Table Of Content

Volume 48, Number 1, July 1, 2000 PRIORITY COMMUNICATION 1 Lithium Increases N-Acetyl-Aspartate in the Human Brain: In Vivo Evidence in Support of bcl-2’s Neurotrophic Effects? Gregory J. Moore, Joseph M. Bebchuk, Khondakar Hasanat, Guang Chen, Navid Seraji-Bozorgzad, Ian B. Wilds, Michael W. Faulk, Susanne Koch, Debra A. Glitz, Libby Jolkovsky, and Husseini K. Manji REVIEW 9 Attention-Deficit/Hyperactivity Disorder in Adults: An Overview Stephen V. Faraone, Joseph Biederman, Thomas Spencer, Tim Wilens, Larry J. Seidman, Eric Mick, and Alysa E. Doyle ORIGINAL ARTICLES 21 Attention-Deficit Disorder and Conduct Disorder in Girls: Evidence for a Familial Subtype Stephen V. Faraone, Joseph Biederman, and Michael C. Monuteaux 30 Differential Limbic—Cortical Correlates of Sadness and Anxiety in Healthy Subjects: Implications for Affective Disorders Mario Liotti, Helen S. Mayberg, Stephan K. Brannan, Scott McGinnis, Paul Jerabek, and Peter T. Fox 43 Activation of Anterior Paralimbic Structures during Guilt-Related Script-Driven Imagery Lisa M. Shin, Darin D. Dougherty, Scott P. Orr, Roger K. Pitman, Mark Lasko, Michael L. Macklin, Nathaniel M. Alpert, Alan J. Fischman, and Scott L. Rauch 51 A Pilot Study of Amygdala Volumes in Pediatric Generalized Anxiety Disorder Michael D. De Bellis, B.J. Casey, Ronald E. Dahl, Boris Birmaher, Douglas E. Williamson, Kathleen M. Thomas, David A. Axelson, Karin Frustaci, Amy M. Boring, Julie Hall, and Neal D. Ryan 58 Lithium Regulation of Aldolase A Expression in the Rat Frontal Cortex: Identification by Differential Display Len V. Hua, Marty Green, Jerry J. Warsh, and Peter P. Li 65 Elevated Plasma Thymopoietin Associated with Therapeutic Nonresponsiveness in Major Depression Gideon Goldstein, Maurizio Fava, Michael Culler, Alan Fisher, Karl Rickels, R. Bruce Lydiard, and Jerrold Rosenbaum Similarity in Saliva Cortisol Measures in Monozygotic Twins and the Influence of Past Major Depression Elizabeth A. Young, Steven H. Aggen, Carol A. Prescott, and Kenneth S. Kendler BRIEF REPORT 75 Acute Effects of Mirtazapine on Sleep Continuity and Sleep Architecture in Depressed Patients: A Pilot Study Andrew Winokur, Michael J. Sateia, J. Boyd Hayes, Wendy Bayles-Dazet, Mary M. MacDonald, and Keith A. Gary ABSTRACTS ON THE INTERNET Volume 48, Number 2, July 15, 2000 REVIEW 81 The Imbalanced Brain: From Normal Behavior to Schizophrenia Stephen Grossberg ORIGINAL ARTICLES 99 Schizophrenic Subjects Show Aberrant fMRI Activation of Dorsolateral Prefrontal Cortex and Basal Ganglia during Working Memory Performance Dara S. Manoach, Randy L. Gollub, Etienne S. Benson, Meghan M. Searl, Donald C. Goff, Elkan Halpern, Clifford B. Saper, and Scott L. Rauch 110 Regional Frontal Abnormalities in Schizophrenia: A Quantitative Gray Matter Volume and Cortical Surface Size Study Benedicto Crespo-Facorro, Jae-Jin Kim, Nancy C. Andreasen, Daniel S. O’Leary, and Vincent Magnotta 120 Neuropsychologic Functioning among the Nonpsychotic Relatives of Schizophrenic Patients: The Effect of Genetic Loading Stephen V. Faraone, Larry J. Seidman, William S. Kremen, Rosemary Toomey, John R. Pepple, and Ming T. Tsuang 127 Emotion Recognition Deficit in Schizophrenia: Association with Symptomatology and Cognition Christian G. Kohler, Warren Bilker, Michael Hagendoorn, Raquel E. Gur, and Ruben C. Gur 137 Age and Neuropsychologic Function in Schizophrenia: A Decline in Executive Abilities beyond That Observed in Healthy Volunteers Robert Fucetola, Larry J. Seidman, William S. Kremen, Stephen V. Faraone, Jill M. Goldstein, and Ming T. Tsuang 147 An MRI Study of Temporal Lobe Structures in Men with Bipolar Disorder or Schizophrenia Lori L. Altshuler, George Bartzokis, Tom Grieder, John Curran, Tanya Jimenez, Kristin Leight, Jeffery Wilkins, Robert Gerner, and Jim Mintz BRIEF REPORT 163 Long-Term Adaptive Life Functioning in Relation to Initiation of Treatment with Antipsychotics over the Lifetime Trajectory of Schizophrenia John Quinn, Maria Moran, Abbie Lane, Anthony Kinsella, and John L. Waddington CASE REPORT 167 H, Antagonist Nizatidine May Control Olanzapine-Associated Weight Gain in Schizophrenic Patients Emilio Sacchetti, Laura Guarneri, and Daniele Bravi ABSTRACTS ON THE INTERNET Erratum Volume 48, Number 3, August 1, 2000 REVIEW 173 Meeting Report; “Molecular Neurobiological Mechanisms in Schizophrenia: Seeking a Synthesis,” April 11-14, 1999 Ann B. Goodman and Arthur B. Pardee ORIGINAL ARTICLES 184 Levels of mRNAs Encoding Synaptic Vesicle and Synaptic Plasma Membrane Proteins in the Temporal Cortex of Elderly Schizophrenic Patients Boris P. Sokolov, Andrew A. Tcherepanov, Vahram Haroutunian, and Kenneth L. Davis 197 Smooth Pursuit Eye Movements in Schizophrenia and Attentional Dysfunction: Adults with Schizophrenia, ADHD, and a Normal Comparison Group Randal G. Ross, Ann Olincy, Josette G. Harris, Bernadette Sullivan, and Allen Radant 204 Cerebellar Functional Abnormalities in Schizophrenia Are Suggested by Classical Eyeblink Conditioning Lonnie L. Sears, Nancy C. Andreasen, and Daniel S. O'Leary 210 An Event-Related Potential Investigation of Response Inhibition in Schizophrenia and Psychopathy Kent A. Kiehl, Andra M. Smith, Robert D. Hare, and Peter F. Liddle 222 Effects of Stimulus Intensity on the Efficacy of Bilateral ECT in Schizophrenia: A Preliminary Study Worrawat Chanpattana, M.L. Somchai Chakrabhand, Wanchai Buppanharun, and Harold A. Sackeim 229 5-HT,, Receptor Activation Contributes to Ziprasidone-Induced Dopamine Release in the Rat Prefrontal Cortex Hans Rollema, Yi Lu, Anne W. Schmidt, Jeffrey S. Sprouse, and Stevin H. Zorn 238 Inhibitory Control in Children with Attention-Deficit/Hyperactivity Disorder: Event- Related Potentials Identify the Processing Component and Timing of an Impaired Right-Frontal Response-Inhibition Mechanism Steven R. Pliszka, Mario Liotti, and Marty G. Woldorff 247 Hypothalamic Pituitary Adrenocortical and Sympathetic Nervous System Responses to the Cold Pressor Test in Alzheimer’s Disease Marcella Pascualy, Eric C. Petrie, Kayla Brodkin, Elaine R. Peskind, Charles W. Wilkinson, and Murray A. Raskind ABSTRACTS ON THE INTERNET Volume 48, Number 3, August 15, 2000 ORIGINAL ARTICLES 259 Serotonin Transporter Gene Polymorphisms, Alcoholism, and Suicidal Behavior Philip Gorwood, Philippe Batel, Jean Adés, Michel Hamon, and Claudette Boni 265 Factors Predicting the Onset of Adolescent Drinking in Families at High Risk for Developing Alcoholism Shirley Y. Hill, Sa Shen, Lisa Lowers, and Jeannette Locke 276 Auditory P3a Assessment of Male Alcoholics Michio Hada, Bernice Porjesz, Henri Begleiter, and John Polich 287 The Relationship of Obsessive-Compulsive Disorder to Possible Spectrum Disorders: Results from a Family Study O. Joseph Bienvenu, Jack F. Samuels, Mark A. Riddle, Rudolf Hoehn-Saric, Kung-Yee Liang, Bernadette A.M. Cullen, Marco A. Grados, and Gerald Nestadt 294 Thalamic Volume in Pediatric Obsessive-Compulsive Disorder Patients before and after Cognitive Behavioral Therapy David R. Rosenberg, Nili R. Benazon, Andrew Gilbert, April Sullivan, and Gregory J. Moore Hippocampal Volume in Geriatric Depression David C. Steffens, Christopher E. Byrum, Douglas R. McQuoid, Daniel L. Greenberg, Martha E. Payne, Timothy F. Blitchington, James R. MacFall, and K. Ranga Rama Krishnan TECHNIQUES & METHODS Plasma Adrenocorticotropin Responses to Opioid Blockade with Naloxone: Generating A Dose-Response Curve in a Single Session Deborah Mangold, Mary Elizabeth McCaul, Mahmood Ali, and Gary Steven Wand BRIEF REPORTS CSF Oxytocin and Vasopressin Levels after Recovery from Bulimia Nervosa and Anorexia Nervosa, Bulimic Subtype Guido K. Frank, Walter H. Kaye, Margaret Altemus, and Catherine G. Greeno Possible Association between Serotonin Transporter Gene Polymorphism and Violent Suicidal Behavior in Mood Disorders Frank Bellivier, Andrei Széke, Chantal Henry, Jérome Lacoste, Corinne Bottos, Marika Nosten-Bertrand, Patrick Hardy, Frederic Rouillon, Jean-Marie Launay, Jean-Louis Laplanche, and Marion Leboyer Thyroid Function and Response to 48-Hour Sleep Deprivation in Treatment-Resistant Depressed Patients Michela M. David, James A. Owen, Gebrehiwot Abraham, Nicholas J. Delva, Stephen E. Southmayd, Eric Wooltorton, and J. Stuart Lawson Tryptophan Depletion and Risk of Depression Relapse: A Prospective Study of Tryptophan Depletion as a Potential Predictor of Depressive Episodes Francisco A. Moreno, George R. Heninger, Cynthia A.M cGahuey, and Pedro L. Delgado CASE REPORT Vasopressin, Major Depression, and Hypothalamic—Pituitary—Adrenocortical Desensitization Marianne B. Miiller, Rainer Landgraf, and Martin E. Keck CORRESPONDENCE Cautionary Note: Complex (Dys)function of the Serotonin Transporter Marco Battaglia, Anna Ogliari, Cesare Maffei, Cecilia Marino, Massimo Molteni, and Maria Nobile ABSTRACTS ON THE INTERNET Volume 48, Number 5, September 1, 2000 REVIEWS PET Imaging of Transgene Expression Duncan C. MacLaren, Tatsushi Toyokuni, Simon R. Cherry, Jorge R. Barrio, Michael E. Phelps, Harvey R. Herschman, and Sanjiv S. Gambhir Towards the Prevention of Schizophrenia Ming T. Tsuang, William S. Stone, and Stephen V. Faraone Magnetic Resonance Spectroscopy in Schizophrenia: Methodological Issues and Findings—Part I Jeff A. Stanley, Jay W. Pettegrew, and Matcheri S. Keshavan Magnetic Resonance Spectroscopy in Schizophrenia: Methodological Issues and Findings—Part II Matcheri S. Keshavan, Jeff A. Stanley, and Jay W. Pettegrew ORIGINAL ARTICLES 381 Decreased Muscarinic Receptor Binding in Subjects with Schizophrenia: A Study of the Human Hippocampal Formation Jeremy M. Crook, Eva Tomaskovic-Crook, David L. Copolov, and Brian Dean 389 Normal Cellular Levels of Synaptophysin mRNA Expression in the Prefrontal Cortex of Subjects with Schizophrenia Leisa A. Glantz, Mark C. Austin, and David A. Lewis 398 A Geometric Morphometric Assessment of Change in Midline Brain Structural Shape following a First Episode of Schizophrenia Waleed S. Gharaibeh, F. James Rohlf, Dennis E. Slice, and Lynn E. DeLisi 406 Effects of Contextual Processing on Visual Conditional Associative Learning in Schizophrenia James M. Gold, Joel A. Bish, Virginia N. lannone, Mary P. Hobart, Caleb A. Queern, and Robert W. Buchanan 415 Object Retrieval/Detour Deficits in Monkeys Produced by Prior Subchronic Phencyclidine Administration: Evidence for Cognitive Impulsivity J. David Jentsch, Robert H. Roth, and Jane R. Taylor ABSTRACTS ON THE INTERNET Volume 48, Number 6, September 15, 2000 EDITORIALS 427 Bipolar Disorder: Can Studies of Natural History Help Us Define Clinically and Neurobiologically Relevant Subtypes? Dennis S. Charney 428 Models of Bipolar Disease and Their Clinical Implications David J. Kupfer 430 Treatment Advances in Bipolar Disorder—Making Up for Lost Time Paul E. Keck, Jr. 433. On Clinical Trials in Psychiatry Joel B. Greenhouse COMMENTARIES 436 Goals for Research on Bipolar Disorder: The View from NIMH Steven E. Hyman 442 A Consumer Perspective Concerning the Diagnosis and Treatment of Bipolar Disorder Lydia Lewis NATURAL HISTORY 445 Historical Perspectives and Natural History of Bipolar Disorder Jules Angst and Robert Sellaro 458 Pediatric Mania: A Developmental Subtype of Bipolar Disorder? Joseph Biederman, Eric Mick, Stephen V. Faraone, Thomas Spencer, Timothy E. Wilens, and Janet Wozniak 467 The McLean-Harvard First-Episode Project: 6-Month Symptomatic and Functional Outcome in Affective and Nonaffective Psychosis Mauricio Tohen, Stephen M. Strakowski, Carlos Zarate, Jr., John Hennen, Andrew L. Stoll, Trisha Suppes, Gianni L. Faedda, Bruce M. Cohen, Priscilla Gebre-Medhin, and Ross J. Baldessarini The Impact of Substance Abuse on the Course of Bipolar Disorder Stephen M. Strakowski, Melissa P. DelBello, David E. Fleck, and Stephan Arndt MODELS OF DISEASE 486 Neuropathology of Bipolar Disorder Marquis P. Vawter, William J. Freed, and Joel E. Kleinman 505 Neuroimaging in Bipolar Disorder: What Have We Learned? Andrew L. Stoll, Perry F. Renshaw, Deborah A. Yurgelun-Todd, and Bruce M. Cohen 518 Signaling: Cellular Insights into the Pathophysiology of Bipolar Disorder Husseini K. Manji and Robert H. Lenox 531 Are Schizophrenic and Bipolar Disorders Related? A Review of Family and Molecular Studies Wade H. Berrettini THERAPEUTIC APPROACHES 539 Pharmacologic Agents for the Treatment of Acute Bipolar Mania Susan L. McElroy and Paul E. Keck, Jr. 558 Bipolar Depression: Pharmacotherapy and Related Therapeutic Strategies Michael E. Thase and Gary S. Sachs 573 Bipolar Disorder Therapeutics: Maintenance Treatment Gary S. Sachs and Michael E. Thase 582 Family-Focused Treatment of Bipolar Disorder: 1-Year Effects of a Psychoeducational Program in Conjunction with Pharmacotherapy David J. Miklowitz, Teresa L. Simoneau, Elizabeth L. George, Jeffrey A. Richards, Aparna Kalbag, Natalie Sachs-Ericsson, and Richard Suddath 593 Interpersonal and Social Rhythm Therapy: Managing the Chaos of Bipolar Disorder Ellen Frank, Holly A. Swartz, and David J. Kupfer RESEARCH DESIGN 605 Flexible Treatment Strategies in Chronic Disease: Clinical and Research Implications Philip W. Lavori, Ree Dawson, and A. John Rush 615 Methodological Issues in Developing New Acute Treatments for Patients with Bipolar Illness A. John Rush, Robert M. Post, Willem A. Nolen, Paul E. Keck, Jr., Trisha Suppes, Lori Altshuler, and Susan L. McElroy 625 ABSTRACTS ON THE INTERNET Volume 48, Number 7, October 1, 2000 PRIORITY COMMUNICATIONS 627 Modulation of Amphetamine-Induced Striatal Dopamine Release by Ketamine in Humans: Implications for Schizophrenia Lawrence S. Kegeles, Anissa Abi-Dargham, Yolanda Zea-Ponce, Janine Rodenhiser-Hill, J. John Mann, Ronald L. Van Heertum, Thomas B. Cooper, Arvid Carlsson, and Marc Laruelle 641 Cortical Bcl-2 Protein Expression and Apoptotic Regulation in Schizophrenia L. Fredrik Jarskog, John H. Gilmore, Elzbieta S. Selinger, and Jeffrey A. Lieberman ORIGINAL ARTICLES Abnormalities in the Thalamus and Prefrontal Cortex during Episodic Object Recognition in Schizophrenia Stephan Heckers, Tim Curran, Donald Goff, Scott L. Rauch, Alan J. Fischman, Nathaniel M. Alpert, and Daniel L. Schacter Chronic Valproate Treatment Increases Expression of Endoplasmic Reticulum Stress Proteins in the Rat Cerebral Cortex and Hippocampus Biao Chen, Jun Feng Wang, and L. Trevor Young Associated Disturbances in Calcium Homeostasis and G Protein—Mediated cAMP Signaling in Bipolar I Disorder Masoumeh Emamghoreishi, Peter P. Li, Lyanne Schlichter, Sagar V. Parikh, Robert Cooke, and Jerry J. Warsh Neuropsychologic Impairments in Bipolar and Unipolar Mood Disorders on the CANTAB Neurocognitive Battery John A. Sweeney, Julie A. Kmiec, and David J. Kupfer Proton Magnetic Resonance Spectroscopy of Human Basal Ganglia: Response to Cocaine Administration James D. Christensen, Marc J. Kaufman, Blaise deB. Frederick, Stephanie L. Rose, Constance M. Moore, Scott E. Lukas, Jack H. Mendelson, Bruce M. Cohen, and Perry F. Renshaw Basal Plasma Dehydroepiandrosterone Sulfate Level: A Possible Predictor for Response to Electroconvulsive Therapy in Depressed Psychotic Inpatients Rachel Maayan, Yana Yagorowski, Daniel Grupper, Mordechai Weiss, Biana Shtaif, Mahmoud Abou Kaoud, and Abraham Weizman BRIEF REPORTS Lateralized P3 Deficit in Schizotypal Personality Disorder Margaret A. Niznikiewicz, Martina M. Voglmaier, Martha E. Shenton, Chandlee C. Dickey, Larry J. Seidman, EngKeat Teh, Richard Van Rhoads, and Robert W. McCarley No Evidence for a Parent-of-Origin Effect Detected in the Pattern of Inheritance of Schizophrenia Lynn E. DeLisi, Kamran Razi, John Stewart, Margaret Relja, Gail Shields, Angela B. Smith, Nigel Wellman, Veronica W. Larach, Josephine Loftus, Antonio Vita, Margherita Comazzi, and Timothy J. Crow ABSTRACTS ON THE INTERNET Volume 48, Number 8, October 15, 2000 EDITORIAL Structural Plasticity: Cause, Result, or Correlate of Depression Fred H. Gage MOLECULAR AND CELLULAR HYPOTHESES OF ANTIDEPRESSANT ACTION Regulation of Hippocampal Neurogenesis in Adulthood Elizabeth Gould, Patima Tanapat, Tracy Rydel, and Nicholas Hastings Effects of Adverse Experiences for Brain Structure and Function Bruce S. McEwen Neuronal Plasticity and Survival in Mood Disorders Ronald S. Duman, Jessica Malberg, Shin Nakagawa, and Carrol D’Sa Clinical and Preclinical Evidence for the Neurotrophic Effects of Mood Stabilizers: Implications for the Pathophysiology and Treatment of Manic—Depressive Illness Husseini K. Manji, Gregory J. Moore, and Guang Chen The Possibility of Neurotoxicity in the Hippocampus in Major Depression: A Primer on Neuron Death Robert M. Sapolsky DYSFUNCTION IN NEURAL CIRCUITS INVOLVED IN THE PATHOPHYSIOLOGY OF MOOD DISORDERS 766 Postmortem Studies in Mood Disorders Indicate Altered Numbers of Neurons and Glial Cells Grazyna Rajkowska 778 Effects of Early Adverse Experiences on Brain Structure and Function: Clinical Implications Joan Kaufman, Paul M. Plotsky, Charles B. Nemeroff, and Dennis S. Charney 791 3D MRI Studies of Neuroanatomic Changes in Unipolar Major Depression: The Role of Stress and Medical Comorbidity Yvette I. Sheline 801 Imaging Serotonergic Neurotransmission in Depression: Hippocampal Pathophysiology May Mirror Global Brain Alterations Masahiro Fujita, Dennis S. Charney, and Robert B. Innis 813 Neuroimaging Studies of Mood Disorders Wayne C. Drevets 830 Regional Metabolic Effects of Fluoxetine in Major Depression: Serial Changes and Relationship to Clinical Response Helen S. Mayberg, Steven K. Brannan, Janet L. Tekell, J. Arturo Silva, Roderick K. Mahurin, Scott McGinnis, and Paul A. Jerabek 844 Pindolol Augmentation of Antidepressant Treatment: Recent Contributions from Brain Imaging Studies Diana Martinez, Allegra Broft, and Marc Laruelle ORIGINAL ARTICLES 854 Effects of Estradiol and Progesterone Administration on Human Serotonin 2A Receptor Binding: A PET Study Eydie L. Moses, Wayne C. Drevets, Gwenn Smith, Chester A. Mathis, Brinda N. Kalro, Meryl A. Butters, Mark P. Leondires, Phil J. Greer, Brian Lopresti, Tammy L. Loucks, and Sarah L. Berga 861 Glial Fibrillary Acidic Protein Immunoreactivity in the Prefrontal Cortex Distinguishes Younger from Older Adults in Major Depressive Disorder José Javier Miguel-Hidalgo, Christie Baucom, Ginny Dilley, James C. Overholser, Herbert Y. Meltzer, Craig A. Stockmeier, and Grazyna Rajkowska 874 ABSTRACTS ON THE INTERNET Volume 48, Number 9, November 1, 2000 EDITORIALS 875 Antidepressant Selection in the Postgenomic Era Larry J. Siever Comorbidity of PTSD and Depression: Linked or Separate Incidence Yuval Neria and Evelyn J. Bromet REVIEW 881 The Effects of Steroid Hormones in HIV-Related Neurotoxicity: A Mini Review Sheila M. Brooke and Robert M. Sapolsky ORIGINAL ARTICLES 894 Placebo-Controlled Comparison of the Selective Serotonin Reuptake Inhibitors Citalopram and Sertraline Stephen M. Stahl 902 A Second Look at Comorbidity in Victims of Trauma: The Posttraumatic Stress Disorder—Major Depression Connection Naomi Breslau, Glenn C. Davis, Edward L. Peterson, and Lonni R. Schultz 910 Imidazoline Receptor Proteins Are Decreased in the Hippocampus of Individuals with Major Depression John E. Piletz, He Zhu, Gregory Ordway, Craig Stockmeier, Ginny Dilly, Donald Reis, and Angelos Halaris 920 Cortisol Circadian Rhythms during the Menstrual Cycle and with Sleep Deprivation in Premenstrual Dysphoric Disorder and Normal Control Subjects Barbara L. Parry, Suryabanu Javeed, Gail A. Laughlin, Richard Hauger, and Paul Clopton 932 Imidazoline and a,,-Adrenoceptor Binding Sites in Postmenopausal Women before and after Estrogen Replacement Therapy John E. Piletz and Uriel Halbreich 940 Initial Posttraumatic Urinary Cortisol Levels Predict Subsequent PTSD Symptoms in Motor Vehicle Accident Victims Douglas L. Delahanty, A. Jay Raimonde, and Eileen Spoonster 948 Casino Gambling Increases Heart Rate and Salivary Cortisol in Regular Gamblers Gerhard Meyer, Berthold P. Hauffa, Manfred Schedlowski, Cornelius Pawlak, Michael A. Stadler, and Michael S. Exton CORRESPONDENCE 954 Paroxetine Binding to the Rat Norepinephrine Transporter In Vivo Robert T. Rubin ABSTRACTS ON THE INTERNET Volume 48, Number 10, November 15, 2000 EDITORIAL 959 Repetitive Transcranial Magnetic Stimulation: What Are the Next Steps? Harold A. Sackeim PRIORITY COMMUNICATIONS 962 A Controlled Trial of Daily Left Prefrontal Cortex TMS for Treating Depression Mark S. George, Ziad Nahas, Monica Molloy, Andrew M. Speer, Nicholas C. Oliver, Xing-Bao Li, George W. Arana, S. Craig Risch, and James C. Ballenger 971 Reduction of Orbital Frontal Cortex Volume in Geriatric Depression Te-Jen Lai, Martha E. Payne, Christopher E. Byrum, David C. Steffens, and K. Ranga R. Krishnan ORIGINAL ARTICLES 976 Child’s Stress Hormone Levels Correlate with Mother’s Socioeconomic Status and Depressive State Sonia J. Lupien, Suzanne King, Michael J. Meaney, and Bruce S. McEwen 981 Low Growth Hormone Response to Growth Hormone-Releasing Hormone in Child Depression Ronald E. Dahl, Boris Birmaher, Douglas E. Williamson, Lorah Dorn, James Perel, Joan Kaufman, David A. Brent, David A. Axelson, and Neal D. Ryan 989 Altered Salivary Dehydroepiandrosterone Levels in Major Depression in Adults Albert Michael, Alison Jenaway, Eugene S. Paykel, and Joe Herbert 996 Birth Outcomes following Prenatal Exposure to Fluoxetine Lee S. Cohen, Vicki L. Heller, Jennie W. Bailey, Lynn Grush, J. Stuart Ablon, and Suzanne M. Bouffard 1001 Does Obstructive Sleep Apnea Confound Sleep Architecture Findings in Subjects with Depressive Symptoms? Wayne A. Bardwell, Polly Moore, Sonia Ancoli-Israel, and Joel E. Dimsdale 1010 High Internight Reliability of Computer-Measured NREM Delta, Sigma, and Beta: Biological Implications Xin Tan, Ian Glenn Campbell, Laura Palagini, and Irwin Feinberg BRIEF REPORTS 1020 Regional Cerebral Metabolism Associated with Anxiety Symptoms in Affective Disorder Patients Elizabeth A. Osuch, Terence A. Ketter, Timothy A. Kimbrell, Mark S. George, Brenda E. Benson, Mark W. Willis, Peter Herscovitch, and Robert M. Post 1024 Increase of NK-T Cells in Aged Depressed Patients Not Treated with Antidepressive Drugs Frans Flentge, Marjan D. van den Berg, Antoinette L. Bouhuys, and Hauw T. The CASE REPORTS 1028 Comorbid Bipolar Disorder in Tourette’s Syndrome Responds to the Nicotinic Receptor Antagonist Mecamylamine (Inversine) R. Douglas Shytle, Archie A. Silver, and Paul R. Sanberg 1032 Amniotic Fluid and Umbilical Cord Blood Concentrations of Antidepressants in Three Women Amy Hostetter, James C. Ritchie, and Zachary N. Stowe 1035 ABSTRACTS ON THE INTERNET Volume 48, Number 11, December |, 2000 ORIGINAL ARTICLES 1037 Parsing the Association between Bipolar, Conduct, and Substance Use Disorders: A Familial Risk Analysis Joseph Biederman, Stephen V. Faraone, Janet Wozniak, and Michael C. Monuteaux 1045 Increased Anterior Cingulate and Caudate Activity in Bipolar Mania Hilary P. Blumberg, Emily Stern, Diana Martinez, Sally Ricketts, Jose de Asis, Thomas White, Jane Epstein, P. Anne McBride, David Eidelberg, James H. Kocsis, and David A. Silbersweig