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Biol. Chem., Vol. 386, pp. 1329-1335, December 2005 - Copyright © by Walter de Gruyter - Berlin - New York. DOI 10.1515/BC.2005.153 Contents Biological Chemistry, Volume 386, 2005 Guest Editorials Giehl, K. Oncogenic Ras in tumour progression and Signaling in Biochemical Pharmacology and metastasis Toxicology Hedderich, R., N. Hamann and M. Bennati Highlight: Molecular Machines Heterodisulfide reductase from methanogenic archaea: a new Catalytic role for an iron-sulfur Highlight: Radicals in Enzymatic Catalysis cluster Highlight: RNA Biochemistry Kurakin, A Self-organization versus Watchmaker: stochastic dynamics of cellular organization Paper of the Year 2004 Layer, G., E. Kervio, G. Morlock, D.W. Heinz, D. Jahn, J. Retey and W.-D. Schubert Reviews Structural and functional comparison of HemN to other radical SAM enzymes Agmon, |., A. Bashan, R. Zarivach and A. Yonath Symmetry at the active site of the ribosome: Schmidt, M., J. Hanna, S. Elsasser and D. Finley structural and functional implications Proteasome-associated proteins: regulation of a proteolytic machine Barthel A. and L.-O. Klotz Phosphoinositide 3-kinase signaling in the cellular Selmer, T., A.J. Pierik and J. Heider response to oxidative stress New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria Bennati, M., F. Lendzian, M. Schmittel and H. Zipse Spectroscopic and theoretical approaches for Vogel, A., O. Schilling, B. Spath and A. Marchfelder studying radical reactions in class | ribonucle The tRNase Z family of proteins: physiological tide reductase functions, substrate specificity and structural properties Boll, M. and G. Fuchs Unusual reactions involved in anaerobic metabolism Vogel, J. and C.M. Sharma of phenolic compounds How to find small noncoding RNAs in bacteria . Boll, M., B. Schink, A. Messerschmidt and Will, C.L. and R. Lahrmann P.M.H. Kroneck Splicing of a rare class of introns by the Novel bacterial molybdenum and tungsten enzymes: U12-dependent spliceosome three-dimensional structure, spectroscopy, and reaction mechanism Wilson, D.N., J.M. Harms, K.H. Nierhaus, F. Schiiinzen and P. Fucini Buckel, W., B.M. Martins, A.M esserschmidt and Species-specific antibiotic-ribosome interactions: B.T. Golding implications for drug development Radical-mediated dehydration reactions in anaerobic bacteria Minireviews Chaudhuri, P., K. Wieghardt, T. Weyhermiiller, T.K. Paine, S. Mukherjee and C. Mukherjee Eberharter, A., R. Ferreira and P. Becker Biomimetic metal-radical reactivity: aerial oxidation Dynamic chromatin: concerted nucleosome of alcohols, amines, aminophenols and catechols remodelling and acetylation catalyzed by transition metal complexes Friedrich, P. and Z. Bozdéky Chen, P.Y. and G. Meister Digestive veisus regulatory proteases: on calpain microRNA-guided posttranscriptional gene action in vivo regulation Hui, J. and A. Bindereif Gailili, G., R. Amir, R. Hoefgen and H. Hesse Alternative pre-mRNA splicing in the human system: Improving the levels of essential amino acids and unexpected role of repetitive sequences as sulfur metabolites in plants regulatory elements 1330 Contents Volume 386, 2005 Weibezahn, J., C. Schlieker, P. Tessarz, A. Mogk Merino, V.F., J.A. Silva Jr., R.C. Aratjo, M.C.W. Avelilar, and B. Bukau J.-L. Bascands, J.P. Schanstra, A.C.M. Paiva, Novel insights into the mechanism of chaperone- M. Bader and J.B. Pesquero assisted protein disaggregation Molecular structure and transcriptional regulation by nuclear factor-«B of the mouse kinin B; receptor Willkomm, D.K. and R.K. Hartmann 6S RNA - an ancient regulator of bacterial RNA polymerase rediscovered Neth, P., M. Arnhold, V. Sidarovich, K.D. Bhoola and E. Fink Expression of the plasma prekallikrein gene: Research Articles/Short Communications utilization of multiple transcription start sites and alternative promoter regions Genes and Nucleic Acids Smith, A.E.F., F. Farzaneh and K.G. Ford Aceto, S., A. Di Maro, B. Conforto, G.G. Siniscaico, Single zinc-finger extension: enhancing A. Parente, P. Delli Bovi and L. Gaudio transcriptional activity and specificity of three-zinc- Nicking activity on pBR322 DNA of ribosome finger proteins inactivating proteins from Phytolacca dioica L. leaves . Sok, A.J., K. Czajewska, A. Ozyhar and M. Kochman The Structure of the juvenile hormone binding Al Sarraj, J., C. Vinson and G. Thiel protein gene from Galleria mellonelia Regulation of asparagine synthetase gene transcription by the basic region leucine zipper Van Kuilenburg, A.B.P., R. Meinsma, E. Beke, transcription factors ATF5 and CHOP B. Bobba, P. Boffi, G.M. Enns, D.R. Witt and D. Dobritzsch Burk, O., K.A. Arnold, A. Geick, H. Tegude and M. Identification of three novel mutations in the Eichelbaum dihydropyrimidine dehydrogenase gene A role for constitutive androstane receptor in the associated with altered pre-mRNA splicing or regulation of human intestinal MDAR1 expression . . .503 protein function Cramer, M., |. Nagy, B.J. Murphy, M. Gassmann, Waldminghaus, T., A. Fippinger, J. Alfsmann M.O. Hottiger, O. Georgiev and W. Schaffner and F. Narberhaus NF-«B contributes to transcription of placenta RNA thermometers are common in a- and rowth factor and interacts with metal responsive y-proteobacteria transcription factor-1 in hypoxic human cells Werk, D., S. Schubert, V. Lindig, H.-P. Grunert, Cruciani, V and S.-O. Mikalsen H. Zeichhardt, V.A. Erdmann and J. Kurreck The connexin gene family in mammals Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of Di Valentin, E., S. Bontems, L. Habran, O. Jolois, coxsackievirus B3 and its cognate coxsackievirus- N. Markine-Goriaynoff, A. Vanderplasschen, adenovirus receptor C. Sadzot-Delvaux and J. Piette Varicella-zoster virus E63 protein represses the basal transcription machinery by disorganizing Protein Structure and Function the pre-initiation complex ... Abdel-Wahab, Y.H.A., L. Marenah, D.F. Orr, Gowrishankar, G., R. Winzen, F. Bollig, B. C. Shaw and P.R. Flatt Ghebremedhin, N. Redich, B. Ritter, K. Resch, Isolation and structural characterisation of a M. Kracht and H. Holtmann novel 13-amino acid insulin-releasing peptide from Inhibition of mRNA deadenylation and degradation the skin secretion of Agalychnis calcarifer by ultraviolet light Akoachere, M., R. lozef, S. Rahifs, M. Deponte, B. Hillebrand, A., R. Wurm, A. Menzel and R. Wagner Mannervik, D.J. Creighton, H. Schirmer and The seven E. coli ribosomal RNA operon upstream K. Becker regulatory regions differ in structure and transcription Characterization of the glyoxalases of the malarial factor binding efficiencies parasite Plasmodium falciparum and comparison with their human counterparts Hofer, T., C. Badouard, E. Bajak, J.-L. Ravanat, A. Mattsson and |.A. Cotgreave Araujo, A.P.U., D. Hansen, D.F. Vieira, C. de Oliveira, Hydrogen peroxide causes greater oxidation in L.A. Santana, L.M. Beltramini, C.A.M. Sampaio, cellular RNA than in DNA M.U. Sampaio and M.L.V. Oliva Kunitz-type Bauhinia bauhinioides inhibitors llyushik, E., D.W. Pryce, D. Walerych, T. Riddell, devoid of disulfide bridges: isolation of the cDNAs, J.A. Wakeman, C.J. Mcinerny and R.J. McFarlane heterologous expression and structural studies ... .561 Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms Contents Volume 386, 2005 1331 Caffrey, C.R., L. Placha, C. Barinka, M. Hradilek, Illarionov, B., |. Haase, M. Fischer, A. Bacher and J. Dostal, M. Sajid, J.H. McKerrow, P. Majer, N. Schramek J. Konvalinka and J. Vondrasek Pre-steady-state kinetic analysis of riboflavin Homology modeling and SAR analysis of synthase using a pentacyclic reaction intermediate Schistosoma japonicum cathepsin D (SjCD) with as substrate statin inhibitors identify a unique active site steric barrier with potential for the design of specific Jung, C., V. Schiinemann, F. Lendzian, A.X. Trautwein, inhibitors J. Contzen, M. Galander, L.H. Béttger, M. Richter and A.-L. Barra Catharino, S., J. Buchner and S. Walter Spectroscopic characterization of the iron-oxo Characterization of oligomeric species in the intermediate in cytochrome P450 fibrillization pathway of the yeast prion Ure2p Krause-Buchholz, U., K. Schébel, S. Lauffer and Chu, K.T. and T.B. Ng G. Rédel Purification and characterization of a chitinase-like Saccharomyces cerevisiae translational activator antifungal protein from black turtle bean with Cbs1p is associated with translationally active stimulatory effect on nitric oxide production by mitochondrial ribosomes macrophages Lamkemeyer, T., R.J. Paul, W. Stécker, |. Yiallouros Deponte, M., K. Becker and S. Rahlifs and B. Zeis Plasmodium falciparum glutaredoxin-like proteins ... . Macromolecular isoforms of Daphnia magna haemoglobin Dihazi, H., R. Kessler, G.A. Miller and K. Eschrich Lysine 3 acetylation regulates the phosphorylation Leal, S.S. and C.M. Gomes of yeast 6-phosphofructo-2-kinase under hypo- Linear three-iron centres are unlikely cluster osmotic stress degradation intermediates during unfolding of iron-sulfur proteins Eberth, A., R. Dvorsky, C.F.W. Becker, A. Beste, R.S. Goody and M.R. Ahmadian Leffers, K.-W., H. Wille, J. Stohr, E. Junger, Monitoring the real-time kinetics of the hydrolysis S.B. Prusiner and D. Riesner reaction of guanine nucleotide-binding proteins .. . .1105 Assembly of natural and recombinant prion protein into fibrils Farkasovsky, M., P. Herter, B. Vo and A. Wittinghofer Nucleotide binding and filament assembly of Leukert, N., C. Sorg and J. Roth recombinant yeast septin complexes Molecular basis of the complex formation between the two calcium-binding proteins S100A8 (MRP8) Fenoll, L.G., F. Garcia-Molina, M.A. Gilabert, and S100A9 (MRP 14) R. Var6on, P.A. Garcia-Ruiz, J. Tudela, F. Garcia- Canovas and J.N. Rodriguez-L6pez Liu, X. and H. Bisswanger Interpretation of the reactivity of peroxidase Interaction of thiamin diphosphate with compound II with phenols and anilines using the phosphorylated and dephosphorylated mammalian EE hiig4s 5 ork eave Sawers t res 351 pyruvate dehydrogenase complex Fischer, M., |. Haase, R. Feicht, N. Schramek, Longu, S., A. Padiglia, J.Z. Pedersen, A. Finazzi P. Kohler, P. Schieberle and A. Bacher Agro, A. Mura, P. Maccioni, G. Floris and R. Medda Evolution of vitamin B, biosynthesis: riboflavin Nitric oxide covalently labels a 6-hydroxydopa-derived synthase of Arabidopsis thaliana and its inhibition free radical intermediate in the catalytic cycle of by riboflavin copper/quinone-containing amine oxidase from lentil seedlings Ganea, E. and J.J. Harding Trehalose and 6-aminohexanoic acid stabilize and Ma, Q.-H. and B. Tian renature glucose-6-phosphate dehydrogenase Biochemical characterization of a cinnamoyl-CoA inactivated by glycation and by guanidinium reductase from wheat hydrochloride Miller, !.B., R.D. Walter and C. Wrenger Hahnefeld, C., D. Moll, M. Goette and F.W. Herberg Structural metal dependency of the arginase from Rearrangements in a hydrophobic core region the human malaria parasite Plasmodium mediate cAMP action in the regulatory subunit falciparum Nickel, C., M. Trujillo, S. Rahifs, M. Deponte, Happel, N., E. Schulze and D. Doenecke R. Radi and K. Becker Characterisation of human histone H1x Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite 1332 Contents Volume 386, 2005 Schlieker, C., H. Zentgraf, P. Dersch and A. Mogk Membranes, Lipids, Glycobiology ClipV, a unique Hsp100/Cip member of pathogenic proteobacteria Bakker, H., B. Kieczka, R. Gerardy-Schahn and F.H. Routier Schmidt-Schultz, T.H. and M. Schultz Identification and partial characterization of two Intact growth factors are conserved in the eukaryotic UDP-galactopyranose mutases extracellular matrix of ancient human bone and teeth: a storehouse for the study of human evolution in Carvalho de Souza, A., A. van Remoortere, C.H health and disease Hokke, A.M. Deelder, J.F.G. Vliegenthart and J.P. Kamerling Sherman, W.A., G.E. Blouse, M.J. Perron, T. Tran, Determination of the specificity of monoclonal J.D. Shore and A. Gafni antibodies against Schistosoma mansoni CAA Enthalpy measurement using calorimetry shows glycoprotein antigen using neoglycoconjugate a significant difference in potential energy between variants the active and latent conformations of PAI-1 Dergunov, A.D., A.V. Novoselov, S. Visvikis, Than, M.E., G.P. Bourenkov, S. Henrich, K. Mann G. Siest, V.V. Yakushkin and V. Tsibulsky and W. Bode The composition, structural properties and binding The NC1 dimer of human placental basement of very low density lipoproteins and low density membrane collagen IV: does a covalent crosslink lipoproteins to the LDL receptor in normo- and hypertriglyceridemia: relation to the apolipoprotein E phenotype Valbuena, J., R. Vera, A. Puentes, M. Ocampo, J. Garcia, H. Curtidor, R. Lopez, L. Rodriguez, Desmaret, S., L. Qian, B. Vanloo, K. Meerschaert, J. Rosas, J. Cortes, M. Forero, M. Pinto and J. Van Damme, J. Grooten, J. Vandekerckhove, M.E. Patarroyo G.D. Prestwich and J. Gettemans P. falciparum pro-histoaspartic protease (proHAP) Lysophosphatidic acid affinity chromatography protein peptides bind specifically to erythrocytes and reveals pyruvate kinase as a specific LPA-binding inhibit the invasion process in vitro protein van der Kraan, M.1.A., K. Nazmi, A. Teeken, Dumpitak, C., M. Beekes, N. Weinmann, S. Metzger, J. Groenink, W. van 't Hof, E.C.1. Veerman, K.F. Winkihofer, J. Tatzelt and D. Riesner J.G.M. Bolscher and A.V. Nieuw Amerongen The polysaccharide scaffold of PrP 27-30 is a Lactoferrampin, an antimicrobial peptide of bovine common compound of natural prions and consists lactoferrin, exerts its candidacidal activity by a cluster of a-linked polyglucose of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part . .137 Molecular Medicine Vopel, S., H. Miihibach and A. Skerra Rational engineering of a fluorescein-binding Bureik, M., A. Mion, C.J. Kenyon and R. Bernhardt anticalin for improved ligand affinity Inhibition of aldosterone biosynthesis by staurosporine Welfle, K., F. Pratto, R. Misselwitz, J. Behike, J.C. Alonso and H. Welfle Groneberg, D.A., C. Peiser, P.R. Eynott, P. Welker, Role of the N-terminal region and of B-sheet residue R. Erbes, C. Witt, K.F. Chung and A. Fischer Thr29 on the activity of the @, global regulator from Transcriptional down-regulation of neurotrophin-3 the broad-host range Streptococcus pyogenes in chronic obstructive pulmonary disease plasmid pSM19035 Jenne, D.E., R.A. Kley, M. Vorgerd, J.M. Schréder, Werner, A., K.-H. R6hm and H.-J. Miller J. Weis, H. Reimann, B. Albrecht, P. Nirnberg, Mapping of B-cell epitopes in E. coli asparaginase Il, H. Thiele, C.R. Miller, G. Meng, C.C. Witi an enzyme used in leukemia treatment and S. Labeit Limb girdle muscular dystrophy in a sib pair with Yoshinaga, Y., K. Nakatome, J. Nozaki, M. Naitoh a homozygous Ser606Leu mutation in the J. Hoseki, H. Kubota, K. Nagata and A. Koizumi alternatively spliced IS2 region of calpain 3 Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita tends to aggregate due to the exposed Meyer, R.P., R.L.P. Lindberg, F. Hoffmann and hydrophobic surface U.A. Meyer Cytosolic persistence of mouse brain CYP1A1 in Zorn, H., H. Bouws, M. Takenberg, M. Nimtz, R. chronic heme deficiency Getzlaff, D.E. Breithaupt and R.G. Berger An extra-cellular carboxylesterase from the basid- iomycete Pleurotus sapidus hydrolyses xanthophyli Contents Volume 386, 2005 Cell Biology and Signaling Lienau, J., C. Kaletta, M. Teifel, K. Naujoks, K. Bhoola and J. Plend! Abdelmohsen, K., C. von Montfort, D. Stuhimann, Morphology and transfection study of human P.A. Gerber, U.K.M. Decking, H. Sies and L.-O. Klotz microvascular endothelial cell angiogenesis: an Doxorubicin induces EGF receptor-dependent in vitro three-dimensional model downregulation of gap junctional intercellular communication in rat liver epithelial cells Ludwig-Miuller, J., S.V. Tokalov, A. Franz and H.O. Gutzeit Breidert, S., R. Jacob, A. Ngezahayo, H.-A. Kolb and Quercetin metabolism in vital and apoptotic human H.Y. Naim leukaemia cells Trafficking pathways of Cx49-GFP in living mammalian cells Moodley, R., C. Snyman, B. Odhav and K.D. Bhoola Visualisation of transforming growth factor-B1, Derouet-Himbert, E., K. Roemer and M. Bureik tissue kallikrein, and kinin and transforming growth Adrenodoxin (Adx) and CYP11A1 (P450scc) factor-B receptors on human clear cell renal induce apoptosis by the generation of reactive carcinoma cells oxygen species in mitochondria Nieva, C., T. Gw6zdzZ, J. Dutko-Gw6zdz, Dobreva, |., O. Zschérnig, G. Waeber, R.W. James J. Wiedenmann, M. Spindler-Barth, E. Wieczorek, and C. Widmann J. Dobrucki, D. Dus, V. Henrich, A. Ozyhar and Cholesterol is the major component of native K.-D. Spindler lipoproteins activating the p38 mitogen-activated Ultraspiracle promotes nuclear localization of protein kinases ecdysteroid receptor in mammalian cells Déring, F., R. Schmitt, W.M. Bernhardt, M. Klapper, Oberle, C., U. Massing and H.F. Krug S. Bachmann, H. Daniel and D.A. Groneberg On the mechanism of alkylphosphocholine (APC)- Hypothyroidism induces expression of the peptide induced apoptosis in tumour cells transporter PEPT2 Osanai, K., K. Takahashi, K. Nakamura, M. Takahashi, Fulgosi, H., H. Lepedus, V. Cesar and N. Ljubesi¢ M. Ishigaki, T. Sakuma, H. Toga, T. Suzuki and D.R. Differential accumulation of plastid preprotein Voelker translocon components during spruce (Picea abies L. Expression and characterization of Rab38, a new Karst.) needle development member of the Rab small G protein family Hart, S., O.M. Fischer, N. Prenzel, E. Zwick-Wallasch, Robubi, A., T. Mueller, J. Fueller, M.H ekman, M. Schneider, L. Hennighausen and A. Ullrich U.R. Rapp and T. Dandekar GPCR-induced migration of breast carcinoma cells B-Raf and C-Raf signaling investigated in a simplified depends on both EGFR signal transactivation and model of the mitogenic kinase cascade EGFR-independent pathways Rovida, E., B. Lugli, V. Barbetti, S. Giuntoli, Imamichi, Y., O. Waidmann, R. Hein, P. Eleftheriou, M. Olivotto and P. Dello Sbarba K. Giehl and A. Menke Focal adhesion kinase is redistributed to focal TGFB-induced focal complex formation in epithelial complexes and mediates cell spreading in cells is mediated by activated ERK and JNK MAP macrophages in response to M-CSF kinases and is independent of Smad4 Schattner, M., M. Fritzen, J. de Souza Ventura, Irwin, N., V.A. Gault, B.D. Green, B. Greer, P. Harriott, J.C. de Albuquerque Modesto, R.G. Pozner, C.J. Bailey, P.R. Flatt and F.P.M. O’Harte A.M. Moura-da-Silva and A.M. Chudzinski-Tavassi Antidiabetic potential of two novel fatty acid derivatised, The snake venom metalloproteases berythractivase N-terminally modified analogues of glucose-dependent and jararhagin activate endothelial cells insulinotropic polypeptide (GIP): N-AcGIP(LysPAL"'®) and N-AcGIP(LysPAL97) Shen, H.C., G. Buchanan, L.M. Butler, J. Prescott, M. Henderson, W.D. Tilley and G.A. Coetzee Kagemann, G., B. Henrich, M. Kuhn, H. Kleinert GRIP1 mediates the interaction between the amino- and O. Schnorr and carboxyl-termini of the androgen receptor Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of Teber, |., F. Nagano, J. Kremerskothen, K. Bilbilis, the human and murine iNOS gene B. Goud and A. Barnekow Rab6 interacts with the mint3 adaptor protein Komolov, K.E., D.V. Zinchenko, V.A. Churumova, S.A. Vaganova, O.H. Weiergraber, |.1. Senin, Thomadaki, H., C.M. Tsiapalis and A. Scorilas P.P. Philippov and K.-W. Koch Polyadenylate polymerase modulations in human One of the Ca?*+ binding sites of recoverin exclusively epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell controls interaction with rhodopsin kinase cycle rather than apoptosis induction 1334 Contents Volume 386, 2005 Townley, H.E., K. McDonald, G.!. Jenkins, Ghosh, M., S. Shanker, |. Siwanowicz, K. Mann, M.R. Knight and C.J. Leaver W. Machleidt and T.A. Holak Ceramides induce programmed cell death in Proteolysis of insulin-like growth factor binding Arabidopsis cells in a calcium-dependent manner . .161 proteins (IGFBPs) by calpain Wessler, S., P. Muenzner, T.F. Meyer and M. Naumann Gregorc, U., S. lvanova, M. Thomas, V. Turk, The anti-inflammatory compound curcumin inhibits L. Banks and B. Turk Neisseria gonorrhoeae-induced NF-«B signaling, hDLG/SAP97, a member of the MAGUK protein release of pro-inflammatory cytokines/chemokines family, is a novel caspase target during cell-cell and attenuates adhesion in late infection detachment in apoptosis Guyot, N., M.-L. Zani, P. Berger, S. Dallet-Choisy Proteolysis and T. Moreau Proteolytic susceptibility of the serine protease Avrutina, O., H.-U. Schmoldt, D. Gabrijelcic-Geiger, inhibitor trappin-2 (pre-elafin): evidence for D. Le Nguyen, C.P. Sommerhoff, U. Diederichsen tryptase-mediated generation of elafin and H. Kolmar Trypsin inhibition by macrocyclic and open-chain Hejgaard, J. variants of the squash inhibitor MCoTI-II Inhibitory plant serpins with a sequence of three glutamine residues in the reactive center de Souza, A.F., R.J.S. Torquato, A.S. Tanaka and C.A.M. Sampaio Hook, V., T. Toneff, M. Bogyo, D. Greenbaum, Cloning, expression and characterization of K.F. Medzihradszky, J. Neveu, W. Lane, G. Hook Bauhinia variegata trypsin inhibitor BvT| and T. Reisine Inhibition of cathepsin B reduces B-amyloid Di Gennaro, S., A.G. Ficca, D. Panichi and E. Poerio production in regulated secretory vesicles of cDNA cloning and heterologous expression of a neuronal chromaffin cells: evidence for cathepsin wheat proteinase inhibitor of subtilisin and chymotrypsin B as a candidate f-secretase of Alzheimer’s ‘WSCl) that interferes with digestive enzymes of disease insect pests Horn, M., L. Doleékova-Maresova, L. Rulisek, Dostal, J., H. Diouha, P. Malo, |. Pichova and M. Masa, O. Vasiljeva, B. Turk, T. Gan-Erdene, O. HruSkova-Heidingsfeldova M. Baudys and M. Mares The precursor of secreted aspartic proteinase Activation processing of cathepsin H impairs Sapp1p from Candida parapsilosis can be activated recognition by its propeptide both autocatalytically and by a membrane-bound processing proteinase Kita, M., Y. Okumura, S.D. Ohdachi, Y. Oba, M. Yoshikuni, Y. Nakamura, H. Kido and D. Uemura Felber, L.M., C.A. Borgono, S.M. Cloutier, C. Kindig, Purification and characterisation of blarinasin, a T. Kishi, J. Ribeiro Chagas, P. Jichlinski, C.M. Gygi, new tissue kallikrein-like protease from the H.-J. Leisinger, E.P. Diamandis and D. Deperthes short-tailed shrew Blarina brevicauda: comparative Enzymatic profiling of human kallikrein 14 using studies with blarina toxin phage display substrate technology Kihikamp, T., V. Keitel, A. Helmer, D. Haussinger Florent, |., F. Lecaille, J.-J. Montagne, F. Gauthier, and R. Kubitz J. Schrevel and G. Lalmanach Degradation of the sodium taurocholate Labelling of four distinct trophozoite falcipains of cotransporting polypeptide (NTCP) by the ubiquitin- Plasmodium falciparum by a cystatin-derived probe .401 proteasome-system .. Fuentes, M.-E., R. Var6én, M. Garcia-Moreno and Meh, P., M. Pavsié, V. Turk, A. Baici and E. Valero B. Lenaréié Kinetics of autocatalytic zymogen activation Dual concentration-dependent activity of thyroglobulin measured by a coupled reaction: pepsinogen type-1 domain of testican: specific inhibitor and autoactivation substrate of cathepsin L Gandia-Herrero, F., M. Jiménez-Atiénzar, J. Mezyk-Kopeéc, R., M. Bzowska, M. Bzowska, B. Cabanes, F. Garcia-Carmona and J. Escribano Mickowska, P. Mak, J. Potempa and J. Bereta Evidence for a common regulation in the activation Effects of elastase and cathepsin G on the levels of of a polyphenol oxidase by trypsin and sodium membrane and soluble TNFa .................... 801 dodecyl sulfate Modesto, J.C.A., |.L.M. Junqueira-de-Azevedo, Gelhaus, C., R. Vicik, T. Schirmeister and M. Leippe A.G.C. Neves-Ferreira, M. Fritzen, M.L.V. Oliva, Blocking effect of a biotinylated protease inhibitor P.L. Ho, J. Perales and A.M. Chudzinski-Tavassi on the egress of Plasmodium falciparum merozoites Insularinase A, a prothrombin activator from from infected red blood cells Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains Contents Volume 386, 2005 1335 Puzer, L., J. Vercesi, M.F.M. Alves, N.M.T. Barros, Romero-Ldépez, C., A. Barroso-delJesus, E. Puerta- M.S. Araujo, M.A. Juliano, M.L. Reis, L. Juliano Fernandez and A. Berzal-Herranz and A.K. Carmona Interfering with hepatitis C virus IRES activity using A possible alternative mechanism of kinin RNA molecules identified by a novel in vitro generation in vivo by cathepsin L selection method Puzer, L., S.S. Cotrin, M.H.S. Cezari, |.Y. Hirata, Siess, A.A. and M.M. Hofstetter M.A. Juliano, |. Stefe, D. Turk, B. Turk, L. Juliano Purification of Mg2+-dependent phosphatidate and A.K. Carmona phosphohydrolase from rat liver: new steps and Recombinant human cathepsin X is a aspects carboxymoncpeptidase only: a comparison with cathepsins B and L Stemp, M.J., S. Guha, F.U. Hartl and J.M. Barral Efficient production of native actin upon translation Sawano, Y., K.-i. Hatano and M. Tanokura in a bacterial lysate supplemented with the Susceptibility of the interchain peptide of a bromelain eukaryotic chaperonin TRiC inhibitor precursor to the target proteases bromeliain, chymotrypsin, and trypsin Errata Schechter, N.M., E.-J. Choi, Z.-M. Wang, Y. Hanakawa, J.R. Stanley, Y. Kang, G.L. Clayman Erratum to the article ‘Isolation and structural and A. Jayakumar characterisation of a novel 13-amino acid insulin- Inhibition of human kallikreins 5 and 7 by the serine releasing peptide from the skin secretion of protease inhibitor lympho-epithelial Kazal-type Agalychnis calcarifer inhibitor (LEKT1) Erratum to the article ‘Identification of three novel von Janowsky, B., K. Knapp, T. Major, M. Krayl, mutations in the dihydropyrimidine dehydrogenase B. Guiard and W. Voos gene associated with altered pre-mRNA splicing or Structural properties of substrate proteins protein function’ determine their proteolysis by the mitochondrial AAA+ protease Pim1 Erratum to the article ‘Inhibition of cathepsin B reduces f-amyloid production in regulated secretory Yasuda, Y., K. Kohmura, T. Kadowaki, T. Tsukuba vesicles of neuronal chromaffin cells: evidence for and K. Yamamoto cathepsin B as a candidate -secretase of A new selective substrate for cathepsin E based Alzheimer’s disease’ on the cleavage site sequence of «2-macroglobulin .299 Novel Techniques Acknowledgment Berkessel, A., M. Dousset, S. Bulat and K. Glaubitz Author Index Combinatorial approaches to functional models for galactose oxidase Subject Index ae3 e e : va, +2 aa ‘& S1aa tye ageo eehieT r o