British Journal of Haematology 1996: Vol 94 Table of Contents

11 Pages·1996·2.6 MB·English

BRITISH JOURNAL
OF
HAEMATOLOGY
EDITOR: I. R. PEAKE
DEPUTY EDITOR: M. GREAVES
ASSOCIATE EDITORS
A. K. Burnett, F. Cotter, M. Y. Gordon, I. Hann, G. D. O. Lowe, J. A. F. Napier,
A. C. Newland, D. G. Oscier, M. J. Pippard, J. Reilly, N. Russell, N. Testa, W. G. Wood,
ANNOTATIONS EDITORS
M. Y. Gordon, D. Hoelzer, N. Russell, S. L. Thein
EDITORIAL BOARD
A. V. Hoffbrand Chairman
T. Baglin, M. K. Brenner, E. Briet, C. Camaschella, L. Degos, C. J. Eaves, P. Fenaux, R. Foa,
E. C. Gordon-Smith, A. R. Green, D. Hoelzer, J. H. Kersey, M. Le Beau, B. Lowenberg,
P. M. Mannucci, C. Mecucci, S. L. Thein, E. G. D. Tuddenham, H. van den Berghe
Volume 94
Pages 1—776
b
Blackwell
Science
1996
PUBLISHED BY BLACKWELL SCIENCE LTD, OSNEY MEAD, OXFORD
© 1996 Blackwell Science Ltd. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is
granted by Blackwell Science for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service,
provided that the base fee of $11.50 per copy is paid directly to CCC, 222 Rosewood Drive, Suite 910, Danvers, MA 01923, U.S.A. Special
requests should be addressed to the Editor, British Journal of Haematology 0007-1048/96 $11.50.
Typeset and printed in Great Britain by Alden, Oxford, Didcot and Northampton.
BRITISH JOURNAL OF HAEMATOLOGY
VOL. 94 NO. 1 JULY 1996 SHORT REPORT
62 Clonal expansion of T cells
Annotation
expressing two distinct T-cell receptors
1 Estimation of the number of mutations Thomas Hinz, Sibylle Marx, Christoph Nerl
necessary to cause chronic myeloid leukaemia and Dieter Kabelitz
from epidemiological data
Mark Vickers
Erythrocytes
Haemopoiesis and growth factors
RESEARCH PAPER
RESEARCH PAPERS
65 Unrelated donor bone marrow transplantation
2- Interaction of the receptor tyrosine kinase p145°*
to treat severe aplastic anaemia in children
with the p210”/“”' kinase in myeloid cells
and young adults
Michael Hallek, Susanne Danhouser-Riedl,
David Margolis, Bruce Camitta, Daniel Pietryga,
Ronald Herbst, Markus Warmuth, Almut Winkler,
Carolyn Keever-Taylor, Lee Ann Baxter-I owe,
Hans-Jochen Kolb, Brian Druker, James D. Griffin,
Karen Pierce, Mary Jo Kupst, James French, III,
Bertold Emmerich and Axel Ullrich
Robert Truitt, Colleen Lawton, Kevin Murray,
Regulation of colony forming cell generation Frederick Garbrecht, Neal Flomenberg and
by fit-3 ligand
James Casper
Carolyn Brashem-Stein, David A. Flowers
and Irwin D. Bernstein
Expression of the multidrug resistance-associated
protein (MRP) mRNA and protein in normal
peripheral blood bone marrow haemopoietic cells SHORT REPORT
Ollivier Legrand, Jean-Yves Perrot, RuoPing Tang, 73 Flutamide-induced cyanosis
Ghislaine Simonin, Sandeep Gurbuxani, refractory to methylene blue therapy
Robert Zittoun and Jean-Pierre Marie Peter A. Kouides, Camille N. Abboud
and Virgil F. Fairbanks
A role of GAGs in ECM on morphogenesis
of megakaryocytes
Kenji Tajika, Kenji Ikebuchi, Kazuo Dan
and Shigetaka Asano
Malignancy
Leucocytes RESEARCH PAPERS
76 The labelling index of primitive plasma cells
RESEARCH PAPERS determines the clinical behaviour
40 Granulocyte colony-stimulating factor (G-CSF) of patients with myelomatosis
increases neutrophil migration across vascular Doug Joshua, Amarette Petersen, Ross Brown,
endothelium independent of an effect on adhesion: Belinda Pope, Leonie Snowdon and John Gibson
comparison with granulocyte-macrophage colony-
A population-based study of 272 children
stimulating factor (GM-CSF)
with acute myeloid leukaemia treated on two
Kwee L. Yong
consecutive protocols with different intensity:
Heparin induces apoptosis in human peripheral best outcome in girls, infants, and
blood neutrophils children with Down’s syndrome
J. Manaster, J. Chezar, R. Shurtz-Swirski, Sverre O. Lie, Gudmundur Jonmundsson,
G. Shapiro, Y. Tendler, B. Kristal, S. M. Shasha Lotta Mellander, Martti A. Siimes, Minna Yssing
and S. Sela and Goran Gustafsson
Interleukin-6 is required for pristane-induced
plasma cell hyperplasia in mice Dose intensification in acute myeloid leukaemia:
Douglas A. Dedera, Mitsuyoshi Urashima, greater effectiveness at lower cost. Principal report
Dharminder Chauhan, David P. LeBrun, of the Medical Research Council’s AML9 study
Roderick T. Bronson and Kenneth C. Anderson J. K. H. Rees, R. G. Gray and K. Wheatley
Volume Contents
Expression and prognostic value of the 133 A case of mature B-cell ALL
retinoblastoma tumour suppressor gene (RB-1) with coexistence of t(1;19) and t(14;18)
in childhood acute lymphoblastic leukaemia and expression of the E2A/PBX1 fusion gene
Axel Sauerbrey, Gerd Stammler, Felix Zintl David Rowe, Prema E. Devaraj, Julie A. E. Irving,
and Manfred Volm Linda Hogarth, Andrew G. Hall
and Gillian E. Turner
The der(21)t(12;21) chromosome is always formed
in a 12;21 translocation associated with childhood Multiplex PCR for rapid detection of T-cell receptor-
acute lymphoblastic leukaemia gamma chain gene rearrangements in patients
Hirofumi Kobayashi, Noriko Satake, Nobuo Maseki, with lymphoproliferative diseases
Akiko Sakashita and Yasuhiko Kaneko Manuela Fédinger, Heido Buchmayer,
Ilse Schwarzinger, Ingrid Simonitsch,
Karin Winkler, Ulrich Jager, Robert Knobler
SHORT REPORTS and Christine Mannhalter
112 Low incidence of specific anti-platelet antibodies
detected by the MAIPA assay in the serum of
thrombocytopenic MDS patients and lack of Bone marrow transplantation
correlation between platelet autoantibodies,
platelet lifespan and response to danazol therapy RESEARCH PAPERS
M. Hebbar, C. Kaplan, M. T. Caulier, 140 A randomized study comparing the effect of
E. Wattel, P. Morel, M. Wetterwald, F. Bauters GM-CSF and G-CSF on immune reconstitution
and P. Fenaux after autologous bone marrow transplantation
Prognostic factors in myelodysplastic syndromes: J. F. San Miguel, M. D. Hernandez, M. Gonzalez,
critical analysis of the impact of age and gender M. C. Lopez-Berges, M. D. Caballero, L. Vazquez,
and failure to identify a very-low-risk group A. Orfao, M. J. Nieto, M. Corral and M. C. del Canizo
using standard mortality ratio techniques Collection and transplantation of peripheral blood
Pierre Morel, Christophe Declercq, progenitor cells mobilized by G-CSF alone
Mohamed Hebbar, Francis Bauters in children with malignancies
and Pierre Fenaux M. A. Diaz, M. Villa, A. Alegre, M. L. Lamana,
Graft failure after donor leucocyte infusion A. de la Vega, A. Granda and L. Madero
in relapsed chronic myeloid leukaemia:
successful treatment with cyclophosphamide
and antithymocyte globulin followed by peripheral SHORT REPORT
blood stem cell infusion 155 Transient neutropenia in normal donors
Felix Keil, Peter Kalhs, Oskar A. Haas, after G-CSF mobilization and stem cell apheresis
Gerhard Fritsch, Gerlinde Mitterbauer, Paolo Anderlini, Donna Przepiorka, David Seong,
Stefan Brugger, Klaus Lechner, Ilse Schwarzinger, Richard Champlin and Martin K6rbling
Christine Mannhalter,
Werner Linkesch, Martin Kurz
and Hildegard T. Greinix
Haemostasis and thrombosis
Second transplantation with CD34* bone marrow
cells selected from a two-loci HLA-mismatched RESEARCH PAPER
sibling for a patient with chronic myeloid 159 Investigation of chronic hepatitis C infection
leukaemia in individuals with haemophilia:
Yoshihiro Fujimori, Akihisa Kanamaru, Naoaki assessment of invasive and non-invasive methods
Hashimoto, Takahiro Okamoto, Masaya Okada, John P. Hanley, Lisa M. Jarvis, Janet Andrews,
Kohotaro Kawaguchi, Ako Mori, Kaname Saheki, Rosemary Dennis, Robert Lee, Peter Simmonds,
Hiroyuki Takatsuka, Hiroshi Wada, Juan Piris, Peter Hayes and Christopher A. Ludlam
Yoshinobu Takemoto, Masatoshi Kohsaki,
Nobuyuki Imai, Eizo Kakashita and Kiyoyasu Nagai
Fanconi’s anaemia presenting as acute myeloid SHORT REPORTS
leukaemia in adulthood 166 Coexistence of familial antiphospholipid syndrome
J. D. Cavenagh, D. S. Richardson, R. A. Gibson, and factor V Leiden: impact on thrombotic diathesis
C. G. Mathew and A. C. Newland B. Brenner, S. L. Vulfsons, N. Lanir and M. Nahir
) GM-CSF raises serum levels of 3-microglobulin Clinical usefulness of desmopressin for prevention
and thymidine kinase in patients with chronic of surgical bleeding in patients with symptomatic
lymphocytic leukaemia heterozygous factor XI deficiency
Maija Itala, Tarja-Terttu Pelliniemi and Giancarlo Castaman, Marco Ruggeri
Kari Remes and Francesco Rodeghiero
Volume Contents V
171 Cyclic change of cytokines in a patient with cyclic VOL. 94 NO. 2 AUGUST 1996
thrombocytopenia
Fumihiko Kimura, Yukistugu Nakamura, Annotation
Ken Sato, Naoki Wakimoto, Takashi Kato,
217 Multiple myeloma: almost all patients are
Tomoyuki Tahara, Muneo Yamada,
cytogenetically abnormal
Naokazu Nagata and Kazuo Motoyoshi
Marc Zandecki, Jean-Luc Lai and Thierry Facon
Blood transfusion
RESEARCH PAPERS Haemopoiesis and growth factors
175 Antigen topography is critical for interaction of
IgG2 anti-red-cell antibodies with Fc receptors RESEARCH PAPERS
Belinda M. Kumpel, Jan G. J. van de Winkel, 228 Activity of the ligand for c-mpl, thrombopoietin,
Nomdo A. C. Westerdaal, Andrew G. Hadley, in early haemopoiesis
J. Michel Dugoujon and Antoine Blancher Ryugo Itoh, Naoyuki Katayama, Takashi Kato,
Nadim Mahmud, Masahiro Masuya, Kohshi Ohishi,
Evaluation of a new, integral, whole blood filter
Nobuyuki Minami, Hiroshi Miyazaki and
(RS2000) system for prestorage leucodepletion
Hiroshi Shiku
of SAG-M red cells
J. R. Rider, G. Moore, J-M. Payrat, D. Chan, Haemopoietic growth factor tyrosine kinase
C. Morse, G. R. Standen and D. H. Pamphilon receptor expression profiles in normal haemopoiesis
Monique Visser, Renate D. Sonneveld,
Roel Willemze and James E. Landegent
Tron
A possible change in doubling time of haemopoietic
RESEARCH PAPER progenitor cells with stem cell development
Nadim Mahmud, Naoyuki Katayama, Ryugo Itoh,
191 A novel mutation in the ferrochelatase gene
Ryuhei Tanaka, Kohski Ohishi, Masahiro Masuya,
associated with erythropoietic protoporphyria
Nobuyuki Minami and Hiroshi Shiku
S. Imoto, Y. Tanizawa, Y. Sato, K. Kaku
and Y. Oka Constitutive expression of granulocyte-colony
stimulating factor receptor
on a human B-lymphoblastoid cell line
Rapid papers Keiko Morikawa, Shigeru Morikawa,
198 Phenotype, genotype and clonality of Reed- Toshio Miyawaki, Makoto Nagasaki,
Sternberg cells in nodular sclerosis Hodgkin’s Ikuko Torii and Katsuyuki Imai
disease: results of a single-cell study Cryopreserved human bone marrow stroma
Jan Delabie, Anne Tierens, Theodora Gavriil, is fully functional in vitro
Gang Wu, Dennis D. Weisenburger and Andrew Nicol, Mie Nieda, Craig Donaldson,
Wing C. Chan Patricia Denning-Kendall, Carol Truman,
Ben Bradley and Jill Hows
The bone marrow aspirate
of healthy subjects
Barbara J. Bain
Erythrocytes
Correspondence
RESEARCH PAPERS
210 Aprotinin employment in patients with acute
leukaemia to prevent haemorrhage 266 The behaviour of red cells ir narrow tubes in vitro
during pulmonary aspergillosis as a model of the microcirculation
Livio Pagano, Elettra Ortu La Barbera, Kazuo Kubota, Jun’ichi Tamura, Takuo Shirakura,
Roberto Marra, Giulia Morace, Simona Sica Masanori Kimura, Kazunori Yamanaka,
and Giuseppe Leone Tatsuo Isozaki and Izumi Nishio
IL-10 serum levels Isolated beta-globin chains reproduce, in normal
in B-cell chronic lymphocytic leukaemia red cell membranes, the defective binding of
Alexander Egle, Ingrid Marschitz, spectrin to alpha-thalassaemic membranes
Barbara Posch, Manfred Herold, Richard Greil Oded Shalev, Eilat Shinar and Samuel E. Lux
and Jan Sjoberg Haematologica! abnormalities
in Shwachman-Diamond syndrome
213 Book Reviews
Owen P. Smith, lan M. Hann, Judith M. Chessells,
216 Announcements Brian R. Reeves and Peter Milla
vi Volume Contents
SHORT REPORT 342 The retinoblastoma gene (rb1) in acute myeloid
leukaemia: analysis of gene rearrangements,
285 Second transplantation using allogeneic peripheral
protein expression and comparison of disease
blood stem cells in a 3-thalassaemia major patient
outcome
featuring stable mixed chimaerism
Rahman Jamal, Rosemary E. Gale, N. Shaun,
R. Or, J. Kapelushnik, E. Naparstek, A. Nagler,
B. Thomas, Keith Wheatley and David C. Linch
D. Filon, A. Oppenheim, A. Amar, M. Aker,
The ultrastructure of mantle cell lymphoma
S. Samuel and S. Slavin
and other B-cell disorders with translocation
t(11;14)(q133;q32)
Peretz Resnitzky, Estela Matutes, Michael Hedges,
Malignancy Ricardo Morilla, Vasantha Brito-Babapulle,
Tariq Khokhar and Daniel Catovsky
RESEARCH PAPERS Interferon-alpha 2b (IFN)
288 The effect of iron chelation on haemopoiesis in MDS for early-phase chronic lymphocytic leukaemia
patients with transfusional iron overload with high risk for disease progression:
P. D. Jensen, L. Heickendorff, Bent Pedersen, results of a randomized multicentre study
K. Bendix-Hansen, F. T. Jensen, T. Christensen, Irmgard Langenmayer, Christoph Nerl,
A. M. Boesen and J. Ellegaard Wolfgang Knauf, Sarah Dempster, Michael Hallek,
Dagmar Adorf, Hermann Dietzfelbinger,
Neutralizing anti-interferon- antibodies and
Raymonde Busch, Hans Werner Ziegler-Heitbrock,
response to treatment in patients with Ph*
Eckhard Thiel and Bertold Emmerich
chronic myeloid leukaemia sequentially treated
with recombinant (a2a) and lymphoblastoid
interferon-a
SHORT REPORTS
Domenico Russo, Anna Candoni, Eliana Zuffa,
370 Elevated platelet count features the variant type
Rosalba Minisini, Federico Silvestri, Renato Fanin,
of BCR/ABL junction in chronic myelogenous
Francesco Zaja, Giovanni Martinelli, Sante Tura,
leukaemia
Giuseppe Botta and Michele Baccarani
Tetsuya Yamagata, Kinuko Mitani,
Analysis of the « light chain variable region Yoshinobu Kanda, Yoshio Yazaki
in multiple myeloma and Hisamaru Hirai
Christos Kosmas, Nora-Athina Viniou, Additional neoplasma and HCV infection
Kostas Stamatopoulos, Nigel S. Courtenay-Luck, in low-grade lymphoma of MALT type
Theodora Papadaki, Panagoula Kollia,
Mario Luppi, Giuseppe Longo, Maria Grazia Ferrari,
George Paterakis, Dimitra Anagnostou,
Leonardo Ferrara, Roberto Marasca,
Xenophon Yataganas and Dimitris Loukopoulos
Patrizia Barozzi, Monica Morselli, Giovanni Emilia
A plasmocyte selective monoclonal antibody (B-B4) and Giuseppe Torelli
recognizes syndecan-1 Clinical and molecular remission after
John Wijdenes, Wim C. Vooijs, Claude Clément, allogeneic blood cell transplantation
Jacob Post, Florence Morard, Natalio Vita, in a patient with mantle-cell lymphoma
Patrick Laurent, Ren-Xiao Sun, Bernard Klein and Paolo Corradini, Marco Ladetto, Monica Astolfi,
Jean-Michel Dore Claudia Voena, Corrado Tarella, Andrea Bacigalupo
and Alessandro Pileri
Effect of interferon on the health-related quality
of life of multiple myeloma patients: An aggressive nasal lymphoma
results of a Nordic randomized trial comparing accompanied by high levels of soluble Fas ligand
melphalan—prednisone to Ken Sato, Fumihiko Kimura, Yukitsugu Nakamura,
melphalan—prednisone + a-interferon Hideaki Murakami, Masayoshi Yoshida,
Finn Wisloff, Martin Hjorth, Stein Kaasa Masato Tanaka, Shigekazu Nagata, Yasuhiro
and Jan Westin Kanatani, Naoki Wakimoto, Naokazu Nagata
and Kazuo Motoyoshi
Treatment of acute myelogenous leukaemia
in patients aged 50-65: idarubicin is more effective
than zorubicin for remission induction and Haemostasis and thrombosis
prolonged disease-free survival can be obtained
using a unique consolidation course RESEARCH PAPERS
B. Pignon, F. Witz, B. Desablens, P. Y. Leprise, 383 Cryosupernatant as replacement fluid
S. Francois, C. Linassier, C. Berthou, D. Caillot, for plasma exchange in thrombotic
B. Lioure, J. Y. Cahn, P. Casassus, A. Sadoun, thrombocytopenic purpura
B. Audhuy, D. Guyotat, J. Briere, J. P. Vilque, G. Rock, Kenneth H. Shumak,
L. Baranger, V. Polin, P. Berthaud, P. Hurtleloup, David M. C. Sutton, Noel A. Buskard
P. Herve and J. L. Harousseau and Rama C. Nair
Volume Contents vii
Recombinant human c-Mpl ligand is not VOL. 94 NO. 3 SEPTEMBER-I 1996
a direct stimulator of proplatelet formation
in mature human megakaryocytes Annotation
Toshiharu Ito, Yoji Ishida, Rieko Kashiwagi
425 Cytokine therapy in multiple myeloma
and Shin-ichiro Kuriya
Dietrich Peest, Joan Bladé, Jean-Luc Harousseau,
Mature micromegakaryocytes: an unusual Bernhard Klein, Anders Osierborg and
developmental pattern in term infants Jesus F. San Miguel
R. F. Levine, T. A. Olson, P. K. Shoff,
M. K. Miller and L. E. Weisman Haemopoiesis and growth factors
Mutations in a subgroup of patients with mild
RESEARCH PAPERS
haemophilia A and a familial discrepancy between
433 The development of human megakaryocytes. II.
the one-stage and two-stage factor VIII:C methods
CD4 expression occurs during haemopoietic
Zbigniew Rudzki, Elizabeth M. Duncan,
differentiation and is an early step in
Graeme J. Casey, Maureen Neumann,
Emmanuel J. Favaloro and John V. Lloyd megakaryocyte maturation
Ross S. Basch, Alexandr Dolzhanskiy,
Age-related changes in factor VII proteolysis in vivo Xin-Min Zhang and Simon Karpatkin
F. A. Ofosu, S. Craven, L. Dewar, N. Anvari,
In vivo effect of platelet factor 4 (PF4) and
M. Andrew and M. A. Blajchman
tetrapeptide ACSDKP on haemopoiesis of mice
treated with 5-fluorouracil
Sallouha Aidoudi, Martine Guigon,
Isabelle Lebeurier, Jacques P. Caen
SHORT REPORT and Zhong Chao Han
413 Acute arterial thrombosis due to platelet The purification of CD34° cells from human cord
aggregation in a patient receiving granulocyte blood: comparison of separation techniques and
colony-stimulating factor cytokine requirements for optimai growth of
Yasunori Kawachi, Ayako Watanabe, clonogenic progenitors
Tatsumi Uchida, Kiyoshi Yoshizawa, Pierre Charbord, Isobel Newton, Laurent Voillat,
Nobuaki Kurooka and Kojun Setsu Jean Patrick Schaal and Patrick Herve
BMX tryosine kinase gene is expressed
in granulocytes and myeloid leukaemias
Jaakko Kaukonen, Isto Lahtinen, Sinikka Laine,
Blood transfusion Kari Alitalo and Aarno Palotie
RESEARCH PAPER
SHORT REPORT
417 Denaturing gradient gel electrophoresis:
a novel method for determining Rh phenotype 461 Rapid quantitative analysis of protein tryosine
residue phosphorylation in defined cell populations
from genomic DNA
in whole blood and bone marrow aspirates
Fiona Steers, Maura Wallace, Philip Johnson,
Ben Carritt and Geoff Daniels C. Miiller, J. Kremerskothen, M. Ziihlsdorf,
U. Cassens, Th. Biichner, A. Barnekow and
O. M. Koch
Leucocytes
CORRESPONDENCE
RESEARCH PAPER
422 Further improvement of t(8;21) detection
by RT-PCR 464 The use of rh-G-CSF in chronic autoimmune
Caroline Lynas, Denise Howe, Marion Sweeney neutropenia: reversal of autoimmune phenomena,
and Michael Wagstaff a case history
Taco W. Kuijpers, Masja de Haas, Cees J. de Groot,
Bone marrow transplantation for Fanconi’s
Albert E. G. Kr. von dem Borne and Ron S. Weening
anaemia: conditioning with reduced doses
of cyclophosphamide without radiation Erythrocytes
Inderjeet S. Dokal and Irene A. G. Roberts
Therapy with recombinant erythropoietin RESEARCH PAPERS
in paroxysmal nocturnal haemoglobinuria 470 Expression of spectrin a'/°> hereditary eliiptocytosis
E. Balleari, C. Mareni, A. M. Marmont, R. Ghio, in patients from Brazil
M. F. McMullin, P. Hillmen, G. E. Elder, Patricia H. L. Pranke, Danieia S. Basseres,
T. R. J. Lappin and L. Luzzatto Fernando F. Costa and Sara T. O. Saad
viii Volume Contents
476 Molecular genetics of 3-thalassaemia in Pakistan: Haemostasis and thrombosis
a basis for prenatal diagnosis
Suhaib Ahmed, Mary Petrou RESEARCH PAPER
and Mohammad Saleem 517 Induction of monocyte tissue factor procoagulant
activity during coronary artery bypass surgery is
reduced with heparin-coated extracorporeal circuit
R. Marius Barstad, Eivind Ovrum,
SHORT REPORT
Mari-Anne L. Kingdal, Rolf Oystese,
483 Hb Utrecht (a, 129(H12)Leu — Pro), Maria J. A. G. Hamers, Ole P. Veiby, Torill Rolfsen,
a new unstable a-thalassaemic phenotype
Ross W. Stephens and Kjell S. Sakariassen
C. L. Harteveld, P. C. Giordano, M. Losekoot,
J. G. A. M. Heister, D. Batelaan, P. van Delft,
M. C. A. Bruin and L. F. Bernini
SHORT REPORT
526 Fibrinogen Matsumoto Il:
Malignancy 4398 Asn — Lys (AAT — AAG) mutation
associated with bleeding tendency
RESEARCH PAPERS
Nobuo Okumura, Kenichi Furihata,
486 Parathyroid hormone-related protein in Fumiko Terasawa, Shinsuke Ishikawa,
hypercalcaemia associated with haematological Ichiro Ueno and Tsutomu Katsuyama
malignancy
Frank Firkin, John F. Seymour,
Anne-Marie Watson, Vivian Grill
and T. John Martin Iron
Incidence and implication of additional
RESEARCH PAPER
chromosome aberrations in acute promyelocytic
529 Parenteral iron increase serum erythropoietin
leukaemia with translocation t(15;17)(q22;21):
concentration during the ‘early anaemia’
a report on 50 patients
of 10-—20-day-old mice
Claudia Schoch, Detlef Haase, Torsten Haferlach,
Anne Grete Bechensteen and Sverre Halvorsen
Mathias Freund, Hartmut Link, Eva Lengfelder,
Helmut Loffler, Thomas Biichner and
Christa Fonatsch
Putative normal counterparts of leukaemic cells Viral infections
from CD7-positive acute myeloid leukaemia can be
demonstrated in human haemopoietic tissues RESEARCH PAPERS
Hwei-Fang Tien, Chen-Cheng Chou, Chiu-Hwa 533 Kaposi's sarcoma-associated herpesvirus DNA
Wang, Chun-Hui Chang and Chen-Chen Hsing sequences in AIDS-related and AIDS-unrelated
lymphomatous effusions
Antonino Carbone, Annunziata Gloghini,
Emanuela Vaccher, Vitterina Zagonel,
Cristina Pastore, Paolo Dalla Palma, Fabio Branz,
SHORT REPORTS
Giuseppe Saglio, Rachele Volpe,
507 Spontaneous complete remission and recovery of Umberto Tirelli and Gianluco Gaidano
donor haemopoiesis without GVHD after relapse
and apparent marrow graft rejection in poor- Hepatitis C virus and non-Hodgkin’s lymphomas
prognosis myelodysplastic syndrome Cesare Mazzaro, Vittorina Zagonel,
Yves Beguin, Joelle Collignon, Christian Laurent Silvio Monfardini, Patrizia Tulissi,
and Georges Fillet Elisabetta Pussini, Massimiliano Fanni,
Roberto Sorio, Roberto Bortolus, Marina Crovatto,
Myelodysplasia following asplastic anaemia— Gianfranco Santini, Claudio Tiribelli, Franco Sasso,
paroxysmal nocturnal haemoglobinuria syndrome
Roberto Masutti and Gabriele Pozzato
after treatment with immunosuppression and G-CSF:
evidence for the emergence of a separate clone
Jong-Youl Jin, Jennifer A. Tooze, Judith C. W. Marsh,
Francis Matthey and Edward C. Gordon-Smith SHORT REPORT
Growth stimulatory effect of thrombopoietin 551 Development of anti-interferon antibodies
on the blast cells of acute myelogenous leukaemia and breakthrough hepatitis during treatment
Toshiko Moteji, Minoko Takanashi, for HCV infection in haemophiliacs
Sayuri Motomura, Wang Yan-Hua, Hiroko John P. Hanley, Lisa M. Jarvis, Peter Simmonds
Shiozaki, Masako Aoyama and Hideaki Mizoguchi and Christopher A. Ludlam
Volume Contents ix
Rapid papers 592 Haemopoietic progenitor homing and mobilization
M. L. Turner and J. W. Sweetenham
557 Establishing the presence of the t(15;17)
in suspected acute promyelocytic leukaemia:
cytogenetic, molecular and PML Haemopoiesis and growth factors
immunofluorescence assessment of patients
entered into the M.R.C. ATRA trial
David Grimwade, Kathy Howe, Stephen Langabeer, Research papers
Lynne Davies, Fiona Oliver, Helen Walker, 597 Differences in the distribution of CD34 epitopes
David Swirsky, Keith Wheatley, on normal haemopoietic progenitor cells and
Anthony Goldstone, Alan Burnett leukaemic blast cells
and Ellen Solomon Rita Steen, Geir E. Tjonnfjord, Gustav Gandernack,
Lorentz Brinch and Torstein Egeland
Unrelated donor bone marrow transplantation Umbilical vein endothelial cells are an important
for children with relapsed acute lymphoblastic source of c-kit and stem cell factor which regulate
leukaemia in second complete remission the proliferation of haemopoietic progenitor cells
A. Oakhill, D. H. Pamphilon, M. N. Potter, Hideto Yamaguchi, Eiichi Ishii, Shigeru Saito,
C. G. Steward, S. Goodman, A. Green, P. Goulden, Katsuya Tashiro, Ichiro Fujita, Seiko Yoshidomi,
N. J. Goulden, G. Hale, H. Waldmann and Masamichi Ohtubo, Kouhei Akazawa and
J. M. M. Cornish Sumio Miyaza’*
In leukaemic CD5* Bc ells
the expression of BCL-2 gene family
Correspondence is shifted toward protection from apoptosis
D. Gottardi, A. Alfarano, A. M. De Leo, A. Stacchini,
579 Intractable pruritus in non-Hodgkin lymphoma/ M. Aragno, A. Rigo, D. Veneri, R. Zanotti, G. Pizzolo
CLL: rapid response to IFN and F. Caligaris-Cappio
Paolo Radossi, Tiziana Tison, Fabrizio Vianello
In vivo haemoprotective activity of tetrapeptide
and Francesco Dazzi
AcSDKP combined with granulocyte-colony
stimulating factor following sublethal irradiation
Is T-cell CLL a disease entity? Tsutomu Watanabe, Linda S. Kelsey, Yun Yan,
D. Catovsky, E. Matutes and V. Brito-Babapulle Gregory S. Brown, John D. Jackson, Cynthia Ewel
and James E. Talmadge
Serum levels of soluble ICAM-1
in patients with malignant lymphoma: Leucocytes
an association with treatment response
Caterina Musolino, Andrea Alonci, Alessandro SHORT REPORT
Allegra, Giovanna Spatari, Giacomo Bellomo
628 Chronic neutrophil leukaemia in adolescence
and Melchiorre Quartarone and young adulthood
Henrik Hasle, Gitte Olesen, Gitte Kerndrup,
Congenital dyserythropoiesis type I Preben Philip and Niels Jacobsen
and alpha-interferon therapy
Shareen Virjee and Chris Hatton Erythrocytes
Hypoplastic myelodysplasia (MDS) RESEARCH PAPERS
C. G. Geary, J. C. W. Marsh, E. C. Gordon-Smith, 631 Gene expression in somatic cell hybrids
Nuket Tuzuner, Chris Cox, Jacob Rowe, derived from embryonic mice
Dennis Waltrous and John M. Bennett transgenic for human globin genes
S. J. Stanworth, N. A. Roberts, J. A. Sharpe
and W. G. Wood
Announcements
Haemoglobin Lleida:
a new a>2-globin variant (12 bp deletion)
with mild thalassaemic phenotype
S. Ayala, D. Colomer, A. Pujades, M. Aymerich
VOL. 94 NO. 4 SEPTEMBER-II 1996 and J. Ll. Vives Corrons
Diamond-Blackfan anaemia in the U.K.:
Annotations
analysis of 80 cases from a 20-year birth cohort
585 New insights into G6PD deficiency S. E. Ball, C. P. McGuckin, G. Jenkins and
Philip J. Mason E. C. Gordon-Smith
x Volume Contents
Malignancy 705 Detection of bcl-2 rearrangement
in HIV-related follicular lymphoid hyperplasia
RESEARCH PAPERS Thierry J. Molina, Francis Devez, Claude Bigorgne,
654 BCR-ABL-positive lymphoblastoid cells Agnes Le Tourneau, Virginie Joulin, Josée Audouin
display limited proliferative capacity and Jacques Diebold
under in vitro culture conditions Fludarabine, as well as 2-chlorodeoxyadenosine,
Andrew Spencer, Xiu-Hua Yan, Andrew Chase, can induce eosinophilia during treatment of
John M. Goldman and Junia V. Melo
lymphoid malignancies
A randomized study of VAD therapy with either Gerd Larfars, Ann-Mari Udén-Blohmé
concurrent or maintenance interferon in patients and Jan Samuelsson
with newly diagnosed multiple myeloma Successful treatment of HTLV-1 associated acute
G. M. Abrahamson, J. M. Bird, A. C. Newland,
adult T-cell leukaemia lymphoma by allogeneic
E. Gaminara, Chrissie Giles, M. Joyner, S. M. Kelsey, bone marrow transplantation
D. Lewis, D. M. McCarthy, A. W. Roques, C. J. Tew,
Anton Borg, John A. Liu Yin, Peter R. E. Johnson,
M. Treacy, J. van de Pette and Diana Samson Jennifer Tosswill, Melanie Saunders and
The CDKN2 gene alterations David Morris
in various types of adult T-cell leukaemia
Toshiki Uchida, Tomohiro Kinoshita,
Takashi Watanabe, Hirokazu, Nagai, Bone marrow transplantation
Takashi Murate, Hidehiko Saito and
RESEARCH PAPER
Tomomitsu Hotta
716 Combined negative and positive selection
Down-regulation of bcl-2 in AML blasts by all-trans
of mobilized CD34* blood cells
retinoic acid and its relationship to CD34 antigen
Massimo Di Nicola, Marco Bregni, Salvatore Siena,
expression
Pier Adelchi Ruffini, Marco Milanesi,
D. A. Bradbury, S. Aldington, Y-M. Zhu
Fernando Ravagnani and A. Massimo Gianni
and N. H. Russell
Oligonucleotide clonospecific probes directed
against the junctional sequence of t(14;18): Haemostasis and thrombosis
a new tool for the assessment of minimal
residual disease in follicular lymphomas RESEARCH PAPER
Sandrine Galoin, Talal Al Saati, Daniel Schlaifer, 722 Effect of recombinant human thrombopoietin in
Anne Huynh, Michel Attal and Georges Delsol nonhuman primates with chemotherapy-induced
thrombocytopenia
Molecular analysis of the leukaemic B cell in adult
and childhood acute lymphoblastic leukaemia Hiromichi Akahori, Kazunori Shibuya,
Masako Obuchi, Yoshito Nishizawa, Akio Tsuji,
Luke A. Coyle, Maria Papaioannou, John C. Yaxley,
Koji Kabaya, Masaru Kusaka, Hideya Ohashi,
James S. Chim, M. Attard, A. Victor Hoffbrand
Haruhiko Tsumura, Takashi Kato and
and Letizia Foroni
Hiroshi Miyazaki
SHORT REPORTS Evidence for the involvement of compiement
694 Intermediae-dose busulphan before autografting proteins in platelet aggregation by Streptococcus
for advanced-phase chronic myeloid leukaemia sanguis NCTC 7863
Simon A. J. Rule, David G. Savage, I. Ford, C. W. I. Douglas, J. Heath, C. Rees
Stephen G. O’Brien, Kim Orchard, Christine and F. E. Preston
McDonald, John Davidson, Francis Matthey,
Pharmacokinetics of von Willebrand factor
John T. Reilly, G. Bardhan, Elizabeth Miller,
and factor VIIIC in patients with severe
Tanya Cranfield, Jane F. Apperley
von Willebrand disease (type 3 VWD):
and John M. Goldman
estimation of the rate of factor VIIIC synthesis
Successful treatment of acute promyelocytic Doris Menache, David L. Aronson, Fred Darr,
leukaemia with all-trans-retinoic-acid Robert R. Montgomery, and the Cooperative Study
during late pregnancy Group: Joan C. Gill, Craig M. Kessler,
M. M. Lipovsky, D. H. Biesma, Jeanne M. Lusher, Pradyumna D. Phatak,
G. C. M. L. Christiaens and E. J. Petersen Amy D. Shapiro, Arthur R. Thompson and
Gilbert C. White, IT
Acute myeloid leukaemia with t(8;16)(p11;p13)
in a child after intrauterine X-ray exposure The natural history of chronic hepatitis C
Stireyya Savasan, Anwar N. Mohamed, in haemophiliacs
David R. Lucas, Michael C. Dugan, James R. Ryan M. Makris, F. E. Preston, F. R. Rosendaal,
and Yaddanapudi Ravindranath J. C. E. Underwood, K. M. Rice and D. R. Triger