Journal of Nucleic Acids DNA Damage, Mutagenesis, and DNA Repair Guest Editors: Ashis Basu, Suse Broyde, Shigenori Iwai, and Caroline Kisker DNA Damage, Mutagenesis, and DNA Repair Journal of Nucleic Acids DNA Damage, Mutagenesis, and DNA Repair Guest Editors: Ashis Basu, Suse Broyde, Shigenori Iwai, and Caroline Kisker Copyright©2010sage-HindawiPublishingCorporation.Allrightsreserved. Thisisaspecialissuepublishedinvolume2010of“JournalofNucleicAcids.”Allarticlesareopenaccessarticlesdistributedunderthe CreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedthe originalworkisproperlycited. Journal of Nucleic Acids Editorial Board LuigiA.Agrofoglio,France Ramo´nEritja,Spain P.E.Nielsen,Germany HiroyukiAsanuma,Japan MarinaGottikh,Russia SatoshiObika,Japan AshisBasu,USA JohnA.Hartley,UK TatianaS.Oretskaya,Russia BenBerkhout,TheNetherlands RolandK.Hartmann,Germany TobiasRestle,Germany AnnL.Beyer,USA TapasKHazra,USA MitsuoSekine,Japan ChristianeBranlant,France HyoutaHimeno,Japan JacekStawinski,Sweden EmeryH.Bresnick,USA RobertHudson,Canada DmitryA.Stetsenko,UK TomBrown,UK ShigenoriIwai,Japan HiroshiSugiyama,Japan JanuszM.Bujnicki,Poland B.H.Kim,Korea ZucaiSuo,USA JyotiChattopadhyaya,Sweden JørgenKjems,Denmark AkioTakenaka,Japan GrigoryDianov,UK XingguoLiang,Japan YitzhakTor,USA AidanDoherty,UK LuisA.Marky,USA DmitryVeprintsev,UK JoachimEngels,Germany AtsushiMaruyama,Japan BirteVester,Denmark Contents DNADamage,Mutagenesis,andDNARepair,AshisBasu,SuseBroyde,ShigenoriIwai,andCarolineKisker Volume2010,ArticleID182894,1pages FromDNARadiationDamagetoCellDeath:TheoreticalApproaches,FrancescaBallarini Volume2010,ArticleID350608,8pages TheBiologicalandMetabolicFatesofEndogenousDNADamageProducts,SimonWanChanand PeterC.Dedon Volume2010,ArticleID929047,13pages DNA-DestabilizingAgentsasanAlternativeApproachforTargetingDNA:MechanismsofActionand CellularConsequences,Gae¨lleLengletandMarie-He´le`neDavid-Cordonnier Volume2010,ArticleID290935,17pages StructuralDeterminantsofPhotoreactivityofTriplexFormingOligonucleotidesConjugatedto Psoralens,RajagopalKrishnanandDennisH.Oh Volume2010,ArticleID523498,7pages DifferentialToxicityofDNAAdductsofMitomycinC,JillBargonetti,EliseChampeil,andMariaTomasz Volume2010,ArticleID698960,6pages CellularResponsestoCisplatin-InducedDNADamage,AlakanandaBasuandSoumyaKrishnamurthy Volume2010,ArticleID201367,16pages IntracellularDNADamagebyLysine-AcetyleneConjugates,Wang-YongYang,QiangCao, CatherineCallahan,CatalinaGalvis,Qing-XiangSang,andIgorV.Alabugin Volume2010,ArticleID931394,6pages CurrentStudiesintotheGenotoxicEffectsofNanomaterials,Cheng-TengNg,JasmineJ.Li, Boon-HuatBay,andLin-YueLanryYung Volume2010,ArticleID947859,12pages FormationandRepairofTobaccoCarcinogen-DerivedBulkyDNAAdducts,BoHang Volume2010,ArticleID709521,29pages Formation,Repair,andGenotoxicPropertiesofBulkyDNAAdductsFormedfromTobacco-Specific Nitrosamines,LisaA.Peterson Volume2010,ArticleID284935,11pages Smoking,DNAAdductsandNumberofRiskDNARepairAllelesinLungCancerCases,inSubjectswith BenignLungDiseasesandinControls,MarcoPeluso,ArmelleMunnia,SaraPiro,AlessandraArmillis, MarcelloCeppi,GiuseppeMatullo,andRiccardoPuntoni Volume2010,ArticleID386798,7pages InsightsintotheStructuresofDNADamagedbyHydroxylRadical:CrystalStructuresofDNADuplexes Containing5-Formyluracil,MasaruTsunoda,TakeshiSakaue,SatokoNaito,TomokoSunami,NaokoAbe, YoshihitoUeno,AkiraMatsuda,andAkioTake´naka Volume2010,ArticleID107289,10pages ElevatedLevelsofDNAStrandBreaksInducedbyaBaseAnalogintheHumanCellLinewiththeP32T ITPAVariant,IrinaS.-R.Waisertreiger,MiriamR.Menezes,JamesRandazzo,andYouriI.Pavlov Volume2010,ArticleID872180,11pages SOD1IsEssentialfortheViabilityofDT40CellsandNuclearSOD1FunctionsasaGuardianofGenomic DNA,EriInoue,KeizoTano,HanakoYoshii,JunNakamura,ShusukeTada,MasamiWatanabe, MasayukiSeki,andTakemiEnomoto Volume2010,ArticleID795946,11pages Mus308ProcessesOxygenandNitrogenEthylationDNADamageinGermCellsofDrosophila, NancyD´ıaz-Valde´s,MiguelA.Comendador,andL.Mar´ıaSierra Volume2010,ArticleID416364,7pages IstheCometAssayaSensitiveProcedureforDetectingGenotoxicity?,SatomiKawaguchi, TakanoriNakamura,AyumiYamamoto,GishoHonda,andYuF.Sasaki Volume2010,ArticleID541050,8pages DevelopmentofaNovelFluorescenceAssayBasedontheUseoftheThrombin-BindingAptamerforthe DetectionofO6-Alkylguanine-DNAAlkyltransferaseActivity,MariaTintore´,AnnaAvin˜o´, FedericoM.Ruiz,Ramo´nEritja,andCarmeFa`brega Volume2010,ArticleID632041,9pages TheEmergingRoleofTelomeraseReverseTranscriptaseinMitochondrialDNAMetabolism, DonnaM.GordonandJanineHertzogSantos Volume2010,ArticleID390791,7pages TargetingtheOB-FoldsofReplicationProteinAwithSmallMolecules,VictorJ.AncianoGranadillo, JenniferN.Earley,SarahC.Shuck,MillieM.Georgiadis,RichardW.Fitch,andJohnJ.Turchi Volume2010,ArticleID304035,11pages TheRolesofUmuDinRegulatingMutagenesis,JayleneN.Ollivierre,JingFang,andPennyJ.Beuning Volume2010,ArticleID947680,12pages Error-ProneTranslesionDNASynthesisbyEscherichiacoliDNAPolymeraseIV(DinB)onTemplates Containing1,2-dihydro-2-oxoadenine,MasakiHori,Shin-IchiroYonekura,TakehikoNohmi,PetrGruz, HiroshiSugiyama,ShujiYonei,andQiu-MeiZhang-Akiyama Volume2010,ArticleID807579,10pages ArchitectureofY-FamilyDNAPolymerasesRelevanttoTranslesionDNASynthesisasRevealedin StructuralandMolecularModelingStudies,SushilChandani,ChristopherJacobs,andEdwardL.Loechler Volume2010,ArticleID784081,20pages CharacterizationofaY-FamilyDNAPolymeraseetafromtheEukaryoticThermophileAlvinella pompejana,SayoKashiwagi,IsaoKuraoka,YoshieFujiwara,KenichiHitomi,QuenJ.Cheng,JillO.Fuss, DavidS.Shin,ChikahideMasutani,JohnA.Tainer,FumioHanaoka,andShigenoriIwai Volume2010,ArticleID701472,13pages DNAPolymerase:StructuralHomology,ConformationalDynamics,andtheEffectsofCarcinogenic DNAAdducts,RichardG.FederleyandLouisJ.Romano Volume2010,ArticleID457176,15pages KineticApproachestoUnderstandingtheMechanismsofFidelityoftheHerpesSimplexVirusType1 DNAPolymerase,YaliZhu,JasonStroud,LipingSong,andDeborahS.Parris Volume2010,ArticleID631595,15pages MechanisticStudieswithDNAPolymerasesRevealComplexOutcomesfollowingBypassofDNA Damage,RobertL.Eoff,Jeong-YunChoi,andF.PeterGuengerich Volume2010,ArticleID830473,12pages Pre-Steady-StateKineticAnalysisofTruncatedandFull-LengthSaccharomycescerevisiaeDNA PolymeraseEta,JessicaA.Brown,LikuiZhang,ShanenM.Sherrer,John-StephenTaylor, PeterM.J.Burgers,andZucaiSuo Volume2010,ArticleID871939,11pages ReplicationPasttheγ-Radiation-InducedGuanine-ThymineCross-LinkG[8,5-Me]TbyHumanand YeastDNAPolymeraseη,ParomitaRaychaudhuryandAshisK.Basu Volume2010,ArticleID101495,10pages TheRoleofPCNAPosttranslationalModificationsinTranslesionSynthesis,MontaserShaheen, IlanchezhianShanmugam,andRobertHromas Volume2010,ArticleID761217,8pages MouseWRNHelicaseDomainIsNotRequiredforSpontaneousHomologousRecombination-Mediated DNADeletion,AdamD.Brown,AlisonB.Claybon,andAlexanderJ.R.Bishop Volume2010,ArticleID356917,6pages TheEffectofMitochondrialDysfunctiononCytosolicNucleotideMetabolism,ClausDesler,AnneLykke, andLeneJuelRasmussen Volume2010,ArticleID701518,9pages BLMDeficiencyIsNotAssociatedwithSensitivitytoHydroxyurea-InducedReplicationStress, KenzaLahkimBennani-Belhaj,Ge´raldineBuhagiar-Labarche`de,NadaJmari,RosineOnclercq-Delic, andMouniraAmor-Gue´ret Volume2010,ArticleID319754,8pages Rev1,Rev3,orRev7siRNAAbolishesUltravioletLight-InducedTranslesionReplicationinHeLaCells:A ComprehensiveStudyUsingAlkalineSucroseDensityGradientSedimentation,JunTakezawa,Yukio Ishimi,NaomiAiba,andKouichiYamada Volume2010,ArticleID750296,12pages TranslesionSynthesisPolymerasesinthePreventionandPromotionofCarcinogenesis, L.JayStallonsandW.GlennMcGregor Volume2010,ArticleID643857,10pages AMathematicalModelforDNADamageandRepair,PhilipS.CrookeandFritzF.Parl Volume2010,ArticleID352603,7pages BaseSequenceContextEffectsonNucleotideExcisionRepair,YuqinCai,DinshawJ.Patel,SuseBroyde, andNicholasE.Geacintov Volume2010,ArticleID174252,9pages TrueLies:TheDoubleLifeoftheNucleotideExcisionRepairFactorsinTranscriptionandDNARepair, NicolasLeMay,Jean-MarcEgly,andFre´de´ricCoin Volume2010,ArticleID616342,10pages InfluenceofXRCC1GeneticPolymorphismsonIonizingRadiation-InducedDNADamageandRepair, SilviaSterponeandRenataCozzi Volume2010,ArticleID780369,6pages StimulationofDNAGlycosylaseActivitiesbyXPCProteinComplex:RolesofProtein-Protein Interactions,YuichiroShimizu,YasuhiroUchimura,NaoshiDohmae,HisatoSaitoh,FumioHanaoka, andKaoruSugasawa Volume2010,ArticleID805698,12pages CoincidentInVitroAnalysisofDNA-PK-Dependentand-IndependentNonhomologousEndJoining, CynthiaL.Hendrickson,ShubhadeepPurkayastha,ElzbietaPastwa,RonaldD.Neumann, andThomasA.Winters Volume2010,ArticleID823917,11pages SelectiveIncisionoftheα-N5-Methyl-FormamidopyrimidineAnomerbyEscherichiacoliEndonuclease IV,PlamenP.Christov,SurajitBanerjee,MichaelP.Stone,andCarmeloJ.Rizzo Volume2010,ArticleID850234,10pages RegulationofHuRbyDNADamageResponseKinases,HyeonHoKim,KotbAbdelmohsen, andMyriamGorospe Volume2010,ArticleID981487,8pages DNAMismatchRepairinEukaryotesandBacteria,KenjiFukui Volume2010,ArticleID260512,16pages H2AXPhosphorylation:ItsRoleinDNADamageResponseandCancerTherapy,MonikaPodhorecka, AndrzejSkladanowski,andPrzemyslawBozko Volume2010,ArticleID920161,9pages DifferentialDynamicsofATR-MediatedCheckpointRegulators,DanilO.Warmerdam,RolandKanaar, andVeroniqueA.J.Smits Volume2010,ArticleID319142,16pages RoleofTopoisomeraseIIβinDNADamageResponsefollowingIRandEtoposide,NicolaJ.Sunter, IanG.Cowell,ElaineWillmore,GaryP.Watters,andCarolineA.Austin Volume2010,ArticleID710589,8pages StructuralBiologyofDNARepair:SpatialOrganisationoftheMulticomponentComplexesof NonhomologousEndJoining,TakashiOchi,BancinyaneLynnSibanda,QianWu,DimitriY.Chirgadze, VictorM.Bolanos-Garcia,andTomL.Blundell Volume2010,ArticleID621695,19pages TheRolesofSeveralResiduesofEscherichiacoliDNAPhotolyaseintheHighlyEfficientPhoto-Repairof CyclobutanePyrimidineDimers,LeiXuandGuopingZhu Volume2010,ArticleID794782,7pages ParametersofReserpineAnalogsThatInduceMSH2/MSH6-DependentCytotoxicResponse, AksanaVasilyeva,JillE.Clodfelter,MichaelJ.Gorczynski,AnthonyR.Gerardi,S.BruceKing, FreddieSalsbury,andKarinD.Scarpinato Volume2010,ArticleID162018,13pages EarlyStepsintheDNABaseExcisionRepairPathwayofaFissionYeastSchizosaccharomycespombe, KyoichiroKanamitsuandShogoIkeda Volume2010,ArticleID450926,9pages NonhomologousDNAEndJoininginCell-FreeExtracts,SheetalSharmaandSatheesC.Raghavan Volume2010,ArticleID389129,11pages BRCA1FormsaFunctionalComplexwithγ-H2AXas aLateResponsetoGenotoxicStress,SusanA.Krum,EstherdelaRosaDalugdugan, GustavoA.Miranda-Carboni,andTimothyF.Lane Volume2010,ArticleID801594,9pages ModulationoftheRibonucleotideReductase-AntimetaboliteDrugInteractioninCancerCellLines, JunZhou,PaulaOliveira,XueliLi,ZhengmingChen,andGeroldBepler Volume2010,ArticleID597098,10pages OverviewofDNARepairinTrypanosomacruzi,TrypanosomabruceiandLeishmaniamajor, DanielleGomesPassos-Silva,MatheusAndradeRaja˜o,PedroHenriqueNascimentodeAguiar,Joa˜oPedro Vieira-da-Rocha,CarlosRenatoMachado,andCarolinaFurtado Volume2010,ArticleID840768,14pages DNADamageInducedbyAlkylatingAgentsandRepairPathways,NatsukoKondo,AkihisaTakahashi, KojiOno,andTakeoOhnishi Volume2010,ArticleID543531,7pages MolecularMechanismsofUltravioletRadiation-InducedDNADamageandRepair,RajeshP.Rastogi, Richa,AshokKumar,MadhuB.Tyagi,andRajeshwarP.Sinha Volume2010,ArticleID592980,32pages
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