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Human Hybridomas and Monoclonal Antibodies Human H ybridomas and Monoclonal Antibodies Edited by Edgar G. Engleman and Steven K. H. Faung Stanford University Medical Center Stanford, California J ames Larrick and Andrew Raubitschek Cetus Immune Research Laboratories Palo Alto, California Plenum Press • N ew York and London Library of Congress Cataloging in Publication Data Main entry under title: Human hybridomas and monoclonal antibodies. Includes bibliographies and index. I. Antibodies, Monoclonal. 2. Hybridomas. 1. Engleman, Edgar C. [DNLM: I. Anti bodies, Monoclonal. 2. Hybridomas. 3. Immunologic Technics. QW 575 H918] QRI86.85.H86 1985 616.99/4079 85-12401 ISBN-13: 978-1-4684-4951-8 e-ISBN-13: 978-1-4684-4949-5 DOl: 10.1007/978-1-4684-4949-5 ©1985 Plenum Press, New York Softcover reprint of the hardcover 1 st edition 1985 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Contributors JULIAN L. AMBRUS, JR., Laboratory of Immunoregulation, National Institute of Al lergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205 ANN ARVIN, Department of Pediatrics, Stanford University School of Medicine, Stan ford University Medical Center, Stanford, California 94305 MAKOTO ASADA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan TSEHAY ATLAW, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 CLAUDIA J. BENIKE, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford, California 94305 MARCIA BIEBER, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 WARREN C. BOGARD, JR., Centocor, Malvern, Pennsylvania 19355 S. J. L. BOL, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands. R. L. H. BOLHUIS, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands PETER BRAMS, Cancer Biology Laboratory, State University Hospital (Rigshospitalet), DK-2100 Copenhagen, Denmark KAREN G. BURNETT, Hybritech, San Diego, California 92121 JOSEPH L. BUTLER, Laboratory of Immunoregulation, National Institute of Allergy v VI CONTRIBUTORS and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205. Present address: Division of Pediatric Rheumatology, University of Alabama in Birmingham, Birmingham, Alabama 35294 BARBARA G. CAMPLING, Department of Medicine and Radiation Oncology, Queen's University, Kingston, Ontario, Canada K7L 3N6 DENNIS A. CARSON, Scripps Clinic and Research Foundation, La Jolla, California 92037 TONY CHAN, Cetus Immune Research Laboratories, Palo Alto, California 94303 SUSAN P. C. COLE, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 RICHARD J. COTE, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 STEVEN COUTRE, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 DOROTHY H. CRAWFORD, Department of Haematology, Faculty of Clinical Sciences, University College London, London WCIE 6HX, England CARLO M. CROCE, The Wistar Institute of Anatomy and Biology, Philadelphia, Penn sylvania 19104 KATHLEEN A. DENIS, Departments of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024 BRADLEY J. DYER, Cetus Immune Research Laboratories, Palo Alto, California 94303 AUDREY M. EATON, Cetus Immune Research Laboratories, Palo Alto, California 94303 EDGAR G. ENGLEMAN, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford, California 94305 KARIM ESSANI, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 ANTHONY S. FAUCI, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205 BRIAN M. FENDLY, Cetus Immune Research Laboratories, Palo Alto, California 94303 DIANNE FISHWILD, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 CONTRIBUTORS Vll STEVEN K. H. FOUNG, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford California 94305 KIRK E. FRY, Cancer Biology Research Laboratory, Department of Radiology, Stan ford University School of Medicine, Stanford, California 94305 CARLO GARZELLI, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 MARK C GLASSY, Cancer Center, University of California, San Diego, and Veterans Administration Medical Center, San Diego, California 92103 C. GRAVEKAMP, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands F. CARL GRUMET, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 A. HAGEMEIJER, Department of Cell Biology and Genetics, Erasmus University, Rot terdam, The Netherlands HAROLD H. HANDLEY, Cancer Center, University of California, San Diego, and Vet erans Administration Medical Center, San Diego, California 92103 WOLF HANISCH, Cetus Corporation, Emeryville, California 94608. SARAH M. HART, Cetus Immune Research Laboratories, Palo Alto, Cali forma 94303 JOAN M. HEBERT, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 MASAHIRO HIGUCHI, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan ]em]\; A. HIRST, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 MICHAEL K. HOFFMANN, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 ELIZABETH HORNBERGER, Centocor, Malvern, Pennsylvania 19355 ALAN N. HOUGHTON, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 SYLVIA T. HSIEH-MA, Cetus Immune Research Laboratories, Palo Alto, California 94303 Vlll CONTRIBUTORS MARK C.JAHNSEN, Cetus Immune Research Laboratories, Palo Alto, California 94303 JEFFREY A. KASSEL, Cetus Immune Research Laboratories, Palo Alto, California 94303 YOSHIRO KOBAYASHI, Division of Chemical Toxicology and Immunochemistry, Fac ulty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan DANUTA KOZBOR, The Wistar Institute of Anatomy and Biology, Philadelphia, Penn sylvania 19104 PATRICK C. KUNG, Centocor, Malvern, Pennsylvania 19355. Present address: T cell Sciences, Inc., Lexington, MA 02173 KIT S. LAM, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 JAMES W. LARRICK, Cetus Immune Research Laboratories, Palo Alto, California 94303 JUNMING LE, Department of Microbiology, New York University School of Medicine, New York, New York 10016 JULIA P. LEUNG, Hybritech, San Diego, California 92121 JEFFREY LIFSON, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 DAVID LIPPMAN, Cetus Immune Research Laboratories, Palo Alto, California 94303 MARK E. LOSTROM, Genetic Systems, Seattle, Washington 98121 JOANNE MARTINIS, Hybritech, San Diego, California 92121 LLOYD MAYER, Department of Medicine, Division of Gastroenterology, Mount Sinai Medical Center, New York, New York 10029 RONALD C. MCGARRY, Department of Microbiology and Immunology, Queen's Uni versity, Kingston, Ontario, Canada K7L 3N6 NAHID MOHAGHEGHPOUR, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 RICHARD Moss, Children's Hospital at Stanford, Palo Alto, California 94305 ABNER LOUIS NOTKINS, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 LENNART OLSSON, Cancer Biology Laboratory, State University Hospital (Rigshospitalet), DK-1200 Copenhagen, Denmark CONTRIBUTORS IX TOSHIAKI OSAWA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan SUSAN PERKINS, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 WOLF PRENSKY, Department of Hematology-Oncology, Hahnemann University Hos pital, Philadelphia, Pennsylvania 19102 ANDREW A. RAUBITSCHEK, Cetus Immune Research Laboratories, Palo Alto, Califor nia 94303. Present address: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205. GREGORY R. REYES, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 DAVID B. RING, Cetus Immune Research Laboratories, Palo Alto, California 94303 JOHN C. RODER, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 IVOR ROYSTON, Cancer Center, University of California, San Diego, and Veterans Administration Medical Center, San Diego, California 92103 JO SATOH, Laboratory of Oral Medicine, National Institute of Dental Research, Na tional Institutes of Health, Bethesda, Maryland 20205 ANDREW SAXON, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024 JIM SCHRODER, Folkhalsan Institute of Genetics, Helsinki 10, Finland ROBERT S. SCHWARTZ, Hematology-Oncology Division, New England Medical Center, Boston, Massachusetts 02111 GEORGE SENYK, Cetus Immune Research Laboratories, Palo Alto, California 94303 JERRY W. SHAY, Department of Cell Biology, University of Texas Health Science Center at Dallas, Dallas, Texas 75235 Rosy SHENG-DONG, Cetus Immune Research Laboratories, Palo Alto, California 94303 YEHUDA SHOENFEI.D, Department of Medicine "D" (Research Laboratory of Autoim mune Diseases), Beilinson Medical Center, Petach Tiqva, Israel ANTHONY W. SIADAK, Genetic Systems, Seattle, Washington 98121 FLOYD T AUB, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 x CONTRIBUTORS NELSON N. H. TENG, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305 FRANK TRINGALE, Cetus Immune Research Laboratories, Palo Alto, California 94303 SHU-ICHI TSUCHlYA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan MARY A. VALENTINE, Scripps Clinic and Research Foundation, La Jolla, California 92037 JAN VILCEK, Department of Microbiology, New York University School of Medicine, New York, New York 10016 RANDOLPH WALL, Departments of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024 JANET WANG, Cetus Immune Research Laboratories, Palo Alto, California 94303 HOWARD WEINTRAUB, Cetus Immune Research Laboratories, Palo Alto, California 94303

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Soon after Kohler and Milstein described the use of somatic cell hybridization for the production of murine monoclonal antibodies of desired specificity, this relatively simple technique became widely applied. Indeed, production of murine monoclonal antibodies is now considered routine by immunologi
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528 Pages·1985·15.56 MB·English
by  Jerry W. Shay (auth.)
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Human Hybridomas and Monoclonal Antibodies Human H ybridomas and Monoclonal Antibodies Edited by Edgar G. Engleman and Steven K. H. Faung Stanford University Medical Center Stanford, California J ames Larrick and Andrew Raubitschek Cetus Immune Research Laboratories Palo Alto, California Plenum Press • N ew York and London Library of Congress Cataloging in Publication Data Main entry under title: Human hybridomas and monoclonal antibodies. Includes bibliographies and index. I. Antibodies, Monoclonal. 2. Hybridomas. 1. Engleman, Edgar C. [DNLM: I. Anti bodies, Monoclonal. 2. Hybridomas. 3. Immunologic Technics. QW 575 H918] QRI86.85.H86 1985 616.99/4079 85-12401 ISBN-13: 978-1-4684-4951-8 e-ISBN-13: 978-1-4684-4949-5 DOl: 10.1007/978-1-4684-4949-5 ©1985 Plenum Press, New York Softcover reprint of the hardcover 1 st edition 1985 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Contributors JULIAN L. AMBRUS, JR., Laboratory of Immunoregulation, National Institute of Al lergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205 ANN ARVIN, Department of Pediatrics, Stanford University School of Medicine, Stan ford University Medical Center, Stanford, California 94305 MAKOTO ASADA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan TSEHAY ATLAW, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 CLAUDIA J. BENIKE, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford, California 94305 MARCIA BIEBER, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 WARREN C. BOGARD, JR., Centocor, Malvern, Pennsylvania 19355 S. J. L. BOL, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands. R. L. H. BOLHUIS, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands PETER BRAMS, Cancer Biology Laboratory, State University Hospital (Rigshospitalet), DK-2100 Copenhagen, Denmark KAREN G. BURNETT, Hybritech, San Diego, California 92121 JOSEPH L. BUTLER, Laboratory of Immunoregulation, National Institute of Allergy v VI CONTRIBUTORS and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205. Present address: Division of Pediatric Rheumatology, University of Alabama in Birmingham, Birmingham, Alabama 35294 BARBARA G. CAMPLING, Department of Medicine and Radiation Oncology, Queen's University, Kingston, Ontario, Canada K7L 3N6 DENNIS A. CARSON, Scripps Clinic and Research Foundation, La Jolla, California 92037 TONY CHAN, Cetus Immune Research Laboratories, Palo Alto, California 94303 SUSAN P. C. COLE, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 RICHARD J. COTE, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 STEVEN COUTRE, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 DOROTHY H. CRAWFORD, Department of Haematology, Faculty of Clinical Sciences, University College London, London WCIE 6HX, England CARLO M. CROCE, The Wistar Institute of Anatomy and Biology, Philadelphia, Penn sylvania 19104 KATHLEEN A. DENIS, Departments of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024 BRADLEY J. DYER, Cetus Immune Research Laboratories, Palo Alto, California 94303 AUDREY M. EATON, Cetus Immune Research Laboratories, Palo Alto, California 94303 EDGAR G. ENGLEMAN, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford, California 94305 KARIM ESSANI, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 ANTHONY S. FAUCI, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20205 BRIAN M. FENDLY, Cetus Immune Research Laboratories, Palo Alto, California 94303 DIANNE FISHWILD, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 CONTRIBUTORS Vll STEVEN K. H. FOUNG, Department of Pathology, Stanford University School of Medi cine, Stanford University Medical Center, Stanford California 94305 KIRK E. FRY, Cancer Biology Research Laboratory, Department of Radiology, Stan ford University School of Medicine, Stanford, California 94305 CARLO GARZELLI, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 MARK C GLASSY, Cancer Center, University of California, San Diego, and Veterans Administration Medical Center, San Diego, California 92103 C. GRAVEKAMP, Rotterdam Radiotherapeutic Institute, Rotterdam, The Netherlands F. CARL GRUMET, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 A. HAGEMEIJER, Department of Cell Biology and Genetics, Erasmus University, Rot terdam, The Netherlands HAROLD H. HANDLEY, Cancer Center, University of California, San Diego, and Vet erans Administration Medical Center, San Diego, California 92103 WOLF HANISCH, Cetus Corporation, Emeryville, California 94608. SARAH M. HART, Cetus Immune Research Laboratories, Palo Alto, Cali forma 94303 JOAN M. HEBERT, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 MASAHIRO HIGUCHI, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan ]em]\; A. HIRST, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 MICHAEL K. HOFFMANN, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 ELIZABETH HORNBERGER, Centocor, Malvern, Pennsylvania 19355 ALAN N. HOUGHTON, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 SYLVIA T. HSIEH-MA, Cetus Immune Research Laboratories, Palo Alto, California 94303 Vlll CONTRIBUTORS MARK C.JAHNSEN, Cetus Immune Research Laboratories, Palo Alto, California 94303 JEFFREY A. KASSEL, Cetus Immune Research Laboratories, Palo Alto, California 94303 YOSHIRO KOBAYASHI, Division of Chemical Toxicology and Immunochemistry, Fac ulty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan DANUTA KOZBOR, The Wistar Institute of Anatomy and Biology, Philadelphia, Penn sylvania 19104 PATRICK C. KUNG, Centocor, Malvern, Pennsylvania 19355. Present address: T cell Sciences, Inc., Lexington, MA 02173 KIT S. LAM, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 JAMES W. LARRICK, Cetus Immune Research Laboratories, Palo Alto, California 94303 JUNMING LE, Department of Microbiology, New York University School of Medicine, New York, New York 10016 JULIA P. LEUNG, Hybritech, San Diego, California 92121 JEFFREY LIFSON, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 DAVID LIPPMAN, Cetus Immune Research Laboratories, Palo Alto, California 94303 MARK E. LOSTROM, Genetic Systems, Seattle, Washington 98121 JOANNE MARTINIS, Hybritech, San Diego, California 92121 LLOYD MAYER, Department of Medicine, Division of Gastroenterology, Mount Sinai Medical Center, New York, New York 10029 RONALD C. MCGARRY, Department of Microbiology and Immunology, Queen's Uni versity, Kingston, Ontario, Canada K7L 3N6 NAHID MOHAGHEGHPOUR, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 RICHARD Moss, Children's Hospital at Stanford, Palo Alto, California 94305 ABNER LOUIS NOTKINS, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 LENNART OLSSON, Cancer Biology Laboratory, State University Hospital (Rigshospitalet), DK-1200 Copenhagen, Denmark CONTRIBUTORS IX TOSHIAKI OSAWA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan SUSAN PERKINS, Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, Stanford, California 94305 WOLF PRENSKY, Department of Hematology-Oncology, Hahnemann University Hos pital, Philadelphia, Pennsylvania 19102 ANDREW A. RAUBITSCHEK, Cetus Immune Research Laboratories, Palo Alto, Califor nia 94303. Present address: Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205. GREGORY R. REYES, Cancer Biology Research Laboratory, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 DAVID B. RING, Cetus Immune Research Laboratories, Palo Alto, California 94303 JOHN C. RODER, Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6 IVOR ROYSTON, Cancer Center, University of California, San Diego, and Veterans Administration Medical Center, San Diego, California 92103 JO SATOH, Laboratory of Oral Medicine, National Institute of Dental Research, Na tional Institutes of Health, Bethesda, Maryland 20205 ANDREW SAXON, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024 JIM SCHRODER, Folkhalsan Institute of Genetics, Helsinki 10, Finland ROBERT S. SCHWARTZ, Hematology-Oncology Division, New England Medical Center, Boston, Massachusetts 02111 GEORGE SENYK, Cetus Immune Research Laboratories, Palo Alto, California 94303 JERRY W. SHAY, Department of Cell Biology, University of Texas Health Science Center at Dallas, Dallas, Texas 75235 Rosy SHENG-DONG, Cetus Immune Research Laboratories, Palo Alto, California 94303 YEHUDA SHOENFEI.D, Department of Medicine "D" (Research Laboratory of Autoim mune Diseases), Beilinson Medical Center, Petach Tiqva, Israel ANTHONY W. SIADAK, Genetic Systems, Seattle, Washington 98121 FLOYD T AUB, Laboratory of Oral Medicine, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20205 x CONTRIBUTORS NELSON N. H. TENG, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305 FRANK TRINGALE, Cetus Immune Research Laboratories, Palo Alto, California 94303 SHU-ICHI TSUCHlYA, Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan MARY A. VALENTINE, Scripps Clinic and Research Foundation, La Jolla, California 92037 JAN VILCEK, Department of Microbiology, New York University School of Medicine, New York, New York 10016 RANDOLPH WALL, Departments of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California 90024 JANET WANG, Cetus Immune Research Laboratories, Palo Alto, California 94303 HOWARD WEINTRAUB, Cetus Immune Research Laboratories, Palo Alto, California 94303

Description:
Soon after Kohler and Milstein described the use of somatic cell hybridization for the production of murine monoclonal antibodies of desired specificity, this relatively simple technique became widely applied. Indeed, production of murine monoclonal antibodies is now considered routine by immunologi
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