Regenerative Pharmacology

386 Pages·2013·19.05 MB·English

by  George J. Christ

more information - www.cambridge.org/9780521899499

REGENERATIVE PHARMACOLOGY
Regenerativemedicineisbroadlydefinedastherepairorreplacementofdamagedcells,tissues,andorgans.
Itisamultidisciplinaryeffortinwhichtechnologiesderivefromthefieldsofcell,developmental,andmolec-
ular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation;
immunology;moleculargenetics;physiology;andpharmacology.Asregenerativemedicinetechnologiescon-
tinuetoevolveandexpandacrosstheboundariesofnumerousscientificdisciplines,theyremainattheforefront
ofthetranslationalresearchfrontierwiththepotentialtoradicallyalterthetreatmentofawidevarietyofdis-
easeanddysfunction.Thegoalofthisbookistodrawattentiontothecriticalrolethatthepharmacological
scienceswillundeniablyplayintheadvancementofthesetreatments.Thisbookisinvaluableforadvanced
students,postdoctoralFellows,researchersnewtothefieldofregenerativemedicineanditscompanionfield,
tissue engineering, as well as experienced investigators looking for new research avenues. This is the first
state-of-the-artbookinthisrapidlyevolvingfieldofresearch.
george j. christisProfessorofRegenerativeMedicineandTranslationalScienceandheadoftheProgram
inCell,TissueandOrganPhysiologyattheWakeForestInstituteforRegenerativeMedicine.Heisanaffiliate
facultyintheMolecularMedicineandMolecularGeneticsPrograms,aswellastheVirginiaTech–WakeForest
UniversitySchoolforBiomedicalEngineeringandSciences.HealsoholdsappointmentsintheDepartments
ofUrologyandPhysiologyandPharmacologyandtheStichtCenterforAging.Heistheformerdirectorand
founderoftheInstituteforSmoothMuscleBiologyattheAlbertEinsteinCollegeofMedicine.Dr.Christis
aninternationallyrecognizedexpertinmusclephysiology.HeisthepastchairmanoftheDivisionofSystems
and Integrative Pharmacology of the American Society of Pharmacology and Experimental Therapeutics
(ASPET)andpastpresidentoftheNorthCarolinaTissueEngineeringandRegenerativeMedicineSociety.
HecurrentlyservesontheExecutiveCommitteeoftheDivisionforIntegrativeSystems,Translationaland
ClinicalPharmacologyofASPET.Heisontheeditorialboardoffivejournalsandhasauthoredmorethan
200scientificpublications.Dr.Christhasservedonbothnationalandinternationalcommitteesrelatedtohis
expertiseandhasalsoservedonNIHstudysectionsintheNIDDK,NICHD,NCRR,andNHLBI.Hehas
chairedworkinggroupsforboththeNIHandtheWorldHealthOrganization.Dr.Christisaco-inventoron
morethan24patents(nationalandinternational),whichareeitherissuedorpending,relatedtogenetherapyfor
thetreatmentofhumansmoothmuscledisordersandtissueengineeringtechnologies.Heisaco-founderand
directingmemberofIonChannelInnovations,LLC,adevelopment-stagebiotechnologycompanypioneering
theuseofgenetherapyforthetreatmentofhumansmoothmuscledisorders.Inaddition,heisaco-founder
and board member of Creative Bioreactor Design, Inc., another early-stage biotechnology company in the
expandingfieldofregenerativemedicineandtissueengineering.
karl-erik andersson, MD, PhD, is Professor of Regenerative Medicine and Urology at Wake Forest
Institute for Regenerative Medicine. He also holds appointments in the Departments of Physiology and
Pharmacology and Molecular Medicine at Wake Forest University School of Medicine. He has Swedish
Specialist Degrees in internal medicine and clinical pharmacology and a PhD in pharmacology from the
University of Lund, Sweden. From 1978 to 2006, he was Professor and Chairman of the Department of
ExperimentalandClinicalPharmacology,UniversityofLund,andfrom1993to2000,hewasViceDeanofthe
MedicalFacultyattheUniversityofLund.Dr.Anderssonhasreceivedseveralawards,includingaLifetime
AchievementAwardfromtheSocietyforUrodynamicsandFemaleUrology.Dr.Anderssonisamemberof
many international societies, including the American Urological Association, the European Association of
Urology,andtheInternationalSocietyforSexualMedicine.Hehasservedonbothnationalandinternational
committeesrelatedtohisexpertiseinbasicandclinicalphysiologyandpharmacologyandhasalsoserved
onNIHstudysectionsintheNIDDK.HehaschairedworkinggroupsfortheInternationalConsultationof
UrogenitalDiseases,supportedbytheWorldHealthOrganization.Healsoservesontheeditorialboardsof
severaljournals,includingtheJournalofUrology(sectioneditor),NeurourologyandUrodynamics(associate
editor),andEuropeanUrology,andiseditor-in-chiefoftheUrotodayInternationalJournal.Dr.Anderssonhas
authoredmorethan800articlesinpeer-reviewedinternationaljournals.Hiscurrentresearchinterestsinclude
clinicalandbasicphysiologyandpharmacologyoftheurogenitaltractandregenerativemedicine.

REGENERATIVE PHARMACOLOGY
Editedby
GEORGE J. CHRIST
WakeForestInstituteforRegenerativeMedicine
KARL-ERIK ANDERSSON
WakeForestInstituteforRegenerativeMedicine
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Regenerativepharmacology/[editedby]GeorgeJ.Christ,Karl-ErikAndersson.
p.;cm.
Includesbibliographicalreferencesandindex.
ISBN978-0-521-89949-9(hardback)
I.Christ,GeorgeJ.(GeorgeJoseph),1960– II.Andersson,Karl-Erik.
[DNLM: 1.RegenerativeMedicine–methods. 2.TissueEngineering. 3.DrugTherapy. 4.Pharmacology,
Clinical–methods.WO515]
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Contents
Contributors pageix
ForewordbyDennisC.Marshall xv
Preface xix
Acknowledgments xxi
SectionI: BasicPrinciplesofRegenerativePharmacology
1. IntroductiontoRegenerativePharmacology:AShortPrimeronthe
RoleofPharmacologicalSciencesinRegenerativeMedicine 3
george j. christ and karl-erik andersson
2. RegenerativePharmacologyoftheBladder 15
david burmeister, karl-erik andersson, and george j.
christ
3. MechanicalControlofAdultMesenchymalStemCellsinCardiac
Applications 34
peter a. galie and jan p. stegemann
4. KidneyandBladderRegeneration:PharmacologicMethods 52
timothy a. bertram, belinda j. wagner, and bert
spilker
SectionII: EnablingTechnologiesforRegenerativePharmacology
5. StemandProgenitorCellsinRegenerativePharmacology 75
mark e. furth, martin k. childers, and lola m. reid
6. Micro-andNanoscaleDeliveryofTherapeuticAgentsforRegenerative
Therapy 127
justin m. saul and benjamin s. harrison
vii
viii Contents
7. BioreactorTechnologiesforTissueEngineeringaReplacementHeart
Valve 157
stefanie biechler, michael j. yost, richard l. goodwin,
and jay d. potts
8. IncorporationofActiveFactors(PharmacologicalSubstances)in
BiomaterialsforTissueEngineering 167
roche de guzman and mark van dyke
9. EnablingDrugDiscoveryTechnologiesforRegenerativePharmacology 190
g. sitta sittampalam
10. AnimalModelsofRegenerativeMedicine 219
j. koudy williams, james yoo, and anthony atala
SectionIII: FutureApplicationsofRegenerativePharmacology
11. GapJunction–MediatedTherapiestoEliminateCardiacArrhythmias 237
peter r. brink, virginijus valiunas, and ira s. cohen
12. RegenerativeCardiacPharmacology:TranslatingStemCellBiology
intoTherapeuticSolutions 252
atta behfar and andre terzic
13. WoundHealingandCellTherapyforMuscleRepair 270
j.b. vella and johnny huard
14. RegenerativePharmacologyofImplantedMaterialsand
Tissue-EngineeredConstructs 290
emily ongstad, michael j. yost, richard l. goodwin,
harold i. friedman, stephen a. fann, gautam s.
ghatnekar, and robert g. gourdie
15. ThePast,Present,andFutureofTissueRegeneration 311
m. natalia vergara and panagiotis a. tsonis
Index 329
Colorplatesappearafterpage234