eduard Vieta, Antoni Benabarre and Andreas Marneros 9 Depressive syndromes in schizophrenia 156 Wolfgang Gaebel, Ellen Bittner and Wolfgang Wölwer v vi Contents 10 The overlapping ofthe spectra: briefand acute psychoses 182 Frank Pillmann and Andreas Marneros 11 Overlapping ofthe spectra: physical comorbidity between schizophrenia and affective disorders 207 William S. Stone, Andrea H. Roe and Ming T. Tsuang 12 The overlapping ofthe spectra suicide 224 Simavi Vahip 13 Biological treatment ofschizoaffective disorders 248 Christopher Baethge 14 Psychological therapies and schizoaffective disorders 264 Jan Scott Epilogue: The interface ofaffective and schizophrenic disorders: a cross between two spectra? 277 Hagop S. Akiskal Index 293 Contributors Hagop S.Akiskal Ellen Bittner International Mood Center Department ofPsychiatry University ofCalifornia at San Diego Heinrich-Heine-Universität Düsseldorf VA Psychiatry Service 116A Bergische Landstrasse 2 3350 La Jolla Village Drive Postbox 12 05 10 San Diego, CA 92161 D-40605 Düsseldorf USA Germany Jules Angst Luke Clark Psychiatrische Universitätsklinik Zürich Department ofExperimental Psychology Postfach 68 University ofCambridge CH_8029 Zürich Downing Street Switzerland Cambridge CB2 3EB UK Christopher Baethge Department ofPsychiatry and William Coryell Psychotherapy University ofIowa University ofCologne Medical School Department ofPsychiatry Kerpener Str. 69 500 Newton Rd 50 924 Cologne Iowa City Germany IA 52242 USA Antoni Benabarre Bipolar Disorders Program T.J.Crow Institute ofNeuroscience SANE Prince ofWales International Centre Hospital Clinic Warneford Hospital University ofBarcelona Oxford OX3 7JX Spain UK vii viii List of contributors Wolfgang Gaebel Maria Reinares Department ofPsychiatry Bipolar Disorders Program Heinrich-Heine-Universität Düsseldort Institute ofNeuroscience Bergische Landstrasse 2 Hospital Clinic Postbox 12 05 10 University ofBarcelona D-40605 Düsseldorf Spain Germany Andrea H.Roe John R.Kelsoe Department ofPsychiatry, 0603 Christian Scharfetter University ofCalifornia, San Diego Psychiatrische Universitätsklinik Zürich 9500 Gilman Drive Postfach 68 La Jolla, CA 92093 CH-8029 Zürich USA Switzerland Andreas Marneros Jan Scott Klinik und Poliklinik für Psychiatrie und P. O. Box 96 Psychotherapie Department ofPsychological Medicine Martin Luther Universität Institute ofPsychiatry Julius-Kühn-Strasse 7 Denmark Hill 06097 Halle/Saale London, SE5 9AF Germany UK Ahmed Okasha Hans H.Stassen Director, WHO Collaborating Center for Psychiatrische Universitätsklinik Zürich Training and Research in Mental Health Postfach 68 Institute ofPsychiatry CH-8029 Zürich Ain Shams University Switzerland Cairo Egypt William S.Stone Frank Pillmann Ming T.Tsuang Department ofPsychiatry and Psychotherapy Massachusetts Mental Health Center Division Martin Luther Universität of Public Sector Psychiatry, Beth Israel Julius-Kühn-Strasse 7 Deaconess Medical Center and Harvard 06097 Halle/Saale Medical School Departments ofPsychiatry Germany Boston, MA USA
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