Cancer of the Liver, Esophagus, and Nasopharynx PDF
Preview Cancer of the Liver, Esophagus, and Nasopharynx
Cancer of the Liver, Esophagus, and Nasopharynx Edited by Gustav Wagner and You-Hui Zhang With 46 Figures and several Tables Springer-Verlag Berlin Heidelberg NewY ork London Paris Tokyo Professor Dr. med. Gustav Wagner Deutsches Krebsforschungszentrum 1m Neuenheimer Feld 280 D-6900 Heidelberg 1. FRG Professor Zhang You-Hui Director, Cancer Institute and Hospital Chinese Academy of Medical Sciences Pan Jia Yao Zuo Anmen Wai Beijing, P. R. China Sponsored by the Federal Ministry for Science and Technology, Bonn, and Behringwerke A. G., Marburg ISBN-13 :978-3-540-16967-3 e-ISBN-13 :978-3-642-71510-5 DOl: 10.1007/978-3-642-71510-5 Library of Congress Cataloging in Publication Data. Cancer of the liver, esophagus, and nasopharynx. Proceedings of the Chinese-German Symposium on Cancer of the Liver, the Esophagus, and the Nasopharynx, held in Heidelberg, July 3-5, 1985, and sponsored by the German Cancer Research Center. Includes index. 1. Liver-Cancer-Congresses. 2. Esophagus-Cancer-Congresses. 3. Nasopharynx Cancer-Congresses. 4. Cancer-China-Congresses. I. Wagner, Gustav. II. Zhang, You-Hui. Ill. Chinese-German Symposium on Cancer of the Liver, the Esophagus, and the Nasopharynx (1985: Heidelberg, Germany) IV. Deutsches Krebsforschungszentrum Heidelberg. [DNLM: 1. Esophageal Neoplasms-congresses. 2. Liver Neoplasms-congresses. 3. Nasopharyngeal Neoplasms-congresses. WI735 C215 1985] RC280.L5C36 1986 616.99'436 86-26029 ISBN-13 :978-3-540-16967-3 (U. S.) This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law, where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich. © Springer-Verlag Berlin Heidelberg 1987 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book, in every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2119/3020-543210 List of Contributors Bannasch, P. Institut fUr Experimentelle Pathologie, Deutsches Krebsforschungszentrum, D-6900 Heidelberg, FRG Bomkamm, G. W. Institut fUr Virologie, Zentrum fUr Hygiene der Universitiit, D-7S00 Freiburg, FRG Chen Ai-Mei Cancer Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou, PRC Chen Han Changhai Hospital of the Second Military Medical College, Shanghai, PRC Chui Shao-Xing Cancer Institute, Chinese Academy od Medical Sciences, Beijing, PRC De The, G. Laboratoire d'epidemiologie et immunologie des tumeurs, Faculte de medecine Alexis Carrel F-69372 Lyon, Cedex OS, France Dhom, G. Pathologisches Institut des Saarlandes, D-6650 Homburg/Saar, FRG Dong Zhic Wei Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology, Beijing, PRC Ebbers, J. Hals-, Nasen-und Ohrenklinik der Universitiit, D-4000 Dusseldorf, FRG Fang Ru-Kang Huatung Teschers University, Shanghai, PRC VI List of Contributors Feng Luo Cancer Institute, Chinese Academy of Medical Sciences, Beijing, PRC Freytag von Loringhoven, A. HerwarthstraBe 25 D-5300 Bonn, FRO de Villiers, E.-M. Deutsches Krebsforschungszentrum, D-6900 Heidelberg, FRO Gao Ru-Nie Shanghai Cancer Institute, Dept. of Epidemiology, Shanghai 200032, PRC Gu Biu-Chang Shanghai Medical Laboratory, Shanghai, PRC Gu lian-Ren Dept. of Biochemistry and Molecular Biology, Shanghai Cancer Institute, Shanghai, 200032, PRC Gu Xiang-Zhi Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, PRC He Li-li Cancer Hospital, Yangcheng County, Shanxi Province, Taiyuan, PRC Hecker, E. Biochemisches Institut am Deutschen Krebsforschungszentrum, D-6900 Heidelberg, FRO Hong ling-Xing Shanghai Cancer Institute, Dept. of Immunology and Cell Biology, Shanghai200032,PRC Hu Li-Fu Shanghai Cancer Institute, Dept. of Biochemistry and Molecular Biology, Shanghai200032,PRC Huang Guo-Chun Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, PRC Huang Yu-Long Chongming County Center Hospital Chongming Island, PRC List of Contributors VII Jiang Ji-Wen Dept. of Hygiene Chemistry, Hunan Medical College, Changsha, PRC Li Chen-Chuan Tumor Hospital and Cancer Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou, PRC Li Guang-Weng Vice President, Chinese Anti-Cancer Association, Tianjin, PRC Li Jun-Yao Cancer Institute, Chinese Academy of Medical Sciences, Dept. of Epidemiology, Beijing, PRC Li Zhen-Pu Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology, Beijing, PRC Liang Hao-Cai Wuhan Medical College, Unit of Cancer Epidemiology, Wuhan 430033, PRC Liang Yi-Ren Cancer Institute, Sun Yat-Sen University of Medical Sciences, Guangzhou, PRC Liu Yu-Gu Wuhan Medical College, Dept. of Environmental Toxicology, Wuhan 430033, PRC Lu Jiang-Bang Dept. of Epidemiology, Henan Cancer Institute, Zheng Zhou, PRC Lu Shih-Hsin Cancer Institute, Chinese Academy of Medical Sciences, Beijing, PRC Montesano, R. International Agency for Research on Cancer, F-69372 Lyon, France Munoz, N. International Agency for Research of Cancer, F-69372 Lyon, France Pan Jie-Ping Shanghai Municipal Anti-epidemic Station, Shanghai, PRC VIII List of Contributors Preuflmann, R. Institut fUr Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, D-6900 Heidelberg, FRG Rabes, H.M. Pathologisches Institut der Universitat, 8000 Munchen, FRG Rajewsky, M. F. Institut fUr Zellbiologie, Universitat Essen, D-4300 Essen, FRG Rimkus, K. Pathologisches Institut des Saarlandes, D-6650 Homburg/Saar, FRG Saffhill, R. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK Shanmugaratnam, K. University Department of Pathology, General Hospital, Singapore 0316 Tang Zhao-You Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit, Shanghai 200031, PRC Tu Ji-Tao Shanghai Cancer Institute, Dept. of Epidemiology, Shanghai 200032, PRC Umbenhauer, D. Dept. of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Vosteen, K. H. Hals-, Nasen-und Ohrenklinik der Universitat, D-4000 Dusseldorf, FRG Wagner, G. Institut fUr Dokumentation, Information und Statistik des Deutschen Krebsforschungszentrums, D-6900 Heidelberg, FRG Wahrendoif, J. International Agency for Research on Cancer, F-69372 Lyon, France Wan Da-Feng Shanghai Cancer Institute, Dept. of Biochemistry and Molecular Biology, Shanghai 200032, PRC List of Contributors IX Wan Wen-Hui Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology, Beijing, PRC Wang Ru-Kuan At present Deutsches Krebsforschungszentrum, Institut fUr Dokumentation, Information und Statistik, D-6900 Heidelberg, FRG Wei Shu-Min Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology, Beijing, PRC Wolf, H. Max von Pettenkofer Institut der Ludwig-Maximilians-Universitat, Molekulare und Tumorbiologie, D-8000 MUnchen, FRG WuBo-Wen Changhai Hospital of the Second Military Medical College, Shanghai, PRC Wu Meng-Chao Changhai Hospital ofthe Second Military Medical College, Dept. of Hepatobiliary Surgery, Shanghai, PRC Wu Peng-Nian Dept. of Epidemiology, Hunan Medical College, Changsha, PRC Xu Guang-Xiong Shanghai Cancer Institute, Dept. of Epidemiology, Shanghai 200032, PRC Xu Guan-Nan Changhai Hospital of the Second Military Medical College, Shanghai, PRC Xu Xiu-Lai Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology, Beijing, PRC Yang Bing-Hui Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit, Shanghai200031,PRC Yang lia-Mei Changhai Hospital of the Secondary Military Medical College, Shanghai, PRC x List of Contributors Yao Kai-Tai Cancer Research Laboratory, Hunan Medical College, Changsha, PRC Yao Xiao-Ping Changhai Hospital of the Second Military Medical College, Shanghai, PRC YuHe Shanghai Cancer Institute, Dept. of Epidemiology, Shanghai 200032, PRC Yu Song-Ling Wuhan Medical College, Unit of Cancer Epidemiology, Wuhan 430033, PRC Yu Ye-Qiu Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit, Shanghai 200031, PRC Zeng Yi National Centre for Preventive Medicine, Institute of Virology, Beijing 100052, PRC Zerban, Heide Institut fUr Experimentelle Pathologie am Deutschen Krebsforschungszentrum, D-6900 Heidelberg, FRG Zhang Dan-Hua Chongming County Anti-epidemic Station, Chongming Island, PRC Zhang Ming-Shu Cancer Institute, Chinese Academy of Medical Sciences, Beijing, PRC Zhang Yiao-Hua Changhai Hospital of the Second Military Medical College, Shanghai, PRC Zhang You-Hui Cancer Institute, Chinese Academy of Medical Sciences, Beijing, PRC Zhou Xiao-Han Shanghai First Municipal Hospital, Shanghai, PRC zur Hausen, H. Deutsches Krebsforschungszentrum, D-6900 Heidelberg, FRG Preface To stimulate greater German-Chinese cooperation in the field of oncology, the Ger man Cancer Research Center (DKFZ) carried through a "Chinese-German Sympo sium on Cancer of the Liver, the Esophagus, and the Nasopharynx" in Heidelberg from 3 to 5 July 1985. These three forms of cancer were chosen as they are extremely rare in Europe but some of the most frequently found forms in China. Almost half of the roughly 260000 cases of primary liver cancer occurring annually worldwide are Chinese; of the roughly 300000 esophagus cancers occurring annually, more than half are Chinese; nasopharyngeal cancer is roughly 100 times more frequent among Chinese people than in Caucasians. Under these circumstances, it is not surprising that the Chinese guest speakers of the Heidelberg symposium - selected specialists in the three subsections of oncolo gy mentioned - were able to report about extensive experiences with patient popu lations of a size hardly imaginable in Europe. The great clinical experience of the Chinese guests was supplemented by special contributions of European experts. Thus, this volume permits a topical survey of the state of the art in these three can cers, with subsections of epidemiology, pathology, and clinical treatment. The editors wish to thank the Federal Ministry of Research and Technology (BMFT) for their encouragement and direct help in preparing and carrying through the symposium, the Management Board of the DKFZ for their generous assistance and Springer-Verlag for the publication and excellent production of this volume. Heidelberg, Peking, October 1986 Gustav Wagner Zhang You-Hui
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