Molecular Regulation of Arousal States (Cellular and Molecular Neuropharmacology Series)

229 Pages·1997·3.69 MB·English

by  Ralph Lydic

CRC Press
Boca Raton New York

Library of Congress Cataloging-in-Publication Data
Molecular regulation of arousal states / edited by Ralph Lydic.
p. cm. — (CRC Press methods in the life sciences. Cellular
and molecular neuropharmacology)
Includes bibliographical references and index.
ISBN 0-8493-3361-X (alk. paper)
1. Molecular neurobiology—Laboratory manuals. 2. Arousal
(Physiology)—Research—Laboratory manuals. 3. Sleep—Research-
-Laboratory manuals. I. Lydic, Ralph. II. Series.
[DNLM: 1. Arousal—physiology. 2. Sleep—physiology. 3. In Situ
Hybridization. WL 103 M7185 1997]
QP356.2.M665 1997
612.8′21—dc21
DNLM/DLC
for Library of Congress 97-21353
CIP
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The Editor
Ralph Lydic, Ph.D., is Director of Anesthesia and Neuroscience Research and
Professor of Anesthesia and Cellular & Molecular Physiology at The Pennsylvania
State University, College of Medicine, Hershey, PA. Dr. Lydic’s research career has
maintained a focus on the neurobiology of sleep and breathing. His 1979 Ph.D. in
physiology from Texas Tech University used single-cell recording techniques to test
the hypothesis that the onset of rapid eye movement (REM) sleep caused diminished
discharge of pontine respiratory neurons. Postdoctoral years were spent in the
Department of Physiology and Biophysics at Harvard Medical School. In 1981, Dr.
Lydic joined the Laboratory of Neurophysiology at Harvard Medical School, where
he served as Assistant Professor of Physiology. In 1986, Dr. Lydic moved his
laboratory to the Pulmonary Division of The Pennsylvania State University’s College
of Medicine, where his research emphasized the neural control of breathing. In 1989,
Dr. Lydic was appointed Director of the Division of Anesthesia and Neuroscience
Research. Since 1991, he has served as Professor in the Department of Anesthesia
and in the Department of Cellular & Molecular Physiology.
Awards and honors resulting from Dr. Lydic’s research include an Upjohn
Pharmaceutical Scholarship (Harvard Medical School); Neurobiology Program
Scholarship (Woods Hole Marine Biological Laboratory); Neurobiology Program
Scholarship (Cold Spring Harbor Laboratory, NY); National Research Service Award
(Harvard Medical School); William F. Milton Award (Harvard Medical School);
Mentor for Scholl Fellowship, National SIDS Foundation (Pennsylvania State Uni-
versity); Mentor for Parker B. Francis Fellowship (Pennsylvania State University);
Visiting Scientist, NASA Division of Space Life Sciences, Johnson Space Center
(1994 to 1995); Dunaway-Burnham Visiting Scholar, Dartmouth Medical School
(1995); Mentor for Proctor and Gamble Award from the American Physiological
Society (1996); and Mentor for Precollege Science Education Initiative, Howard
Hughes Medical Institute (1996).
Dr. Lydic has served the American Physiological Society (APS) in a variety
of offices including Chairman, Central Nervous System (CNS) Section; Program
Advisory Committee; CNS Section Advisory Committee; Long-Range Planning
© 1998 by CRC Press LLC
Committee; Chairman, FASEB Theme Committee: “Nervous System Function and
Disorder”; Nominating Committee; Committee on Committees; and Public Affairs
Committee.
Dr. Lydic’s research program spans issues from the level of transmembrane cell
signaling to integrative aspects of respiratory and arousal state control. His studies
aim to elucidate the cellular and molecular mechanisms that cause respiratory depres-
sion during the loss of waking consciousness. These basic studies are funded by the
National Heart, Lung, and Blood Institute of the National Institutes of Health because
of their potential clinical relevance for disorders such as sudden infant death syn-
drome, adult sleep apnea, and anesthesia-induced respiratory depression.
© 1998 by CRC Press LLC
Contributors
H. Elliott Albers, Ph.D. Sophie Burlet, Doctorant
Laboratory of Neuroendocrinology Department of Experimental Medicine
and Behavior INSERM U, CNRS ERS
Departments of Biology and Claude Bernard University
Psychology Lyon, France
Georgia State University
Raymond Cespuglio, Ph.D.
Atlanta, GA
Department of Experimental Medicine
INSERM U, CNRS ERS
Helen A. Baghdoyan, Ph.D.
Claude Bernard University
Departments of Anesthesia and
Lyon, France
Pharmacology
The Pennsylvania State University
Zutang Chen
College of Medicine
Department of Veterinary Comparative
Hershey, PA
Anatomy, Physiology, and
Pharmacology
Radhika Basheer, Ph.D.
Washington State University
VA Medical Center and Harvard
Pullman, WA
Medical School
Brockton, MA Chiara Cirelli, M.D., Ph.D.
The Neurosciences Institute
Maja Bucan, Ph.D. San Diego, CA
Center for Neurobiology and
Luis de Lecea, Ph.D.
Behavior
Department of Molecular Biology
Department of Psychiatry
The Scripps Research Institute
University of Pennsylvania
La Jolla, CA
Philadelphia, PA
Charles W. Emala, M.D.
Jerry J. Buccafusco, Ph.D.
Department of Anesthesiology and
Department of Pharmacology and
Critical Care Medicine
Toxicology
Johns Hopkins School of Medicine
Alzheimer’s Research Center
Baltimore, MD
Medical College of Georgia
and Marek Fischer, Ph.D.
Medical Research Service Institute of Molecular Biology
VA Medical Center University of Zürich
Augusta, GA Zürich, Switzerland
© 1998 by CRC Press LLC
Mary Ann Greco, Ph.D. Miroslaw Mackiewicz, Ph.D.
VA Medical Center and Harvard Division of Sleep and Chronobiology
Medical School Department of Psychiatry
Brockton, MA University of Pennsylvania School of
Medicine
Steven Henriksen, Ph.D. Philadelphia, PA
The Scripps Research Institute
Jean C. Manson, Ph.D.
La Jolla, CA
Institute for Animal Health
BBSRC/MRC
A. Urban Höglund, Ph.D.
Neuropathogenesis Unit
Department of Comparative Medicine
Edinburgh, Scotland
Biomedical Center
Uppsala, Sweden
Patrick M. Nolan, Ph.D.
Center for Neurobiology and Behavior
Thomas A. Houpt, Ph.D. Department of Psychiatry
E.W. Bourne Behavioral Research University of Pennsylvania
Laboratory Philadelphia, PA
Department of Psychiatry
Cornell Medical College Allan I. Pack, M.D., Ph.D.
White Plains, NY Center for Sleep and Respiratory
Neurobiology
Kim L. Huhman, Ph.D. Pulmonary and Critical Care Division
Department of Psychology Department of Medicine
Georgia State University University of Pennsylvania School of
Atlanta, GA Medicine
Philadelphia, PA
Thomas S. Kilduff, Ph.D.
Maria Pompeiano, M.D., Ph.D.
Center for Sleep and Circadian
The Neurosciences Institute
Neurobiology
San Diego, CA
Departments of Biological Sciences and
Psychiatry and Behavioral Sciences
Tarja Porkka-Heiskanen, M.D., Ph.D.
Stanford University
Department of Psychiatry
Stanford, CA
Harvard Medical School and Brockton
VA Medical Center
James M. Krueger, Ph.D. Brockton, MA
Department of Veterinary Comparative
Anatomy, Physiology, and Mark A. Prendergast, Ph.D.
Pharmacology Department of Pharmacology and
Washington State University Toxicology
Pullman, WA Alzheimer’s Research Center
Medical College of Georgia
Clete A. Kushida, M.D., Ph.D. and
Stanford Sleep Disorders Clinic and Medical Research Service
Research Center VA Medical Center
Stanford, CA Augusta, GA
© 1998 by CRC Press LLC