Natural compounds as inducers of cell death: volume 1

512 Pages·2012·7.31 MB·English

by  Asser Ghoneim Ph.D. (auth.)

Natural Compounds as Inducers of Cell Death

Marc Diederich (cid:129) Karoline Noworyta
Editors
Natural Compounds
as Inducers of Cell Death
Volume 1
Editors
Marc Diederich Karoline Noworyta
Laboratoire de Biologie Laboratoire de Biologie
Moléculaire et Cellulaire du Cancer Moléculaire et Cellulaire du Cancer
Hôpotal Kirchberg Hôpotal Kirchberg
Steichen, Luxembourg Steichen, Luxembourg
ISBN 978-94-007-4574-2 ISBN 978-94-007-4575-9 (eBook)
DOI 10.1007/978-94-007-4575-9
Springer Dordrecht Heidelberg New York London
Library of Congress Control Number: 2012947412
© Springer Science+Business Media Dordrecht 2012
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Editorial
Natural Products Research in the Greater Saar-Lor-Lux
Region: Corena
This book was edited under the patronage of CORENA, a network aiming to create
an internationally competitive cluster within the Greater Region (Saarland, Lorraine,
Luxembourg, Wallonia, Rhineland-Palatinate). CORENA is co-funded by European
Regional development fund within the INTERREG IVA Greater Region program.
The European Union invests in your future.
Since its of fi cial foundation in April 2009, the CORENA Network has brought
together existing researchers and research structures from various scienti fi c and
institutional backgrounds throughout the greater Saar-Lor-Lux region to join forces
in the fi eld of natural product research. Since then, the Network has been a catalyst
to initiate and deepen cross-border research and development – and has resulted in
a crystallization point for natural product research involving various universities,
research institutes, and companies in the Greater Region.
The CORENA network is the combination of research, development, and
applications. The aim of the project is to create an internationally competitive cluster
that links the particular research institutions and companies within the Greater Region
(Saarland, Lorraine, Luxembourg, Wallonia, Rhineland-Palatinate). Scienti fi cally,
the Network aims at the promotion of the use of natural products in medicine and
agriculture. In biomedical research, natural ingredients, such as antioxidants and
chemopreventive agents, have recently come back into focus. Here, ageing Societies
provide an impetus to (re-)consider nutri-therapeutics, from simple vitamins to highly
promising, natural product based nutri-epigenetic substances. At the same time, the
CORENA Network supports the idea of green, eco-friendly pesticides extracted
from natural substances such as plants or fungi. Within this context, the focus has
been no substances derived from edible plants, which promise low or now toxicity
to animals and humans, yet may be effective against common agricultural pests.
The CORENA Network established in the Saar-Lor-Lux region is a highly suc-
cessful network of major research institutions, companies, producers and users.
v
vi Editorial
During the last three years, existing expertise in the fi eld of natural products within
the greater Saar-Lor-Lux area has been bundled, thereby increasing the scienti fi c
potential and industrial competitiveness of the whole region. As part of the network,
closer cross-border cooperation between industry and research in the fi eld of natural
products is now easily possible. Thus, small and medium enterprises (SMEs) have
gained access to the latest research, while the researchers in exchange have bene fi ted
from new ideas and stimuli provided by the companies. This mutually bene fi cial
exchange has contributed signi fi cantly to the innovation potential of the Greater
Region in this area of Science. The CORENA Network will certainly grow and
deepen further in the years to come, attracting researchers and companies from
throughout the Region and beyond.
Marc Diederich and Karoline Noworyta
(Recherchhes Scienti fi ques Luxembourg asbl), editors
Claus Jacob
(Universität des Saarlandes, Germany)
Gilbert Kirsch
(Université de Metz, France)
Contents
Part I Phytochemicals as Inducers of Cell Death Mechanisms
1 Phytochemicals and Amino Acids:
Inducers or Inhibitors of Cell Death? ................................................... 3
Asser Ghoneim
2 Pomegranate-Derived Constituents as Inducers of Cell Death:
Implications in Cancer Prevention and Therapy ................................. 33
Anupam Bishayee and Altaf S. Darvesh
3 Antitumor Effects of Anthocyanins: Focus on Apoptosis ................... 49
Carmela Fimognari
4 Anti-proliferative and Apoptosis-Inducing Properties
of Xanthohumol, a Prenylated Chalcone from Hops
(Humulus lupulus L.) .............................................................................. 69
Julia Strathmann and Clarissa Gerhauser
5 Bioavailability and Metabolism of Curcuminoids ............................... 95
Wolfgang W. Quitschke
Part II Natural Compounds from Animal Origins
6 Melatonin in Cell Fate Decisions: Mechanistic
Perspectives and Therapeutical Potential ............................................. 127
M. Sánchez-Hidalgo, J.M. Guerrero, I. Villegas,
and Catalina Alarcón De La Lastra
7 Pharmacologically Active Compounds from Ticks
and Other Arthropods and Their Potential Use
in Anticancer Therapy ............................................................................ 163
Mária Kazimírová
vii
viii Contents
Part III Polyphenols as Inducers of Cell Death
8 Induction of Apoptosis by Polyphenolic
Compounds in Cancer Cells ................................................................... 185
Didem Turgut Cosan and Ahu Soyocak
9 Encapsulation of Natural Polyphenols with Antioxidant
Properties in Polyelectrolyte Capsules and Nanoparticles .................. 215
Tatsiana G. Shutava and Yuri M. Lvov
10 Induction of Autophagy by Polyphenolic
Compounds in Cancer: A Novel Strategy
to induce cell death and to Treat Cancer .............................................. 237
Bulent Ozpolat, Kevin Dalby, and Gabriel Lopez-Berestein
Part IV Redox Active Natural Compounds
11 Total Antioxidant Capacity: A Useful Tool
in Assessing Antioxidant Intake Status ................................................. 265
Ying Wang, Meng Yang, Sang-Gil Lee, Catherine Davis,
Christopher Masterjohn, Anne Kenny, Richard S. Bruno,
and Ock K. Chun
12 Natural Sulfur Products as Redox Modulators
and Selective Inducers of Cell Death ..................................................... 293
Brigitte Czepukojc, Thomas Schneider, Torsten Burkholz,
Vincent Jamier, and Claus Jacob
13 Diallyl Sulfides and the Decision About Life
and Death of a Cell .................................................................................. 329
Mathias Montenarh
Part V Effect of Natural Compounds on Cell Signaling Pathways
14 Natural Compounds as Specific Inhibitors
of Cyclin-Dependent Kinases – Past, Present and Future ................... 347
Margarita Maurer, Oxana Komina, and Józefa Węsierska-Gądek
15 Plant-Derived Isoprenoids Mediate Regulation
of mTOR Signaling in Tumor Cells ....................................................... 373
Dennis M. Peffley and Patricia Hentosh
16 Regulation of MicroRNAs by Natural Compounds:
Implications for Cancer Therapy .......................................................... 401
Devarajan Karunagaran, Maitreyi Subramanian,
and Rao Srinivasa Rao
Contents ix
Part VI Phytochemicals in In fl ammation and Cancer
17 Interference with Estrogen Receptor-a by Dietary Components:
Impact on the Balance Between Cell Proliferation
and Cell Death ......................................................................................... 431
Józefa Węsierska-Gądek, Margarita Maurer, and Oxana Komina
18 Natural Triterpenoids from Olive Oil:
Potential Activities Against Cancer ....................................................... 447
Rosalia Rodriguez-Rodriguez and Ulf Simonsen
19 Dietary Sources of Natural Inducers of Cell Death:
Considerations for Cancer Therapy and Prevention ........................... 463
Yvonne Chukwumah
Part VII Phytochemicals in Health and Disease
20 Tocotrienols in the Control of Pathological
Fibroinflammatory Processes ................................................................. 477
Eva C. Vaquero and Xavier Molero
21 Anthocyanins: Janus Nutraceuticals Displaying
Chemotherapeutic and Neuroprotective Properties ............................ 491
Erika K. Ross, Natalie K. Kelsey, and Daniel A. Linseman
Index ................................................................................................................. 515