Micro- and Nanofluidics for Bionanoparticle Analysis

140 Pages·2019·29.9 MB·English

by  Xuanhong Cheng (editor), Yong Zeng (editor)

Micro- and
Nanofluidics for
Bionanoparticle
Analysis
Edited by
Xuanhong Cheng and Yong Zeng
Printed Edition of the Special Issue Published in Micromachines
www.mdpi.com/journal/micromachines
Micro- and Nanofluidics for
Bionanoparticle Analysis

Micro- and Nanofluidics for
Bionanoparticle Analysis
SpecialIssueEditors
XuanhongCheng
YongZeng
MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade
SpecialIssueEditors
XuanhongCheng YongZeng
LehighUniversity UniversityofKansas
USA USA
EditorialOffice
MDPI
St.Alban-Anlage66
4052Basel,Switzerland
This is a reprint of articles from the Special Issue published online in the open access journal
Micromachines(ISSN2072-666X)from2018to2019(availableat: https://www.mdpi.com/journal/
micromachines/specialissues/MicroNanofluidicsBionanoparticleAnalysis)
Forcitationpurposes,citeeacharticleindependentlyasindicatedonthearticlepageonlineandas
indicatedbelow:
LastName,A.A.; LastName,B.B.; LastName,C.C.ArticleTitle. JournalNameYear,ArticleNumber,
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ISBN978-3-03921-594-2(Pbk)
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(cid:2)c 2019bytheauthors. ArticlesinthisbookareOpenAccessanddistributedundertheCreative
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Contents
AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
XuanhongChengandYongZeng
EditorialfortheSpecialIssueon“Micro-andNanofluidicsforBionanoparticleAnalysis”
Reprintedfrom:Micromachines2019,10,600,doi:10.3390/mi10090600 . . . . . . . . . . . . . . . 1
VeasnaSoum,SooyongPark,AlbertusIvanBrilian,Oh-SunKwonandKwanwooShin
ProgrammablePaper-BasedMicrofluidicDevicesforBiomarkerDetections
Reprintedfrom:Micromachines2019,10,516,doi:10.3390/mi10080516 . . . . . . . . . . . . . . . . 3
YiWang,KeelyKellerandXuanhongCheng
TangentialFlowMicrofiltrationforViralSeparationandConcentration
Reprintedfrom:Micromachines2019,10,320,doi:10.3390/mi10050320 . . . . . . . . . . . . . . . 28
NingYang,ChiyuanChen,TaoLi,ZhuoLi,LirongZou,RongbiaoZhangandHanpingMao
PortableRiceDiseaseSporesCaptureandDetectionMethodUsingDiffractionFingerprintson
MicrofluidicChip
Reprintedfrom:Micromachines2019,10,289,doi:10.3390/mi10050289 . . . . . . . . . . . . . . . 41
Chi-YungCheng,Shih-ShienHuang,Chia-MinYang,Kea-TiongTangandDa-JengYao
Detection of Cigarette Smoke Using a Surface-Acoustic-Wave Gas Sensor with
Non-Polymer-BasedOxidizedHollowMesoporousCarbonNanospheres
Reprintedfrom:Micromachines2019,10,276,doi:10.3390/mi10040276 . . . . . . . . . . . . . . . 54
HolgerBolze,PeerErfle,JulianeRiewe,HeikeBunjes,AndreasDietzelandThomasP.Burg
AMicrofluidicSplit-FlowTechnologyforProductCharacterizationinContinuousLow-Volume
NanoparticleSynthesis
Reprintedfrom:Micromachines2019,10,179,doi:10.3390/mi10030179 . . . . . . . . . . . . . . . 65
VeasnaSoum, YunpyoKim, SooyongPark, MaryChuong, SooRyeonRyu, SangHoLee,
GeorgiTanev,JanMadsen,Oh-SunKwonandKwanwooShin
AffordableFabricationofConductiveElectrodesandDielectricFilmsforaPaper-BasedDigital
MicrofluidicChip
Reprintedfrom:Micromachines2019,10,109,doi:10.3390/mi10020109 . . . . . . . . . . . . . . . 81
LaanLuoandYongqingHe
Magnetically Induced Flow Focusing of Non-Magnetic Microparticles in Ferrofluids under
InclinedMagneticFields
Reprintedfrom:Micromachines2019,10,56,doi:10.3390/mi10010056 . . . . . . . . . . . . . . . . 91
Chia-Jung Liao, Chia-Hsun Hsieh, Tzu-Keng Chiu, Yu-Xian Zhu, Hung-Ming Wang,
Feng-ChunHung,Wen-PinChouandMin-HsienWu
An Optically Induced Dielectrophoresis (ODEP)-Based Microfluidic System for the
Isolation of High-Purity CD45neg/EpCAMneg Cells from the Blood Samples of Cancer
Patients—DemonstrationandInitialExplorationoftheClinicalSignificanceofTheseCells
Reprintedfrom:Micromachines2018,9,563,doi:10.3390/mi9110563 . . . . . . . . . . . . . . . . . 109
v

About the Special Issue Editors
XuanhongChengisanassociateprofessorintheDepartmentofMaterialsScienceandEngineering
andtheDepartmentofBioengineeringatLehighUniversity.ShereceivedherPh.D.inBioengineering
fromUniversityofWashingtonin2004,afterwhichshehadapostdoctoraltrainingintheDepartment
ofSurgeryatMassachusettsGeneralHospital. Thefocusofherresearchistodevelopmicrofluidic
devices for cell and pathogen analysis. In combination with nanomaterials and biosensors, these
microfluidic devices are expected to perform automated sample processing and sensitive analyte
detection towards point-of-care uses. She has published more than 60 referred technical papers,
hasbeengrantedseveralU.S.patentsandhasobtainedresearchfundingfromNIH,NSF,andDoD.
Yong Zeng currently is a Docking Scholar Associate Professor in the Department of Chemistry
andKUCancerCenterattheUniversityofKansas. HereceivedhisPh.D.inChemistryfromthe
UniversityofAlberta,Canada,completedhispostdoctoraltrainingattheUniversityofCalifornia,
Berkeley, andjoinedKUasassistantprofessorin2012. Workingattheinterfaceofchemistryand
biology,aprimaryaimofhisresearchistodevelopnewenablingtoolsforliquidbiopsy-basedcancer
diagnosis and precision medicine. His work has led to many highly recognized publications on
high-profile journals, including Nature Biomed. Eng., Chem. Sci., and Angew. Chem. Int. Ed. He
receivedtheJ.R.&InezJayAwardin2014,andwasnamedastheprestigiousDockingFamilyFaculty
Scholarin2017. HehasreceivedseveralmillionresearchfundingfromNationalInstituteofHealth
(NIH)andotherfundingagencies.
vii

micromachines
Editorial
Editorial for the Special Issue on “Micro- and
Nanofluidics for Bionanoparticle Analysis”
XuanhongCheng1,*andYongZeng2,*
1 MaterialsScienceandEngineering/Bioengineering,LehighUniversity,5E.PackerAve,
Bethlehem,PA18015,USA
2 DepartmentofChemistry,UniversityofKansas,1251WescoeHallDrive,Lawrence,KS66045,USA
* Correspondence:[email protected](X.C.);[email protected](Y.Z.)
Received:10September2019;Accepted:11September2019;Published:12September2019
Bionanoparticlessuchasmicroorganismsandexosomesarerecognizedasimportanttargetsfor
clinicaldiagnosticandtherapeuticapplicationsaswellasforfoodsafetyandenvironmentalmonitoring.
Othernanoscalebiologicalparticlesincludingliposomes, micelles, andfunctionalizedpolymeric
particlesarewidelyusedinnanomedicine.Therecentdevelopmentofmicrofluidicandnanofluidic
technologies has enabled lab-on-a-chip platforms for separating and analyzing bionanoparticles;
however,manychallengesexistbeforetheseplatformsarewidelyadopted.Forexample,thecomplex
compositionofbiologicalfluidscreatesahighbackgroundfordetection.Thesmalldimensionandoften
lowconcentrationoftargetspeciesrequiresignificantamplificationofthesensingsignal.Thisspecial
issuecollectssomerecentdiscoveriesanddevelopmentsofmicro-andnanofluidicstrategiesforthe
processingandanalysisofbiologicalnanoparticles.
Eight papers are published in this special issue and cover the design of microfluidics for
bioseparation[1–6],incorporationofsensorswithmicrofluidicsforparticledetection[6,7],andmodular
deviceswithbothfunctions[1,6,7].Nanomaterialshavebeencombinedwithmicrofluidicsforboth
separation[5]andsensing[7]purposes.Thespecialissuealsoincludesareviewonprogrammable
paper-basedmicrofluidics[8].
The collection of papers describe a wide spectrum of separation and sensing mechanisms.
Forexample,Wangetal.[5]incorporatednanoporousmembranesintomicrofluidicchannels,and
demonstratedtheseparationandenrichmentofvirusfrombiologicalfluidsthroughnanofiltration.
Yangetal.[6]tookadvantageofparticleinertiaincurvedmicrofluidicchannelstoseparateand
containparticlesinmicro-tanks,whichwerefurtherresolvedbyopticaldiffraction.Chengetal.[7]
coatedasurfaceacousticwavesensorwithoxidizedmesoporouscarbonnanospherestotrapchemical
compoundsinsmoke,wherethecoatingincreasedthesensitivityandselectivityoftheacousticwave
sensor. Boltzetal.[1]designedasplit-flowdevicetoperformcontinuous,in-linequalitycontrol
ofnanoparticlesynthesis. Nanoparticlesweredetectedbyincorporatingafluorescencedetector
withthesidechannel. Soumetal.[4]fabricatedconductiveelectrodesanddielectricfilmsona
paper-basedmicrofluidicchiptofacilitatedropletmanipulationbasedonelectrowettingondielectric
materials.Luoetal.[3]studiedtheseparationofnon-magneticparticlesinferrofluidsunderamagnetic
field.Liaoetal.[2]employedopticallyinduceddielectrophoresistoseparatecancercellsfromblood.
ThereviewpaperbySoum[8]examinedvariouspaper-basedmicrofluidicsthatareprogrammable
anddiscussedtheutilityofsuchdevicesforthedetectionofbiomarkers.
Weappreciatealloftheauthorswhosubmittedpaperstothisspecialissue.Wewouldalsoliketo
thankallofthereviewersfordedicatingtheirtimetohelpimprovethequalityofthesubmittedpapers.
Thecollectionofpaperswillhopefullybringoutmoreinnovativeideasandfundamentalinsightsto
overcomethehurdlesfacedintheseparationandanalysisofbionanoparticles.
ConflictsofInterest:Theauthordeclaresnoconflictofinterest.
Micromachines2019,10,600;doi:10.3390/mi10090600 1 www.mdpi.com/journal/micromachines