Biochemical Pharmacology 2002: Vol 63 Table of Contents

17 Pages·2002·3.3 MB·English

oN Biochemical
ie Pharmacology
ELSEVIER Biochemical Pharmacology 63 (2002) 2208-2222
Contents of Volume 63
1 January 2002 Selvanayagam Nirthanan, Jeremiah S. Joseph,
Ponnampalam Gopalakrishnakone, Hoon-Eng Khoo,
Li-Sam Cheah and Matthew C.E. Gwee
Commentary
"TT. oxicological consequences of altered peroxisome E‘ftfeecc ts of the > antidep“prree ssant/a/ ntipanic ‘ dr" ug phenweall.
proliferator-activated receptor y (PPARy) expression zine and its putative metabolite phenylethylidene-
in the liver: insights from models of obesity and type 2 hydrazine on extracellular y-aminobutyric acid
diabetes levels in the striatum
Urs A. Be rli and Marc Bedoucha Marise B. Parent, Sangeeta Master, Shauna Kashlub
and Glen B. Baker
MOLECULAR A} R PHARMA( ' INFLAMMATION AND IMMUNOPHARMACOI!
Protein levels ot neurotilament subunits in the hen Human neutrophil migration in_ vitro induced by
central nervous system following prevention and secretory phospholipases A>: a role for cell surface
potentiation of diisopropyl phosphorofluoridate glycosaminoglycans
(DFP)-induced delayed neurotoxicity Alessandra Gambero, Elen C.T. Landucci,
Kegin Xie, Ram P. Gupta and Mohamed B. Abou-Donia Marcos H. Toyama, Sergio Marangoni,
Jose R. Giglio, Helena B. Nader, Carl P. Dietrich,
Atte> nuation of 6-e hydr. oxydloopnaamn ine . (6--OOHHDDAA ) )- Ci' dcees Yhe Moy ock andl Bi. les Minteiies
induced nuclear factor-kappaB (NF-«B) activation
z ee ee a
and cell death by tea extracts in neuronal cultures Inhibition of cyclooxygenase and prostaglandin E;
) Stee oe BH. Youd synthesis by y-mangostin, a xanthone derivative in
ona Levites, Moussa B. oudim,
: mangosteen, in C6 rat glioma cells
Gila Maor and Silvia Mandel
Keigo Nakatani, Norimichi Nakahata, Tsutomu Arakawa,
Hideyuki Yasuda and Yasushi Ohizumi
Cell-impermeant pyridinium derivatives of psoralens INTESTINA
as inhibitors of keratinocyte growth Fluorescein uptake by a monocarboxylic acid trans-
Thomas M. Mariano, Anna M. Vetrano, porter in human intestinal Caco-2 cells
Shannon L. Gentile, Diane E. Heck,
Kenji Kuwayama, Seiji Miyauchi, Ryoko Tateoka,
Marilyn S. Whittemore, Christophe D. Guillon,
Hiroshi Abe and Naoki Kamo
Ivan Jabin, Robert D. Rapp, Ned D. Heindel
and Jeffrey D. Laskin
15 January 2002
Induction of apoptosis by diallyl disulfide through
activation of caspase-3 in human leukemia HL-60 cells
Commentary
Kang-Beom Kwon, Su-Jin Yoo, Do-Gon Ryu,
A novel mechanism of action and potential use for
Jeong-Yeh Yang, Hye-Won Rho, Jong-Suk Kim,
: lobeline as a treatment for psychostimulant abuse
Jin-Woo Park, Hyung-Rho Kim and Byung-Hyun Park
Linda P. Dwoskin and Peter A. Crooks
_ eS — Rapid Communication
49 = Biochemical and pharmacological characterization Antimicrobial effect of resveratrol on dermatophytes
of the venom of the black scorpion Heterometrus and bacterial pathogens of the skin
spinifer Marion Man-Ying Chan
PII: SO006-2952(02)01134-6
oN Biochemical
ie Pharmacology
ELSEVIER Biochemical Pharmacology 63 (2002) 2208-2222
Contents of Volume 63
1 January 2002 Selvanayagam Nirthanan, Jeremiah S. Joseph,
Ponnampalam Gopalakrishnakone, Hoon-Eng Khoo,
Li-Sam Cheah and Matthew C.E. Gwee
Commentary
"TT. oxicological consequences of altered peroxisome E‘ftfeecc ts of the > antidep“prree ssant/a/ ntipanic ‘ dr" ug phenweall.
proliferator-activated receptor y (PPARy) expression zine and its putative metabolite phenylethylidene-
in the liver: insights from models of obesity and type 2 hydrazine on extracellular y-aminobutyric acid
diabetes levels in the striatum
Urs A. Be rli and Marc Bedoucha Marise B. Parent, Sangeeta Master, Shauna Kashlub
and Glen B. Baker
MOLECULAR A} R PHARMA( ' INFLAMMATION AND IMMUNOPHARMACOI!
Protein levels ot neurotilament subunits in the hen Human neutrophil migration in_ vitro induced by
central nervous system following prevention and secretory phospholipases A>: a role for cell surface
potentiation of diisopropyl phosphorofluoridate glycosaminoglycans
(DFP)-induced delayed neurotoxicity Alessandra Gambero, Elen C.T. Landucci,
Kegin Xie, Ram P. Gupta and Mohamed B. Abou-Donia Marcos H. Toyama, Sergio Marangoni,
Jose R. Giglio, Helena B. Nader, Carl P. Dietrich,
Atte> nuation of 6-e hydr. oxydloopnaamn ine . (6--OOHHDDAA ) )- Ci' dcees Yhe Moy ock andl Bi. les Minteiies
induced nuclear factor-kappaB (NF-«B) activation
z ee ee a
and cell death by tea extracts in neuronal cultures Inhibition of cyclooxygenase and prostaglandin E;
) Stee oe BH. Youd synthesis by y-mangostin, a xanthone derivative in
ona Levites, Moussa B. oudim,
: mangosteen, in C6 rat glioma cells
Gila Maor and Silvia Mandel
Keigo Nakatani, Norimichi Nakahata, Tsutomu Arakawa,
Hideyuki Yasuda and Yasushi Ohizumi
Cell-impermeant pyridinium derivatives of psoralens INTESTINA
as inhibitors of keratinocyte growth Fluorescein uptake by a monocarboxylic acid trans-
Thomas M. Mariano, Anna M. Vetrano, porter in human intestinal Caco-2 cells
Shannon L. Gentile, Diane E. Heck,
Kenji Kuwayama, Seiji Miyauchi, Ryoko Tateoka,
Marilyn S. Whittemore, Christophe D. Guillon,
Hiroshi Abe and Naoki Kamo
Ivan Jabin, Robert D. Rapp, Ned D. Heindel
and Jeffrey D. Laskin
15 January 2002
Induction of apoptosis by diallyl disulfide through
activation of caspase-3 in human leukemia HL-60 cells
Commentary
Kang-Beom Kwon, Su-Jin Yoo, Do-Gon Ryu,
A novel mechanism of action and potential use for
Jeong-Yeh Yang, Hye-Won Rho, Jong-Suk Kim,
: lobeline as a treatment for psychostimulant abuse
Jin-Woo Park, Hyung-Rho Kim and Byung-Hyun Park
Linda P. Dwoskin and Peter A. Crooks
_ eS — Rapid Communication
49 = Biochemical and pharmacological characterization Antimicrobial effect of resveratrol on dermatophytes
of the venom of the black scorpion Heterometrus and bacterial pathogens of the skin
spinifer Marion Man-Ying Chan
PII: SO006-2952(02)01134-6
Contents of Volume 63 2209
MOLECULAR AND CELLULAR PHARMACOLOGY Laetitia Devy, Patrick Hollender, Carine Munaut,
Alain Colige, Roselyne Garnotel, Jean-Michel Foidart,
Multiple mechanisms of resistance to methotrexate
Agnes Noél and Pierre Jeannesson
and novel antifolates in human CCRF-CEM leuke-
mia cells and their implications for folate homeostasis The polymorphic human glutathione transferase
Robert Mauritz, Godefridus J. Peters, David G. Priest, Tl-1, the most efficient glutathione transferase in
Yehuda G. Assaraf, Stavit Drori, letje Kathmann, the denitrosation and inactivation of the anticancer
Paul Noordhuis, Marlene A. Bunni, Andre Rosowsky, drug 1,3-bis(2-chloroethyl)-1-nitrosourea
Jan H. Schornagel, Herbert M. Pinedo and Gerrit Jansen Samantha Lien, Anna-Karin Larsson and
Bengt Mannervik
Pathways for &-D-ribose utilization for nucleobase
salvage and 5-fluorouracil activation in rat brain Inhibitory effect of the plant-extract osthole on
Catia Barsotti and Piero Luigi Ipata L-type calcium current in NG108-15 neuronal cells
Sheng-Nan Wu, Yuk-Kang Lo, Chien-Chich Chen,
Influence of t-butylhydroquinone and B-naphthofla-
Hui-Fang Li and Hung-Ting Chiang
vone on formation and transport of 4-methylumbel-
liferone glucuronide in Caco-2/TC-7 cell monolayers Influence of isomerisation on the growth inhibitory
Barbara §. Bock-Hennig, Christoph Kohle, effects and cellular activity of 13-cis and all-trans reti-
Karl Nill and Karl Walter Bock noic acid in neuroblastoma cells
Gareth J. Veal, Julie Errington, Christopher
Interaction of specifically chemically modified dex-
trans with transforming growth factor B1: potentia- P.F. Redfern, Andrew D.J. Pearson and
Alan V. Boddy
tion of its biological activity
Delphine Logeart-Avramoglou, Rémi Huynh, Structure—activity studies of bufokinin, substance P
Frédéric Chaubet, Laurent Sedel and and their C-terminal fragments at bufokinin receptors
Alain Meunier in the small intestine of the cane toad, Bufo marinus
Lu Liu, Michael Murray and Elizabeth Burcher
Activation of transcription factors by drugs inducing
oxidative stress in rat liver Wogonin and fisetin induce apoptosis in human pro-
Lorenza Tacchini, Daniela Fusar-Poli and myeloleukemic cells, accompanied by a decrease of
Aldo Bernelli-Zazzera reactive oxygen species, and activation of caspase 3
and Ca**-dependent endonuclease
Inhibitory effect of adrenomedullin on basal and
tumour necrosis factor alpha-stimulated endothelin- | Woan-Rouh Lee, Shing-Chuan Shen, Hui-Yi Lin,
synthesis in bovine aortic endothelial cells is inde- Wen-Chi Hou, Ling-Ling Yang and Yen-Chou Chen
pendent of cyclic AMP
Clofibric acid down-regulation of metallothionein
Stewart Barker, Delphine M. Lees, IIA in HepG2 human hepatoma cells
Elizabeth G. Wood and Roger Corder
Arnaud Bianchi, Philippe Bécuwe, Philippe Collet,
Binding thermodynamics at the human A; adenosine Jean Marie Keller, Lionel Domenjoud and Michel Dauca
receptor
The effect of methylglyoxal-bis( guanylhydrazone) on
Stefania Merighi, Katia Varani, Stefania Gessi, mitochondriaCla ~~ fluxes
Karl-Norbert Klotz, Edward Leung,
Mauro Salvi and Antonio Toninello
Pier Giovanni Baraldi and Pier Andrea Borea
Role of redox status on the activation of mitogen-
CHEMOTHERAPY AND METABOLIC INHIBITORS
activated protein kinase cascades by NSAIDs
Ana Maria Lennon, Martine Ramauge Inhibition of nucleotide excision repair and sensitisa-
and Michel Pierre tion of cells to DNA cross-linking anticancer drugs by
F 11782, a novel fluorinated epipodophylloid
Sensitivity of HaCat keratinocytes to diabetogenic
Jean-Marc Barret, Mathilde Cadou and Bridget T. Hill
toxins
Avikam Harel, Olga Bloch, Pnina Vardi Reduced DNA ligase activity in etoposide resistant
and Konstantin Bloch human lymphatic leukaemia CEM cells
Matrix and serine protease expression during leuke- Eva Fredriksson, Eva Liliemark,
mic cell differentiation induced by aclacinomycin Anya Polischouk, Stefan Séderhall,
and all-trans-retinoic acid Freidoun Albertioni and Siv Ljungquist
2210 Contents of Volume 63
265 5-Fluoroindole-3-acetic acid: a prodrug activated by a 1 February 2002
peroxidase with potential for use in targeted cancer
therapy
Commentary
Lisa K. Folkes, Olga Greco, Gabi U. Dachs,
Is inhibition of cyclooxygenase required for the anti-
Michael R.L. Stratford and Peter Wardman
tumorigenic effects of nonsteroidal, anti-inflamma-
tory drugs (NSAIDs)? In vitro versus in vivo results
HORMONES AND GROWTH FA‘ and the relevance for the prevention and treatment
273
of cancer
The signalling pathway for BCG-induced inter-
leukin-6 production in human bladder cancer cells Amiram Raz
Ye Zhang, Ratha Mahendran, Lai Lai Yap,
Kesavan Esuvaranathan and Hoon Eng Khoo
MOLECULAR AND CELLULAR PHARMACOLOGY
283 Role of mitochondria in Ca~* oscillations and shape Intracellular mechanisms mediating the inhibition of
of Ca~” signals in pancreatic acinar cells apoB-containing lipoprotein synthesis and secretion
in HepG2 cells by avasimibe (CI-1011), a novel acyl-
C. Camello-Almaraz, G.M. Salido,
coenzyme A: cholesterol acyltransferase (ACAT)
J.A. Pariente and P.J. Camello
inhibitor
Changiz Taghibiglou, Stephen C. Van Iderstine,
Agnes Kulinski, Debbie Rudy and Khosrow Adeli
293 Effects of 5-aminoisoquinolinone, a water-soluble,
Identification of «-dicarbonyl scavengers for cellular
potent inhibitor of the activity of poly (ADP-ribose)
protection against carbonyl stress
polymerase, in a rodent model of lung injury
Georg T. Wondrak, Daniel Cervantes-Laurean,
Salvatore Cuzzocrea, Michelle C. McDonald,
Michael J. Roberts, Jaber G. Qasem, Moonsun Kim,
Emanuela Mazzon, Laura Dugo, Ivana Serraino,
Elaine L. Jacobson and Myron K. Jacobson
Mike Threadgill, Achille P. Caputi and
Christoph Thiemermann Vanadyl as a catalyst of human lipoprotein oxidation
Domenico Lapenna, Giuliano Ciofani, Cristiana Bruno,
305 The involvement of |-y-glutamyl-l-cysteinyl-glycine Sante D. Pierdomenico, Livio Giuliani,
(glutathione/GSH) in the mechanism of redox Maria Adele Giamberardino and Franco Cuccurullo
signaling mediating MAPK'’’-dependent regulation
Methionine synthase activity and sulphur amino acid
of pro-inflammatory cytokine production
levels in the rat liver tumour cells HTC and Phi-1
John J. Haddad
Susan H. Kenyon, Catherine J. Waterfield,
John A. Timbrell and Anna Nicolaou
CARDIOVASCULAR AND PULMONARY PHARMACOLOGY
Differential effects of 4-aminoquinoline-containing
321 Identification of the phospholipase A> isoforms that
antimalarial drugs on hemoglobin digestion in Plas-
contribute to arachidonic acid release in hypoxic modium falciparum-infected erythrocytes
endothelial cells: limits of phospholipase A» inhibi-
Oleg Famin and Hagai Ginsburg
tors
Selective inhibition of the activities of both eukaryo-
Carine Michiels, Patricia Renard,
tic DNA polymerases and DNA topoisomerases by
Najat Bouaziz, Nathalie Heck,
Francois Eliaers, Noélle Ninane, elenic acid
Rozenn Quarck, Paul Holvoet and Yoshiyuki Mizushina, Chikako Murakami,
Martine Raes Keisuke Ohta, Hirosato Takikawa, Kenji Mori,
Hiromi Yoshida, Fumio Sugawara and Kengo Sakaguchi
OINTESTINAL AND RENAL PHARMACOLOGY) UDP-glucuronosyltransferase activity, expression and
cellular localization in human placenta at term
333 Differential regulation of multidrug resistance-asso-
ciated protein 2 (MRP2) and cytochromes P450 Abby C. Collier, Natalie A. Ganley,
2B1/2 and 3A1/2 in phenobarbital-treated hepato- Malcolm D. Tingle, Marion Blumenstein,
Keith W. Marvin, James W. Paxton,
cytes
Murray D. Mitchell and Jeffrey A. Keelan
Arnaud Courtois, Léa Payen, Eric Le Fervec,
George L. Scheffer, Yolande Trinquart, André Guillouzo Actions of derivatives of dehydroaltenusin, a new
and Olivier Fardel mammalian DNA polymerase &-specific inhibitor
Contents of Volume 63 2211
Shinji Kamisuki, Chikako Murakami, Keisuke Ohta, Mariela M. Gironacci, Maria del Carmen Ferndndez-
Hiromi Yoshida, Fumio Sugawara, Kengo Sakaguchi Tomé, Emir Speziale, Norma Sterin-Speziale and
and Yoshiyuki Mizushina
Clara Pena
429 Lack of association between CYP2A5 induction and In vitro and in vivo effects of new insulin releasing
apoptosis in mouse primary hepatocytes agents
Sami Tetri, Minna Ruhanen, Pirkko Viitala, Quynh-Anh Nguyen, Marie-Héléne Antoine,
Olavi Pelkonen, Markku Pasanen and Hannu Raunio Raogo Ouedraogo, Marcel Hermann,
Jacqueline Sergooris, Bernard Pirotte,
437 In vitro induction of apoptosis vs. necrosis by widely
Bernard Masereel and Philippe Lebrun
used preservatives: 2-phenoxyethanol, a mixture of
isothiazolinones, imidazolidinyl urea and 1,2-penta-
nediol INFLAMMATION AND IMMUNOPHA
Cecilia Anselmi, Anna Ettorre, Marco Andreassi, Effects of a selective cyclooxygenase-2 inhibitor, cel-
Marisanna Centini, Paolo Neri and Anna Di Stefano ecoxib, on bone resorption and osteoclastogenesis in
vitro
CHEMOTHERAPY AND METABOLIC INHIBITORS Kaoru Igarashi, Je-Tae Woo and Paula H. Stern
455 Anti-cancer action of 4-iodo-3-nitrobenzamide in Regulatory effects of deoxycholic acid, a component
combination with buthionine sulfoximine: inactiva- of the anti-inflammatory traditional Chinese medi-
tion of poly(ADP-ribose) polymerase and tumor cine Niuhuang, on human leukocyte response to
chemoattractants
glycolysis and the appearance of a poly(ADP-ribose)
polymerase protease Xin Chen, Richard Daniel Mellon, Lu Yang,
Huifang Dong, Joost J. Oppenheim and
Pal I. Bauer, Jerome Mendeleyeva, Eva Kirsten,
John A. Comstock, Alaeddin Hakam, Ola Mae Zack Howard
Kalman G Buki and Ernest Kun
CARDIOVA PULMONARY PHARMA(
Activation of protein kinase C for protection of cells
against apoptosis induced by the immunosuppressor Mitochondrial gene expression and ventricular fibril-
prodigiosin lation in ischemic/reperfused nondiabetic and dia-
betic myocardium
Beatriz Montaner Ramoneda and Ricardo Pérez-Tomas
Levente Szendrei, Tibor Turoczi, Peter Kovacs,
Modulation of apoptosis by mitochondrial uncou- Miklos Vecsernyes, Dipak K. Das and Arpad Tosaki
plers: apoptosis-delaying features despite intrinsic
Cytotoxicity GASTROINTESTINAL AND RENAI PHARMA(
Oliver J. Stoetzer, Alexei Pogrebniak,
Effect of malondialdehyde—acetaldehyde—protein
Renate Pelka-Fleischer, Max Hasmann,
adducts on the protein kinase C-dependent secretion
Wolfgang Hiddemann and Volkmar Nuessler
of urokinase-type plasminogen activator in hepatic
In vivo nitric oxide transfer of a physiological NO
stellate cells
carrier, dinitrosyl dithiolato iron complex, to target Kusum K. Kharbanda, Kris A. Shubert, Todd A. Wyatt,
complex
Michael F. Sorrell and Dean J. Tuma
Takaharu Ueno, Yasuhiro Suzuki, Satoshi Fujii,
Anatoly F. Vanin and Tetsuhiko Yoshimura
15 February 2002
NeEuR SCIENCE
Commentary
Protective effect of boldine on dopamine-induced
563 Alzheimer’s disease and oxygen radicals: new insights
membrane permeability transition in brain mito-
chondria and viability loss in PC12 cells Domenico Pratico
Young Chul Youn, Oh Sang Kwon, Eun Sook Han,
Jin Ho Song, Yong Kyu Shin and Chung Soo Lee MOLECUI AR AND CELLULAR PBHatA RMAoeC OLOG_Y
Hydrogen peroxide-induced current in Xenopus
}
HORMONES AND GROWTH FACTORS oocytes: current characteristics similar to those
507 Enhancement of phosphatidylcholine biosynthesis by induced by the removal of extracellular calcium
angiotensin-(1—7) in the rat renal cortex Myung-Jun Kim and Jin-Kwan Han
Contents of Volume 63
Inhibition of superoxide anion generation by YC-1 in structures impeding the inhibition of cytosolic cyclic
rat neutrophils through cyclic GMP-dependent and - AMP-specific phosphodiesterase
independent mechanisms Doris Marko, Karl-Heinz Merz, Claudia Kunz,
Jih-Pyang Wang, Ling-Chu Chang, Shue-Ling Raung, Anja Miiller, Nadya Tarasova and
Mei-Feng Hsu, Li-Jiau Huang and Sheng-Chu Kuo Gerhard Eisenbrand
Dual coupling of MT; and MT> melatonin receptors Monoamine neurotoxins-induced apoptosis in lym-
to cyclic AMP and phosphoinositide signal transduc- phocytes by a common oxidative stress mechanism:
tion cascades and their regulation following melato- involvement of hydrogen peroxide (H2O>), caspase-3,
nin exposure and nuclear factor kappa-B (NF-«B), p53, c-Jun tran-
Renee S. MacKenzie, Melissa A. Melan, scription factors
Deepshikha K. Passey and Paula A. Witt-Enderby Marlene Jimenez Del Rio and Carlos Velez-Pardo
Involvement of the muscarinic acetylcholine recep- Mechanisms of apoptosis by the tyrphostin AG957 in
tor in inhibition of cell migration hematopoietic cells
Kimberly A. Varker and Carol L. Williams Alexander Urbano, Gullu Gorgun and Francine Foss
Enhanced clearance of topoisomerase | inhibitors Associations between human liver and_ kidney
from human colon cancer cells by glucuronidation cadmium content and immunochemically detected
Jeffrey Cummings, Gary Boyd, Bria r 1 T. Ethell, CYP4A11 apoprotein
Janet S. Macpherson, Brian Burchel l, John F. Smyth Jason R. Baker, Soisungwan Satarug,
and Duncan I. Jodrell Supanee Urbenjapol, Robert J. Edwards,
David J. Williams, Michael R. Moore and
Bilirubin and uroporphyrinogen oxidation by induced
Paul E.B. Reilly
cytochrome P4501A and cytochrome P4502B. Role
of polyhalogenated biphenyls of different configura-
tion
CHEMOTHERAPY AND METABOLIC INHIBITORS
Francesco De Matteis, Sally J.D awson,
Nicoletta Pons and Sandra Pipino Inhibition of hepatic stellate cell collagen synthesis
by N-(methylamino)isobutyric acid
The modulation of the DNA-damaging effect of poly-
Thomas L. Freeman, Kusum K. Kharbanda,
cyclic aromatic agents by xanthines. Part I. Reduc-
Dean J. Tuma and Mark E. Mailliard
tion of cytostatic effects of quinacrine mustard by
caffeine Inhibition of tubulin polymerization by vitilevu-
Jan Kapuscinski, Barbara Ardelt, Jacek Piosik, amide, a bicyclic marine peptide, at a site distinct
Malgorzata Zdunek and Zbigniew Darzynkiewicz from colchicine, the vinca alkaloids, and dolastatin 10
Michael C. Edler, Annette M. Fernandez, Peter Lassota,
The modulation by xanthines of the DNA-damaging
Chris M. Ireland and Louis R. Barrows
effect of polycyclic aromatic agents. Part II. The
stacking complexes of caffeine with doxorubicin Modifications of deoxycytidine kinase and deaminase
and mitoxantrone activities by docosahexaenoic acid in normal and
Jacek Piosik, Malgorzata Zdunek and transformed rat fibroblasts
Jan Kapuscinski Ming C. Cha and Kelly A. Meckling-Gill
Alterations in cellular Ca“* and free iron pool by Effect of the new matrix metalloproteinase inhibitor
sulfur amino acid deprivation: the role of ferritin light RO-28-2653 on mitochondrial function
chain down-regulation in prooxidant production Jens R. Opalka, Frank N. Gellerich, Lothar Kling,
Hye Jung Kim and Sang Geon Kim Bernd Miiller-Beckmann and Stephan Zierz
7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino- Variation in the kineticso f caspase-3 activation, Bcl-2
pteridine, a potent inhibitor of cAMP-specific phos- phosphorylation and apoptotic morphology in un-
phodiesterase, enhancing nuclear protein binding to selected human ovarian cancer cell lines as a response
the CRE consensus sequence in human tumour cells
to docetaxel
Barbara Wagner, Sandra Jakobs, Michael Habermeyer, Geertruida M. Kolfschoten, Theresia M. Hulscher,
Frankie Hippe, Yoon Sang Cho-Chung, Monique C.A. Duyndam, Herbert M. Pinedo
Gerhard Eisenbrand and Doris Marko and Epie Boven
Intracellular localization of 7-benzylamino-6-chloro- Investigations on the effects of oltipraz on the nucleo-
‘
2-piperazino-4-pyrrolidino-pteridine in membrane tide excision repair in the liver
Contents of Volume 63
Lydie Sparfel, Sophie Langouét, Alain Fautrel, GASTROINTESTINAL AND RENAL PHARMACOLOG)
Bernard Salles and André Guillouzo
Tissue levels of S-adenosylhomocysteine in the rat
Thenoyltrifluoroacetone, a potent inhibitor of car- kidney: effects of ischemia and homocysteine
boxylesterase activity Doris Kloor, Ursula Delabar, Bernd Miihlbauer,
Jin-Gang Zhang and Marc W. Fariss Gerd Luippold and Hartmut Osswald
NEUROSCIENCI
1 March 2002
Inhibition of crotoxin phospholipase A» activity by
manoalide associated with inactivation of crotoxin
Commentary
toxicity and dissociation of the heterodimeric neuro-
toxic complex Selective cyclooxygenase-2 (COX-2) inhibitors and
potential risk of cardiovascular events
Frédéric Dorandeu, Rémi Hesters, Fabien Girard,
Debabrata Mukherjee
Elise Four, Annie Foquin, Cassian Bon,
Guy Lallement and Grazyna Faure
MOLECULAR AND CELLULAR PHARMACOLOGY
HorRMONES AND GROWTH FACTORS
Alterations in the expression of cytochrome c oxidase
Effect of isatin on nitric oxide-stimulated soluble gua-
subunits in doxorubicin-resistant leukemia K562 cells
nylate cyclase from human platelets
Fabienne Grandjean, Laure Brémaud,
Alexei Medvedev, Olga Bussygyna, Natalia Pyatakova,
Jacques Robert and Marie-Heléne Ratinaud
Vivette Glover and Irene Severina
Novel phenothiazine antimalarials: synthesis, anti-
malarial activity, and inhibition of the formation of
GENE ExpRESSION AND DEVELOPMENT
B-haematin
Induction of UDP-glucuronosyltransferase 1A8 Martha Kalkanidis, Nectarios Klonis, Leann Tilley
mRNA by 3-methylcholanthene in rat hepatoma and Leslie W. Deady
cells Increased rate of glutathione synthesis from cystine in
Yuet Kin Leung and John W. Ho
drug-resistant MCF-7 cells
Modulation of mdrla and CYP3A gene expression in Michael P. Gamesik, George R. Dubay and
the intestine and liver as possible cause of changes in Brandon R. Cox
the cyclosporin A disposition kinetics by dexametha-
Effects of sanguiin H-6, a component of Sanguisorbae
sone Radix, on lipopolysaccharide-stimulated nitric oxide
Koichi Yokogawa, Tsutomu Shimada, Yasuhiko Higashi, production
Yoshie Itoh, Toshiko Masue, Junko Ishizaki,
Takako Yokozawa, Cui Ping Chen,
Mariko Asahi and Ken-ichi Miyamoto
Takashi Tanaka and
Kenichi Kitani
INFLAMMATION AND IMMUNOPHARMACOL
Association of dopamine D; receptors with actin-
Protective effects of Celecoxib on lung injury and red binding protein 280 (ABP-280)
blood cells modification induced by carrageenan in Ming Li, Chuanyu Li, Paul Weingarten,
the rat James R. Bunzow, David K. Grandy and
Salvatore Cuzzocrea, Emanuela Mazzon, Qun-Yong Zhou
Lidia Sautebin, Laura Dugo, Ivana Serraino,
Phentermine inhibition of recombinant human liver
Angela De Sarro and Achille P. Caputi
monoamine oxidases A and B
Ravi K. Nandigama, Paige Newton-Vinson and
CARDIOVASCULAR AND PULMONARY PHARMACOLOGY Dale E. Edmondson
Regulation of cyclic AMP in rat pulmonary micro- p53-Independent induction of Fas and apoptosis in
vascular endothelial cells by rolipram-sensitive cyclic leukemic cells by an adenosine derivative, Cl-IB-
AMP phosphodiesterase (PDE4) MECA
W. Joseph Thompson, Takashi Ashikaga, Seong Gon Kim, Gnana Ravi, Carsten Hoffmann,
John J. Kelly, Li Liu, Bing Zhu, Yun-Jin Jung, Min Kim, Aishe Chen and
Lakshimi Vemavarapu and Samuel J. Strada Kenneth A. Jacobson
2214 Contents of Volume 63
881 Fas/CD95-mediated apoptosis in human glioblastoma CHEMOTHERAPY AND METABOLIC INHIBITORS
cells: a target for sensitisation to topoisomerase | inhi-
967 Bleomycin genotoxicity and amifostine (WR-2721)
bitors
cell protection in normal leukocytes vs. K562 tumoral
Emilio Ciusani, Paola Perego, Nives Carenini,
cells
Elisabetta Corna, Federica Facchinetti,
Annamaria Buschini, Chiara Alessandrini,
Amerigo Boiardi, Andrea Salmaggi and
Anna Martino, Luca Pasini, Vittorio Rizzoli,
Franco Zunino
Carmelo Carlo-Stella, Paola Poli and Carlo Rossi
Substrate specificity for rat cytochrome P450 (CYP)
isoforms: screening with cDNA-expressed systems of HORMONES AND GROWTH FACTORS
the rat
Stimulation of catecholamine biosynthesis via the
Kaoru Kobayashi, Kikuko Urashima, Noriaki Shimada
protein kinase C pathway by endothelin-1 in PC12
and Kan Chiba rat pheochromocytoma cells
Kazuhiro Takekoshi, Kiyoaki Ishii, Shunsuke Shibuya,
A doxorubicin-CNGRC-peptide conjugate with pro-
Yasushi Kawakami, Kazumasa Isobe and Toshiaki Nakai
drug properties
Yvette van Henshergen, Henk J. Broxterman, Effect of clofibrate administration on the esterifica-
Yvonne W. Elderkamp, Jan Lankelma, tion and deesterification of steroid hormones by liver
Judith C.C. Beers, Marc Heijn, Epie Boven, and extrahepatic tissues in rats
Klaas Hoekman and Herbert M. Pinedo Shiyao Xu, Bao Ting Zhu and Allan H. Conney
Exendin-4 increases insulin sensitivity via a PI-3-
Selective dopaminergic neurotoxicity of isoquinoline
kinase-dependent mechanism: contrasting effects of
derivatives related to Parkinson’s disease: studies
GLP- |
using heterologous expression systems of the dop-
amine transporter Iskandar Idris, Divina Patiag, Samuel Gray and
Richard Donnelly
Alexander Storch, Stefanie Ott, Yu-I] Hwang,
Rainer Ortmann, Andreas Hem, Stefan Frenzel,
Kazuo Matsubara, Shigeru Ohta, Hans-Uwe Wolf GENE EXPRESSION AND DEVELOPMENT
and Johannes Schwarz
Effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-
ethane (p,p'’-DDT) on 3T3-L1 and 3T3-F442A adi-
Reduction of acute photodamage in skin by topical
pocyte differentiation
application of a novel PARP inhibitor
Maria J. Moreno-Aliaga and Fumio Matsumura
I3 eatrix Farkas, Marta Magyarlaki, Bela Csete,
ay
Jozs eC]f Nemeth, Gyorgy Rabl1l oczky, Sandor Bernath, Differentiation-dependent repression of c-myc, B22,
I) eter Literati Nagy and Balazs Stimegi COX II and COX IV genes in murine erythroleuke-
mia (MEL) cells
Human cytochrome P450s involved in the metabo- loannis S. Vizirianakis, loannis $. Pappas and
lism of 9-cis- and 13-cis-retinoic acids Asterios S. Tsiftsoglou
Julie Marill, Claude C. Capron, Nadia Idres and
Guy G. Chabot
STRUCTURAL BIOLOGY)
Pharmacological characterization of the ATP-depen- Dimerumic acid as an antioxidant from the mold,
dent low K guanosine 3’,5'-cyclic monophosphate Monascus anka: the inhibition mechanisms against
(cGMP) transporter in human erythrocytes lipid peroxidation and hemeprotein-mediated oxida-
Elisabeth Sundkvist, Ragnhild Jaeger and tion
Georg Sager Junsei Taira, Chika Miyagi and Yoko Aniya
Jolkinolide B induces neuroendocrine differentiation
of human prostate LNCaP cancer cell line
W.K. Liu, J.C.K. Ho, Guowei Qin and Chun-Tao Che 15 March 2002
Involvement of phosphatidylinositol-3-kinase in
membrane ruffling induced by P-glycoprotein sub- Commentary
strates in multidrug-resistant carcinoma cells GTP-binding proteins in cell survival and demise: the
Jin-Ming Yang, Andrew Vassil and emerging picture in the pancreatic B-cell
William N. Hait Anjaneyulu Kowluru and Noel G. Morgan
Contents of Volume 63 2215
Rapid Communication 1119 Apoptosis induced by extracellular ATP in the mouse
1037 «-Opioid receptor agonist inhibition of HIV-1 envel- neuroblastoma cell line N1E-115: studies on involve-
ope glycoprotein-mediated membrane fusion and ment of P2 receptors and adenosine
CXCR4 expression on CD4 lymphocytes
S. Mariétte Schrier, Bogdan I. Florea, Gerard J. Mulder,
James R. Lokensgard, Genya Gekker and J. Fred Nagelkerke and Ad P. IJzerman
Phillip K. Peterson
Inhibition of rat lipoprotein oxidation after tetra-
decylthioacetic acid feeding
Ziad A. Muna, Oddrun A. Gudbrandsen,
MOLECULAR AND CELLULAR PHARMACOLOGY
Hege Wergedahl, Pavol Bohov, Jon Skorve and
Induction of arginase II in livers of bile duct-ligated Rolf K. Berge
rats
Lack of involvement of extracellular signal-regulated
Chang-Li Wei, Wei-Min Hon,
kinase (ERK) in the agonist-induced endothelial
Kang-Hoe Lee, Masataka Mori,
nitric oxide synthesis
Tomomi Gotoh and Hoon-Eng Khoo
Kurt Schmidt, Hanan D. Gibraeil and Bernd Mayer
Cytoprotective role of taurine in a renal epithelial
Characterization of anthracenediones and_ their
cell culture model
photoaffinity analogs
Barbel Eppler and Ralph Dawson Jr.
Kai-Ming Chou, A. Paul Krapcho, David Horn
A glutamate-gated chloride channel subunit from and Miles Hacker
Haemonchus contortus: Expression in a mammalian
cell line, ligand binding, and modulation of anthel-
CHEMOTHERAPY AND METABOLIC INHIBITORS
mintic binding by glutamate
Sean G. Forrester, Roger K. Prichard and Overexpression of sorcin, a calcium-binding protein,
Robin N. Beech induces a low level of paclitaxel resistance in human
ovarian and breast cancer cells
Inhibition of type | protein phosphatase activity by
Hemant K. Parekh, Hong Bing Deng,
activation of B-adrenoceptors in ventricular myo-
Khuram Choudhary, Steven R. Houser and
cardium
Henry Simpkins
Ramesh C. Gupta, John Neumann,
August M. Watanabe and Hani N. Sabbah
NEUROSCIENCE
Relative importance of maternal and embryonic
microsomal epoxide hydrolase in 7,12-dimethylbenz- The distribution of copper, zinc- and manganese-
[aJanthracene-induced developmental toxicity superoxide dismutase, and glutathione peroxidase
messenger ribonucleic acid in rat basal ganglia
Masaaki Miyata, Kazuko Motoki, Etsuko Tamura,
Masayuki Furukawa, Frank J. Gonzalez and Grazyna Kunikowska and Peter Jenner
Yasushi Yamazoe
HORMONES AND GROWTH FACTORS
Bcl-2 family-mediated apoptotic effects of 3,3’-diin-
dolylmethane (DIM) in human breast cancer cells 1165 Structure—activity relationships for inhibition of
human 5a-reductases by polyphenols
Chibo Hong, Gary L. Firestone and
Leonard F. Bjeldanes Richard A. Hiipakka, Han-Zhong Zhang, Wei Dai,
Qing Dai and Shutsung Liao
BGP-15 —a_ novel poly(ADP-ribose) polymerase
inhibitor — protects against nephrotoxicity of cispla- 1177 The effects of natural ligands of hormone receptors
tin without compromising its antitumor activity and their antagonists on telomerase activity in the
Ildiko Racz, Kalman Tory, Ferenc Gallyas Jr., androgen sensitive prostatic cancer cell line LNCaP
Zoltan Berente, Erzsebet Osz, Laszlo Jaszlits, Jan Bouchal, Zdenék Kolay, Jana Mad’ arova,
Sandor Bernath, Balazs Sumegi, Gyorgy Rabloczky Alice Hlobilkovd and Erwin von Angerer
and Peter Literati-Nagy
INFLAMMATION AND IMMUNOPHARMACOLOG)
Characterization of the mechanism underlying sto-
nustoxin-mediated relaxant response in the rat aorta 1183 Inhibition of inducible prostaglandin E, synthase by
c 12,14
in vitro 15-deoxy-A’~"'*-prostaglandin J) and polyunsaturated
fatty acids
Julia Mei Li Sung, Kerwin Siew Yang Low and
Hoon Eng Khoo Omar Quraishi, Joseph A. Mancini and Denis Riendeau
Contents of Volume 63
1 April 2002 Miriam Cnop, Jean Claude Hannaert and
Daniel G. Pipeleers
Commentary 1287 Effect of protein-bound uraemic toxins on the
1191 Chemokines as novel therapeutic targets in inflam- thermodynamic characteristics of human albumin
matory diseases Veronika V. Samatskaya, W. Edward Lindup,
Toshimitsu Niwa, Andrey I. Ivanov, Larisa A. Yushko,
Maureen N. Ajuebor, Mark G. Swain and
John Tjia, Vitaly N. Maslenny, Ludmila N. Korneeva
Mauro Perretti
and Vladimir G. Nikolaev
1297 Dose-dependent cysteine-mediated protection of
M
insulin-producing cells from damage by hydrogen per-
Selective inhibition of STAT3 phosphorylation by oxide
sodium salicylate in cardiac fibroblasts
Suvi Rasilainen, Jenni M. Nieminen,
Zhongyan Wang, Bingbing Jiang and Peter Brecher Anna-Liisa Levonen, Timo Otonkoski and Risto Lapatto
In vitro pharmacokinetics and pharmacodynamics of 1305 Modulation of apoptosis and improved redox meta-
1 ,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) bolism with the use of a new antioxidant formula
Hiroko Ueda-Kawamitsu, Terence A. Lawson and Luciana Mosca, Sonia Marcellini, Marzia Perluigi,
Peter R. Gwilt Paola Mastroiacovo, Sonia Moretti, Giuseppe Famularo,
Ilaria Peluso, Gino Santini and Claudio De Simone
Biochemical changes associated with a multidrug-
resistant phenotype of a human glioma cell line with 1315 A selective plasmin inhibitor, trans-aminomethylcy-
temozolomide-acquired resistance clohexanecarbonyl-L-(O-picolyl)tyrosine-octylamide
Jianguo Ma, Maureen Murphy, Peter J. O’ Dwyer, (YO-2), induces thymocyte apoptosis
Eric Berman, Karin Reed and James M. Gallo Eibai Lee, Rivo Enomoto, Kazu Takemura,
Chronic ethanol administration decreases the ligan1d¢ Yuko Tsuda and Yoshio Okada
binding properties and the cellular content of the
mannose 6-phosphate/insulin-like growth factor II] HERAPY AND METABO
receptor in rat hepatocytes
1325 Protection by ascorbic acid from denaturation and
Jan 1 es Haorah, Daniel L. McVicker, James C. Byrd,
release of cytochrome c, alteration of mitochondrial
Richard G. MacDonald and Terrence M. Donohue Jr
membrane potential and activation of multiple cas-
Sensitization of human neutrophil defense activities pases induced by H2O>, in human leukemia cells
through activation of platelet-activating factor recep- Tal Gruss-Fischer and Ina Fabian
tors by ginkgolide B, a bioactive component of the
1337 Stem cell toxicity of oxazaphosphorine metabolites in
Ginkgo biloba extract EGB 761
comparison to their antileukemic activity
Monique Lenoir, Eric Pedruzzi, Samira Rais,
Katy Drieu and Axel Perianin Svenja K. Brueggemann, Peter Schlenke,
Stephanie Klich, Michael Deeken, Stefan O. Peters
Induction of G>/M arrest and inhibition of c-myc and and Thomas Wagner
p53 transcription by WP631 in Jurkat T lymphocytes
Silvia Villamarin, Neus Ferrer-Miralles, Sylvia Mansilla,
Waldemar Priebe and José Portugal
Obligatory role of membrane events in the regulatory
1343 Modulation of dendritic release of dopamine by meta-
effect of metformin on the respiratory chain function botropic glutamate receptors in rat substantia nigra
Dominique Detaille, Bruno Guigas, Xavier Leverve,
Jorge M. Campusano, Jorge Abarca, Maria Inés Forvay,
Nicolas Wiernsperger and Pierre Devos Katia Gysling and Gonzalo Bustos
Distinct binding properties of the AT, receptor
antagonist [’H]candesartan to intact cells and mem-
brane preparations GENE EXPRESSION AND DEVELOPMENT
Frederik L.P. Fierens, Patrick M.L. Vanderheyden, 1353 Developmental regulation of — flavin-containing
Chantal Roggeman, Pascal Vande Gucht, monooxygenase form | in the liver and kidney of fetal
Jean-Paul De Backer and Georges Vauquelin and neonatal rabbits
Troglitazone does not protect rat pancreatic f cells Shelley A. Larsen-Su, Sharon K. Krueger, Mei-Fei Yueh,
against free fatty acid-induced cytotoxicity Clifford B. Pereira and David E. Williams