Table Of Content

Biological Psychiatry A Journal of Psychiatric Research Volume 30, Number 1, July 1, 1991 Contents EDITORIAL Sleep and Sexual Function in the Elderly Male Raymond C. Rosen ARTICLES Polysomnographic Characteristics of Healthy Elderly Subjects with Somnambulism-like Behaviors N. Tachibana, Y. Sugita, K. Terashima, Y. Teshima, T. Shimizu, and Y. Hishikawa Aging, Sleep Disorders, and Male Sexual Function Raul C. Schiavi, John Mandeli, Patricia Schreiner-Engel, and Anthony Chambers 24-Hour Cortisol Measures in Adolescents with Major Depression: A Controlled Study Ronald E. Dahl, Neal D. Ryan, Joaquim Puig-Antich, Nga A. Nguyen, Mayadah Al-Shabbout, Viveca A. Meyer, and James Perel Circadian Patterns of Cortisol, Prolactin, and Growth Hormonal Secretion During Bingeing and Vomiting in Normal Weight Bulimic Patients Theodore E. Weltzin, Claire McConaha, Monica McKee, L.K. George Hsu, James Perel, and Walter H. Kaye Lactate Vulnerability After Alprazolam Versus Placebo Treatment of Panic Disorder Deborah §. Cowley, Stephen R. Dager, Peter P. Roy-Byrne, David H. Avery, and David L. Dunner Response of Depression to Very High Plasma Levels of Imipramine Plus Desipramine Michael Garvey, Robert J. DeRubeis, Steve D. Hollon, Mark D. Evans, and V.B. Tuason Subtype Diagnosis in Schizophrenia and Its Relation to Neuropsychological and Computerized Tomography Measures Richard B. Rosse, Barbara L. Schwartz, John Mastropaolo, Richard L. Goldberg, and Stephen I. Deutsch Neuroendocrine Effects of Diazepam in Panic and Generalized Anxiety Disorders Peter P. Roy-Byrne, Deborah S. Cowley, Daniel Hommer, James Ritchie, David Greenblatt, and Charles Nemeroff Reduced Cerebrospinal Fluid Dynorphin A,_, in Alzheimer’s Disease Trey Sunderland, Wade H. Berrettini, Susan E. Molchan, Brian A. Lawlor, Rick A. Martinez, Benedetto Vitiello, Pierre N. Tariot, and Robert M. Cohen CASE REPORTS Buspirone Alone or with Serotonergic Diet Reduced Aggression in a Developmentally Disabled Adult A. Gedye The Amygdala in Down’s Syndrome and Familial Alzheimer’s Disease: Four Clinicopathological Case Reports Greer M. Murphy, Jr., and William G. Ellis Volume 30, Number 2, July 15, 1991 EDITORIAL Where There’s Smoke . . . Nicotine and Psychiatric Disorders Darrell G. Kirch ARTICLES Smoking and Movement Disorders in Psychiatric Patients Matthew A. Menza, Nancy Grossman, Margaret Van Horn, Ronald Cody, and Nancy Forman Effect of Electroconvulsive Therapy on Serum Concentration of Alpha-1-Acid Glycoprotein C. Lindsay DeVane, Carolyn Lim, Stanley W. Carson, David Tingle, Lynn Hackett, and Michael R. Ware Platelet 5-HT, Serotonin Receptor Binding Sites in Autistic Children and Their First-Degree Relatives | Bruce D Perry, Edwin H. Cook, Jr., Bennett L. Leventhal, Mark §. Wainwright, and Daniel X. Freedman Serotonin Uptake and Imipramine Binding in the Bood Platelets of Obsessive—Compulsive Disorder Patients Bijan Bastani, Ramesh C. Arora, and Herbert Y. Meltzer A Pilot Placebo-Controlled Study of Chronic m-CPP Administration in Alzheimer’s Disease Brian A. Lawlor, Trey Sunderland, Alan M. Mellow, Susan E. Molchan, Rick Martinez, and Dennis L. Murphy Plasma Phenylethylamine in Schizophrenic Patients R. O'Reilly, B.A. Davis, D.A. Durden, L. Thorpe, H. Machnee, and A.A. Boulton Dose Dependent Inhibition of REM Sleep in Normal Volunteers by Biperiden, a Muscarinic Antagonist J. Christian Gillin, Laura Sutton, Caroline Ruiz, Shahrokh Golshan, Sharon Hirsch, Christine Warmann, and P.. Shiromani The Effects of Scopolamine on Sleep and Mood in Depressed Patients with a History of Alcoholism and a Normal Comparison Group J. Christian Gillin, Laura Sutton, Caroline Ruiz, Denis Darko, Shahrokh Golshan, S. Craig Risch, and David Janowsky The Effects of NMDA Receptor Blockade on the Acquisition of a Conditioned Emotional Response Rudof Hoehn-Saric, Daniel R. McLeod, and John R. Glowa Endogenous Event-Related Brain Potentials and Psychometric Performance in Children at Risk for Schizophrenia H. Schreiber, G. Stolz—Born, J. Rothmeier, A. Kornhuber, H.H. Kornhuber, and J. Born COMMENT Fluoxetine-Induced Suicidality, Serotonin, and Seasonality Timothy D. Brewerton CASE REPORT Clinical Outcome and Psychoendocrinological Findings in a Case of Lethal Catatonia Filippo M. Ferro, Luigi Janiri, Caterina De Bonis, Renata Del Carmine, and Enrico Tempesta BRIEF REPORTS Reduced Lymphocyte Response to PHA and OKT3 in Drug-Free and Neuroleptic-Treated Chronic Schizophrenics Palmiero Monteleone, Bruno Valente, Mario Maj, and Dargut Kemali Sleep Onset REM Periods in Schizophrenic Patients Stephan F . Taylor, Rajiv Tandon, James E. Shipley, Alan S. Eiser, and JoAnn Goodson Nuclear Magnetic Resonance Spectrometry in Mood Disorder: A Preliminary Report G.F. Placidi, F. Mercadante, D. Catalano, P. Baschieri, L. Dell’Osso, and H.L. Meltzer Volume 30, Number 3, August 1, 1991 EDITORIAL Is Investment in Molecular Genetics Worthwhile? Wade H. Berrettini ARTICLES Pineal and Adrenal Function Before and After Refeeding in Anorexia Nervosa Sidney H. Kennedy, Gregory M. Brown, Gail McVey, and Paul E. Garfinkel Dopamine Blocking Activity of Clomipramine in Patients with Obsessive-Compulsive Disorder Linda §. Austin, R. Bruce Lydiard, James C. Ballenger, Bruce M. Cohen, Michele T. Laraia, Joseph J. Zealberg, Mark D. Fossey, and Everett H. Ellinwood Event-Related Potentials in Depression: Influence of Task, Stimulus Hemifield and Clinical Features on P3 Latency Gerard E. Bruder, James P. Towey, Jonathan W. Stewart, David Friedman, Craig Tenke, and Frederic M. Quitkin Higher Postdexamethsone Serum Cortisol Levels in Agoraphobic Than in Nonagoraphobic Panic Disorder Patients Peter Westberg, Kjell Modigh, Pia Lisjé, and Elias Eriksson Phototherapy in Nonseasonal Depression Arthur Mackert, Hans-Peter Volz, Rolf-Dieter Stieglitz, and Bruno Miiller-Oerlinghausen Alterations of Local Cerebral Blood Flow and Glucose Uptake by Electroconvulsive Shock in Rats Amiram I. Barkai, Isak Prohovnik, William L. Young, Margaret Durkin, and Henry D. Nelson REVIEW Biological Studies of Dysthymia Robert H. Howland and Michael E. Thase BRIEF REPORTS Neurocognition in Acute and Chronic Depression: Personality Disorder, Major Depression, and Schizophrenia J. Wesley Burgess Serotonin-Stimulated Ca** Response Is Increased in the Blood Platelets of Depressed Patients Ichiro Kusumi, Tsukasa Koyama, and Itaru Yamashita 313 Prolactin Response to the Dopamine Antagonist, Metoclopramide, in Depression lan M. Anderson and Philip J. Cowen 317 Potentiated 5-Hydroxytryptophan Response Suppression Following 5, 7-Dihydroxytryptamine Raphe Lesions in an Animal Model of Depression E. A. Engleman, J. N. Hingtgen, F. C. Zhou, J. M. Murphy, and M. H. Aprison Volume 30, Number 4, August 15, 1991 EDITORIAL Negative Symptoms of Schizophrenia: The Need for Conceptual Clarity Rajiv Tandon and John F.. Greden ARTICLES Left-Handedness in Male Schizophrenic Patients Is Associated with Increased Impairment on the Luria-Nebraska Neuropsychological Battery William O. Faustman, James A. Moses, Jr., David L. Ringo, and John W. Newcomer EEG Power Variation in Schizophrenic Subgroups: Effects of Emotionally Salient Stimuli Christopher Kessler and Arthur Kling Decreased Histamine H, Receptors in the Frontal Cortex of Brains from Patients with Chronic Schizophrenia Takashi Nakai, Noboru Kitamura, Takeshi Hashimoto, Yasuo Kajimoto, Naoki Nishino, Tatsuo Mita, and Chikako Tanaka Essential and Other Fatty Acids in Plasma in Schizophrenics and Normal Individuals from Japan H. Kaiya, D. F. Horrobin, M. S. Manku, and N. Morse Fisher Lateralized Abnormality in the EEG of Persistently Violent Psychiatric Inpatients A. Convit, P. Czobor, and J. Volavka The Effects of Exogenous Melatonin on the Total Sleep Time and Daytime Alertness of Chronic Insomniacs: A Preliminary Study James G. MacFarlane, John M. Cleghorn, Gregory M. Brown, and David L. Streiner Effect of Fluoxetine on Noradrenergic Mediated Growth Hormone Release: A Double Blind, Placebo-Controlled Study Karen O’ Flynn, Veronica O’ Keane, James V. Lucey, and Timothy G. Dinan COMMENT Limbic/Mesolimbic Connections and the Pathogenesis of Schizophrenia John G. Csernansky, Greer M. Murphy, and William O. Faustman CASE REPORTS Manic Psychosis after Coffee and Phenylpropanolamine C. Raymond Lake Nortriptyline in Chronic Fatigue Syndrome: A Double Blind, Placebo-Controlled Single Case Study Barbara Gracious and Katherine L. Wisner BRIEF REPORTS Enzymes of the Antioxidant Defense System in Chronic Schizophrenic Patients Ravinder Reddy, Mahadik P. Sahebarao, Sukdeb Mukherjee, and Jayasimha N. Murthy Panic Attacks in Healthy Volunteers Treated with a Catecholamine Synthesis Inhibitor Una D. McCann, David M. Penetar, and Gregory Belenky A Double Blind, Placebo-Controlled Trial of Demeclocycline Treatment of Polydipsia-Hyponatremia in Chronically Psychotic Patients Robert C. Alexander, Barbara Illowsky Karp, Seth Thompson, Vikram Khot, and Darrell G. Kirch Serum Prolactin Levels in Manic Patients Alice Kuruvilla, Geetha Srikrishna, Jacob Peedicayil, K. Kuruvilla, and A. S. Kanagasabapathy Impaired Neuropsychological Functioning in Symptomatic Volunteers with Schizotypy: Preliminary Findings Michael J. Lyons, Mary E. Merla, Leslie Young, and William S. Kremen Volume 30, Number 5, September 1, 1991 EDITORIAL Putting the “Public” Back in Mental Health, the “Mental” Back in Public Health Julius B. Richmond and Leon Eisenberg ARTICLES Midlatency Auditory Evoked Responses in Schizophrenia Roland J. Erwin, Maureen Mawhinney-Hee, Ruben C. Gur, and Raquel E. Gur The Agonist-Stimulated Accumulation of Inositol Phosphates Is Attenuated in Neutrophils from Male Patients under Chronic Lithium Therapy Waldemar Greil, Raimund Steber, and Dietrich van Calker Ventricular Enlargement and Caudate Hyperdensity in Elderly Depressives Barbara Beats, Raymond Levy, and Hans Forstl Behavioral and Biochemical Effects of Methylphenidate in Schizophrenic and Nonschizophrenic Patients Rajiv P. Sharma, Javaid I. Javaid, Ghanshyam N. Pandey, Philip G. Janicak, and John M. Davis Platelet “H-Imipramine Binding Sites in Obsessive-Compulsive Behavior Suck Won Kim, Maurice W. Dysken, Ghanshyam N. Pandey, and John M. Davis Plasma Free Homovanillic Acid (HVA) as a Predictor of Clinical Response in Acute Psychosis Carolyn M. Mazure, J. Craig Nelson, Peter I. Jatlow, and Malcolm B. Bowers Patterns of Manual Dominance in Patients with Neuroleptic-Induced Movement Disorders Robert S. Kern, Michael F. Green, Paul Satz, and William C. Wirshing Enhanced Retrieval of Unpleasant Memory in Helpless Rats K. Balachandra Kumar and K. Sudhakar Karanth BRIEF REPORTS Hypothalamic—Pituitary—Adrenocortical Activity in Panic Disorder: Relationship to Plasma Catecholamine Metabolites George N. M. Gurguis, Ivan N. Mefford, and Thomas W. Uhde Blood Glucose and Insulin Response in Patients with Senile Dementia of the Alzheimer’s Type Carol H. Winograd, Daniel H. Jacobson, Jerome R. Minkoff, Cecilia A. Peabody, Brian §. Taylor, Leslie Widrow, and Jerome A. Yesavage CSF Opioids in Panic Disorder K. T. Brady, R. B. Lydiard, J. C. Ballenger, J. Shook, M. Laraia, and M. Fossey Lithium Lengthens Circadian Period but Fails to Counteract Behavioral Helplessness in Rats Karen T. Stewart, Donald L. McEachron, Alan M. Rosenwasser, and Norman T. Adler DSM-III-R State Anxiety Symptoms in Anxiety Disorder Patients Malcolm Bruce and Malcolm Lader Treatment of Chronic Schizophrenia with Cyproheptadine: A Double-Blind Placebo- Controlled Study Henry Silver, Michael Blacker, Malcolm P.1. Weller, and Bernard Lerer CORRESPONDENCE Pericallosal Arterial Ectasia and Manic-Depressive Illness; Lorazepam, Amitriptyline, and Sulpiride: Withdrawal Effects; Alfred Hoche and the Elimination of the Unfit; Response; Opiate Receptor Antagonists for Delusions of Parasitosis; Propanolol for Fluoxetine-Induced Akathisia Volume 30, Number 6, September 15, 1991 EDITORIAL What We Don’t Know About Psychotic Depression Steven L. Dubovsky ARTICLES A Model of Smooth Pursuit Performance Illustrates the Relationship between Gain, Catch-up Saccade Rate, and Catch-up Saccade Amplitude in Normal Controls and Patients with Schizophrenia Lee Friedman, John A. Jesberger, and Herbert Y. Meltzer Failure of Haloperidol to Block the Effects of Phencyclidine and Dizocilpine on Prepulse Inhibition of Startle Valli A. Keith, Robert S. Mansbach, and Mark A. Geyer The TRH Stimulation Test in Alzheimer’s Disease and Major Depression: Relationship to Clinical and CSF Measures Susan E. Molchan, Brian A. Lawlor, James L. Hill, Alan M. Mellow, Candace L. Davis, Rick Martinez, and Trey Sunderland Decreased Serum Dipeptidyl Peptidase IV Activity in Major Depression M. Maes, I. De Meester, G. Vanhoof, S. Scharpé, E. Bosmans, C. Vandervorst, R. Verkerk, B. Minner, E. Suy, and J. Raus Tardive Dyskinesia: Neuropsychological, Computerized Tomographic, and Psychiatric Symptom Findings James M. Gold, Michael F. Egan, Darrell G. Kirch, Terry E. Goldberg, David G. Daniel, Llewellyn B. Bigelow, and Richard Jed Wyatt Longitudinal Effect of Amitriptyline and Fluoxetine Treatment on Plasma Phenylacetic Acid Concentrations in Depression Bruce A. Davis, Alan A. Boulton, Peter H. Yu, David A. Durden, David L. Keegan, Rudradeo C. Bowen, Stella Blackshaw, Carl D’Arcy, A. J. Remillard, N. Dayal, Satish Shrikhande, S. Saleh, Gabriel H. Stegeman, and I. Alick Paterson Increased Serotonin Platelet Uptake after Tianeptine Administration in Depressed Patients Geneviéve Chamba, Patrick Lemoine, Elisabeth Flachaire, Nicole Ferry, Claude Quincy, Jean Sassard, Chantal Ferber, Elisabeth Mocaér, Annie Kamoun, and Bernard Renaud Elevated Awakening Thresholds in Sleep Stage 3-4 in War-Related Posttraumatic Stress Disorder Y. Dagan, P. Lavie, and A. Bleich BRIEF REPORTS Antidepressant and Memory Effects of Combined Thyroid Hormone Treament and Electroconvulsive Therapy: Preliminary Findings Robert A. Stern, Charles T. Nevels, Mark E. Shelhorse, Mark L. Prohaska, George A. Mason, and Arthur J. Prange, Jr. Hypertonic Saline Infusion Induces Panic in Patients with Panic Disorder Carl F.. Jensen, Elaine R. Peskind, Richard C. Veith, James Hughes, Deborah §. Cowley, Peter Roy-Byrne, and Murray A. Raskind Abnormal Sensitivity of Erythrocyte Membrane Na/K ATPase of Bipolar Subjects to Inhibition by Calmodulin and Calcium Suham Kassir and Herbert L. Meltzer CORRESPONDENCE Lithium and Calcium Channel Blockers: Possible Neurotoxicity NEWS & NOTES Volume 30, Number 7, October 1, 1991 ARTICLES EEG Sleep Profiles and Recurrent Depression David J. Kupfer, Cindy L. Ehlers, Ellen Frank, Victoria J. Grochocinski, and Ann B. McEachran '°9F Nuclear Magnetic Resonance Spectroscopy of Neuroleptics: The First In Vivo Pharmacokinetics of Trifluoperazine in the Rat Brain and the First In Vivo Spectrum of Fluphenazine in the Human Brain Mathias Bartels, Ulrich Giinther, Klaus Albert, Karl Mann, Norbert Schuff, and Herbert Stuckstedte Skin Conductance Orienting Response in Unmedicated RDC Schizophrenic, Schizoaffective, Depressed, and Control Subjects Douglas F. Levinson Serum Dehydroepiandrosterone Sulfate in Alzeheimer’s Disease and in Multi-infarct Dementia Birgitta Ndsman, Tommy Olsson, Torbjérn Backstrém, Sture Eriksson, Kjell Grankvist, Matti Viitanen, and Gésta Bucht Sleep EEG and Amitryptiline Treatment in Depressed Inpatients J. Mendlewicz, C. Kempenaers, and V. de Maetelaer Perceptual Asymmetry, Plasma Cortisol, and Response to Treatment in Depressed Outpatients Michael W. Otto, Maurizio Fava, Jerrold F. Rosenbaum, and Christopher F. Murphy Average Total Energy Expenditure in Anorexia Nervosa, Bulimia Nervosa, and Healthy Young Women Karl M. Pirke, Peter Trimborn, Petra Platte, and Manfred Fichter Subtle Signs of Prenatal Maldevelopment of the Hand Ectoderm in Schizophrenia: A Preliminary Monozygotic Twin Study H. Stefan Bracha, E. Fuller Torrey, Llewellyn B. Bigelow, James B. Lohr, and Beverly B. Linington BRIEF REPORTS P300 in Methamphetamine Psychosis Akira Iwanami, Nobukatsu Kato, and Yoji Nakatani Elevated IGG and IGM Anticardiolipin Antibodies in a Subgroup of Medicated and Unmedicated Schizophrenia Patients K. N. Roy Chengappa, A. Betts Carpenter, M. S. Keshavan, Zan W. Yang, R. H. Kelly, B.S. Rabin, and Rohan Ganguli Memory Disturbances and Dexamethasone Suppression Test in Major Depression Jacques Wauthy, Marc Ansseau, Rémy von Frenckell, Christian Mormont, and Jean-Jacques Legros Propranolol and Response Bias: An Extension of Findings Reported by Corwin Et Al Enoch Callaway, Roy Halliday, E. J. Perez-Stable, T. J. Coates, and W. W. Hauck NEWS & NOTES Volume 30, Number 8, October 15, 1991 EDITORIAL Chronic Fatigue Syndrome: The Need for an Integrative Approach Mark A. Demitrack and John F. Greden ARTICLES Magnetic Resonance Imaging in Schizophrenia: Altered Brain Morphology Associated with P300 Abnormalities and Eye Tracking Dysfunction Douglas H. R. Blackwood, Allan H. Young, Judith K. McQueen, Mike J. Martin, Hilary M. Roxborough, Walter J. Muir, David M. St. Clair, and David M. Kean The MCPP Challenge Test in Schizophrenia: Hormonal and Behavioral Responses Naveed Iqbal, Gregory M. Asnis, Scott Wetzler, Rene S. Kahn, Stanley R. Kay, and Herman M. van Praag Maladaptive Anticipatory Saccades in Schizophrenia David W. Hommer, Thomas Clem, Robert Litman, and David Pickar Fatty Acid Levels in the Brains of Schizophrenics and Normal Controls David F. Horrobin, Mehar S. Manku, Harold Hillman, A. lain, and M. Glen Neurological “Hard” Signs and Family History of Psychosis in Schizophrenia Bryan T. Woods, Dennis K. Kinney, and Deborah A. Yurgelun-Todd Effects of Partial Sleep Deprivation on the Diurnal Variation of Mood and Motor Activity in Major Depression Martin P. Szuba, Lewis R. Baxter, Jr., Lynn A. Fairbanks, Barry H. Guze, and Jeffrey M. Schwartz HLA DR2 in Narcolepsy with Sleep-Onset REM Periods but not Cataplexy Leon Rosenthal, Timothy A. Roehrs, Hajime Hayashi, Frank J. Zorick, Robert M. Wittig, Jorge Rosenthal, and Thomas Roth BRIEF REPORTS Increased Platelet Membrane Lysophosphatidylcholine in Schizophrenia Andreas M. Pangerl, Andrea Steudle, Hans W. Jaroni, Roderich Riifer, and Wagner F. Gattaz Sphingomyelinase Fibroblast Activity and Psychoactive Drugs M. Lejoyeux, J. C. Maziére, L. Mora, M. Auclair, and C. Maziére CORRESPONDENCE Neuroleptic Dysphoria in Animals; Neuroleptic Depression in Schizophrenia; Response NEWS & NOTES Volume 30, Number 9, November 1, 1991 EDITORIAL Biological Research in Geriatric Psychiatry Dilip V. Jeste and Michael P. Caligiuri REVIEW & COMMENT Positron Emission Tomography and Magnetic Resonance Imaging: A Review and a Local Circuit Neurons Hypo(dys)function Hypothesis of Schizophrenia Svetlozar A. Bachneff ARTICLES Lack of a Bimodal Distribution of Ventricular Size in Schizophrenia: A Gaussian Mixture Analysis of 1056 Cases and Controls David G. Daniel, Terry E. Goldberg, Robert D. Gibbons, and Daniel R. Weinberger Effect of Neuroleptic Treatment on Polysomnographic Measures in Schizophrenia Stephan F . Taylor, Rajiv Tandon, James E. Shipley, and Alan S. Eiser Three-Year Follow-Up of Older Schizophrenics: Extrapyramidal Syndromes, Psychiatric Symptoms, and Ventricular Brain Ratio William F . Hoffman, Linda Ballard, Erick H. Turner, and Daniel E. Casey Pretreatment EEG Predicts Short-Term Response to Haloperidol Treatment Pal Czobor and Jan Volavka The Limbic-Hypothalamic-Pituitary-Adrenal Axis in Huntington’s Disease Isabella J. E. Heuser, Thomas N. Chase, and N. Maral Mouradian BRIEF REPORT The Effect of Tetrahydroaminoacridine (THA) on P300 in Alzheimer’s Disease Willem A. van Gool, Jozef Waardenburg, F. Eelco Posthumus Meyjes, Henry C. Weinstein, and Anton de Wilde NEWS & NOTES Volume 30, Number 10, November 15, 1991 EDITORIAL Annual Meeting Theme for 1992: Developmental Neurobiology and Clinical Course John F. Greden ARTICLES Changes in Serine Metabolism by a Serum Factor Present in a Group of Episodic Psychotic Patients D. Fekkes, L. Pepplinkhuizen, and J. Bruinvels Anxiogenic Effects of m-CPP in Patients with Panic Disorder: Comparison to Caffeine’s Anxiogenic Effects Ehud Klein, Joseph Zohar, Marilla F. Geraci, Dennis L. Murphy, and Thomas W. Uhde A. E. BENNETT AWARD PAPER: Expression of the Dopamine D, Receptor Gene in Brain James H. Meador-Woodruff and Alfred Mansour Incidences of Hypercortisolism and Dexamethasone Resistance Increase with Age among Wild Baboons Robert M. Sapolsky and Jeanne Altmann Neuroendocrine Responses to Serotonergic Agents in Alcoholics Myung A. Lee and Herbert Y. Meltzer REVIEW Hypothalamic—Pituitary—Adrenal Dysfunction in Posttraumatic Stress Disorder Rachel Yehuda, Earl L. Giller, Steven M. Southwick, Martin T. Lowy, and John W. Mason CASE REPORT Childhood Obsessive—Compulsive Disorder and Cingulate Epilepsy Bonnie Levin and Michael Duchowny BRIEF REPORTS Platelet *H-Imipramine and *H-Paroxetine Binding during Treatment with Psychoactive Drugs Erling T. Mellerup, Henrik Dam, Lise Lauritzen, and Per Plenge Mismatch Negativity: An Index of a Preattentive Processing Deficit in Schizophrenia A. M. Shelley, P. B. Ward, S. V. Catts, P. T. Michie, S. Andrews, and N. McConaghy CORRESPONDENCE Haloperidol and Soluble Interleukin-2 Receptors; Serum Iron and Akathesia; Response NEWS AND NOTES Volume 30, Number 11, December 1, 1991 EDITORIAL Is There a Specific Membrane Defect in Bipolar Disorders? Herbert L. Meltzer ARTICLES Memory Effects of Clomipramine Treatment: Relationship to CSF Monoamine Metabolites and Drug Concentrations in Plasma Aniko Bartfai, Marie Asberg, Bjérn Martensson, and Petter Gustavsson