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276 Pages·2020·8.824 MB·English
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Complications in Uveitis Francesco Pichi Piergiorgio Neri Editors 123 Complications in Uveitis Francesco Pichi • Piergiorgio Neri Editors Complications in Uveitis Editors Francesco Pichi Piergiorgio Neri Cleveland Clinic Abu Dhabi Cleveland Clinic Abu Dhabi Eye Institute Eye Institute Abu Dhabi Abu Dhabi United Arab Emirates United Arab Emirates Case Western Reserve University Case Western Reserve University Cleveland Clinic Lerner College Cleveland Clinic Lerner College of Medicine of Medicine Cleveland Cleveland USA USA ISBN 978-3-030-28391-9 ISBN 978-3-030-28392-6 (eBook) https://doi.org/10.1007/978-3-030-28392-6 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland “Here’s a sigh to those who love me, And a smile to those who hate; And whatever sky’s above me, Here’s a heart for every fate” —“To Thomas Moore”, Lord Byron “Talent hits a target no one else can hit; Genius hits a target no one else can see.” —Arthur Schopenhauer Foreword Complication: Latin—to fold together. Complex combination or intricate intermingling Medicine—a secondary disease, accident or adverse reaction that aggravates an already existing disease The myriad complications associated with uveitis involve every anatomical part of the eye and surrounding structures. It is a herculean task to not only document and describe these associated complications, but perhaps more importantly to offer concise management options for these often problematic and sometimes devastating problems. Dr. Pichi and Dr. Neri have put together a book that offers an excellent road map to enable us to diagnose and treat the secondary complications of uveitis. They have been able to “unfold” this complex intermingling of multiple problems providing the practitioner a road map to forecast, to recognize and to appropriately treat these sequelae. Dr. Pichi and Dr. Neri have assembled an excellent group of subspecialists who tackle the complex and often frustrating problem of managing uveitic compli- cations by subdividing these complications anatomically. It is thus easier to diag- nose the occurrence of these complications and then be able to offer an appropriate algorithm for treatment. Kudos to Dr. Pichi and Dr. Neri and their co-authors for addressing these complex problems in a concise and organized manner. Allen Z. Verne Founding Member of the American Society of Retina Specialists vii Contents Part I C ornea Complications in Uveitis 1 Band Keratopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Alfonso Iovieno, Tony Ng, and Sonia N. Yeung 2 Limbal Stem Cell Deficiency in Inflammatory Disorders . . . . . . . . . . 13 Paolo Rama 3 Herpetic Corneal Opacities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Luigi Fontana Part II I ris Complications in Uveitis 4 Iris Complications in Uveitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Alexander Chen, Careen Y. Lowder, and Angela Bessette Part III Lens Complications from Uveitis 5 Lens Complications in Uveitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Jennifer Lee and Debra A. Goldstein 6 The Repair of Dislocated Intraocular Lenses and the Placement of Secondary Intraocular Lenses in the Setting of Uveitis . . . . . . . . . . . 61 Jason A. Goldsmith, Albert T. Vitale, Nick Mamalis, Arwa M. Alsamarae, and Alan S. Crandall Part IV C iliary Processes Complications from Uveitis 7 Ciliary Processes Complications from Uveitis . . . . . . . . . . . . . . . . . . . 93 Ilir Arapi, Piergiorgio Neri, Vilma Mema, Biljana Kuzmanovic Eljaber, Vittorio Pirani, and Alfonso Giovannini ix x Contents Part V Glaucoma Complications in Uveitis 8 Hypertensive Uveitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111 Francesco Pichi and Scott D. Smith 9 Medical and Surgical Management of Uveitic Glaucoma . . . . . . . . . . 127 Rajesh Sasikumar and Piergiorgio Neri Part VI I nflammatory Choroidal Neovascular Membranes and Inflammatory Deposits Complicating Uveitis 10 Inflammatory Choroidal Vascular Membranes . . . . . . . . . . . . . . . . . 139 Assaf Hilely, Adrian Au, and David Sarraf 11 Treatment of Inflammatory Choroidal Neovascular Membranes . . . 159 Piergiorgio Neri Part VII Cystoid Macular Edema Complicating Uveitis 12 Pathophysiology of Uveitic Macular Edema . . . . . . . . . . . . . . . . . . . . 171 Ilaria Testi, Andres Rousselot, Rupesh Agrawal, and Carlos Pavesio 13 Differential Diagnosis of Uveitic Macular Edema . . . . . . . . . . . . . . . . 183 Ilaria Testi, Andres Rousselot, Rupesh Agrawal, and Carlos Pavesio 14 Multimodal Imaging of Uveitic Macular Edema . . . . . . . . . . . . . . . . . 195 Ilaria Testi, Andres Rousselot, Rupesh Agrawal, and Carlos Pavesio 15 Treatment of Uveitic Macular Edema . . . . . . . . . . . . . . . . . . . . . . . . . . 205 Ilaria Testi, Andres Rousselot, Rupesh Agrawal, and Carlos Pavesio 16 Epiretinal Membranes and Subretinal Fibrosis . . . . . . . . . . . . . . . . . . 217 Blanca C. Flores-Sánchez and Lyndon da Cruz Part VIII Retinal Detachment Secondary to Uveitis 17 Retinal Detachment in Uveitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 Arjun B. Sood and Sumit Sharma 18 Surgical Considerations in the Uveitic Patient . . . . . . . . . . . . . . . . . . . 247 Parisa Emami and Sunil K. Srivastava Part IX I nvasive Technique for Diagnosis of Complications in Uveitis 19 The Role of Endoscopy in Uveitic Eyes . . . . . . . . . . . . . . . . . . . . . . . . . 263 Nicolas A. Yannuzzi, Yale Fisher, and Thomas Albini 20 Retinal and Choroidal Biopsies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271 Rehan M. Hussain, Thomas A. Albini, and Harry W. Flynn Jr. Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Part I Cornea Complications in Uveitis Chapter 1 Band Keratopathy Alfonso Iovieno, Tony Ng, and Sonia N. Yeung Introduction The term band keratopathy refers to band-shaped superficial corneal degeneration that usually involves the interpalpebral area. The degeneration can occur in calcific and non-calcific forms. The disease most commonly intended as band keratopathy implies calcium deposition in the superficial layers of the cornea. Non-calcific superficial corneal depositions, such as those in climatic droplet keratopathy or in the context of gout from urate depositions, are not going to be further discussed in this chapter. Pathogenesis Ever since its first description by Dixon in 1948, the disease has remained some- what mysterious in its pathogenesis [1, 2]. The initial histologic change observed in corneas with band keratopathy is baso- philic staining of the epithelial basement membrane, reflecting early calcific change (Fig. 1.1a). This is followed by overt calcium depositions at the level of Bowman layer and the anterior most layers of the stroma. Later changes include Bowman layer fragmentation, deposition of hyaline material within fragmented Bowman layer and corneal fibrosis (Fig. 1.1b) [1, 3]. The calcium granules are commonly extracel- A. Iovieno (*) · S. N. Yeung Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada T. Ng Department of Pathology, University of British Columbia, Vancouver, BC, Canada © Springer Nature Switzerland AG 2020 3 F. Pichi, P. Neri (eds.), Complications in Uveitis, https://doi.org/10.1007/978-3-030-28392-6_1

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