Smart Materials for Drug Delivery: Complete Set (Volumes 1 & 2)

841 Pages·2013·26.761 MB·English

by  Carmen Alvarez-Lorenzo, Angel Concheiro

Smart Materials for Drug Delivery
Volume 1
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RSC Smart Materials
Series Editor:
Hans-Jo¨rg Schneider, Saarland University, Germany
Mohsen Shahinpoor, University of Maine, USA
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How to obtain future titles on publication:
A standing order plan is available for this series. A standing order will bring
delivery of each new volume immediately on publication.
For further information please contact:
BookSalesDepartment,RoyalSocietyofChemistry,ThomasGrahamHouse,
Science Park, Milton Road, Cambridge, CB4 0WF, UK
Telephone: [phone],Fax:[phone]
Email:[email protected]
Visit our website atwww.rsc.org/books
View Online
Smart Materials for Drug
Delivery
Volume 1
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18 Carmen Alvarez-Lorenzo
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Down 25 rTheRoyalSocietyofChemistry2013
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PublishedbyTheRoyalSocietyofChemistry,
ThomasGrahamHouse,SciencePark,MiltonRoad,
CambridgeCB40WF,UK
RegisteredCharityNumber207890
Forfurtherinformationseeourwebsiteatwww.rsc.org
PrintedintheUnitedKingdombyHenryLingLimited,Dorchester,DT11HD,UK
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F Foreword
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0.1 Inrecent yearssmartmaterials havefoundnewandpromising applications as
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oi: drug carriers for delivery of new therapeutic agents. At a time when present
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5. g | uses of drug delivery have become rather difficult to launch commercially
3 10:25:4ubs.rsc.or bpfoerrocmavuiudsleeatnoioefwntshahepappvlreicenasstouitornefosf,urenosdmpegcogieoanldleyruiiscne.dthIrnuedgterededaet,limvineetrneytlliosgyfesndtetismbeaiso,semssmawtaehrrteiarmel capatrererrsiieeanrlsst
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d on 01/09/20013 on http:// hpoahfTvyaeshnieaoallpyotttrgreeiasscceartnleetsdcpobonosnidogsikntibiioifilsencasafonowrtfeatlihcnpeotaembrroteeisdcatyud,lbadberiutcidtaoiuanslesseatoosetot.ofhertehfispeelodpnrdooftmosmiesleaervttaopteodrleyqsmpuoearnnsdtiatniteods
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Downloadn 25 April cdPoermloivfeeessrsyto.orAsfiCsllwaaremmreeanajdoArtlhvneaerveedazr-iiLonoutrshecnehzuaospeatneordsfAistmnbgaeercltoCmmoeanstceahrpieapilrasoraeosnftcthtaherarUitertnhsivefeoerrdsiidttyorurosgf,
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d Santiago de Compostela, have set specific goals for this book and have spent
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sh numerousdaystryingtoeditthechaptersandbalancethebook.Theirgoalsare
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u to highlight the design, characterization and investigation of the next
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generation of ‘‘intelligent’’ or smart polymeric structures and biohybrids that
can be used for drug delivery and can ‘‘communicate’’ with their surrounding
environment.
The use of smart polymer carriers is a natural approach to the solution of
manydelivery problemsasthediscoveryanddelivery ofdrugstocurechronic
diseaseshavebeenachievedbyacombinationofintelligentmaterialdesignand
advancesinnanotechnology.Inparticular,therehasbeenconsiderableworkin
preparing nanostructured biomaterials for various applications, such as
carriers for controlled and targeted drug delivery, micropatterned devices,
systems for biological recognition, and others. Since many drugs act as
protagonistsorantagoniststodifferentchemicalsinthebody,adeliverysystem
that can respond to the concentrations of certain molecules in the body is
RSCSmartMaterialsNo.2
SmartMaterialsforDrugDelivery:Volume1
EditedbyCarmenAlvarez-LorenzoandAngelConcheiro
rTheRoyalSocietyofChemistry2013
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
v
View Online
vi Foreword
invaluable. For this purpose, intelligent therapeutics or ‘‘smart drug delivery’’
call for the design of the next generation of responsive devices and materials,
bothfrompurelysyntheticmaterialsaswellasthroughcombinationofnatural
and biological molecules with synthetic materials.
In other advanced pharmaceutical applications, biomimetic materials,
05 especially polymeric networks, capable of biological recognition can be
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0-
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3 interactionsbyathree-dimensionalstructure.Inaddition,biomimeticmethods
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4 are now used to build biohybrid systems or even biomimetic materials
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81 (mimicking biological recognition) for drug targeting and tissue engineering
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9/9 devices.Additionally,micro-andnanofabricationtechniqueshaveenabledthe
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0 developmentofnovelbiomedicalsystems,sensorsanddeliverydevicesthatcan
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10. improve the therapeutic effect of drugs, such as micro- and nanoscale needles,
doi: pumps, valves, and implantable drug delivery devices. These advances are
5. g | expertly presented in this book.
3 10:25:4ubs.rsc.or devWelhoypmdoenwtoefonbasneorvpearstuiccuhlaatneseyxsptelomssiofnoribniorleosgeaicraclhapinpltihcaistiofinelsdhnasowta?keTnhae
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he inorganic and organic materials, dendrimers, self-assembled monolayers and
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bli biological/synthetic constructs.
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engineering for scientists with a broad, but strong, background in materials
engineering and biological sciences, this book will promote the investigation
and utilization of novel macromolecular structures, biohybrid systems and
biopolymers with ability to interact with or recognize external phenomena
associated with biological or physiological solutions. The book incorporates
educational and research components with emphasis on the synthesis, design,
development and analysis of novel structures useful in the biomedical,
biochemical, cellular and related fields.
Nanostructuredmaterialshavethuscreatedgreatexcitementinresearchand
industrial circles because of numerous and diverse applications in electronic
devices, automobile engines, industrial catalysts, and cosmetics. To date, and
despite their great promise, applications of nanophase materials in the
biomedical field (other than in drug delivery) have been close to nonexistent.
Undoubtedly,thecapabilityofsynthesizingandprocessingnanomaterialswith
tailoredstructuresandenhancedpropertiesprovidestremendousopportunities
for designing novel biomaterials of exceptional promise for biomedical
applications.
View Online
Foreword vii
Finally, the book addresses some of the novel applications of intelligent
materials which can be used in electronic devices. This raises exciting possi-
bilities for combining microelectronics and biotechnology to develop new
technologieswithunprecedentedpowerandversatility.Thus,inrecentyearswe
haveseenanexplosioninthefieldofnovelmicrofabricatedandnanofabricated
05 devices for drug delivery.
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3 chapters.Afteracarefulintroductionoftheimportanceofintelligentpolymers
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4 indrugdeliverybytheeditorsCarmenAlvarez-LorenzoandAngelConcheiro,
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81 expert reviews of temperature and pH-sensitive liposomes are presented by
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9/9 David Needham of Duke University and S. P. Vyas and associates of Dr.
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0 Harisingh Gour University. The corresponding behavior of temperature and
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10. pH-sensitive micelles is addressed by C. Kojima of Osaka Prefecture
doi: University. William Pitt and associates of the University of Utah address
5. g | interesting and important applications of ultrasound-triggered release from
3 10:25:4ubs.rsc.or miPceolllyems.ersomes are a relatively new class of important intelligent polymer
d on 01/09/201013 on http://p sbicnteyrtluleGulclltiiaguuresrneedsptrputshegyaBsdttaeectlmaitvansegrbluyieat,iulaoiszsfeetcdhareirenedUfuduncrlilutvyigoeprndsr-eiestlseyievnnoesrtifteyiSd.vheTbehffiyniaseRnlsd.ou.CsbTyjhsewetcenotmgii,smsFepmx.opMoretsratetlnnlyytg,aafodsCprd.ericDentstsesrneoadgf-
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Dowon 25 StrIanthsuclbysdeeq.uentchapters,theeditorshavetriedtopresentimportantbiological
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bli associatesfromtheUniversityofNottinghamaddresstheuseofbioresponsive
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latest knowledge on UV and near-IR triggered release from nanoparticles.
Another important triggering mechanism is heating via remote irradiation of
gold nanoparticles-based systems, which is addressed by E. K. Lim and
associatesofYonseiUniversity.Finally,magnetic-responsivenanoparticlesfor
drug delivery are expertly presented by Ting-Yu Liu of the National Taiwan
University and associates.
Recentadvances innanoscalesystemsbasedon inorganicmaterials thatare
findingapplicationsindrugdeliveryarepresentedbyMariaVallet-Regiofthe
Complutense University (silica nanoparticles) and Gerard Tobias and
EmmanuelFlahautofCMAB-CSIC,Barcelona,SpainandtheUniversityPaul
Sabatier (smart carbon nanotubes). The use of smart layer-by-layer films is a
powerful new method with important applications in drug delivery and is
expertly discussed by S. Sukhishvili and S. Pavlukhina of Stevens Institute of
Technology.
Inthenextfewchapters,theeditorshaveelectedtopresentnewapplications
of intelligent hydrogels, a subject of major interest to the medical and phar-
maceuticalfields.Thus,FrancescoPuociandManuelaCurciooftheUniversity
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viii Foreword
of Calabria discuss temperature- and pH-responsive hydrogels, Jose Carlos
Rodriguez-Cabello and associates of the University of Valladolid address
elastin-like hydrogels and self-assembled nanostructures, while Mario and
Ilaria Casolaro discuss multiple stimuli-responsive hydrogels. The editors
CarmenAlvarez-LorenzoandAngelConcheiroofferanexpertpresentationof
05 molecularly-imprinted hydrogels and associated techniques. These materials
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81 control of cells and related biological organisms. Numerous surface micro-
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doi: fromthecells.TeruoOkanoandH.TakahashioftheTokyoWomen’sMedical
5. g | University present a thorough review of the latest research on intelligent
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Downloadn 25 April pptrrhiogygcseeiosrsilnoingggiocfarolsrwvcaritercaihatibinnlgegsoc,antr/oroiffeirllsdnroeufsgsvramerlieaeardksaeerracsrheoitaredctdtourreees,sxeatdenrdinnathtlhesertipemsrpeusoleinnsutivsbeeofnuoelkss.foItonr
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d additiontosmallsyntheticdrugs,otherclassesoftherapeuticmoleculesoreven
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sh cells are covered. A balance between novelty and clinical possibilities was the
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thecarrierarchitectureandthestimulusthatactivatestherelease.Drug-device
combinationproductswerealsotakenintoaccount.Anefforthasbeenmadeto
not be lost in the particular details, but to prioritize the general concepts that
are behind the design and functioning of intelligent drug delivery systems.
Itwastrulyrewardingwhentheinvitedcontributorsansweredverypositively
tothebookproject.Weareindebtwithallofthemfortheireffortsonwriting
comprehensive as well as educational chapters, covering in detail the state-
of-the-art in each assigned topic. Our acknowledgement goes also to Prof.
NicholasPeppasforhisalwaysencouragingcommentsandthekindforeword,
and to the people of the RSC editorial office, particularly Mrs. Alice Toby-
Brant,forprovidinganinvaluablehelpwithformalandnotsoformalaspects.
RSCSmartMaterialsNo.2
SmartMaterialsforDrugDelivery:Volume1
EditedbyCarmenAlvarez-LorenzoandAngelConcheiro
rTheRoyalSocietyofChemistry2013
PublishedbytheRoyalSocietyofChemistry,www.rsc.org
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