British Journal of Haematology 1999: Vol 106 Table of Contents

15 Pages·1999·3 MB·English

BRITISH JOURNAL
HAEMATOLOGY
EDITORS: MIKE GREAVES, IAN HANN, DAVID OSCIER
ASSOCIATE EDITORS
B. Bennett, H. E. Broxmeyer, A. K. Burnett, FE. Cotter, R. Foa, M. Y. Gordon,
G. D. O. Lowe, J. A. F. Napier, I. R. Peake, M. J. Pippard, J. T. Reilly, N. Russell, S. L. Thein
ANNOTATIONS EDITORS
D. Hoelzer, N. Russell, S. L. Thein
EDITORIAL BOARD
A. V. Hoffbrand Chairman
T. Baglin, B. J. Bain, Y. Beuzard, M. K. Brenner, E. Briet, C. Camaschella,
C. J. Eaves, P. Fenaux, A. R. Green, J. D. Griffin, H. Heslop, D. Hoelzer, J. H. Kersey,
M. Le Beau, B. Lowenberg, P. M. Mannucci, C. Mecucci, D. R. Miller,
G. Prentice, E. G. D. Tuddenham, T. Uchiyama, M. Worwood
Volume 106
Pages 1—1076
D
Blackwell
Science
1999
© 1999 British Journal of Haematology Blackwell Science Ltd
Published by Blackwell Science Ltd
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ISSN 0007-1048
Typeset and printed by the Alden Group, Oxford.
BRITISH JOURNAL OF HAEMATOLOGY
VOL. 106 NO. 1 JULY 1999 5 5 A monoclonal antibody, 3G12, reacts
with a novel surface molecule, Hal-1,
with high expression in CD30-positive
Images in Haematology
anaplastic large cell lymphomas
] Normal and neoplastic mast cells Hiroko Asanuma, Shuji Takahashi,
Bridget S. Wilkins and Barbara J. Bain Masako Ishikawa, Kenjiro Kamiguchi,
Noriyuki Sato, Sibrand Poppema,
Jun-ichiro Fujimoto and Kokichi Kikuchi
Reviews
Involvement of the CD27-CD70 co-stimulatory
? Hairy cell leukaemia: biology and management
pathway in allogeneic T-cell response to
A. R. Pettitt, M. Zuzel and J. C. Cawley
follicular lymphoma cells
9 Systemic mastocytosis and other mast cell Doris Schmitter, Ursula Bolliger,
neoplasms Michael Hallek and Gabriella Pichert
Barbara J. Bain
Prognosis for flurarabine therapy of
Intensive treatment for multiple myeloma: chronic lymphocytic leukaemia based on
where do we stand? ex vivo drug response by DiSC assay
H. M. Lokhorst, P. Sonneveld and L. EF. Verdonck Andrew G. Bosanquet, Stephen A. Johnson
and Sue M. Richards
Haematological malignancy
Common resistance mechanisms to
deoxynucleoside analogues in variants
RESEARCH PAPERS
of the human erythroleukaemic line K652
28 Interleukin-15 blocks apoptosis and induces Charles Dumontet,
proliferation of the human myeloma cell line Krystyna Fabianowska-Majewska,
OH-2 and freshly isolated myeloma cells Danko Mantincic, Evelyne Callet Bauchu,
Henrik Hjorth-Hansen, Anders Waage Isabelle Tigaud, Varsha Gandhi,
and Magne Borset Michel Lepoivre, Godefridus J. Peters,
Marie Odile Rolland, Dorota Wyczechowska,
5 Skeletal survey in advanced multiple myeloma: Xiao Fang, Sophie Gazzo, Daphne A. Voorn,
radiographic versus MR imaging survey
Armelle Vanier-Viornery and John Mackey
Frédéric E. Lecouvet, Jacques Malghem,
Lucienne Michaux, Baudouin Maldague,
Altered drug sensitivity
Augustin Ferrant, Jean-Louis Michaux
in response to idarubicin treatment
and Bruno C. Vande Berg
in K562 human leukaemia cells
Vicki L. Locke, Ross A. Davey
FICTION-TSA analysis of
and Mary W. Davey
the B-cell compartment in myeloma
shows no significant expansion
of myeloma precursor cells Liposome-encapsulated daunorubicin
Faith E. Davies, Andrew C. Rawstron, for PGP-related multidrug resistance
Guy Pratt, Sheila O’Connor, Lela Su’ut, Mariagrazia Michieli, Daniela Damiani,
David Blythe, James Fenton, David Claydon, Anna Ermacora, Paola Masolini,
J. Anthony Child, Andrew S. Jack and Angela Michelutti, Teresa Michelutti,
Gareth J. Morgan Domencio Russo, Federico Pea and
Michele Baccarani
Cost-minimization analysis of CHOP,
fludarabine and rituximab
for the treatment of relapsed indolent B-cell SHORT REPORTS
non-Hodgkin's lymphoma in the U.K. 100 Neurolymphomatosis
John Sweetenham, Klaus Hieke, in Waldenstrém’s macroglobulinaemia
Matthew Kerrigan, Paul Howard, Sébastien Abad, Anne-Marie Zagdanski,
Pamela F. M. Smartt, Ann-Marie McIntyre Sabine Brechignac, Brigitte Thioliere,
and Sarah Townshend Jean-Claude Brouet and Xavier Mariette
Volume Contents
Secondary T-acute lymphoblastic leukaemia 142 In vitro evaluation of the haemopoietic
mimicking blast crisis in chronic myeloid defect of CD34" cells from patients
leukaemia with acute myeloid leukaemia
L. Dawson, R. Slater, A. Hagemeijer, in first remission
A. W. Langerak, R. Willemze and Ph. Herman, D. R. Van Bockstaele,
J. C. Kluin-Nelemans A. Ferrant and N. Straetmans
152 Repeated peripheral stem cell mobilization
Dexamethasone does not counteract the
in healthy donors: time-dependent changes
response of acute promyelocytic leukaemia
in mobilization efficiency
cells to all-trans retinoic acid
André Tichelli, Jakob Passweg,
Marleen C. de Ridder, Arnout J. van der Plas,
Till Hoffmann, Michael Gregor,
Claudia A. J. Erpelinck-Verschueren,
Thomas Kiihne, Genevieve Favre,
Bob Lowenberg and Joop H. Jansen
Alexandra Wodnar-Filipowicz
and Alois Gratwohl
Two-colour FISH detection
of the inv(16) in interphase nuclei
of patients with acute myeloid leukaemia SHORT REPORT
Hans G. Dauwerse, Elizabeth M. E. Smit,
159 Syngeneic blood stem cell transplantation
Rachel H. Giles, Rosalyn Slater,
for infectious mononucleosis-related
Martijn H. Breuning, Anne Hagenmeijer
aplastic anaemia
and Bert A. van der Reijden
Paolo Anderlini, Shirley Ann Riggs,
Martin Korbling and Richard Champlin
Transplantation Haemopoiesis
RESEARCH PAPERS RESEARCH PAPER
LS Myeloablative radiochemotherapy followed 162 Evidence for a continuous decline in
by reinfusion of purged autologous stem haemopoietic cell function from birth:
cells for Waldenstr6m’s macroglobulinaemia application to evaluating bone marrow
Peter Dreger, Bertram Glass, Rolf Kuse, failure in children
Ruth Sonnen, Nils von Neuhoff, S. B. Marley, J. L. Lewis, R. J. Davidson,
Human Bolouri, Michael Kneba I. A. G. Roberts, I. Dokal, J. M. Goldman
and Norbert Schmitz and M. Y. Gordon
Detection of identical T-cell clonotype
SHORT REPORTS
expansions in both the donor and recipient
after allogeneic bone marrow transplantation 167 Human osteoclasts derive from
Livio Trentin, Luisa Imberti, Renato Zambello, CD14-positive monocytes
Alessandra Sottini, Roberto Raimondi, H. M. Massey and A. M. Flanagan
Monica Facco, Sefania Cazzavillan,
SDF-1 suppresses cytokine-induced
Emanuela Bonoldi, Simona Signorini,
adhesion of human haemopoietic
Andrea Bacigalupo, Gianpietro Semenzato,
progenitor cells to immobilized
Francesco Rodeghiero and Daniele Primi
fibronectin
Akihiko Gotoh, Suzanna Reid,
Impact of obstetric factors on cord blood
Keisuke Miyazawa and Hal. E. Broxmeyer
donation for transplantation
Craig Donaldson, W. John Armitage,
Val Laundy, Clive Barron, Ruth Buchanan,
Jill Webster, Ben Bradley and Jill Hows Erythrocytes and iron
FIt3L induces the ex-vivo amplification of RESEARCH PAPER
umbilical cord blood committed progenitors 175 A novel mutation of the erythroid-specific
and early stem cells in short-term cultures 6-aminolaevulinate synthase gene in a
Lidia De Felice, Tiziana Di Pucchio, patient with X-linked sideroblastic anaemia
Maria Grazia Mascolo, Francesca Agostini, Hideo Harigae, Kazumichi Furuyama,
Massimo Breccia, Cesare Guglielmi, Akiro Kimura, Kazuo Neriishi,
Maria Rosaria Ricciardi, Agostino Tafuri, Nobuyasu Tahara, Masao Kondo,
Maria Screnci, Franco Mandelli and Norio Hayashi, Masayuki Yamamoto,
William Arcese Shigeru Sassa and Takeshi Sasaki
Volume Contents
SHORT REPORT Complement-induced procoagulant alteration
of red blood cell membranes with microvesicle
178 Enhanced adherence of 6-thalassaemic
formation in paroxysmal nocturnal
erythrocytes to endothelial cells
haemoglobinuria (PNH):
T. Hovav, A. Goldfarb, G. Artmann,
implication for thrombogenesis in PNH
S. Yedgar and G. Barshtein
Haruhiko Ninomiya, Yasuko Kawashima,
Yuichi Hasegawa and Toshiro Nagasawa
Leucocytes
Pseudohomozygosity for activated
protein C resistance is a risk factor
RESEARCH PAPER
for venous thrombosis
182 Oversecretion of IL-18 Giancarlo Castaman, Alberto Tosetto,
in haemophagocytic lymphohistiocytosis: Marco Ruggeri and Francesco Rodeghiero
a novel marker of disease entity
Hidetoshi Takada, Shouichi Ohga,
SHORT REPORT
Yumi Mizuno, Aiko Suminoe,
Akinobu Matsuzaki, Kenji Ihara, ZL Contribution of the glycoprotein Ia 807TT,
Naoko Kinukawa, Koichi Ohshima, methylene tetrahydrofolate reductase 677TT
Keizo Kohno, Masashi Kurimoto and prothrombin 20210GA genotypes
and Toshiro Hara to prothrombotic risk among
factor V 1691GA (Leiden) carriers
Martin J. Hessner, David M. Dinauer,
Immunodeficiency Robert A. Luhm, Janet L. Endres,
Robert R. Montgomery and
RESEARCH PAPER Kenneth D. Friedman
190 Identification of X-linked severe combined
immunodeficiency by mutation analysis
Transfusion medicine
of blood and hair roots
Suk See Ting, Don Leigh, Robert Lindeman
RESEARCH PAPERS
and John B. Ziegler
240 Preliminary assessment of whole-blood,
red-cell and platelet-leucodepleting filters
Platelets, haemostasis and thrombosis for possible induction of prion release
by leucocyte fragmentation during
RESEARCH PAPERS
room temperature processing
C. V. Prowse, V. S. Hornsey, O. Drummond,
USS immunologic response to
I. R. MacGregor, D. S. Pepper, G. R. Barclay,
recombinant hirudin in HIT type II patients
H. Bethel, B. Walker, G. Barnard,
during long-term treatment
L. Kirby and J. Hope
G. Huhle, U. Hoffmann, X. Song, L. C. Wang,
D. L. Heene and J. Harenberg
Prestorage and bedside leucofiltration of whole
blood modulates strorage-time-dependant
Relationship between size and thiazole orange
suppression of in vitro TNFa release
fluorescence of platelets in patients undergoing
T. Mynster, J. H. Hammer and H. J. Nielsen
high-dose chemotherapy
C. L. Balduini, P. Noris, P. Spedini, S. Belletti,
A. Zambelli and G. A. Da Prada
Correspondence
Platelet activation responses in vitro
to human mast cell activation Ze Alternate use of deferiprone and
C. Gardiner, P. Harrison, N. Chavda, desferrioxamine in primary school
I. J. Mackie and S. J. Machin children with thalassaemia major
Y. Aydinok, G. Nisli and K. Kavakli
The cytoskeletal linker protein moesin:
decreased levels in Wiskott-Aldrich Infectious purpura fulminans:
syndrome platelets and identification of caution needed in the use of protein C
a cleavage pathway in normal platelets Adam Finn, Robert Booy, Michael Levin,
Anna Shcherbina, Anthony Bretscher, Simon Nadel and Saul Faust
Fred S. Rosen, Dianne M. Kenney Reply: Owen P. Smith and
and Eileen Remold-O’Donnell Barry White
Volume Contents
Successful use of recombinant FVIla 281 Time trends in incidence of haematological
(Novaseven’ ) in the management of malignancies and related conditions
pulmonary haemorrhage secondary to R. A. Cartwright, E. A. Gilman and K. A. Gurney
Aspergillus infection in a patient with
leukaemia and acquired FVII deficiency The AML1-ETO transcription factor
B. White, M. Martin, S. Kelleher, P. Brown, in acute myeloid leukaemia:
S. R. McCann and O. P. Smith biology and clinical significance
James R. Downing
Prevention of vitamin K deficiency
in newborns
The role of adoptive immunotherapy in the
Edmund Hey
prevention and treatment of lymphoproliferative
Reply: Alvin Zipursky
disease following transplantation
hae 3 Tanzina Haque and Dorothy H. Crawford
Automated malaria detection
Thomas Hanscheid and Emilia Valadas
Reply: Barry V. Mendelow and
Theresa L. Coetzer Haemopoiesis
Fatal fresh frozen plasma infusion RESEARCH PAPERS
containing HPA-1a alloantibodies % = tb
M. Solenthaler, J. K. Krauss, F. Boehlen, 317 Haemopoietic reconstitution after
sublethal irradiation: comparison of the
R. Koller, M. Hug and B. Lammle
effects of different haemopoietic cytokines
on murine lymphocytes and bone marrow
Monitoring erythropoietin abuse
cells
in athletes
Daniela Frasca, Francesco Guidi,
Mauro Magnani, Dario Corsi,
Paola Barattini and Gino Doria
Marzia Bianchi, Mirko Paiardini,
Luca Galluzzi, Attilio Parisi
and Fabio Pigozzi Erythroblasts from Friend virus infected-
and phenylhydrazine-treated mice
Autoimmune thrombocytopenia after accurately model erythroid differentiation
treatment with Campath 1H ina patient Vivien M. Hodges, Paul C. Winter and
with chronic lymphocytic leukaemia ference R. J. Lappin
S. H. Otton, D. L. Turner, R. Frewin,
S. V. Davies and S. A. Johnson 5 Def-2, -3, -6 and -8, novel mouse genes
differentially expressed in the haemopoietic
263 Book Reviews system
164. Amaiienetamaiites Oombaiuiibis Marc Hotfilder, Sarah Baxendale,
~ ; 7 . Michael A. Cross and Fred Sablitzky
Interaction of thrombopoietin with the
VOL. 106 NO. 2 AUGUST 1999 platelet c-mpl receptor in plasma: binding,
internalization, stability and pharmacokinetics
Junzhi Li, Yuping Xia and David J. Kuter
Images in Haematology
Early progenitor cells from human mobilized
265 Demonstration of an X chromosome peripheral blood express low levels of the
in a neutrophil drumstick flt3 receptor, but exhibit various biological
Ikuo Miura responses to flt3-L
Thérése Aurran-Schleinitz,
Annotation Anne-Marie Imbert, Laurent Humeau,
Florence Bardin, Pierre Charbord and
266 Is albumin harmful? Christian Chabannon
Gordon B. Drummond and Christopher A. Ludlam
SHORT REPORT
Reviews
_ 368 Circadian variation of granulocyte colony
270 Iron deficiency in children: stimulating factor levels in man
detection and prevention B. Jilma, N. Hergovich, P. Stohlawetz,
Brian A. Wharton H.-G. Eichler, P. Bauer and O. F. Wagner
Volume Contents vii
Bone marrow hypoplasia Haemostasis and thrombosis
RESEARCH PAPERS RESEARCH PAPERS
371 Selective effect of cyclosporine monotherapy 416 Thrombomodulin with the Asp468Tyr
for pure red cell aplasia not associated with mutation is expressed on the cell surface
granular lymphocyte-proliferative disorders with normal cofactor activity
Osamu Yamada, Toshiko Motoji and for protein C activation
Hideaki Mizoguchi Fumie Nakazawa, Takatoshi Koyama,
Takako Saito, Misako Shibakura,
High inducibility of heat shock protein (hsp7 2) Haruhiko Yoshinaga, Dong Hui Chung,
in peripheral blood mononuclear cells of Ryuichi Kamiyama and Shinsaku Hirosawa
aplastic anaemia patients: a reliable marker
of immune-mediated aplastic anaemia
responsive to cyclosporine therapy Reproductive choices of haemophilia carriers
Akiyoshi Takami, Shinji Nakao, U. Tedgard, R. Ljung and T. F. McNeil
Yasuaki Tatsumi, Hongbo Wang, Zeng Weihua,
Hirohito Yamazaki, Shizuka Yasue, 7 A novel ELISA-based primer extension assay for
Shintaro Shiobara, Tamotsu Matsuda the detection of the factor V Leiden mutation
and Hideaki Mizoguchi J. T. Wilde, J. J. O'Sullivan, J. L. Roper, P. Aerts,
M. Horowitz and N. Navot
Erythrocytes and iron
Transfusion medicine
SHORT REPORTS
385 Haemochromatosis mutations
RESEARCH PAPER
in North-East Scotland
431 Prevalence of TT virus in plasma pools
Z. Miedzybrodzka, S. Loughlin, D. Baty,
and blood products
A. Terron, K. Kelly, J. Dean, M. Greaves,
Giulio Pisani, Karen Cristiano, Maria Wirz,
M. Pippard and N. Haites
Guillermo Bisso, Francesca Beneduce,
Coil embolization of cerebral aneurysms Graziella Morace, Maria Rapicetta
in patients with sickling disorders and Giuliano Gentili
I. G. McQuaker, T. Jaspan, N. S. McConachie
and G. Dolan
Haematological malignancy
Leucocytes RESEARCH PAPERS
436 Treatment-related deaths during induction
RESEARCH PAPERS
and first remission of acute myeloid leukaemia
391 Circulating platelet—neutrophil complexes represent in children treated on the Tenth Medical
a subpopulation of activated neutrophils primed for Research Council Acute Myeloid Leukaemia
adhesion, phagocytosis and intracellular killing Trial (MRC AML10)
M. J. Peters, G. Dixon, K. T. Kotowicz, Lynne C. Riley, Ian M. Hann, Keith Wheatley
D. J. Hatch, R. S. Heyderman and N. J. Klein and R. F. Stevens
The CD69 early activation molecule
is overexpressed in human bone marrow Isolated isochrome 17q: a distinct type of mixed
mast cells from adults with indolent myeloproliferative disorder/myelodysplastic
systemic mast cell disease syndrome with an aggressive clinical course
Beatriz Diaz-Agustin, Luis Escribano, R. E. McClure, G. W. Dewald, J. D. Hoyer
Pilar Bravo, Sonia Herrero, Rosa Nunez, and C. A. Hanson
Raquel Navalon, Lourdes Navarro,
Antonio Torrelo, Alberto Cantalapiedra,
Cross-validation of prognostic scores
Luz del Castillo, Jesus Villarrubia,
in myelodysplastic syndromes
José L. Navarro, Jesus F. San Miguel
on 386 patients from a single institution
and Alberto Orfao
confirms importance of cytogenetics
Induction of apoptosis and caspase Michael Pfeilst6cker, Regina Reisner,
activation in cells obtained from familial Thomas Nosslinger, Helga Griiner,
haemophagocytic lymphohistiocytosis patients Hadwiga Nowotny, Heinz Tiichler, Ernst Schlégl,
Bengt Fadeel, Sten Orrenius and Jan-Inge Henter Elisabeth Pittermann and Renate Heinz
Vili Volume Contents
464 Ineffective erythropoiesis in myelodysplastic SHORT REPORTS
syndromes: correlation with Fas expression but
520 Complete remission in acute myeloid
not with lack of erythropoietin receptor signal
leukaemia with t(8;21) following treatment
transduction
with G-CSF: flow cytometric analysis of
Michaéla Fontenay-Roupie, Didier Bouscary,
in vivo and in vitro effects on cell maturation
Martine Guesnu, Francoise Picard, Josiane Melle,
Felicetto Ferrara, Rosa Di Noto, Assunta Viola,
Catherine Lacombe, Sylvie Gisselbrecht,
Consiglia Russo, Piernicola Boccuni,
Patrick Mayeux and Francois Dreyfus
Silvia Costantini, Annamaria Dello Russo,
Catia Lo Pardo and Luigi Del Vecchio
Reponse to cladribine in previously treated
patients with chronic lymphocytic leukaemia
a4, integrin-mediated adhesion of CD34°
identified by ex vivo assessment of
cells from patients with chronic myeloid
drug sensitivity by DiSC assay
leukaemia: influence of IL-3
Andrew G. Bosanquet, J. Adrian Copplestone,
K. P. Schofield, J. Duerig, G. Rushton
Stephen A. N. Johnson, Alastair G. Smith,
and J. Chang
Sara J. Povey, Jennifer A. Orchard and
David G. Oscier
Detection of Hodgkin/Reed-Sternberg cell
specific immunoglobulin gene rearrangement
Cyclin D2 promoter disrupted by
in the serum DNA of a patient
t(12;22)(p13;q11.2) during transformation
with Hodgkin’s disease
of chronic lymphocytic leukaemia to
M. Kornacker, A. Jox, M. Vockerodt,
non-Hodgkin's lymphoma
H. Tesch, H. Bohlen, V. Diehl and J. Wolf
L. Qian, J. Gong, J. Liu, J. D. Broome
and P. R. K. Koduru
CD130 rather than CD126 expression
is associated with disease activity
Multiplex PCR reaction for the detection
in multiple myeloma
and identification of immunoglobulin kappa
Sophie Barillé, Wilfrid Thabard, Nelly Robillard,
deleting element rearrangements
Philippe Moreau, Danielle Pineau, Jean-Luc
in B-lineage leukaemias
Harousseau, Régis Bataille and Martine Amiot
Frank Stolz, Simon Panzer and
E. Renate Panzer-Griimayer
Early diagnosis of central nervous system
aspergillosis using polymerase chain reaction,
Aberrant expression and reverse signalling
latex agglutination test, and enzyme-linked
of CD70 on malignant Bc ells
immunosorbent assay
Susanne M. A. Lens, Paul Drillenburg,
Masahiro Kami, Seishi Ogawa,
Bianca F. A. de Drijver, Gijs van Schijndel,
Yoshinobu Kanda, Yuji Tanaka,
Steven T. Pals, René A. W. van Lier and
Utako Machida, Tomoko Matsumura,
Marinus H. J. van Oers
Hisashi Sakamaki and Hisamaru Hirai
Angiogenic growth factors and endostatin
in non-Hodgkin’s lymphoma
Transplantation
Francesco Bertolini, Mara Paolucci,
Fedro Peccatori, Saverio Cinieri, Alberto Agazzi, RESEARCH PAPERS
Pier Francesco Ferrucci, Emilia Cocorocchio,
Aron Goldhirsch and Giovanni Martinelli
538 Use of the haemopoietic progenitor cell count of
the Sysmex SE-9500 to refine apheresis timing
GBV-C/HGV and HCV infection of peripheral blood stem cells
in mixed cryoglobulinaemia Y. Pollard, M. J. Watts, D. Grant, N. Chavda,
Marina Crovatto, Cesare Mazzaro, D. C. Linch and S. J. Machin
Shunji Mishiro, Gianfranco Santini,
Stefano Baracetti, Francesca Zorat
Clonotypic CD20* and CD19* Bc ells in
and Gabriele Pozzato
peripheral blood of patients with multiple
myeloma post high-dose therapy and
Long-term follow-up peripheral blood stem cell transplantation
of patients with hairy cell leukaemia Christof Rottenburger, Katja Kiel,
after treatment with pentostatin or cladribine Tobias Boésing, Friedrich W. Cremer,
C. E. Dearden, E. Matutes, B. L. Hilditch, Gerhard Moldenhauer, Anthony D. Ho,
C. J. Swansbury and D. Catovsky Hartmut Goldschmidt and Marion Moos
Volume Contents
3 A combination of megakaryocyte growth Reviews
and development factor and interleukin-1
578 Detection of minimai residual disease
is sufficient to culture large numbers
in acute myeloid leukaemia: methodologies,
of megakaryocytic progenitors and
clinical and biological significance
megakaryocytes for transfusion purposes
John A. Liu Yin and Khalid Tobal
Sonja van den Oudenrijn, Masja de Haas,
Jero Calafat, C. Ellen van der Schoot
The pathogenesis of acute promyelocytic
and Albert E. G. Kr. von dem Borne
leukaemia: evaluation of the role of molecular
diagnosis and monitoring in the management
Rapid paper of the disease
David Grimwade
564 Presence of mild hyperhomocysteinaemia and
association with thrombophilic genotypes (factor MLL rearrangements in haematological
V Leiden and prothrombin G20210A) in Italian malignancies: lessons from clinical and
patients with venous thromboembolic disease biological studies
Valerio De Stefano, Bruno Zappacosta, Jorge F. DiMartino and Michael L. Cleary
Silvia Persichilli, Elean Rossi, Ida Casorelli,
Katia Paciaroni, Patrizia Chiusolo,
Antonio Maria Leone, Bruno Giardini Haematological malignancy
and Giuseppe Leone
RESEARCH PAPERS
Correspondence 627 High levels of lung resistance related protein
mRNA in leukaemic cells from patients with acute
569 Successful management of concomitant
myelogenous leukaemia are associated with
Diamond-Blackfan anaemia and
inferior response to chemotherapy and prior
aplastic anaemia with splenectomy
treatment with mitoxantrone
Hans-Christoph Rossbach, Nanette H. Grana Dawei Xu, Iréne Arestr6ém, Robert Virtala,
and Jerry L. Barbosa Pavel Pisa, Curt Peterson and Astrid Gruber
An atypical myelodysplastic syndrome
with t(9;12)(q22;p12) and TEL gene Quantification of minimal residual disease
rearrangement in patients with BCR-ABL-positive acute
Yoshie Kuno, Akihiro Abe, Nobohiko Emi, lymphoblastic leukaemia using quantitative
Minako lida, Toshiharu Yamamori, competitive polymerase chain reaction
Mitsune Tanimoto and Hidehiko Saito Gerlinde Mitterbauer, Peter Nemeth,
Stefan Wacha, Nicholas C. P. Cross,
Clonal selection of CD20-negative Ilse Schwarzinger, Ulrich Jaeger, Klaus Geissler,
non-Hodgkin’s lymphoma cells after Hildegard T. Greinix, Peter Kalhs,
treatment with anti-CD20 antibody
Klaus Lechner and Christine Mannhalter
rituximab
Katja Schmitz, Wolfram Brugger, The cyclin-dependent kinase inhibitors p1 8INK4c
Burkhard Weiss, Edwin Kaiserling
and p19INK4d are highly
and Lothar Kanz expressed in CD34* progenitor and
Calcitrol in myelodysplastic syndromes acute myeloid leukaemic cells but not
M. R. Howard and L. R. Bond in normal differentiated myeloid cells
M. P. Tschan, U. R. Peters, J. F. Cajot,
rHuEpo treatment D. C. Betticher, M. F. Fey and A. Tobler
in low-risk myelodysplastic syndromes
Mike Laffan and George Vassiliou
FADD expression and caspase activation
Reply: Alberto Grossi in B-cell lymphomas resistant to
Book Review Fas-mediated apoptosis
Luc Xerri, Elisabeth Devilard,
Announcements
Reda Bouabdallah, Anne-Marie Stoppa,
Jacques Hassoun and Francoise Birg
VOL. 106 NO. 3 SEPTEMBER-I 1999
Telomerase activity in chronic
lymphoproliferative disorders of B-cell lineage
Livio Trentin, Gianna Ballon, Lucia Ometto,
Images in Haematology
Alessandra Perin, Umberto Basso,
577 Malaria in an African penguin Luigi Chieco-Bianchi, Gianpietro Semenzato
E. Lombard, J. J. Brossy and J. Blackbeard and Anita De Rossi
Volume Contents
669 Phenotypic and molecular analysis 720 Additional translocation (8;21)(q22;q22) in
of six human cell lines derived from a patient with Philadelphia-positive chronic
patients with plasma cell dyscrasia myelogenous leukaemia in the blastic phase
R. P. Gooding, A. Bybee, F. Cooke, A. Little, Kensuke Kojima, Masaki Yasukawa,
S. G. E. Marsh, E. Coelho, D. Gupta, Fumihiko Ishimaru, Hiromichi Dansako,
D. Samson and J. F. Apperley Yoshinobu Matsuo, Yukio Kimura,
Yuichiro Nawa, Masamichi Hara
682 Bone marrow effects of anagrelide therapy and Mine Harada
in patients with myelofibrosis
with myeloid metaplasia
Soo-Young Yoon, Chin-Yang Li,
Transplantation
Ruben A. Mesa and Ayalew Tefferi
689 Leucocyte transfusions from rhG-CSF or RESEARCH PAPERS
prednisolone stimulated donors for treatment of 723 Incompatibility for CD31 and human platelet
severe infections in immunocompromised antigens and acute graft-versus-disease
neutropenic patients after bone marrow transplantation
C. Peters, M. Minkov, S. Matthes-Martin, C. L. Balduini, P. Noris, G. Giorgiani,
U. Potschger, V. Witt, G. Mann, P. Hocker, M. Martinetti, C. Klersy, P. Spedini, S. Belletti,
N. Worel, J. Stary, T. Klingebiel and H. Gadner R. Maccario, L. Gusberti and F. Locatelli
697 Hepatosplenic candidiasis Phase III efficacy study of interleukin-3
in patients with acute leukaemia after autologous bone marrow transplantation
Sabah Sallah, Richard C. Semelka, in patients with malignant lymphoma
Robert Wehbie, Waddah Sallah, Rolf E. Brouwer, Edo Vellenga,
Nam P. Nguyen and Paul Vos Koos H. Zwinderman, W. R. Bezwoda,
Simon T. S. Durrant, Richard P. Herrmann, Beate
SHORT REPORTS Kiese, Dominique Maraninchi,
Donald W. Milligan, Ivo Sklenar, A. Tabilio, José-
702 Myelodysplastic syndrome
Luis Pico Volonte, David A. Winfield
in a patient with adult T-cell leukaemia
and Willem E. Fibbe
Hisashi Kawabata, Atae Utsunomiya,
Shuichi Hanada, Torahiko Makino,
The relationship between monoclonal myeloma
Yoshifusa Takatsuka, Shogo Takeuchi, Shiisuke
precursor B cells in the peripheral blood stem cell
Suzuki, Junji Suzumiya,
harvests and the clinical response of multiple
Kouichi Ohshima and Shigeo Horiike
myeloma patients
706 Mutational analysis of the DNA mismatch M. Mitterer, F. Oduncu, A. J. Lanthaler,
repair gene hMLH1 in myeloid leukaemias E. Drexler, G. Amaddii, P. Fabris,
B. Emmerich, P. Coser and C. Straka
Holger W. Auner, Werner Olipitz,
Gerald Hoefler, Claudia Bodner,
Clonal immunoglobulin light chain variable
Dagmar Konrad, Richard Crevenna,
region germline gene use in AL amyloidosis:
Werner Linkesch and Heinz Sill
association with dominant amyloid-related
709 Fas ligand-induced apoptosis of hepatocytes organ involvement and survival after
in natural killer cell leukaemia stem cell transplantation
Ryuzo Tani, Shuji Ozaki, Masaaki Kosaka, Raymond L. Comenzo, Jeremy Wally,
Soichiro Fujiwara, Hironobu Shibata, Geraldina Kica, Jessica Murray,
Shingo Wakatsuki and Toshio Matsumoto Thomas Ericsson, Martha Skinner
and Yana Zhang
713 Monoclonal Epstein-Barr virus-related
lymphoproliferative disorder following
adult acute lymphoblastic leukaemia
Erythrocytes and iron
James M. Foran, Sarah E. Slater,
Andrew J. Norton, Susanna J. Wilkes,
SHORT REPORT
Ian J. Hart and Ama Z. S. Rohatiner
752 Soluble transferrin receptor as a potential
717 P53 is not a frequent event determinant of iron loading in congenital
in multiple myeloma anaemias due to ineffective erythropoiesis
Herve Avet-Loiseau, Jian-Yong Li, Mario Cazzola, Yves Beguin,
Catherine Godon, Nadine Morineau, Gaetano Bergamaschi, Roberta Guarnone,
Axelle Daviet, Jean-Luc Harousseau, Paola Cerani, Susanna Barella,
Thierry Facon and Régis Bataille Antonio Cao and Renzo Galanello