Health Benefits of Green Tea An Evidence-based Approach Health Benefits of Green Tea An Evidence-based Approach Edited by Yukihiko Hara (Editor in Chief), Chung S. Yang, Mamoru Isemura, and Isao Tomita CABI is a trading name of CAB International CABI CABI Nosworthy Way 745 Atlantic Avenue Wallingford 8th Floor Oxfordshire OX10 8DE Boston, MA 02111 UK USA Tel: +44 (0)1491 832111 Tel: +1 (617)682-9015 Fax: +44 (0)1491 833508 E-mail: [email protected] E-mail: [email protected] Website: www.cabi.org © CAB International 2017. All rights reserved. No part of this publication may be reproduced in any form or by any means, electronically, mechanically, by photocopying, recording or otherwise, without the prior permission of the copyright owners. A catalogue record for this book is available from the British Library, London, UK. Library of Congress Cataloging-in-Publication Data Names: Hara, Yukihiko, 1943- editor. | Yang, Chung S., editor. | Isemura, Mamoru, editor. | Tomita, Isao, editor. Title: Health benefits of green tea : an evidence-based approach / edited by Yukihiko Hara (editor in chief), Chung S. Yang, Mamoru Isemura and Isao Tomita. Description: Wallingford, Oxfordshire ; Boston, MA : CABI, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2017016225 (print) | LCCN 2017018726 (ebook) | ISBN 9781786392404 (ePDF) | ISBN 9781786392411 (ePub) | ISBN 9781786392398 (hbk : alk. paper) Subjects: | MESH: Tea | Camellia sinensis | Catechin--therapeutic use | Phytotherapy--methods Classification: LCC RM666.H33 (ebook) | LCC RM666.H33 (print) | NLM WB 438 | DDC 615.3/21--dc23 LC record available at https://lccn.loc.gov/2017016225 ISBN-13: 978 1 78639 239 8 Commissioning editor: Rachael Russell Editorial assistant: Emma McCann Production editor: Shankari Wilford Typeset by SPi, Pondicherry, India Printed and bound in the UK by CPI Group (UK) Ltd, Croydon, CR0 4YY, UK Contents Contributors ix Foreword xi Junichi Shinmura Preface xiii Chung S. Yang PART 1 OVERALL PERSPECTIVE 1 Efficacy of Tea in Human Health 1 Isao Tomita 2 Characteristics of Japanese Green Tea 9 Yoriyuki Nakamura 3 Research on Tea and Human Health in China and the Contribution to the Development of the Chinese Tea Industry 19 Chen Zongmao and Lin Zhi 4 Studies by Japanese Scientists on the Health Effects of Green Tea 29 Koichi Saeki, Takeshi Minami, and Mamoru Isemura 5 Health-related Studies of Tea in Africa 37 Zeno Apostolides 6 Efficient Synthesis of Catechin Probe and its Molecular Dynamics 42 Toshiyuki Kan, Tomohiro Asakawa, and Makoto Inai 7 Bioavailability and Biotransformation of Tea Polyphenols 52 Chung S. Yang and Mao-Jung Lee v vi Contents PART 2 ANTICANCER EFFECTS 8 Tea Catechins in Cancer Prevention and Therapy—Molecular Mechanism and Human Relevance 65 Chung S. Yang and Hong Wang 9 Green Tea Catechins for the Prevention of Colorectal Tumorigenesis: from Bench to Bed 84 Masahito Shimizu and Hisataka Moriwaki 10 Green Tea Polyphenol EGCG-sensing Receptor 89 Hirofumi Tachibana 11 Clinical Trials and New Drug Development 101 Yukihiko Hara PART 3 EFFECTS ON OBESITY, METABOLIC SYNDROME, AND RELATED DISEASES 12 Preventive Effects of Green Tea and its Components on Obesity 108 Kazutoshi Sayama 13 Effects of Tea Galloyl Catechins on the Reduction of Body Fat 116 Takami Kakuda 14 P rotective Effects of Green Tea Catechins on Cardio- and Cerebral Vascular Diseases 124 Takako A. Tomita 15 Anti-obesity Effects of Green Tea Catechins 134 Ichiro Tokimitsu and Shinichi Meguro 16 Antidiabetic Effects 139 Noriyuki Miyoshi PART 4 OTHER HEALTH-BENEFICIAL EFFECTS OF TEA CATECHINS AND OTHER CONSTITUENTS 17 Impact of Green Tea Catechins on Multidrug-resistant Bacterial Pathogens 147 Peter W. Taylor 18 Effects of Green Tea on Influenza Infection and the Common Cold 157 Hiroshi Yamada 19 Immune Regulatory Effect of Green Tea 161 Mari Maeda-Yamamoto, Hirofumi Tachibana, and Manami Monobe 20 Protective Effects of Catechins on Hepatitis and Liver Fibrosis 167 Takuji Suzuki 21 Effects of Green Tea Catechins on Aging and Dementia 178 Keiko Unno 22 Green Tea in the Protection against Neurodegeneration 185 Hidehiko Yokogoshi Contents vii 23 Effects of High-molecular-weight Polyphenol (Mitochondria Activation Factor) Derived from Black Tea and Oolong Tea on Mitochondria Function 191 Osamu Numata 24 Effects of Theanine and Other Ingredients of Tea on Stress and Aging 200 Keiko Unno 25 Green Tea and Oral Health 211 Rupali Agnihotri and Sumit Gaur 26 Radioprotective Effects of Green Tea 220 Shuichi Masuda and Yuko Shimamura 27 Effects of Catechins on Intestinal Flora 230 Yukihiko Hara Index 239 Contributors Agnihotri, R., Department of Periodontics, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India 576104. E-mail: [email protected] Apostolides, Z., Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa. E-mail: [email protected] and [email protected] Asakawa, T., Tokai University Institute of Innovative Science and Technology, Orido, Shizuoka 424-8610, Japan. E-mail: [email protected] Chen, Z.M., Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. E-mail: [email protected] Gaur, S., Department of Periodontics and Preventive Dentistry, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka 576104, India. E-mail: get2sumitgaur@ yahoo.co.in Hara, Y., Tea Solutions, Hara Office Inc. Tokyo 130-0012, Japan. E-mail: ysjrhara@soleil. ocn.ne.jp Inai, M., School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan. E-mail: [email protected] Isemura, M., Tea Science Center, University of Shizuoka, Yada, Shizuoka 422-8526, Japan. E-mail: [email protected] Kakuda, T., Research Center of Composite Materials, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan. E-mail: [email protected] Kan, T., School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan. E-mail: [email protected] Lee, M.-J., Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Frelinghuysen Road, Piscataway, NJ 08854-8020, USA. E-mail: [email protected] Lin, Z., Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. E-mail: [email protected] Maeda-Yamamoto, M., Food Research Institute, National Agriculture and Food Research Organization (NARO), Division of Food Function Research, Kannondai, Tsukuba, Ibaraki 305-8642, Japan. E-mail: [email protected] Masuda, S., Food and Nutritional Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan. E-mail: [email protected] ix
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