Description:Natural products have long been used for the relief of neurological symptoms, yet their mechanisms of action remain elusive. Recent investigations have started to unveil the complex molecular events associated with the therapeutic effects of natural products in neurodegenerative diseases. In this publication, leading experts share their perspectives and latest research findings on the roles of natural products in neuroprotection and neuronal regeneration. Multifunctional properties of constituents of botanicals and their derivatives are discussed to illustrate the possibilities towards the development of effective multitarget therapeutics. Researchers in the fields of neuroscience, molecular biology, alternative medicine and pharmacology will find that this issue provides a useful overview of the various mechanisms underlying the therapeutic effects of natural products in neurodegenerative diseases.