Manual for EYE EXAMINATION AND DIAGNOSIS N I N T H E D I T I O N MARK W. LEITMAN MD Cornea Clear, front part of the eye Iris Colored diaphragm that regulates amount of light entering Aqueous Clear fluid in front part of the eye Ciliary body Produces aqueous and focuses lens Lens Clear, refracting media that focuses light Vitreous Clear jelly filling the back of the eye Sclera Rigid, white outer shell of the eye Conjunctiva Mucous membrane covering sclera and inner lids Retina Inner lining of the eye containing light-sensitive rods and cones Macula Avascular area of the retina responsible for the most acute vision Fovea A pit in the center of the macula corresponding to central fixation of vision Choroid Vascular layer between retina and sclera Optic nerve Transmits visual stimuli from retina to brain Zonule Fibers suspending lens from ciliary body Cover images: Diabetic Retinopathy © Julia Monsonego, CRA, Wills Eye Hospital and Carl Zeiss Meditec, Inc. Upper left corner: Normal OCT angiogram Upper right corner: Diabetic OCT angiogram showing microaneurysms and capillary dropout (non-profusion) Main image: cotton-wool spots, exudates, microaneurysms, flame hemorrhages, silver-wire arterial narrowing with dot and blot hemorrhages Manual for Eye Examination and Diagnosis Mark W. Leitman, MD Clinical Assistant Professor Department of Ophthalmology and Visual Sciences Montefi ore Hospital Albert Einstein College of Medicine Bronx, NY, USA Attending Physician St. Peter’s Medical Center New Brunswick, NJ, USA NINTH EDITION Copyright © 2017 by John Wiley & Sons, Inc. 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Identifi ers: LCCN 2016003738 | ISBN 9781119243618 (pbk.) | ISBN 9781119243632 (Adobe PDF) | ISBN 9781119243625 (ePub) Subjects: | MESH: Eye Diseases--diagnosis | Diagnostic Techniques, Ophthalmological | Handbooks Classifi cation: LCC RE75 | NLM WW 39 | DDC 617.7/15--dc23 LC record available at http://lccn.loc.gov/2016003738 Cover image: Julia Monsenego, CRA, Wills Eye Hospital and Carl Zeiss Meditec, Inc. A serious student is like a seed: with so much potential it will grow almost anywhere it lands. Fig. I A seed introduced into the eye of an 8 year-old boy through a penetrating corneal wound became imbedded in the iris. Many months later, the seed became visible when it began germinating. Courtesy of Solomon Abel, MD, FRCS, DOMS, andArch. Ophthalmol., Sept. 1979, Vol. 97, p. 1651. Copyright 1979, American Medical Association. All rights reserved. Contents Preface vi 5 The orbit 70 Introduction to the eye team and their Sinusitis 72 instruments vii Exophthalmos 74 Enophthalmos 74 1 Medical history 1 Medical illnesses 3 6 Slit lamp examination and glaucoma 76 Medications 4 Cornea 76 Family history of eye disease 7 Corneal epithelial disease 77 Corneal endothelial disease 82 2 Measurement of vision and Corneal transplantation refraction 8 (keratoplasty) 84 Visual acuity 8 Conjunctiva 89 Optics 9 Sclera 96 Refraction 11 Glaucoma 97 Contact lenses 14 Uvea 111 Common problems 18 Cataracts 128 Refractive surgery 18 7 The retina and vitreous 136 3 Neuro-ophthalmology 23 Retinal anatomy 136 Eye movements 23 Fundus examination 138 Strabismus 26 Papilledema (choked disk) 140 Cranial nerves III–VIII 31 Retinal blood vessels 142 Nystagmus 35 Age-related macular degeneration 152 The pupil 41 Central serous chorioretinopathy 156 Visual field testing 44 Pseudoxanthoma elasticum 156 Color vision 47 Albinism 158 Circulatory disturbances affecting Retinitis pigmentosa 158 vision 47 Retinoblastoma 160 Retinopathy of prematurity 161 4 External structures 51 Vitreous 161 Lymph nodes 51 Retinal holes and detachments 164 Lacrimal system 51 Lids 59 Appendix 1: Hyperlipidemia 169 Lashes 62 Appendix 2: Amsler grid 171 Phakomatoses 65 Anterior and posterior blepharitis 66 Index 172 CONTENTS v Preface The first edition of this book was started My special appreciation goes to Johnson when I was a medical student 44 years ago & Johnson eye care division, which pro- during the allotted 2-week rotation in vided a generous grant to distribute the the eye clinic. It was published during my seventh edition to 40,000 students. I spon- first year of eye residency with assistance sored the eighth edition, and this newest and encouragement from my chairman, ninth edition, with distribution to 69,000 Dr Paul Henkind. At that time, all intro- medical students. Many images were ductory books were 500 pages or more generously provided by Pfizer's website, and could not be read quickly enough to Xalatan.com, several journals, Wills Eye understand what was going on. With this Hospital, the University of Iowa, Monte- in mind, each word of this 175-page prac- fiore Hospital, and many colleagues. Elliot tical manual was carefully chosen so that Davidoff, who sat next to me in medical students understand the refraction and school, and who is now Assistant Profes- hundreds of the most commonly encoun- sor at the Ohio State University, surprised tered eye diseases from the onset. They me with many unsolicited contributions, are discussed with respect to anatomy, as did medical student, Lance Lyons. instrumentation, differential diagnosis, This edition has been updated with 50 and treatment in the order in which they new images. I hope you enjoy reading it would be uncovered during the eye exam half as much as I enjoyed writing it. I have and are highlighted with 551 photos and received no monetary funding from and illustrations. I have no association with any company The book is meant to be read in its entirety whose products are mentioned in this in several hours and, hopefully, impart book. to you a foundation on which to grow I would appreciate any recommenda- and enjoy this beautiful and ever-chang- tions and images that would improve ing specialty. The popularity of previous the next edition. You may email me at editions has resulted in translations into [email protected]. Spanish, Japanese, Indonesian, Italian, Russian, Greek, Polish, and Portuguese, MARk W. LEITMAn and an Indian reprint. vi PREfAcE Introduction to the eye team and their instruments The eye exam depends on many sophis- them in frames (laboratory optician) or fit ticated, and costly instruments, together them on the patient (dispensing optician). with highly trained professionals to oper- Their training and certification is highly ate them. variable from state to state, but often includes 2 years at a community college. Ophthalmologist The ophthalmologist attended 4 years of college, 4 years of med- Ocularists (BCO, BRDO, FASO) There are ical (MD) or osteopathic (DO) school, and no schools to teach this craft. These tech- 3 years of specialty eye residency training. nicians learn by apprenticeship. They then They may remain general ophthalmolo- have to pass tests for certification. They gists, but now, more often than not, spend fit the scleral shell needed after removal an additional 1–2 years subspecializing in of an eye (Fig. 395). corneal and external disease, vitreoret- inal disease, cataracts, glaucoma, neu- Ophthalmic technicians Ophthalmic tech- ro-ophthalmology, oculoplastic surgery, nicians have varying degrees of licen- pathology, pediatric (strabismus), or uve- sure. With medical supervision, they itis. They often employ three allied health may take medical histories; measure eye professionals. Ophthalmologists perform pressure; do refractions and visual field all aspects of eye care. They are the sole testing; take visual activities; teach con- professional allowed to perform laser and tact lens fitting; and perform fluores- other ocular surgeries. There are five lasers cein angiography to study retinal blood of different wavelengths. Argon lasers are flow. Technicians use an optical coher- used to treat glaucoma and retinal dis- ence tomography (OCT) instrument to ease, most commonly diabetic retinopathy. measure each layer of the eye and the Nd:YAG lasers are usually used to open sec- blood vessels by reflecting light off the ondary cataracts after cataract extractions intraocular structures. This requires a and to perform peripheral iridotomies for clear medium, as opposed to ultrasound narrow-angle glaucoma. Excimer lasers which utilizes reflective sound waves. To reshape the cornea in the refraction proce- appreciate the precision of ophthalmic dure called LASIK. Femtosecond lasers may testing and procedures one must realize replace certain manual parts of routine cat- a red blood cell is 7 μm (micrometers) in aract extractions. Carbon dioxide lasers are diameter. OCT measures 5 μm changes utilized for dermatologic procedures. in the retinal thickness to evaluate edema and glaucoma loss using 30,000 Optometrist (OD) The optometrist com- A-scans per second. A surgically created pletes 4 years of college and 4 years of LASIK flap is 110 μm (Figs 59 and 60) optometry school. They perform similar and an epi-LASIK flap (Fig. 67) is only tasks to the ophthalmologist, with the 30 μm. A-scan ultrasound measures the exception of surgery. They may estab- length of the eye needed to determine lish their own practice or work for an the power of an intraocular lens used in ophthalmologist. Subspecialities often cataract surgery and B-scan ultrasound include pediatrics and low vision. measures individual layers. Ultrasound Opticians (ABO, American Board of Opti- is useful with opaque media that limit cians) Opticians grind the lenses and put direct visualization or OCT testing. INTRODUCTION TO ThE EYE TEAM AND ThEIR INSTRUMENTS vii Dedicated to Andrea Kase It is impossible to perform a good eye exam without a good support team. Andrea has enthusiastically led our team for 35 years as office manager, ophthalmic technician, and typist of all correspondence, including the last seven editions of this book. By encouraging me to bring my collection of rocks and other objects from nature into the waiting room, she helped create a museum that my patients look forward to seeing.