Recent Advances in Human Retroviruses: Principles of Replication and Pathogenesis - Advances in Retroviral Research

502 Pages·2010·4.785 MB·English

by  Andrew M.L. Lever, Kuan-Teh Jeang, Ben Berkhout, Editors

Recent Advances in
Human Retroviruses:
Principles of Replication and
Pathogenesis
Advances in Retroviral Research
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Recent Advances in
Human Retroviruses:
Principles of Replication and
Pathogenesis
Advances in Retroviral Research
edited by
Andrew ML Lever
University of Cambridge, UK
Kuan-Teh Jeang
National Institutes of Health, USA
Ben Berkhout
University of Amsterdam, The Netherlands
World Scientific
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British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
RECENT ADVANCES IN HUMAN RETROVIRUSES: PRINCIPLES OF
REPLICATION AND PATHOGENESIS
Advances in Retroviral Research
Copyright © 2010 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the Publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
ISBN-13 978-981-4295-30-7
ISBN-10 981-4295-30-2
Typeset by Stallion Press
Email: [email protected]
Printed in Singapore.
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Contents
Chapter 1 The Role of Hematopoietic Progenitor Cells 1
in Retroviral Pathogenesis
Prabal Banerjee,Elizabeth Samuelson and Gerold Feuer
Chapter 2 Human T-Cell Leukemia Virus Type 1,Cellular 47
Transformation,and Adult T-Cell Leukemia
Junichiro Yasunaga and Kuan-Teh Jeang
Chapter 3 Application of Proteomics to HTLV-1:Understanding 69
Pathogenesis and Enhancing Diagnostics
O.John Semmes,Mehdi S.Belgnaoui,Robert Mitchell
and Julius O.Nyalwidhe
Chapter 4 Antisense Transcription in Human T-Cell Leukemia 105
Virus Type 1:Discovery of a New Viral Gene
Benoit Barbeau,Christian Devaux and
Jean-Michel Mesnard
v
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vi Contents
Chapter 5 Regulation of HTLV-1 Transcription by Viral 129
and Cellular Proteins
Nicholas Polakowski and Isabelle Lemasson
Chapter 6 Cellular Factors Involved in HIV-1 RNA Transport 171
Claire A.Williams,Andrew M.L.Lever and
Truus E.M.Abbink
Chapter 7 Integration Site Selection by Retroviruses 211
and Retroviral Vectors
Claudia Cattoglio and Fulvio Mavilio
Chapter 8 Syncytins in Normal and Pathological Placentas 243
André Malassiné,Christian Lavialle,Jean Louis Frendo,
Anne Dupressoir and Danièle Evain-Brion
Chapter 9 Vpu,Tetherin and Innate Immunity:Antiviral 271
Restriction of Retroviral Particle Release
Stuart J.D.Neil
Chapter 10 Retrovirus Replication:New Perspectives on Enzyme 307
and Substrate Dynamics
Jason W.Rausch,Elio Abbondanzieri,Shixin Liu,
Xiaowei Zhuang and Stuart F.J.Le Grice
Chapter 11 Non-Human Primates in HIV-1 Research 345
Willy M.J.M.Bogers
Chapter 12 Lentiviral Integration and the Role of the Cellular 375
Cofactors LEDGF/p75 and Transportin-SR2
Bart van Heertum,Jan De Rijck and Zeger Debyser
Chapter 13 Retrovirus Restriction Factors 407
Reuben S.Harris,Rebecca S.LaRue and
Thomas J.Hope
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Contents vii
Chapter 14 Rev Revisited:Additional Functions of the HIV-1 439
Rev Protein
Bastian Grewe and Klaus Überla
Chapter 15 HIV-1 Interactions with Small RNA Induced 471
Silencing Mechanisms
Joost Haasnoot and Ben Berkhout
Index 491
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CHAPTER 1
The Role of Hematopoietic Progenitor Cells
in Retroviral Pathogenesis
Prabal Banerjee†,‡, Elizabeth Samuelson†and Gerold Feuer*,†,‡
INTRODUCTION
Hematopoiesis is the process by which hematopoietic stem cells (HSCs) give
rise to all the cellular components of the hematopoietic system.HSCs have
the potential to proliferate indefinitely, and can differentiate into mature
hematopoietic lineage-specific cells.The bone marrow is the principal site
for hematopoiesis in adults.HSCs proliferate within the bone marrow and
differentiate to produce the requisite number of highly specialized cells of
the hematopoietic system. HSCs give rise to two different populations of
cells:(1) a common lymphoid progenitor (CLP) population,that generates
B cells,T cells and NK lineage cells;and (2) a common myeloid progenitor
(CMP) population that generates granulocytes, neutrophils, eosinophils,
macrophages and erythrocytes.Lineage commitment by HSCs is a complex
process that can be induced in response to a variety of factors, including
*Corresponding author.E-mail:[email protected].
†Department of Microbiology and Immunology, SUNY Upstate Medical University,
Syracuse,NY.
‡Center for Humanized SCID Mice and Stem Cell Processing Laboratory,SUNY Upstate
Medical University,Syracuse,NY.
1