Volume Contents Volume 12 Number 1 February 1992 ili Obituary: Professor Khrishna Prasad Bhargava l RACHEL RUBINSTEIN & SASSON COHEN: Lack of agonistic activity in McN-A343 may be circumstantial B. E. Bishop & SHEILA A. DOGGRELL: Effects of potassium channel openers and calcium channel blockers on the force responses of the electrically driven rat right ventricle strip KARIM A. ALKADHI & YVONNE H. HOGAN: Effects of 1-methyl- 4-phenyl-1,2,3,6-tetrahydrozypyridine (MPTP) on ganglionic transmission FRANCISO J. MIRANDA, GERMAN TORREGOSA, JUAN B. SALOM, JosE A. ALABAD{, CRISTINA ALVAREZ & ENRIQUE ALBORCH: Direct and neuromodulatory effects of histamine on isolated goat cerebral arteries K. MANDREK & S. KREIS: Regional differentiation of gastric and of pyloric smooth muscle in the pig: mechanical responses to acetylcholine, histamine, substance P, noradenaline and adrenal- ine THOMAS M. BLOMQUIST & DONALD V. PRIOLA: Tachyphylaxis of the intrinsic cardiac nerves to nicotine: effects on A-V nodal conduction Volume 12 Number 2 April 1992 61 A. LUCCHELLI, E. GRANA & M. G. SANTAGOSTINO-BARBONE: Influence of lithium pretreatment and of cooling on the responsi- veness of the rat isolated jejunum and urinary bladder to muscarinic agonists D. D. SMyTH, E. L. PHELAN & CARMEN STANKO: Renal a,- adrenoceptors in New Zealand genetically hypertensive rats F. MuLe, A. GERACI, R. SERIO & A. POSTORINO: On the peptidergic hypothesis for non-adrenergic non-cholinergic inner- vation in the duodenum A. J. DRAPER, M. P. KinGsBury, P. H. REDFERN & M. H. Topp: Effects of chronic administration of atenolol in the in situ perfused mesentery of normotensive and hypertensive rats L. C. Rump, V. WoLk, G. RUFF & P. SCHOLLMEYER: Activation of a- and a,-adrenoceptors inhibits noradrenaline release in rabbit renal arteries: effects of pertussis toxin and N- ethylmaleimide PETER O. O. JuLu: A linear scale for measuring vagal tone in man Volume 12 Number2 June 1992 117 MARGARET D. BROwn: Chronotropic and inotropic responses to adrenoceptor agonists in vitro after chronic dobutamine treat- ment in the rabbit H. R. SCHWIETERT, M.-J. MATHY, D. WILHELM, B. WILFFERT, M. PFAFFENDORF & P. A. VAN ZWIETEN: @,-adrenoceptor- mediated Ca?*-entry from the extracellular fluid and Ca**-release from intracellular stores: no role for @,, ,-adrenoceptor subtypes in the pithed rat R. M. EGLEN, N. ADHAM & R. L. WHITING: Acute desensitiza- tion of muscarinic receptors in the isolated guinea-pig ileal longitudinal muscle C. BLANDizz1, M. C. BERNARDINI, G. NATALE, E. MARTINOTTI & M. Det Tacca: Peripheral 2-hydroxy-saclofen-sensitive GABA-B receptors mediate both vagal-dependent and vagal- independent acid secretory responses in rats J. G. Grous, S. HUBER, G. FISCHER & G. RABERGER: Influence of a,-adrenoceptor blockade and/or 5-HT,, agonism on blood pressure and heart rate at rest and during exercise in hypertensive dogs N. J. MALLARD, R. W. MARSHALL & T. L. B. SPRIGGs: Neurotransmitter feedback is not important in modulating the noradrenergic component of responses of rat vas deferens to twin pulse electrical field stimulation L. RIVERA, M. HERNANDEZ, SARAH BENEDITO, DOLORES PRIETO & A. GARCIA-SACRISTAN: Mediation of contraction by cholinergic muscarinic receptors in the ureterovesical junction Mini-review J. FRYCKSTEDT, B. MEISTER & A. APERIA: Control of electrolyte transport in the kidney through a dopamine- and cAMP-regulated phosphoprotein, DARPP-32 Volume 12 Number 4 August 1992 191 J. Y. Lee, M. E. BRUNE, R. B. WARNER & J. F. DEBERNARDIS: Orthostatic hypotension occurs following a,-adrenoceptor block- ade in chronic prazosin-pretreated conscious spontaneously hy- pertensive rats CLARE E. AUSTIN & RUSSELL CHESS-WILLIAMS: Transient elevation of cardiac B-adrenoceptor responsiveness and receptor number in the streptozotocin-diabetic rat CARLO ALBERTO MAGGI, DAviID H. Coy & SANDRO GIULIANI: Effect of [D-Phe*] bombesin (6-13) methylester, a bombesin receptor antagonist, towards bombesin-induced contractions in the guinea-pig and rat isolated urinary bladder SHEILA A. DOGGRELL: Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine K. LAWSON & P. CHATELAIN: Effects of the divalent cations nickel and cadmium on contractions of rat aorta to endothelin-1 S. B. Guitp, T. C. Murr & J. SCHWARZE: Mechanical and biochemical effects of individual co-transmitters in rat tail arteries G. W. JOHN, F. DEGEORGE & R. MASSINGHAM: Acetycholine- induced relaxation oft he rabbit aorta is preload-independent but markedly dependent upon the degree of excitatory agonist- induced tone MASAYUKI SHIBASAKI, KATSUMI SUDOH, OSAMU INAGAKI, WATARU UCHIDA & Kazuo HOonpa: Effect of the optical isomers of YM-12617 on increased intra-urethral pressure in- duced by phenylephrine in anaesthetized dogs L. ABELLI, F. NAPPI, F. PERRETTI, C. A. MAGGI, S. MANZINI & A. GIACHETTI: Microvascular leakage induced by substance P in rat urinary bladder: involvement of cyclo-oxygenase metabolites of arachidonic acid Volume 12 Number 5 October 1992 277 ROSARIO MAROTO, JULIO MORATINOS & CONSUELO SANCHO: Functional involvement ofa @,- and @,-adrenoceptors in **Rb efflux from liver slices and lipolysis in guinea-pig isolated adipocytes 291 J. ROQUEBERT, A. MORAN & P. DEMICHEL: Effect of quinpirole on neurogenic vasoconstriction in the in situ autoperfused hindquarters and renal vascular beds of the rat S. VENTURA & JOCELYN N. PENNEFATHER: Inhibition of field stimulation-induced contractions of rat cauda epididymis by purinoceptor agonists but not by adrenoceptor agonists J. M. CHILLON, M. GELLOTTE, P. FERRANDON, I. LARTAUD, D. MARTIN, J. M. ARMSTRONG, J. ATKINSON & P. E. HICKs: Haemodynamic effects of the calcium facilitator Bay K-8644 in rats following vascular calcium overload R. M. EGLEN, L. A. PERKINS, L. K. M. WALSH & R. L. WHITING: Agonist action of indole derivatives at 5-H|T; ;, ., 5-HT>, 5-HT; and 5-HT, receptors in vitro C. HARITON: Biphasic dose-dependent effects of dopamine and involvement of dopamine autoreceptors on intra-ocular pressure in the rabbit P. S. LORENZO & E. ALDER-GRASCHINSKY: Gangliosides pre- vent the dimethyl sulphoxide-induced increases in [?H]-noradre- naline release from rat isolated stria C. CHASSAING, M. BOUCHER, C. BREYSSE & P. DUCHENE- MARULLAZ: Contribution of vagal blockade to the tachycardia induced by the antimuscarinic agents atropine and pirenzepine 369 L. BALLaTi, C. A. MaGGi & S. EVANGELISTA: Effects of ruthenium red on the bronchoconstriction induced by capsaicin and by selective tachykinin receptor agonists in anaesthetized guinea-pig MoulIN G. SEIKALY, GILBERT M. EISNER & PEDRO A. JOSE: Contrasting effect of substance P on renal function and dopamine excretion in hydropaenic and volume expanded dogs Volume 12 Number6 December 1992 389 K. R. BoRKOWSKI, R. Gros & HEATHER SCHNEIDER: Vascular f-adrenoceptor-mediated responses in hypertension and ageing in rats 403 PAOLA NIERI, LUISA DAFFONCHIO, CLAUDIO OMINI, ENRICA MARTINOTTI & MARIA C. BRESCHI: Changes in airway reactivity to exogenous and endogenous acetylcholine and substance P after anaphylactic bronchoconstriction in anaesthetized guinea-pigs M. G. C. HENDRIKS, M. PFAFFENDORF & P. A. VAN ZWIETEN: Characterization of the muscarinic receptor subtype mediating vasodilation in the rat perfused mesenteric vascular bed prepara- tion P. SNEDDON & M. MACHALY: Regional variation in purinergic and adrenergic responses in isolated vas deferens of rat, rabbit and guinea-pig NUNO BorGES, FATIMA MARTEL, DOMINGAS BRANCO & WAL- TER OSSWALD: Effects of nebivolol stereoisomers on the action of adrenaline on blood pressure, heart rate and blood levels of noradrenaline and DOPEG J. A. MIcoL & M. L. LAORDEN: Interaction of U-50, 488H with calcium channel agonists and antagonists in different cardiac tissues Review PETER SNEDDON & ANNE GRAHAM: Role of nitric oxide in the autonomic innervation of smooth muscle Author and Subject Indexes to Volume 12