Red Cell Immunohaematology Dianne Armstrong 17/11/14 PDF
Preview Red Cell Immunohaematology Dianne Armstrong 17/11/14
Dianne Armstrong 17/11/14 Red Cell Immunohaematology What is a clinically significant antibody Pre-transfusion testing process Which antibodies are a problem How we provide blood for these patients Red Cell Immunohaematology Increased destruction of red cells (or platelets) due to presence of an antibody Alloantibody - directed against someone else's red cells e.g. anti-D in D- patient = Transfusion reaction Autoantibody - directed against patient's own red cells e.g. anti- D in a D+ patient = AIHA Destruction of fetal cells from maternal antibody = Haemolytic Disease of the Newborn (HDN) Red Cell Immunohaematology Aim of pre-transfusion testing Determine ABO and D type Identify any irregular antibodies Check patient details/results vs. historical record Red Cell Immunohaematology Check Sample vs. Request form Must be NO discrepancies Error = increased risk of WBIT We need enough sample to test! Red Cell Immunohaematology Sample and request form requirements Sample Request form NHS Number Essential (if available) Essential (if available) Name Essential Essential First and last name spelt correctly Date of Birth Essential Essential Hospital Number or Optional (must be used if Desirable (must be used temporary unique NHS number is not if NHS number is identification number available not available) Address Optional Optional Date Essential Essential Time Essential Essential Signature Essential Essential Requesting institution Not required Essential Requesting Clinician Not required Essential Signature of requester Not required Essential Clinical Information/test Not required Essential required Sample source if not Essential Essential peripheral blood Red Cell Immunohaematology Allows checks with any historical record Red Cell Immunohaematology Separate into packed cells and plasma Red Cell Immunohaematology Fully automated walkaway system Electronic transfer of information - no human intervention = patient safety Tested for: ABO and D type Antibody screen Red Cell Immunohaematology Test cells for antigen - A, B or AB Test plasma for antibody - anti-A, anti- B or anti-A,B Allows check of group Red Cell Immunohaematology
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