Hematologic malignancies: acute leukemias

301 Pages·2008·13.56 MB·English

by  Elihu H. Estey

E.H. Estey · S.H. Faderl · H.M. Kantarjian
Hematologic Malignancies: Acute Leukemias
E.H. Estey · S.H. Faderl · H.M. Kantarjian
Hematologic Malignancies:
Acute Leukemias
With 44 Figures and 51 Tables
(cid:2) (cid:3)
E.H. Estey H.M. Kantarjian
Departmentof Leukemia Departmentof Leukemia
The Universityof Texas The Universityof Texas
MDAndersonCancer Center MDAndersonCancer Center
Houston, Texas, USA Houston, Texas, USA
S.H. Faderl
Departmentof Leukemia
The Universityof Texas
MDAndersonCancer Center
Houston, Texas, USA
ISBN 978-3-540-72302-8 SpringerBerlinHeidelbergNewYork
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Table of Contents
Part I – Acute Myeloid Leukemia 8 Diagnosis of AcuteLymphoblastic
Leukemia . . . . . . . . . . . . . . . . . 119
1 Therapy of AML . . . . . . . . . . . . 1
M. Albitar, F.J. Giles, H. Kantarjian
E.H. Estey
9 General Approach to the Therapy
2 Diagnosis and Classification of
of Adult Acute Lymphoblastic
the Acute Myeloid Leukemias
Leukemia . . . . . . . . . . . . . . . . . 131
(with Discussion of the Role of
S.H. Faderl, H.M. Kantarjian
the Myelodysplastic Syndromes
in AML Pathogenesis) . . . . . . . . 21 10 Recent Clinical Trials in Acute
D. Head, M.A. Thompson Lymphoblastic Leukemia by the
Cancer and Leukemia Group B . 137
3 Acute Myeloid Leukemia:
R.A. Larson, D. Yu, B.L. Sanford,
Epidemiology and Etiology . . . . 47
W. Stock
B. Deschler, M. Lübbert
4 Relapsed and Refractory Acute 11 Conventional Therapy in Adult
Myeloid Leukemia . . . . . . . . . . 57 Acute Lymphoblastic Leukemia:
S. Abutalib, M.S. Tallman Review of the LALA Program . . 145
X. Thomas, D. Fiere
PartII–AcuteLymphoblasticLeukemia 12 ALLTherapy: Review of the MD
Anderson Program . . . . . . . . . . 161
5 Acute Lymphoblastic Leukemia:
S.H. Faderl, D.A. Thomas,
Epidemiology and Etiology . . . . 77
H.M. Kantarjian
D. Wartenberg, F.D. Groves,
A.S. Adelman 13 TreatmentofAdultALLAccording
to Protocols of the German
6 Molecular Biology and Genetics 95
Multicenter Study Group for
M. Wetzler, M. Kryzstof
Adult ALL (GMALL) . . . . . . . . . . 167
7 Acute Lymphoblastic Leukemia:
N. Gökbuget, R. Arnold, A. Böhme,
Clinical Presentation, Diagnosis,
R. Fietkau, M. Freund, A. Ganser,
and Classification . . . . . . . . . . . 109
M. Kneba, T. Lipp, W.-D. Ludwig,
R.A. Larson, J.Anastasi G. Maschmeyer, D. Messerer,
H. Rieder, E. Thiel, D. Hoelzer
for the German Multicenter Study
Groupfor Adult ALL (GMALL)
VI TableofContents
14 Philadelphia Chromosome- 19 Novel Therapies in Acute
Positive Acute Lymphoblastic Lymphoblastic Leukemia . . . . . . 237
Leukemia . . . . . . . . . . . . . . . . . . 177 S.H. Faderl, H.M. Kantarjian
O. Sala-Torra, J.P. Radich
20 Minimal Residual Disease
15 Burkitt’s Acute Lymphoblastic Studies in Acute Lymphoblastic
Leukemia (L3ALL) in Adults . . . . 191 Leukemia . . . . . . . . . . . . . . . . . . 247
V. Ribrag, P. Casassus, P. Fenaux S. Abutalib, W. Stock
16 Treatment of Lymphoblastic 21 Central Nervous System Involve-
Lymphoma in Adults . . . . . . . . . 203 ment in Adult Acute Lymphocytic
N. Gökbuget, D. Hoelzer Leukemia . . . . . . . . . . . . . . . . . . 263
R.H. Alvarez, J.E. Cortes
17 The Role of Allogeneic Stem Cell
Transplantation in the Therapy 22 Relapsed Acute Lymphoblastic
of Adult Acute Lymphoblastic Leukemia . . . . . . . . . . . . . . . . . . 275
Leukemia (ALL) . . . . . . . . . . . . . 215
N. Lamanna, M. von Hassel,
P. Kebriaei,R. Champlin M. Weiss
18 The Role of Autologous Stem
23 Emergencies in Acute
Cell Transplantation in the Man-
Lymphoblastic Leukemia . . . . . . 281
agement of Acute Lymphoblastic
O. Frankfurt, M.S. Tallman
Leukemia in Adults . . . . . . . . . . 229
P. Kebriaei,S. Giralt Subject Index . . . . . . . . . . . . . . . . . . 289
Contributors
S. Abutalib A. Böhme
Section of Hematology-Oncology Johann WolfgangGoethe-University
UniversityofIllinois Medical Department II
Chicago, IL, USA Frankfurt, Germany
A.S. Adelman P. Casassus
Departmentof Biostatistics, Bioinformatics Service d’hématologie clinique
and Epidemiology Hôpital Avicennes
Medical Universityof South Carolina Université Paris XIII
Charleston, SC, USA Bobigny, France
M. Albitar R. Champlin
Quest Diagnostics Nichols Institute Departmentof Blood
San Juan Capistrano, CA, USA and Marrow Transplantation
UniversityofTexas
R.H. Alvarez
M.D. AndersonCancer Center
Departmentof Cancer Medicine, Unit 10
Houston, TX, USA
UniversityofTexas
M.D. AndersonCancer Center J.E. Cortes
Houston, TX, USA Departmentof Leukemia
The Universityof Texas
J. Anastasi
M.D. AndersonCancer Center
Section of Hematology/Oncology
Houston, TX, USA
Departmentof Medicine
and Departmentof Pathology B. Deschler
Cancer Research Center Medical Center
UniversityofChicago Departmentof Hematology and Oncology
Chicago, IL, USA UniversityofFreiburg
Freiburg, Germany
R. Arnold
Johann WolfgangGoethe-University E.H. Estey
Medical Department II Departmentof Leukemia
Frankfurt, Germany UniversityofTexas
M.D. AndersonCancer Center
Houston, TX, USA
VIII Contributors
S.H. Faderl F.D. Groves
Departmentof Leukemia Departmentof Epidemiology
The Universityof Texas and Population Health
M.D. AndersonCancer Center SchoolofPublicHealthandInformationSciences
Houston, TX, USA UniversityofLouisville
Louisville, KY, USA
P. Fenaux
Service d’hématologie clinique D. Head
Hôpital Avicennes Departmentof Pathology
Université Paris XIII VanderbiltUniversity School ofMedicine
Bobigny, France Nashville, TN, USA
D. Fiere D. Hoelzer
Groupe d’Etude etde Traitementde la Leucémie Johann WolfgangGoethe-University
Aiguë Lymphoblastique de l’Adulte Medical Department II
(GET-LALAGroup) Frankfurt, Germany
Hematology Department
H.M. Kantarjian
EdouardHerriotHospital
Departmentof Leukemia
Lyon, France
The Universityof Texas
R. Fietkau M.D. AndersonCancer Center
Johann WolfgangGoethe-University Houston, TX, USA
Medical Department II
P. Kebriaei
Frankfurt, Germany
Section of Blood and Marrow Transplantation
O. Frankfurt The Universityof Texas
Northwestern University Feinberg School M.D. AndersonCancer Center
of Medicine Houston, TX, USA
Robert H. Lurie Comprehensive Cancer Center
M. Kneba
Chicago, IL, USA
Johann WolfgangGoethe-University
M. Freund Medical Department II
Johann WolfgangGoethe-University Frankfurt, Germany
Medical Department II
M. Kryzstof
Frankfurt, Germany
Division of Hematology and Oncology
A. Ganser Arthur G. James Cancer Hospital
Johann WolfgangGoethe-University Ohio State University
Medical Department II Columbus, OH, USA
Frankfurt, Germany
N. Lamanna
S. Giralt Memorial Sloan-Kettering CancerCenter
Section of Blood and Marrow Transplantation New York, NY, USA
The Universityof Texas
R.A. Larson
M.D. AndersonCancer Center
Section of Hematology/Oncology
Houston, TX, USA
Departmentof Medicine
N. Gökbuget and Departmentof Pathology
Johann WolfgangGoethe-University Cancer Research Center
Medical Department II UniversityofChicago
Frankfurt, Germany Chicago, IL, USA
a Contributors IX
T. Lipp B.L. Sanford
Johann WolfgangGoethe-University Section of Hematology/Oncology
Medical Department II Departmentof Medicine
Frankfurt, Germany and Departmentof Pathology
Cancer Research Center
M. Lübbert
UniversityofChicago
Medical Center
Chicago, IL, USA
Departmentof Hematology and Oncology
UniversityofFreiburg W. Stock
Freiburg, Germany Departmentof Medicine and University
of Chicago Cancer Research Center
W.D. Ludwig
Chicago, IL, USA
Johann WolfgangGoethe-University
Medical Department II M.S. Tallman
Frankfurt, Germany Division of Hematology-Oncology
Departmentof Medicine
G. Maschmeyer
Northwestern University,
Johann WolfgangGoethe-University
Feinberg School ofMedicine
Medical Department II
Chicago, IL, USA
Frankfurt, Germany
E. Thiel
D. Messerer
Johann WolfgangGoethe-University
Johann WolfgangGoethe-University
Medical Department II
Medical Department II
Frankfurt, Germany
Frankfurt, Germany
D.A. Thomas
J.P. Radich
Departmentof Leukemia
Clinical Research Division
The Universityof Texas
Fred Hutchinson Cancer Research Center
M.D. AndersonCancer Center
Seattle, WA, USA
Houston, TX, USA
V. Ribrag
X. Thomas
Service d’hématologie
Groupe d’Etude etde Traitementde la Leucémie
Institut Gustave Roussy
Aiguë Lymphoblastique de l’Adulte
Villejuif, France
(GET-LALAGroup)
H. Rieder Hematology Department
EdouardHerriotHospital
Johann WolfgangGoethe-University
Lyon, France
Medical Department II
Frankfurt, Germany M. von Hassell
O. Sala-Torra Memorial Sloan-Kettering CancerCenter
New York, NY, USA
Clinical Research Division
Fred Hutchinson Cancer Research Center M.A. Thompson
Seattle, WA, USA
Departmentof Pathology
VanderbiltUniversity School ofMedicine
Nashville, TN, USA
X Contributors
D. Wartenberg D. Yu
Departmentof Environmental Section of Hematology/Oncology
and Occupational Medicine Departmentof Medicine
Robert Wood Johnson Medical School and Departmentof Pathology
Piscataway, NJ, USA Cancer Research Center
UniversityofChicago
M. Weiss
Chicago, IL, USA
Memorial Sloan-Kettering CancerCenter
New York, NY, USA
M. Wetzler
Roswell Park Cancer Institute
Elm and Carlton Streets
Buffalo, NY, USA