Inflammation in the Disease: Mechanism and Therapies 2014

233 Pages·2015·31.83 MB·English

Mediators of Inflammation
Inflammation in the Disease:
Mechanism and Therapies 2014
Guest Editors: M. Seelaender, J. C. Rosa Neto, G. D. Pimentel,
R. S. Goldszmid, and F. S. de Lira
Inflammation in the Disease: Mechanism and
Therapies 2014
Mediators of Inflammation
Inflammation in the Disease: Mechanism and
Therapies 2014
GuestEditors:M.Seelaender,J.C.RosaNeto,G.D.Pimentel,
R. S. Goldszmid, and F. S. de Lira
Copyright©2015HindawiPublishingCorporation.Allrightsreserved.
Thisisaspecialissuepublishedin“MediatorsofInflammation.”AllarticlesareopenaccessarticlesdistributedundertheCreativeCom-
monsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis
properlycited.
Editorial Board
AnshuAgrawal,USA MirellaGiovarelli,Italy JonasMudter,Germany
MuzamilAhmad,India DenisGirard,Canada HannesNeuwirt,Austria
SimiAli,UK RonaldGladue,USA MarjaOjaniemi,Finland
AmedeoAmedei,Italy HermannGram,Switzerland S.HelenaPenhaOliveira,Brazil
JagadeeshBayry,France StuartGray,UK VeraL.Petricevich,Mexico
PhilipBufler,Germany OresteGualillo,Spain MarcPouliot,Canada
ElisabettaBuommino,Italy ElaineHatanaka,Brazil MichalAmitRahat,Israel
LucaCantarini,Italy NinaIvanovska,Bulgaria AlexanderRiad,Germany
ClaudiaCocco,Italy YonaKeisari,Israel SunitKumarSingh,India
DianneCooper,UK AlexKleinjan,TheNetherlands HelenC.Steel,SouthAfrica
JoseCrispin,Mexico MagdalenaKlink,Poland CarolinaTafalla,Spain
FulvioD’Acquisto,UK M.I.Koenders,TheNetherlands DennisD.Taub,USA
PhamMy-ChanDang,France ElzbietaKolaczkowska,Poland KathyTriantafilou,UK
WilcodeJager,TheNetherlands DmitriV.Krysko,Belgium FumioTsuji,Japan
BeatrizDelasHeras,Spain PhilippM.Lepper,Germany PeterUciechowski,Germany
ChiaraDeLuca,Russia ChanglinLi,USA GiuseppeValacchi,Italy
ClaraDiFilippo,Italy EduardoLo´pez-Collazo,Spain LucVallie`res,Canada
MaziarDivangahi,Canada AntonioMaccio`,Italy J.G.C.v.Amsterdam,TheNetherlands
AmosDouvdevani,Israel A.M.-Puchner,Greece ElenaVoronov,Israel
UlrichEisel,TheNetherlands FrancescoMarotta,Italy JyotiJ.Watters,USA
StefanieB.Flohe´,Germany D.-MarieMcCafferty,Canada SohYamazaki,Japan
TaˆniaSilviaFro¨de,Brazil B.N.Melgert,TheNetherlands TeresaZelante,Singapore
JulioGalvez,Spain VinodK.Mishra,USA DezhengZhao,USA
ChristophGarlichs,Germany EevaMoilanen,Finland FreekJ.Zijlstra,TheNetherlands
Contents
InflammationintheDisease:MechanismandTherapies2014,M.Seelaender,J.C.RosaNeto,
G.D.Pimentel,R.S.Goldszmid,andF.S.deLira
Volume2015,ArticleID169852,2pages
TheRoleoftheImmuneSysteminTripletRepeatExpansionDiseases,MartaOlejniczak,
MartynaO.Urbanek,andWlodzimierzJ.Krzyzosiak
Volume2015,ArticleID873860,11pages
RelationshipbetweenGingivalInflammationandPregnancy,MinWu,Shao-WuChen,
andShao-YunJiang
Volume2015,ArticleID623427,11pages
BlockadeoftheJNKSignallingasaRationalTherapeuticApproachtoModulatetheEarlyandLate
StepsoftheInflammatoryCascadeinPolymicrobialSepsis,GabrielePizzino,AlessandraBitto,
GiovanniPallio,NatashaIrrera,FedericaGalfo,MonicaInterdonato,AnnaMecchio,FilippoDeLuca,
LetteriaMinutoli,FrancescoSquadrito,andDomenicaAltavilla
Volume2015,ArticleID591572,7pages
Interleukin-18IncreasesTLR4andMannoseReceptorExpressionandModulatesCytokineProduction
inHumanMonocytes,LucianeAlarca˜oDias-Melicio,ReginaldoKellerFernandes,
DanielaRamosRodrigues,MarjorieAssisGolim,andAngelaMariaVictorianoCamposSoares
Volume2015,ArticleID236839,9pages
RoleofIL-38andItsRelatedCytokinesinInflammation,XianliYuan,XiaoPeng,YanLi,andMingcaiLi
Volume2015,ArticleID807976,7pages
Commenton“TheEffectofaCommunity-Based,PrimaryHealthCareExerciseProgramon
InflammatoryBiomarkersandHormoneLevels”,BunyaminKoc,HakanSarman,andIsmailBoyraz
Volume2015,ArticleID434218,1pages
InfliximabPreferentiallyInducesClinicalRemissionandMucosalHealinginShortCourseCrohn’s
DiseasewithLuminalLesionsthroughBalancingAbnormalImmuneResponseinGutMucosa,
LijuanYu,XuehuaYang,LuXia,JieZhong,WensongGe,JianxinWu,HongchunLiu,FeiLiu,
andZhanjuLiu
Volume2015,ArticleID793764,9pages
MacadamiaOilSupplementationAttenuatesInflammationandAdipocyteHypertrophyinObeseMice,
EdsonA.Lima,LoreanaS.Silveira,LaureaneN.Masi,AmandaR.Crisma,MarianaR.Davanso,
GabrielI.G.Souza,AlineB.Santamarina,RenataG.Moreira,AmandaRoqueMartins,
LuisGustavoO.deSousa,SandroM.Hirabara,andJoseC.RosaNeto
Volume2014,ArticleID870634,9pages
PreventiveEffectsofChitosanCoacervateWheyProteinonBodyCompositionandImmunometabolic
AspectinObeseMice,GabrielIna´ciodeMoraisHonoratodeSouza,AlineBovetoSantamarina,
AlineAlvesdeSantana,Fa´bioSantosLira,RacheldeLaquila,MayaraFranzoiMoreno,
ElianeBeraldiRibeiro,ClaudiaMariadaPenhaOllerdoNascimento,BrunoRodrigues,ElisaEsposito,
andLilaMissaeOyama
Volume2014,ArticleID281097,13pages
TheInfluenceofAutologousBoneMarrowStemCellTransplantationonMatrixMetalloproteinasesin
PatientsTreatedforAcuteST-ElevationMyocardialInfarction,ElineBredalFurenes,TrineBaurOpstad,
SveinSolheim,KetilLunde,HaraldArnesen,andIngebjørgSeljeflot
Volume2014,ArticleID385901,9pages
ResolutionofSterileInflammation:RoleforVitaminC,BassemM.Mohammed,BernardJ.Fisher,
QuocK.Huynh,DayanjanS.Wijesinghe,CharlesE.Chalfant,DonaldF.Brophy,AlphaA.FowlerIII,
andRameshNatarajan
Volume2014,ArticleID173403,15pages
Jussara(EuterpeedulisMart.)SupplementationduringPregnancyandLactationModulatestheGene
andProteinExpressionofInflammationBiomarkersInducedbytrans-FattyAcidsintheColonof
Offspring,CarinaAlmeidaMorais,LilaMissaeOyama,JulianaLopezdeOliveira,
Ma´rciaCarvalhoGarcia,VeridianaVeradeRosso,La´ısSousaMendesAmigo,
ClaudiaMariaOllerdoNascimento,andLucianaPellegriniPisani
Volume2014,ArticleID987927,11pages
NutritionalRecoveryPromotesHypothalamicInflammationinRatsduringAdulthood,
HellenBarbosaFariasSilva,AnaPaulaCarlideAlmeida,KatarineBarbosaCardoso,
Let´ıciaMartinsIgnacio-Souza,SilviaReginadeLimaReis,MariseAuxiliadoradeBarrosReis,
Ma´rciaQueirozLatorraca,MarcianeMilanski,andVanessaCristinaArantes
Volume2014,ArticleID736506,9pages
Flavocoxid,aNutraceuticalApproachtoBluntInflammatoryConditions,AlessandraBitto,
FrancescoSquadrito,NatashaIrrera,GabrielePizzino,GiovanniPallio,AnnaMecchio,FedericaGalfo,
andDomenicaAltavilla
Volume2014,ArticleID790851,8pages
MetforminAttenuatesExperimentalAutoimmuneArthritisthroughReciprocalRegulationof
Th17/TregBalanceandOsteoclastogenesis,Hye-JinSon,JenniferLee,Seon-YeongLee,Eun-KyungKim,
Min-JungPark,Kyoung-WoonKim,Sung-HwanPark,andMi-LaCho
Volume2014,ArticleID973986,13pages
EvidencefortheGutMicrobiotaShort-ChainFattyAcidsasKeyPathophysiologicalMolecules
ImprovingDiabetes,AlessandraPuddu,RobertaSanguineti,FabrizioMontecucco,
andGiorgioLucianoViviani
Volume2014,ArticleID162021,9pages
SerumLevelsofLL-37andInflammatoryCytokinesinPlaqueandGuttatePsoriasis,YoungJiHwang,
HoJungJung,MinJungKim,NamKyungRoh,JaeWookJung,YangWonLee,YongBeomChoe,
andKyuJoongAhn
Volume2014,ArticleID268257,6pages
IonotropicandMetabotropicProton-SensingReceptorsInvolvedinAirwayInflammationinAllergic
Asthma,HarukaAoki,ChihiroMogi,andFumikazuOkajima
Volume2014,ArticleID712962,8pages
RedGinsengExtractAmelioratesAutoimmuneArthritisviaRegulationofSTAT3Pathway,Th17/Treg
Balance,andOsteoclastogenesisinMiceandHuman,JooYeonJhun,JenniferLee,Jae-KyeongByun,
Eun-KyungKim,Jung-WonWoo,Jae-HoLee,Seung-KiKwok,Ji-HyeonJu,Kyung-SuPark,Ho-YounKim,
SungHwanPark,andMi-LaCho
Volume2014,ArticleID351856,13pages
RolesofChronicLow-GradeInflammationintheDevelopmentofEctopicFatDeposition,LuluLiu,
MeiMei,ShuminYang,andQifuLi
Volume2014,ArticleID418185,7pages
TheEffectofaCommunity-Based,PrimaryHealthCareExerciseProgramonInflammatory
BiomarkersandHormoneLevels,CamilaBosquieroPapini,PriscilaM.Nakamura,LucasP.Zorzetto,
JaniceL.Thompson,AnnaC.Phillips,andEduardoKokubun
Volume2014,ArticleID185707,7pages
StudyoftheCorrelationsamongSomeParametersoftheOxidativeStatus,Gelatinases,andTheir
InhibitorsinaGroupofSubjectswithMetabolicSyndrome,E.Hopps,R.LoPresti,M.Montana,
B.Canino,M.R.Averna,andG.Caimi
Volume2014,ArticleID510619,7pages
GuidanceCueNetrin-1andtheRegulationofInflammationinAcuteandChronicKidneyDisease,
PunithavathiRanganathan,RiyazMohamed,CalpurniaJayakumar,andGanesanRamesh
Volume2014,ArticleID525891,13pages
EfficiencyofDoubleLayeredMicroencapsulatedProbiotictoModulateProInflammatoryMolecular
MarkersfortheManagementofAlcoholicLiverDisease,SumehaArora,InduPalKaur,KanwaljitChopra,
andPraveenRishi
Volume2014,ArticleID715130,11pages
Hindawi Publishing Corporation
Mediators of Inflammation
Volume 2015, Article ID 169852, 2 pages
http://dx.doi.org/10.1155/2015/169852
Editorial
Inflammation in the Disease: Mechanism and Therapies 2014
M.Seelaender,1J.C.RosaNeto,2G.D.Pimentel,3R.S.Goldszmid,4 andF.S.Lira5
1CancerMetabolismResearchGroup,InstituteofBiomedicalSciences,UniversityofSa˜oPaulo(USP),05508-000Sa˜oPaulo,SP,Brazil
2ImmunometabolismResearchGroup,InstituteofBiomedicalSciences,UniversityofSa˜oPaulo(USP),05508-000Sa˜oPaulo,SP,Brazil
3DepartmentofInternalMedicine,StateUniversityofCampinas(UNICAMP),13083-970Campinas,SP,Brazil
4LaboratoryofExperimentalImmunology,CancerandInflammationProgram,CenterforCancerResearch,NationalCancerInstitute,
Bethesda,MD21702,USA
5ExerciseandImmunometabolismResearchGroup,DepartmentofPhysicalEducation,StateUniversityofSa˜oPaulo(UNESP),19060-
900PresidentePrudente,SP,Brazil
CorrespondenceshouldbeaddressedtoF.S.Lira;[email protected]
Received31December2014;Accepted31December2014
Copyright©2015M.Seelaenderetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
Inflammation in the face of harming stimuli protects the of perinatal intake of transfatty acids, the beneficial effect
organism; as a result, it is an essential route for survival, in of red genistein extract on autoimmune arthritis, and the
whichbothinnateandadaptiveimmunityareinvolved.This roleofvitaminCintheresolutionofinflammation.Finally,
processmustbetightlycontrolledandterminatedinorderto the promotion, by nutritional intervention, of the recovery
warrantthereestablishmentofbodyhomeostasis.Therefore, of glucose homeostasis is discussed. In addition, results on
activationofresidentinflammatorycellsandtherecruitment theeffectofmicroencapsulatedprobioticsonalcoholicliver
and modulation of migrating inflammatory cells must be diseasearepresented.Takentogether,thesepapersshownew
ceased. When failure in neutralizing acute inflammation encouraging results of nutritional therapy in counteracting
occurs, there is augmented risk of development of chronic thesymptomsofobesityandinsulinresistance.
inflammation,leadingtoseveralmetabolicconsequences.In Theabilityofexercisetomodulatechronicinflammation
the present special issue, original research studies as well was the center of two papers (C. P. Papini et al. and B. Koc
as review articles address the inflammatory process as a etal.,).Thesestudiesreportthatacommunity-basedexercise
key contributor to disease onset and progression. In addi- programresultsindecreaseormaintenanceofinflammatory
tion,pharmacologicalandnonpharmacologicaltherapiesare biomarkersafter1yearandthuspresentsstrongpotentialin
examinedandthemolecularandphysiologicalmechanisms publichealthapproachesforchronicdiseaseprevention.
ofthetreatmentsarediscussed. Inflammation and its mechanisms are discussed in the
Among the 24 accepted papers, 7 approach nutritional development and progression of many diseases, such as in
therapyandinflammation(J.-Y.Jhunetal.;E.A.Limaetal.; ectopicfatdeposition(L.Liuetal.),acuteandchronickidney
H. B. F. Silva et al.; G. I. G. Souza et al.; B. M. Mohammed disease(P.Ranganathanetal.),andpolymicrobialsepsis(G.
et al.; C. A. Morais et al.; S. Arora et al.). The selected Pizzinoetal.).Theroleofinterleukin-(IL-)18intheregula-
papersdiscusstheeffectsofMacadamiaoilsupplementation tion of toll-like receptors and mannose receptor expression
attenuation of adipocyte hypertrophy and of the inflam- (L. A. Dias-Melicio et al.) is examined. Inflammation in
matory response of adipose tissue macrophages. The pro- the metabolic syndrome (E. Hopps et al.) and the effect of
tection induced by supplementation of chitosan coacervate metformin on autoimmune arthritis (H.-J. Son et al.) are
wheyproteinagainstmetabolicchangesandobesity-related debated. Gut microbiota participation in inflammation is
inflammationis investigated. Other papers examine Jussara addressed(MingmingSunetal.;YuLijuanetal.),anditsreg-
supplementation-associated reversal of the adverse effects ulationbyshort-chainfattyacidsindiabetes(A.Pudduetal.)
2 MediatorsofInflammation
contemplated. The contribution of circulating LL-37 and
inflammatorycytokinesinthesettingofplaqueandguttate
psoriasis(Y.J.Hwangetal.)iscommentedon.Otherpapers
considerionotropicandmetabotropicproton-sensingrecep-
torsinallergicasthma(H.Aokietal.)andautologousbone
marrowstemcelltransplantationinmyocardialinfarction(E.
B.Furenesetal.).Flavocoxidandinfliximabareexaminedin
thecontextofclassicalandnutraceuticaltherapies(A.Bitto
et al.; L. Yu et al.). The role of IL-38 and related cytokines
in inflammation (X. Yuan et al.) is discussed, in addition
togingivalinflammationandpregnancy(M.Wuetal.)and
the contribution of the immune system in triplet repeat
expansiondiseases(M.Olejniczaketal.).
Collectively,thisissueprovidesinsightontheroleofacute
andchronicinflammationindifferentdiseasesanddiscusses
mechanismsandnewtreatmentstrategies.
M.Seelaender
J.C.RosaNeto
G.D.Pimentel
R.S.Goldszmid
F.S.Lira