Connexin Cell Communication Channels: Roles in the Immune System and Immunopathology

363 Pages·2013·13.463 MB·English

by  Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans

IMMUNOLOGY O
v
ie
d
o
-
O
r
t
Connexin Cell a | K
w
a
Communication Channels k
| E
v
a
n
s
Roles in the Immune System and Immunopathology
Plasma membrane–associated channels known as gap junctions, along with their protein building
Connexin Cell
C
blocks—connexins—have an important functional role in a range of immunological processes,
o
including heart function, cell growth and specialization, and early development. Spanning basic
n
science and potential clinical applications, Connexin Cell Communication Channels: Roles in the n
Communication
Immune System and Immunopathology assembles and synthesizes four decades of the most e
x
important research carried out in this field.
i
n

The book first provides a historical overview of the discovery of these membrane channels in cells and C Channels
e
tissues of the immune system. It describes their general molecular and biological characteristics and
l
l
examines how they participate in the evolution, organization, function, and regulation of leukocytes,
C
as well as their interaction with other tissues.
o
m Roles in the Immune System and Immunopathology
The next section examines immunologically related disease scenarios where gap junctions and
m
connexins have been shown to play a fundamental role. The contributors explain how gap junctional
u
communication participates in the establishment and maintenance of immunological properties such n
as antibody and cytokine production, as well as lymphocyte immune surveillance in both physiological i
c
and pathological conditions. The book explores the most important technical approaches used and a
how they have been specially adapted to answer key biological questions particular to the mobile t
i
o
nature of leukocytes. It also describes the most recent understanding of how gap junctions and
n
connexins participate in antigen recognition, cross-presentation, lymphocyte activation, and in the
C
assembly and function of the immunological synapse. Edited by
h
a
Finally, the book focuses on the latest progress made on translating the knowledge gained to specific n Ernesto Oviedo-Orta
n
treatment modalities. Topics in this section include approaches for reducing scarring and cardiac
e Brenda R. Kwak
arrhythmia, combating inflammation in the central nervous system, and enhancing epithelial tissue l
s
repair. A comprehensive view of achievements in this promising field, the book will inform and update
William Howard Evans
specialists, clinical practitioners, and those studying the potential for commercial applications.
K12902
6000 Broken Sound Parkway, NW
Suite 300, Boca Raton, FL 33487
711 Third Avenue
New York, NY 10017
an informa business
2 Park Square, Milton Park © 2010 Taylor & Francis Group, LLC
www.taylorandfrancisgroup.com Abingdon, Oxon OX14 4RN, UK www.crcpress.com

Connexin Cell
Communication
Channels
Roles in the Immune System and Immunopathology
© 2010 Taylor & Francis Group, LLC

Connexin Cell
Communication
Channels
Roles in the Immune System and Immunopathology
Edited by
Ernesto Oviedo-Orta
Brenda R. Kwak
William Howard Evans
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
© 2010 Taylor & Francis Group, LLC
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2013 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20130220
International Standard Book Number-13: 978-1-4398-6258-2 (eBook - PDF)
This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
responsibility for the validity of all materials or the consequences of their use. The authors and publishers
have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
copyright holders if permission to publish in this form has not been obtained. If any copyright material has
not been acknowledged please write and let us know so we may rectify in any future reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit-
ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented,
including photocopying, microfilming, and recording, or in any information storage or retrieval system,
without written permission from the publishers.
For permission to photocopy or use material electronically from this work, please access www.copyright.
com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood
Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and
registration for a variety of users. For organizations that have been granted a photocopy license by the CCC,
a separate system of payment has been arranged.
Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used
only for identification and explanation without intent to infringe.
Visit the Taylor & Francis Web site at
http://www.taylorandfrancis.com
and the CRC Press Web site at
http://www.crcpress.com
Contents
Preface.......................................................................................................................ix
Editors .......................................................................................................................xi
Contributors ...........................................................................................................xiii
Prequel: Gap Junctions, Hemichannels, and Cell-to-Cell Signalling ....................xvii
SECTION 1 Immunology and Cell Biology
Chapter 1 Communication in the Immune System by Connexin Channels .........3
Ernesto Oviedo-Orta and William Howard Evans
Chapter 2 Gap Junctions and Connexins in the Hematopoietic-Immune
System: Structural Considerations .....................................................15
Tibor Krenacs, Ivett Zsakovics, Gergo Kiszner, and
Martin Rosendaal
Chapter 3 Approaches for Studying the Role(s) of Gap Junctions in the
Immune System ..................................................................................37
Aaron M. Glass, Thien D. Nguyen, and Steven M. Taffet
Chapter 4 Gap Junctions in Antigen-Presenting Cells ........................................61
Pablo J. Sáez, Kenji F. Shoji, and Juan Carlos Sáez
Chapter 5 Connect the Immune System: Roles of Gap Junctions in
Antigen Presentation and T Cell Activation.......................................89
Baoxu Pang and Jacques Neefjes
Chapter 6 Gap Junctions and Connexins in the Immune Defense
against Tumors ...................................................................................99
Flavio A. Salazar-Onfray
v
© 2010 Taylor & Francis Group, LLC
vi Contents
SECTION 2 Inflammation and Inflammatory
Diseases
Chapter 7 Connexins in Atherosclerosis ...........................................................113
Laurent Burnier and Brenda R. Kwak
Chapter 8 Connexins in Lung Function and Inflammation ..............................137
Marc Chanson and Michael Koval
Chapter 9 Effect of Oxidative Stress on Connexins in the Vasculature ...........157
Marie Billaud, Scott R. Johnstone, Katherine R. Heberlein,
Adam C. Straub, and Brant E. Isakson
Chapter 10 Regulation of Gap Junctions and Cellular Coupling within the
Microvasculature in Response to Acute Inflammation ....................195
Darcy Lidington and Karel Tyml
Chapter 11 Impact of Microglial Activation on Astroglial Connexin
Expression and Function in Brain Inflammation .............................219
Christian Giaume, Nicolas Froger, Juan Andrés Orellana,
Mauricio Retamal, and Juan Carlos Sáez
Chapter 12 A Role for Connexins in Inflammatory Disorders
of the Epidermis ...............................................................................233
Steven Donnelly, Catherine S. Wright, Maurice A. M. van Steensel,
Malcolm B. Hodgins, and Patricia E. Martin
SECTION 3 Connexin-Based Therapeutical
Approaches in Inflammatory
Diseases
Chapter 13 Translating Basic Research on Cx43 Gap Junctions into
Therapies for Reducing Scarring and Cardiac Arrhythmia .............255
Robert G. Gourdie, J. Matthew Rhett, Emily L. Ongstad,
Joseph A. Palatinus, and Michael P. O’Quinn
© 2010 Taylor & Francis Group, LLC
Contents vii
Chapter 14 Connexin-Based Therapeutic Approaches to Inflammation
in the Central Nervous System .........................................................273
Jie Zhang, Simon J. O’Carroll, Helen V. Danesh-Meyer,
Henri C. Van der Heyde, David L. Becker,
Louise F. B. Nicholson, and Colin R. Green
Chapter 15 Enhancing Epithelial Tissue Repair and Reducing
Inflammation by Targeting Connexins .............................................307
David L. Becker, Jeremy E. Cook, Peter Cormie,
Colin R. Green, Ariadna Mendoza-Naranjo, Anthony
R. J. Phillips, Antonio E. Serrano, and Christopher Thrasivoulou
© 2010 Taylor & Francis Group, LLC