DATA AND KNOWLEDGE FOR MEDICAL DECISION SUPPORT Studies in Health Technology and Informatics This book series was started in 1990 to promote research conducted under the auspices of the EC programmes’ Advanced Informatics in Medicine (AIM) and Biomedical and Health Research (BHR) bioengineering branch. A driving aspect of international health informatics is that telecommunication technology, rehabilitative technology, intelligent home technology and many other components are moving together and form one integrated world of information and communication media. The series has been accepted by MEDLINE/PubMed, SciVerse Scopus, EMCare, Book Citation Index – Science and Thomson Reuters’ Conference Proceedings Citation Index. Series Editors: Dr. O. Bodenreider, Dr. J.P. Christensen, Prof. G. de Moor, Prof. A. Famili, Dr. U. Fors, Prof. A. Hasman, Prof. E.J.S. Hovenga, Prof. L. Hunter, Dr. I. Iakovidis, Dr. Z. Kolitsi, Mr. O. Le Dour, Dr. A. Lymberis, Prof. J. Mantas, Prof. M.A. Musen, Prof. P.F. Niederer, Prof. A. Pedotti, Prof. O. Rienhoff, Prof. F.H. Roger France, Dr. N. Rossing, Prof. N. Saranummi, Dr. E.R. Siegel, Prof. T. Solomonides and Dr. P. Wilson Volume 186 Recently published in this series Vol. 185. S. Cohen (Ed.), Biophotonics in Pathology – Pathology at the Crossroads Vol. 184. J.D. Westwood, S.W. Westwood, L. Felländer-Tsai, R.S. Haluck, R.A. Robb, S. Senger and K.G. Vosburgh (Eds.), Medicine Meets Virtual Reality 20 – NextMed / MMVR20 Vol. 183. K.L. Courtney, O. Shabestari and A. Kuo (Eds.), Enabling Health and Healthcare through ICT – Available, Tailored and Closer Vol. 182. A.C. Smith, N.R. Armfield and R.H. Eikelboom (Eds.), Global Telehealth 2012 – Delivering Quality Healthcare Anywhere Through Telehealth – Selected Papers from Global Telehealth 2012 (GT2012) Vol. 181. B.K. Wiederhold and G. Riva (Eds.), Annual Review of Cybertherapy and Telemedicine 2012 – Advanced Technologies in the Behavioral, Social and Neurosciences Vol. 180. J. Mantas, S.K. Andersen, M.C. Mazzoleni, B. Blobel, S. Quaglini and A. Moen (Eds.), Quality of Life through Quality of Information – Proceedings of MIE2012 Vol. 179. M. García-Rojo, B. Blobel and A. Laurinavicius (Eds.), Perspectives on Digital Pathology – Results of the COST Action IC0604 EURO-TELEPATH Vol. 178. A.J. Maeder and F.J. Martin-Sanchez (Eds.), Health Informatics: Building a Healthcare Future Through Trusted Information – Selected Papers from the 20th Australian National Health Informatics Conference (HIC 2012) ISSN 0926-9630 (print) ISSN 1879-8365 (online) DData annd Knoowledgge for Meedical Decission Suupportt Proceedings of the EEFMI Special Topic CConferencee 17––19 April 22013 Praguee, Czech Republic Edited byy Beernd Blobbel eHeaalth Competeence Center, University ooff Regensburrgg Medical CCenter, Regeensburg, Gerrmany Chair EEditorial Commmittee Arrie Hasmman DDepartment ooff Medical Innfformatics, AAcademic Meedical Centerr – Unniversity of AAmsterdam, TThe Netherlaands Chair PProgram Commmittee and Janna Zvároová Eurooppean Centerr for Medicall Informaticss, Statistics aand Epidemioology, Charrles Universiity in Praguee, Czech Reppublic Chair OOrganizing Coommittee Amstterdam • Berrlin • Tokyo •• Washington, DC © 2013 European Federation for Medical Informatics and IOS Press. All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without prior written permission from the publisher. ISBN 978-1-61499-239-4 (print) ISBN 978-1-61499-240-0 (online) Library of Congress Control Number: 2013934901 Cover image by Marie Zítková Publisher IOS Press BV Nieuwe Hemweg 6B 1013 BG Amsterdam Netherlands fax: +31 20 687 0019 e-mail: [email protected] Distributor in the USA and Canada IOS Press, Inc. 4502 Rachael Manor Drive Fairfax, VA 22032 USA fax: +1 703 323 3668 e-mail: [email protected] LEGAL NOTICE The publisher is not responsible for the use which might be made of the following information. PRINTED IN THE NETHERLANDS Data and Knowledge for Medical Decision Support v B. Blobel et al. (Eds.) IOS Press, 2013 © 2013 European Federation for Medical Informatics and IOS Press. All rights reserved. Preface This volume contains the proceedings of the Thirteenth EFMI Special Topic Confer- ence, held in Prague, Czech Republic, from 17–19 April 2013. The EFMI STC 2013 is Europe’s leading forum for presenting the results of current scientific work in health- informatics processes, systems, and technologies this year. EFMI STC 2013 has been organized by the European Federation for Medical In- formatics (EFMI) in cooperation with the Czech Society of Biomedical Engineering and Medical Informatics and the Czech Medical Society J.E. Purkyne. It follows previ- ous conferences in Bucharest, Romania (2001), Nicosia, Cyprus (2002), Rome, Italy (2003), Munich, Germany (2004), Athens, Greece (2005), Timisoara, Romania (2006), Brijuni Island, Croatia (2007), London, UK (2008), Antalya, Turkey (2009), Reykjavik, Iceland (2010), Laško, Slovenia (2011) and Moscow, Russia (2012). Ensuring patient safety and providing high quality health services are the dominant challenges faced by healthcare systems around the world. The sharing of advanced knowledge and best practice in diagnosis, therapy, process optimization and prevention, the inclusion of public health and social sciences, as well as the deployment of any relevant information, is of vital importance. This includes enhanced networking, so- cially and technologically, based on advanced interoperability. EFMI STC 2013 is entitled “Data and Knowledge for Medical Decision Support”, and addresses this important field, linking traditional and translational medicine with natural sciences and technology with a view to the design, implementation and de- ployment of intelligent systems. Medical decision support is an important part of this strategy. It has spawned research in the areas of knowledge discovery, formalization and distribution of knowledge, different ways of reasoning based on that knowledge depending on the nature of facts and processes, establishment and exchange of clinical guidelines, and also the inclusion of decisions not based on knowledge, such as neu- ronal networks and genetic algorithms. Data and knowledge sharing also confronts aspects of concept representation and languages, i.e. terminologies and ontologies. Most of the developed decision support systems can be integrated more or less easily into clinical information systems, both as part of those systems connected through standardized interfaces or as services to be remotely accessed. Knowledge representa- tion must be appropriate for the different stakeholder groups for decision support sys- tems to be accepted. Such systems must meet the expectations of developers, of users, such as physicians, nurses and other health professionals, but also those of patients. The usability of the system and the comprehensibility of the knowledge and decision support offered are critical in this regard. The standardization of principles, methodolo- gies and means, and also the availability of specifications and tools such as open source products and artefacts are crucial to ensure wide and harmonized use. Another impor- tant factor for success is the careful evaluation and certification of systems as regards quality and functionality. EFMI STC 2013 is the latest in a series of events in Prague dedicated to the subject of STC, including the IMIA International Working Conference on Computer-Aided Medical Decision Making in 1985 and the Symposium on Com- puterized Guidelines and Protocols in 2004, which augurs well for a successful confer- ence. The conference will be introduced by two Keynotes: Prof. Marion Ball (Balti- vi more, USA) presents Social and Cognitive Computing for Patient Engagement and Decision Support, in cooperation with Dr. Joseph M. Jasinski, and Prof. Jan van Bem- mel (Rotterdam, The Netherlands) addresses The Future of Computer-Assisted Medical Decision Making: Can We Learn from the Past? Additionally, two invited speeches will frame basics, principles, methods, and advanced results relevant for the main streams of the conference. A rigorous review process has selected the best of the sub- missions, resulting in a scientific programme of 49 oral presentations, 31 poster presen- tations, 1 panel and 7 workshops, bringing active participants from 31 countries to the conference. EFMI STC 2013 is complemented with panels on special topics, plenary poster sessions, and workshops. Most of the workshops are organized by EFMI Working Groups, such as “Sharing Knowledge and Tools for Decision Support in Biomedicine and Health Care”, realized by the EFMI WG Education in Health Informatics, “Deci- sion Support and Decision Making Enabled by Personal Portable Devices”, organized by the EFMI WG Personal Portable Devices, “Using Information to Improve the Qual- ity of Care in Type 2 Diabetes in Primary Care”, performed by the EFMI WG Primary Care Informatics, “Socio-economic Features of Traceability, ePrescription and Phar- macovigilance”, managed by the EFMI WG Traceability, and “Health Information Management for Europe-Ways and Perspectives”, established by the EFMI Project Group Health Information Management Europe. Another workshop addresses “Clinical Decision Support – From Research to Practice”. Finally, HL7 International performs a special workshop on “Standardization of knowledge management and innovations in science – Prerequisite or conflict?” The editors would like to thank all the contributing authors for their excellent work, and the reviewers for lending their expertise to the conference, thereby enabling the final achievement. Furthermore, they are indebted to HL7 International, GS1 Europe, and HL7 Germany for sponsoring the printing of the proceedings. Last but not least, they would also like to thank Thomas Schabetsberger (Innsbruck, Austria), who col- laboratively responded to all requests related to the Online-Submission System, and Roman Muška and Tereza Jeníkova from AIM Group International for managing the EFMI STC 2013 Website, the registration process and a number of communications. Bernd Blobel, Arie Hasman and Jana Zvárová Editors vii EFMI STC 2013 Program Committee and Reviewers Program Committee Arie Hasman, The Netherlands, Chair Bernd Blobel, Germany, Vice-Chair Pirkko Nykanen, Finland, Vice-Chair Riccardo Bellazzi, Italy Rolf Engelbrecht, Germany Josipa Kern, Croatia Ioana Moisil, Romania Jana Zvárová, Czech Republic, Chair LOC Reviewers Elske Ammenwerth, Austria Isabelle Andoulsi, Belgium Riccardo Bellazzi, Italy Petr Berka, Czech Republic Bernd Blobel, Germany Ronald Cornet, The Netherlands Persephone Doupi, Finland Rolf Engelbrecht, Germany Arie Hasman, The Netherlands Mira Hercigonja-Szekeres, Croatia Jacob Hofdijk, The Netherlands Evelyn Hovenga, Australia Josipa Kern, Croatia Petr Lánský, Czech Republic Lenka Lhotská, Czech Republic John Mantas, Greece George Mihalas, Romania Anne Moen, Norway Ioana Moisil, Romania Pirkko Nykanen, Finland Andrej Orel, Slovenia Jan Paralic, Slovak Republic Niels Peek, The Netherlands Jan Rauch, Denmark Pekka Ruotsalainen, Finland Thomas Schabetsberger, Austria viii Brigitte Seroussi, France Mary Sharp, Ireland Michael Shifrin, Russia Patrick Weber, Switzerland Jana Zvárová, Czech Republic ix Information on EFMI Working Groups EFMI is a nonprofit organization concerned with the theory and practice of Information Science and Technology within Health and Health Science in a European context. Its activities focus on annual conferences, MIE (Medical Informatics Europe), STC (Spe- cial Topic conference), tutorials and workshops. EFMI publishes proceedings and spe- cial issues of its activities in scientific journals and books. It has national societies in 31 member countries in the WHO-region Europe and 12 institutional members globally. Personal members are welcome in working groups. The EFMI portal provides very actual international news and information about research and use of computers in health care. http://www.EFMI.org. EDU – Education in Health Informatics MCRO – Casemix, Resources Management John Mantas, Athens; Arie Hasman, Amsterdam and Outcomes of Care ([email protected], [email protected]) Francis Roger-France, Brussels; Jacob Hofdijk, Utrecht EHR – Electronic Health Records ([email protected], [email protected]) Bernd Blobel, Regensburg; Dipak Kalra, London ([email protected], MIP – Medical Image Processing [email protected]) Alexander Horsch, Munich/Tromsø; Thomas Wittenberg, Germany; Vytenis Punys, Kaunas EVAL – Assessment of Health Information ([email protected], [email protected]; Systems [email protected], [email protected]) Elske Ammenwerth, Innsbruck; Pirkko Nykanen, Tampere; Jytte Brender, Aalborg NLU – Natural Language Understanding ([email protected], Patrick Ruch; Robert Baud, Geneva [email protected], [email protected]) ([email protected], [email protected]) HIIC – Health Informatics for Interregional Cooperation NURSIE – Nursing Informatics in Europe Lacramioara Stoicu-Tivadar, Timisoara Patrick Weber, Lausanne; Thomas Buerkle, ([email protected]) Erlangen ([email protected], HIME – Health Information Management [email protected]) Europe Rolf Engelbrecht, Ismaning; Angelika Händel, PCI – Primary Care Informatics Erlangen Simon De Lusignan, Guildford ([email protected]) HOFMI – Human and Organisational Factors of Medical Informatics PPD – Personal Portable Devices Jos Aarts, Rotterdam; Marie-Catherine Lenka Lhotská, Prague; Peter Pharow, Ilmenau Beuscart-Zéphir, Lille ([email protected], [email protected]) ([email protected], [email protected]) SSE – Safety, Security and Ethics IDR – Informatics for the Disabled and Bernd Blobel, Regensburg; Rehabilitation (inactive) Pekka Ruotsalainen, Tampere Cristina Mazzoleni, Pavia ([email protected]) ([email protected], [email protected]) LIFOSS – Libre/Free and Open Source Software in Health Informatics TRACE – Traceability of Supply Chains Thomas Karopka, Germany Christian Lovis, Christian Hay, Geneva ([email protected]) ([email protected], [email protected]) This page intentionally left blank
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