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Biochemistry Demystified PDF

386 Pages·2008·2.623 MB·English
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D o w n lo a d e d b y [ F a c u lty o f N u rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 .1 1 7 ] a t [0 7 /1 8 /1 6 ]. C o p y rig h t © M c G ra w -H ill G lo b a l E d u c a tio n H o ld in g s, L L C . N o t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n . D o w n lo a d e d b y [ F a c u lty o f N u rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 .1 1 7 ] a t [0 7 /1 8 /1 6 ]. C o p y rig h t © M c G ra w -H Biochemistry ill G lo b a l E d Demystifi ed u c a tio n H o ld in g s, L L C . N o t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n . D o w n lo Demystified Series ad e d b y [ F Accounting Demystified Linear Algebra Demystified ac u Advanced Calculus Demystified Macroeconomics Demystified lty o Advanced Physics Demystified Management Accounting Demystified f N u Advanced Statistics Demystified Math Proofs Demystified rsin Algebra Demystified Math Word Problems Demystified g, C Alternative Energy Demystified MATLAB® Demystified hia n Anatomy Demystified Medical Billing and Coding Demystified g m asp.net 2.0 Demystified Medical-Surgical Nursing Demystified ai U Astronomy Demystified Medical Terminology Demystified niv e ABuiodcihoe Dmeismtryys tDifieemdystified MMeicteroobroiolologgyy D Deemmyysstitfiifeiedd rsity 5 Biology Demystified Microeconomics Demystified .62 .1 Biotechnology Demystified Nanotechnology Demystified 58 .1 Business Calculus Demystified Nurse Management Demystified 1 7 Business Math Demystified OOP Demystified ] a Business Statistics Demystified Options Demystified t [07 /1 C++ Demystified Organic Chemistry Demystified 8 /1 Calculus Demystified Personal Computing Demystified 6]. C Chemistry Demystified Pharmacology Demystified o p y Circuit Analysis Demystified Physics Demystified rig h College Algebra Demystified Physiology Demystified t © Corporate Finance Demystified Pre-Algebra Demystified M c Databases Demystified Precalculus Demystified G ra Data Structures Demystified Probability Demystified w -H Diabetes Demystified Project Management Demystified ill G Differential Equations Demystified Psychology Demystified lo b Digital Electronics Demystified Quality Management Demystified al E Earth Science Demystified Quantum Field Theory Demystified du c Electricity Demystified Quantum Mechanics Demystified atio Electronics Demystified Real Estate Math Demystified n H Engineering Statistics Demystified Relativity Demystified old in Environmental Science Demystified Robotics Demystified g Everyday Math Demystified Sales Management Demystified s, L L C Fertility Demystified Signals and Systems Demystified . N FFoinraennsciicasl DPleamnynsintigfi eDdemystified SSipxa Sniigshm Da eDmeymsytisftiiefdied ot to b e French Demystified sql Demystified re d GGeenoemtiectsr yD Dememyystsitfiifeiedd SSttaattiicstsi casn Dd eDmyynsatmifiiecds Demystified istribu te German Demystified Technical Analysis Demystified d o Global Warming and Climate Change Demystified Technical Math Demystified r m o HHeodmgee NFeutnwdosr kDinemg yDsetimfieydstified Tumrigl oDneommyesttriyfi eDdemystified dified in Investing Demystified Visual Basic 2005 Demystified a n Italian Demystified Visual C# 2005 Demystified y w a Java Demystified Vitamins and Minerals Demystified y w JavaScript Demystified XML Demystified ith o Lean Six Sigma Demystified ut p e rm issio n . D o w n lo a d e d b y [ F a c u lty o f N u rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 .1 1 7 ] a t [0 7 /1 8 /1 6 Biochemistry ]. C o p y rig h t © Demystifi ed M c G ra w -H ill G lo b a l E d u c a tio n H o Sharon Walker ld in g David McMahon s, LL C . N o t to b e re d istrib u te d o r m o d ifie d in a n y New York Chicago San Francisco Lisbon London w a y Madrid Mexico City Milan New Delhi San Juan w Seoul Singapore Sydney Toronto itho u t p e rm issio n . D o w n lo a d e d b y [ F a Copyright © 2008 by The McGraw-Hill Companies, Inc. All rights reserved. Manufactured in the United States of America. Except cu as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form lty o or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher. f N u 0-07-164348-6 rsing , C h The material in this eBook also appears in the print version of this title: 0-07-149599-1. ian g m a All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occurrence of a i U n trademarked name, we use names in an editorial fashion only, and to the benefit of the trademark owner, with no intention of iv e infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps. rsity 5 McGraw-Hill eBooks are available at special quantity discounts to use as premiums and sales promotions, or for use in corporate .62 .1 training programs. For more information, please contact George Hoare, Special Sales, at [email protected] or (212) 5 8 904-4069. .11 7 ] a TERMS OF USE t [0 7 /1 8 This is a copyrighted work and The McGraw-Hill Companies, Inc. (“McGraw-Hill”) and its licensors reserve all rights in and to the /1 6 work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and ]. C retrieve one copy of the work, you may not decompile, disassemble, reverse engineer, reproduce, modify, create derivative works op y based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-Hill’s prior rig h consent. You may use the work for your own noncommercial and personal use; any other use of the work is strictly prohibited. Your t © right to use the work may be terminated if you fail to comply with these terms. M c G THE WORK IS PROVIDED “AS IS.” McGRAW-HILL AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES raw AWSO RTOK , TINHCEL AUCDCIUNRGA ACNYY, AINDFEOQRUMAACTYI OONR T CHOAMT CPLAENT BEEN EASCSC EOSFS EODR TRHERSOUULTGSH TTOH EB WE OORBKTA VIINAE HDY FPREORMLI NUKS IONRG O TTHHE- -Hill G ERWISE, AND EXPRESSLY DISCLAIM ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO lob a IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. McGraw-Hill and its l E d licensors do not warrant or guarantee that the functions contained in the work will meet your requirements or that its operation will uc a be uninterrupted or error free. Neither McGraw-Hill nor its licensors shall be liable to you or anyone else for any inaccuracy, error tio n or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill has no responsibility for the H o content of any information accessed through the work. Under no circumstances shall McGraw-Hill and/or its licensors be liable for ld any indirect, incidental, special, punitive, consequential or similar damages that result from the use of or inability to use the work, ing even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim or cause s, L L whatsoever whether such claim or cause arises in contract, tort or otherwise. C . N o DOI: 10.1036/0071495991 t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n . D o w n lo a d e d b y [ F a c u lty o f N u rsin g , C h ia n g m a i U n iv e rsity 5 Professional .6 2 .1 5 8 .1 1 7 ] a t [0 7 /1 8 /1 6 ]. C o p y rig h t © Want to learn more? M c G ra w -H We hope you enjoy this ill G lo McGraw-Hill eBook! If b a l E you’d like more information about this book, du c a its author, or related books and websites, tion H o please click here. ld in g s, L L C . N o t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n . D o w n lo a d e d b y [ F a c u lty o This book is dedicated to our gang: Brandy, Kelpie, Goose, f N u Henry, Red Cloud, Serenity, Sirius, Wendy, and Wishes rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 .1 1 7 ] a t [0 7 /1 8 /1 6 ]. C o p y rig h t © M c G ra w -H ill G lo b a l E d u c a tio n H o ld in g s, L L C . N o t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n . D o w n lo a d e d b y [ F a c u lty o f N u ABOUT THE AUTHORS rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 SHARON WALKER, PH.D., is a Diplomat of the American Board of Toxicology .11 7 (DABT) and has done extensive research in various areas of biomedicine. She has ] a t [0 taught graduate courses in immunology, epidemiology, cell biology, and statistics. 7 /1 8 Dr. Walker is the author of Biotechnology Demystified. /1 6 ]. C o p DAVID MCMAHON holds advanced degrees in physics and mathematics, and works yrig as a researcher at a national laboratory. He has engaged in a wide variety of areas ht © including fusion energy research and quantum information science. David has an M c G interest in the biological sciences and participated for several years in research on ra w the role of neurotransmitters in attention deficit disorder. -H ill G lo b a l E d u c a tio n H o ld in g s, L L C . N o t to b e re d istrib u te d o r m o d ifie d in a n y w a y w ith o u t p e rm issio n Copyright © 2008 by The McGraw-Hill Companies, Inc. Click here for terms of use. . For more information about this title, click here D o w n lo a d e d b y [ F a c u lty o f N u CONTENTS rsin g , C h ia n g m a i U n iv e rsity 5 .6 2 .1 5 8 .1 1 7 ] a t [0 7 Preface xiii /1 8 /1 6 CHAPTER 1 The Chemistry of Biomolecules 1 ]. C o p Review of Basic Chemical Concepts 1 yrig h Forces That Hold Atoms and Molecules Together 2 t © M Forces That Drive Reactions 8 cG ra w The Unique Measurements of Hydrogen Ion -H Concentration—pH 18 ill G lo b The Unique Properties of the Carbon Atom 20 a l E d The Importance of Molecular uc a Arrangement—Stereochemistry 23 tion H o Summary 26 ld in g Quiz 29 s, L L C CHAPTER 2 Cell Structures and Cell Division 31 . N o Introduction 31 t to b e Cell Theory 32 red The Three Domains of Life 32 istrib u te d Cell Containment 35 o r m Introduction to Cell Organelles 38 od ifie Summary 47 d in a Quiz 49 ny w a y w ith o u t p e rm issio n . D o viii Biochemistry Demystifi ed wn lo a d e d b y CHAPTER 3 Carbohydrates 53 [ Fa c u Monosaccharide 54 lty o Reducing and Nonreducing Sugars 63 f N u Derivatives of Carbohydrates 63 rsing , C h Glycosidic Bond and Disaccharides 65 ia n g m Polysaccharides 68 a i U Glycoconjugates 70 niv e Summary 71 rsity 5 Quiz 71 .62 .1 5 8 .1 CHAPTER 4 Lipids 75 1 7 ] a Fatty Acids 76 t [0 7 Triglycerides 80 /18 /1 6 Sphingolipids 81 ]. C o p Nonsaponifi able Lipids 82 y rig h Cholesterol 84 t © M An Overview of the Cell Membrane 85 c G ra Summary 89 w-H Quiz 89 ill G lo b a CHAPTER 5 Lipid Metabolism 93 l E d u Lipases and Phospholipases 93 ca tio n Cholesterol Release 96 H o (cid:3) Oxidation of Fatty Acids 96 ldin g Energy Yield 98 s, LL C Summary 99 . N o t to Quiz 99 b e re d CHAPTER 6 Protein Structure 101 istrib Introduction 101 ute d o General Characteristics of Proteins 102 r m o d Summary 122 ifie d Quiz 124 in a n y w CHAPTER 7 Protein Assembly and Disassembly 127 a y w Introduction 127 ith o u A Few Words about Oxidation-Reduction Potential 128 t p e rm issio n .

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