Molecular and Translational Vascular Medicine PDF
Preview Molecular and Translational Vascular Medicine
Molecular and Translational Medicine Series Editors William B. Coleman Gregory J. Tsongalis For further volumes: http://www.springer.com/series/8176 Jonathon W. Homeister Monte S. Willis ● Editors Molecular and Translational Vascular Medicine Editors Jonathon W. Homeister Monte S. Willis McAllister Heart Institute McAllister Heart Institute The University of North Carolina The University of North Carolina Chapel Hill, NC, USA Chapel Hill, NC, USA ISBN 978-1-61779-905-1 ISBN 978-1-61779-906-8 (eBook) DOI 10.1007/978-1-61779-906-8 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012939117 © Springer Science+Business Media New York 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science+Business Media (www.springer.com) We dedicate this book to our families, Michelle, Hans, and Nolan Homeister, and Tina, Connor, and Declan Willis, who provided the inspiration and support that enabled us to complete this task. Jonathon W. Homeister Monte S. Willis Preface The primary goal of this textbook is to provide an overview of cutting-edge and emerging topics in translational vascular medicine as seen by experts from diverse clinical and biomedical research backgrounds. The premise is to highlight the areas of investigation that are currently (or will be) the topics of keen interest to those practicing cardiovascular medicine or researching translational vascular biology. This book includes chapters on translational topics in vascular medicine that are commonly overlooked in research reviews and vascular medicine texts. Throughout the book, the authors communicate complex molecular mechanisms using easy-to- follow text that is complemented with valuable fi gures that illustrate the key topics. This textbook is intended for physicians, residents, fellows, and graduate students from a variety of specialties related to vascular disease. This book is divided into two broad themes associated with molecular and trans- lational vascular medicine. The fi r st part includes chapters on recent advances toward understanding the pathogenesis of common vascular diseases and presents the unique contributions of molecular imaging to our understanding of their pathogenesis, as well as their diagnosis and treatment. Several chapters review recent insights into the genetics and molecular and cellular biology speci fi c to aneurysms (Chap. 1 ), the vasculitides (Chap. 2 ), and venous thrombosis (Chap. 3 ). These are followed by a chapter more broadly applicable to vascular diseases that reviews recent progress in understanding the role of the ubiquitin proteasome system in modulating the patho- genesis of endothelial dysfunction (Chap. 4 ) . The fi rst part concludes with a chapter unique to most vascular medicine texts on the development of imaging modalities, and cellular and molecular probes, that hold promise to image the molecular and cel- lular pathogenesis of, and perhaps treat vascular diseases (Chap. 5 ) . The second part focuses on the evolving molecular- and cellular-based therapies under development and being used to diagnose and treat vascular disease. The fi rst two chapters discuss recent insights into the mechanisms of vasculogenesis and angiogenesis and translation of this knowledge to treat critical limb ischemia (Chaps. 6 and 7 ). Next is a review of the pathogenesis of restenosis after arterial injury and the latest therapeutic options to modulate it (Chap. 8 ). This is followed vii viii Preface by a more detailed discussion of the evolving use of nanoparticle technology in vascular medicine as it applies to drug-eluting stents, as well as its potential to diag- nose and treat other vascular diseases (Chap. 9 ). We conclude this part with a discussion of the current status and potential of emerging endothelial progenitor cell-based therapies for cardiovascular diseases (Chap. 1 0 ). We believe that this book comprises a unique compilation of reviews that cover many of the exciting and current topics in translational vascular research and medi- cine. The translational focus of the book made it an enjoyable project, and we hope you fi nd it informative and valuable. Chapel Hill, NC, USA Jonathon W. Homeister Chapel Hill, NC, USA Monte S. Willis Acknowledgements We wish to thank the Molecular and Translational Medicine series editors Drs. William B. Coleman and Gregory J. Tsongalis for the opportunity to edit this volume. We also acknowledge the chapter authors for their hard work and invalu- able contributions, Karyn Hede, PhD for her critical editorial assistance, and the developmental editor Michael D. Sova for his expert assistance, guidance, and sup- port throughout the publication process. Chapel Hill, NC, USA Jonathon W. Homeister Chapel Hill, NC, USA Monte S. Willis ix
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