Stimulated Cerebral Blood Flow: Experimental Findings and Clinical Significance PDF
Preview Stimulated Cerebral Blood Flow: Experimental Findings and Clinical Significance
P. Schmiedek K. Einhaupl C.M. Kirsch (Eds.) Stimulated Cerebral Blood Flow Experimental Findings and Clinical Significance With 97 Figures and 48 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Prof. Dr. Peter Schmiedek Prof. Dr. Karl Einhaupl Neurochirurgische Klinik Neurologische Klinik Klinikum GroBhadem Klinikum GroBhadem MarchioninistraBe 15 MarchioninistraBe 15 8000 Miinchen 70 8000 Miinchen 70 Priv.-Doz. Dr. Carl-Martin Kirsch Radiologische Klinik Klinikum GroBhadem MarchioninistraBe 15 8000 Miinchn 70 ISBN-13:978-3-642-77104-0 eISBN-13:978-3-642-77102-6 DOI:10.1007/978-3-642-77102-6 This work is subject to copyright. All rights are reserved, whether the whole or part of the mate rial is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplicati ons of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag, Berlin Heidelberg 1992 Softcover reprint of the hardcover 1st edition 1992 Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof in this book. In every individual case the respective user must check its accu racy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The logo on the cover was designed for the meeting and represents the lateral aspect of the brain at rest (bottom) and during stimulation (top). Typesetting: Fotosatz Reiter, Berchtesgaden 2125/3335-543210 - Printed on acid-free paper List of Authors and Participants Altehoefer, c., Depmtment of Nuclear Medicine, Technical University of Aachen, Aachen, Germany Back, T., Max-Planck-Institute of Neurogical Research, University of Cologne, Colo gne, Germany Baethmann, A., Institute for Surgical Research Ludwig-Maxirhilians-University, Munich, Germany Bares, R., Department of Nuclear Medicine, Technical University of Aachen, Aachen, Germany Batjer, H., Department of Neurological Surgery, University of Texas, Dallas, U.S.A Bauer, C., Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany Boerschel, M., Department of Neurology, Ludwig-Maximilians-University, Munich, Germany Bishop, CCR., Department of Surgery, St. Thomas Hospital, London, UK Bouvard, G., Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France Brandt, TH., Department of Neurology, Ludwig-Maximilians-University, Munich, Germany Buell, U., Department of Nuclear Medicine, Technical University of Aachen, Aachen, Germany Carter, Ph., Department of Neurosurgery, University of Arizona, Tucson, U.S.A. Celsis, P., Department of Neurology, CHU Purpan, Toulouse, France Chambers, I., Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK Chollet, F., Department Neurology, CHU Purpan, Toulouse, France Coull, F., Wessex Neurological Center, Southampton General Hospital, Southampton, UK Dahl, A., Department of Neurology, The National Hospital, University of Oslo, Oslo, Norway Derlon, JM., Department of Neurosurgery, CHU Cote de Nacre, Caen, France Dickman, CA., Department of Nuclear Medicine, University of Arizona, Tucson, U.S.A. Diener, HC., Neurologische Universitatsklinik, Essen, Germany Dietz, H., Department of Neurosurgery, Hannover Medical School, Hannover, Ger many Dimagl, U., Department of Neurology, Ludwig-Maximilians-University, Munich, Ger many VI List of Authors and Participants Droste, DW., Department of Neurosurgery, Technical University of Aachen, Aachen, Germany Einhaupl, K., Department of Neurology, Ludwig-Maximilians-University, Munich, Germany Fink, GR., Max-Planck-Institute of Neurological Research, University of Cologne, Cologne, Germany Fitch, W., Wellcome Surgical Institute, University of Glasgow, Scotland Friberg, L., Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospi tal, Glostrup, Denmark Fiirst, H., Department of Surgery, Ludwig-Maximilians-University, Munich, Germany Gaab, MR., Department of Neurosurgery, Hannover Medical School, Hannover, Ger many Graham, RD., Wellcome Surgical Institute, University of Glasgow, Scotland Grond, M., Max-Planck-Institute of Neurological Research, University of Cologne, Cologne, Germany Gratzl, 0., Department of Neurosurgery, University of Basel, Basel, Switzerland Haase, J., Department of Neurosurgery, Arlborg, Denmark Haberl, R., Department of Neurology, Ludwig-Maximilians-University, Munich, Ger many Hacke, W., Department of Neurology, University of Heidelberg, Heidelberg, Germany Harders, AG., Department of Neurosurgery, Technical University of Aachen, Aachen, Germany Harms, A., Department of Neurology, Humboldt-University, Berlin, Germany Haubitz, B., Department of Neuroradiology, Hannover Medical School, Hannover, Germany Heissler, HE., Department of Neurosurgery, Hannover Medical School, Hannover, Germany Heiss, WD., Max-Planck-Institute of Neurological Research, University of Cologne, Cologne, Germany Holl, K., Department of Neurosurgery, Hannover Medical School, Hannover, Ger- many Houtteville, JP., Department of Neurosurgery, CHU Cote de Nacre, Caen, France Iadecola, c., Department of Neurology, University of Minnesota, Minneapolis, U.S.A. Isensee, K., Department of Nuclear Medicine, Technical University of Aachen, Aachen, Germany Kane, PJ., Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK Kaiser, HJ., Department of Nuclear Medicine, Technical University of Aachen, Aachen; Germany Kempski, 0., Institute for Neurosurgical Pathophysiology, University of Mainz, Mainz, Germany Kim, P., Department of Neurosurgery, University of Tokyo, Tokyo, Japan Kirsch, CM., Department of Radiology/Nuclear Medicine, Ludwig-Maximilians-Uni versity, Munich, Germany Kleiser, B., Department of Neurology, University of Ulm, Ulm, Germany List of Authors and Participants VII Kuschinsky, W., Department of Physiology, University of Heidelberg, Heidelberg, Germany Kummer, v. R., Department of Neurology, University of Heidelberg, Heidelberg, Ger many Labhorde, G., Department of Neurosurgery, Technical University of Aachen, Aachen, Germany Lechevalier, B., Department of Nuclear Medicine, CHU Cote de Nacre, Caen, France Leinsinger, G., Department of Radiology/Nuclear Medicine, Ludwig-Maximilians University, Munich, Germany Lienau, N., Lederle Company, Wolfratshausen, Germany Lissner, I., Department of Radiology, Ludwig-Maximilians-University, Munich, Ger many Lovick, AHI., Department of Neurosurgery, Southampton General Hospital, Sout hampton, UK Marguth, F., Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany Mendelow, AD., Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK Morin, P., Department of Neurology, CHU Cote de Nacre, Caen, France Milller, HR., Department of Neurology, University of Basel, Basel, Switzerland Milller-Brand, I., Department of Nuclear Medicine, University of Basel, Basel, Swit- zerland Nelson, RI., Department of Neurosurgery, Frenchay Hospital, Bristol, UK Nemati, MN., Department of Neurosurgery, Hannover Medical School, Hannover, Germany Nyberg-Hansen, R., Department of Neurology, The National Hospital, University of Oslo, Oslo, Norway Paulson, OB., Department of Neurology, Rigshospitalet, Copenhagen, Denmark Pawlik, G., Max-Planck-Institute of Neurological Research, University of Cologne, Cologne, Germany Petit, ML., PET Laboratory, Caen, France Pickard, ID., University of Cambridge Neurosurgery Unit, Cambridge, UK Piepgras, A., Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany Pietrzyk, U., Max-Planck-Institute of Neurological Research, University of Cologne, Cologne, Germany Radil, EW., Department of Neuroradiology, University of Basel, Basel, Switzerland Read, DH., Department of Neurosurgery, Frenchay Hospital, Bristol, UK Reiche, W., lJepartment of Nuclear Medicine, Technical University of Aachen, Aachen, Germany Rem, IA., Department of Neurosurgery, University of Basel, Basel, Switzerland Ringelstein, EB., Department of Neurology, Technical University of Aachen, Aachen, Germany Rootwelt, K., Institute of Chemical Biochemistry, The National Hospital, University of Oslo, Oslo, Norway VIII List of Authors and Participants Russel, D., Department of Neurology, The National Hospital, University of Oslo, Oslo, Norway Rzesacz, EH., Department of Neurosurgery, Hannover Medical School, Hannover, Germany Schmidt, J., Department of Neurology, Rigshospotalet, Copenhagen, Denmark Schmiedek, P., Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany Schiirer, L., Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany Stanley, Je., Wessex Neurological Center, Southampton General Hospital, Sout hampton, UK Strachan, RD., Department of Neurosurgery, Newcastle General Hospital, Newcastle Upon Tyne, UK Stummer, W., Institute for Surgical Research, Ludwig-Maximilians-University, Munich, Germany Tuor, U., Wellcome Surgical Institute, University of Glasgow, Scotland Unterberg, A W., Department of Neurosurgery, Free University of Berlin, Berlin, Ger many Viader, F., Department of Neurology, CHU Cote de Nacre, Caen, France Vilringer, A., Department of Neurology, Ludwig-Maximilians-University, Munich, Germany Vorstrup, S., Department of Neurology, Righospitalet, Copenhagen, Denmark Wahl, M., Physiological Institute, Ludwig-Maximilians-University, Munich, Germany Waldemar, G., Department of Neurology, Righospitaiet, Copenhagen, Denmark Weissenborn, K., Department of Neurology, Hannover Medical School, Hannover, Germany Widder, B., Department of Neurology, University of Ulm, Ulm, Germany Yonas, H., Department of Neurosurgery, University of Pittsburgh, Pittsburgh, U.S.A. Mailing List of Authors Batjer, H., Department of Neurological Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallars, Texas 75235-8855, U.S.A. Bishop, C.c.R., Department of Surgery, United Medical Schools, St. Thomas Hospital, London, UK Buell, U., Department of Nuclear Medicine, Technical University of Aachen, Pauwels straBe 30, 5100 Aachen, Germany Carter, Ph., Department of Surgery, Section of Neurosurgery, University of Arizona Medical Center, 1501 North Campbell, Tucson, Arizona 85724, U.S.A. Derlon, JM., Department of Neurosurgery, CHU Cote de Nacre, 14033 Caen, France Friberg, L., Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospi tal, 2600 Glostrup, Denmark Haberl, R., Department of Neurology, Klinikum GroBhadern, Ludwig-Maximilians University, MarchioninistraBe 15,8000 Munich, Germany Harders, AG., Department of Neurosurgery, Technical University of Aachen, Pauwels straBe 30, 5100 Aachen, Gennany Holl, K., Department of Neurosurgery, Hannover Medical School, Konstanty-Gut schow-StraBe 8, 3000 Hannover, Germany ladecola, c., Department of Neurology, University of Minnesota, Box 295 UMHC, 420 Delaware Street S.E., Minneapolis, MN, 55455, U.S.A. Kempski, 0., Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-Uni versity of Mainz, LangenbeckstraBe 1, 6500 Mainz, Germany Kim, P., Department of Neurosurgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan Kleiser, B., Department of Neurology, University of Ulm, SteinhovelstraBe 9, 7900 Ulm, Germany Kuschinsky, W., Department of Physiology, University of Heidelberg, 1m Neuenhei mer Feld 326,< 6900 Heidelberg, Germany Kummer, v. R., Department of Neurology, University of Heidelberg, 1m Neuenheimer Feld 326, 6900 Heidelberg, Germany Leinsinger, G., Department of Radiology/Nuclear Medicine, Klinikum GroBhadern, Ludwig-M.aximilians-University, MarchioninistraBe 15,8000 Munich, Germany Mendelow, AD., Department of Neurosurgery, Newcastle General Hospital, Westgate Road, Newcastle Upon Tyne NE4 6BE, UK Nyberg-Hansen, R., Department of Neurology, Rikshospitalet, The National Hospital, University of Oslo, 0027 Oslo 1, Norway X Mailing List of Authors Pawlik, G., Max-Planck-Institute of Neurological Research, University of Cologne, Gleueler StraBe 50, 5000 Cologne 41, Gennany Pickard, JD., University of Cambridge Neurosurgery Unit, Level 4, A Block, Adden brooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK Piepgras, A., Department of Neurosurgery, KLinikum GroBhadem, Ludwig-Maximili ans-University, MarchioninistraBe 15,8000 Munich, Gennany Rem, JA., Department of Neurosurgery, University of Basel, SpitalstraBe 21, 4031 Basel, Switzerland Ringelstein, EB., Department of Neurology, Technical University of Aachen, Pauwels straBe 30, 5100 Aachen, Gennany Schmiedek, P., Department of Neurosurgery, KLinikum GroBhadem, Ludwig-Maxi milians-University, MarchioninistraBe 15, 8000 Munich, Gennany Unterberg, A W., Department of Neurosurgery, Rudolf Virchow Medical Centre, Free University of Berlin, Augustenburger Platz 1, 1000 Berlin 65, Gennany Vilringer, A., Department of Neurology, Klinikum GroBhadem, Ludwig-Maximilians University, MarchioninistraBe 15, 8000 Munich, Gennany Vorstrup, S., Department of Neurology, Righospitalet, 9, Blegdamsvej, 2100 Copenha gen, Denmark Wahl, M., Department of Physiology, Ludwig-Maximilians-University, Pettenkofer straBe 12,8000 Munich 2, Germany Yonas, H., Department of Neurosurgery, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, PA 15213, U.S.A. Contents Preface ........................................................... XV Chapter 1: Regulation of Cerebral Blood Flow Regulation of Cerebral Blood Flow: A Brief Review A. UNTERBERG and M. WAHL ......................................... 3 Capillary Perfusion in the Brain W. KUSCHINSKY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Intrinsic and Extrinsic Neural Regulation of the Cerebral Circulation C. IADECOLA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Endothelium-Dependent Relaxations and Concentrations: Their Physiology in the Cerebral Arteries and Pathology in Experimental Cerebral Vasospasm P. KIM........................................................... 37 Mechanisms of Cerebral Vasodilatation During Neuronal Activation by Bicuculline: A Review M. WAHL......................................................... 50 Postischemic Hyperperfusion and Outcome: An Experimental Study O. KEMPSKI, W. STUMMER, C. BAUER, L. SCIrtiRER, and A. BAETHMANN 55 Chapter 2: Methods for the Measurement of Cerebral Blood Flow Erythrocyte Flow in Cerebral Capillaries Under Resting and Stimulated Conditions A. VILLRINGER, U. DIRNAGL, A. PIEPGRAS, P. SCHMIEDEK, and K.M. EINHAuPL . . . 61 Continuous Measurement of Acetazolamide Stimulated Cerebral Blood Flow by Laser Doppler Flowmetry R.L. HABERL, M. BOERSCHEL, U. DIRNAGL, A. PIEPGRAS, P. SCHMIEDEK, and K.M. EINHAUPL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66
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