Biochemical Pharmacology 1992: Vol 44 Index

33 Pages·1992·11.8 MB·English

BIOCHEMICAL PHARMACOLOGY
SUBJECT INDEX FOR VOLUME 44, 1992
A23187 N-Acetyltransferase(contd. )
effect on glutathione S-transferase in liver, effect of exercise 121
isoenzymes in hepatocytes 2099 Acetyltransferase/cyt P450 system
induced mediator release from lung 6-aminochrysene activation 913
pleura 1609 al-Acid glycoprotein
mitogenic response in thymocytes, in serum, effect of interleukin-6
effect of staurosporine 1563 137
stimulated cyclic AMP production in Acid phosphatase
pancreatic islets, effect of biliary secretion, effect of cyclo-
cyclosporin A 359 sporin A 1105
Acanthocheilonema viteae Acitretin
effect of 2,2'-dicarbomethoaxmiyn]o- binding to plasma proteins and
5,5'-dibenzimidazolyl ketone on erythrocytes 1891
antioxidant defenses 72/7 Actin cytoskeleton
Acetaldehyde role in dopamine formation in
catalase mediated production in kidney 1883
brain homogenates 93 Actinonin
Acetaldehyde-tubulin adducts inhibition of zinc aminopeptidases
inhibition of microtubulin formation 1725
65 Acyl glucuronides, albumin glycation
Acetaminophen 1661
depletion of glutathione and cysteine Adenosine
in aging mouse kidney 129 N6-methylated derivatives, inhibition
glucuronidation in liver, effect of of MEL cell differentiation 927
malaria infection 1879 Adenosine deaminase
effect on glutathione and adenosine inhibition by azapurine ribonucleo-
3'-phosphate 5'-phosphoslufate sides 1697
syntheses in hepatocytes 447 Adenosine-3' ,5'-monophosphate
hepatotoxicity adrenal medullary cells 2105
effect of dietary fat 1303 in brain
hepatic respiration and ATP effect of antidepressants 1067
depletion 163 effect of dopamine agonist and
Acetyl-L-carnitine antagonists following 6-hydroxy-
stimulation of nerve growth factor dopamine lesion 73
receptors in PCl12 cells 577 effect of methylparaben 1053
Acetylcholine effect of reserpine 83
effect on phosphoinositides in adrenal effect on hepatocyte growth factor-
cells 441 induced mitogenesis 1037
Acetylcholine reactivators in pancreatic islets, effect of
binding to proteoglycans in chondro- cyclosporin A 359
cytes and fibroblasts 1927 in parotid cells, effect of monensin
Acetylcholinesterase 1395
inhibition by phenothiazines 15ll in peripheral blood mononuclear cells,
N-Acetylcysteine effect of albumin 351
effect on adriamycin-induced lipid role in histamine-induced different-
peroxidation in heart and liver iation of HL-60 cells 1115
839 Adenosine monophosphate kinase
Acetylenes in L1210 cells, phosphorylation of
inhibition of cyt P450 1Al and acyclic nucleotide analogs 2067
P450 2Bl in liver microsomes 787 Adenosine-3',5'-monophosphate phospho-
N-Acetylglucosaminidase diesterase
release from lysosomes, effect of in adipocytes, effect of flavonoids
flavonoids 1243 1307
N-Acetyltransferase Adenosine 3'-phosphate 5'-phospho-
in human red blood cells 1099 sulfate
BIOCHEMICAL PHARMACOLOGY
Adenosine 3'-phosphate 5'-phospho- Adrenaline
sulfate effect on glucose metabolism and
synthesis in hepatocytes, effects of HO» in macrophages 2235
cysteine and acetaminophen 447 3-Adrénergic agonists
Adenosine A2 receptors characterization in liver plasma
striatum, ion effects on 2365 membranes 2333
Ht+,K*t-Adenosine triphosphatase Bp-Adrenergic receptors
gastric adipocytes, sheep and rat 681
inhibition by cassigarol A 33 colon, atypical 665
effect of stilbene derivatives Adrenergic transmission
1947 effect of antidepressants 1067
Nat,Kt-Adenosine triphosphatase Adrenocortical cells
kidney substance P-induced protein synthesis
effect of calcium antagonists 1529 1357
inhibition by B-eudesmol 373,993 Adriamycin
Adenosine triphosphate accumulation in multidrug-resistant
in liver, effect of acetaminophen 163 cells, effect of Servier 9788
effect on NIE-115 cells 1479 1707
S-Adenosyl-L-methionine effect on glucuronidation and lipid
photoaffinity labeling of thiopurine peroxidation in liver 747, 755
methyltransferase in kidney 775 inactivation in multidrug-resistant
S-Adenosylmethionine/S-adenosylhomo- cells 1869
cysteine ratio resistant Chinese hamster cell lines
in pig tissues, effect of nitrous 1859
oxide 1349 toxicity in mice, effect of ebselen
S-Adenosylmethionine decarboxylase 839
in brain after trauma 401 Adriamycin + carmustine
in Trypanosoma brucei brucei, inhib- nuclear glutathione depletion 1383
ition by S-adenosylmethionine AFK-108
analogues 905 interaction with cyt P450,4pmM 1701
Adenylate cyclase Aging
in liver plasma membranes, effect of acetaminophen-induced depletion of
p3-agonists 2333 glutathione in kidney 129
in peripheral blood mononuclear cells, acetyl-L-carnitine stimulation of
effect of albumin 351 nerve growth factor receptors in
in pituitary tumor cells, effect of PCl12 cells 577
hypothalamic hormones 4/71 effect on cyt P450 IIIA in human
role in hepatocyte growth factor liver 275
induced hepatocyte proliferation AIDS
1037 AZT-induced anaemia 1009
in striatum Albumin
dopamine receptor interaction 73, effect on adenylate cyclase in
83 peripheral blood mononuclear cells
reserpine-induced down regulation 351
83 anthracycline interaction, effect
Adipocytes of pH 2347
p-adrenergic receptors 681 BW348U87 binding 1417
effect of BQ-123 on ET-1l-induced drug binding sites 873
reduction of lipoprotein lipase etretinate and acitretin binding
1431 1891
effect of flavonoids on cyclic AMP fluorescence quenching by xanthines
phosphodiesterase and lipid 824
mobilization 1307 glycation by acylglucuronides 1661
insulin-like effects of molybdate + L-tryptophan and 6-fluoro-DL-
H»02 or tungstate + H207 174 tryptophan binding 2082
adrenal gland warfarin, salicylate and diazepam
cyclic AMP metabolism in medullary binding to variants 1515
cells 2105 Alcohol
clonidine-displacing substance in 733 effect on hepatic gluconeogenesis
effect of ethanol on benzodiazepine 1617
receptors 1335 Alcohol dehydrogenase
phosphoinositides in cultured zona in hepatocytes, effect of serum-free
fasciculata/reticularis cells 441 medium 1461
prostaglandin E2-induced arachidonic in yeast, inactivation by alkyl-
acid release and catecholamine peroxyl radicals 1443
secretion from chromaffin cells Aldehyde dehydrogenase
2315 in liver
regulation of epoxide hydrolase in activation at physiological
liver 815 temperatures 2425
effect of sea urchin toxin on catech- phenobarbital induction, strain
olamine secretion and synthesis and species differences 1651
1779 Aldose reductase
Adrenaline sorbinil binding 2427
BIOCHEMICAL PHARMACOLOGY
Aldose reductase inhibitors Aminopyrine N-demethylase
effect on composition of rat urine in liver microsomes
231 effect of ethylbenzene 1171
Alkylbenzoylacrylic acids effect of interleukin-la 1669
phospholipase A2 inhibition 805 9-Amino-1,2,3,4-tetrahydroacridine
Alkylperoxyl radicals inhibition of histamine-N-methyl-
inactivation of yeast alcohol dehyd- transferase by fragments of 989
rogenase 1443 3-Amino-1,2,4-triazole
Allergic diseases catalase inhibition 1535
alkylbenzoylacrylic acids in treatment Amitriptyline
805 effect on central adrenergic trans-
Alloxan mission 1067
induced hyperglycaemia, inhibition Amsacrine
of 2111 oxidation by myeloperoxidase 1731
Alphazolone Amylase
effect on flunitrazepam binding in induction of nitrogen oxide release
brain 1297 by alveolar macrophages 387
Alveolar macrophages release from parotid cells, effect of
soybean trypsin inhibitor and #-amyl- monensin 1395
ase induced nitrogen oxide release Anaemia
387 AZT-induced 1009
Alveolar type II cells Analgesia
paraquat and putrescine uptake 1029 capsaicin 611
Amastatin Anaphylactic mediators
inhibition of zinc aminopeptidases release from lung pleura 1609
1725 Angiotensin II
Amikacin effect on phosphoinositides in
molecular hydrophobicity potential adrenal cells 441
1967 Angiotensin converting enzyme
Amiloride in lung, inhibition by lisinopril
effect on atrial muscle 425 and its dansyl derivative 565
Amino alcohols in serum, effect of cadmium 187
Ca2+ channel blocking activity 2039
Angiotensin converting enzyme inhibitors
3-Amino-1,2,4-benzotriazene-1,4-dioxide effect on zinc aminopeptidases 1725
reductive bioactivation 25] Aniline hydroxylase
¥-Aminobutyric acid in liver microsomes
metabolism in brain of spontaneously effect of ethylbenzene 1171
hypertensive rats, effect of effect of &-9-tetrahydrocannabinol
propranolol 465 + theophylline 2021
in pancreatic islets l Aniline mustards
release from synaptosomes, effect of cytotoxicity, DNA crosslinking and
depolarizing agents 301 DNA sequence selectivity 59
X-Aminobutyric acid A receptor Ansamycin conjugate
effect of free fatty acids on ligand uptake by liver 2117
binding 11 Anthocyanidin
temperature and anion dependence of a of glutathione reductase
allosteric interactions 1297 603
X¥-Aminobutyric acid transaminase Anthracyclines
in pancreatic islets l effect on membrane phospholipid
6-Aminochrysene homeostasis 1139
activation by rat liver cyt P450s 913 protein binding, effect of pH 2347
2-Aminof luorene Antibody Directed Enzyme Prodrug
oxidative activation by human red Therapy 631, 2289, 2297
blood cell cytosol 2422 Antidepressants
Aminoglycosides effect on central adrenergic trans-
molecular hydrophobicity potential mission 1067
1967 Antiflammins
5-Aminolevulinic acid synthase effect on human phospholipase A2 519
in Gunn rat liver mitochondria 1465 in vitro and in vivo effects 1437
Aminooxyacetate Antimalarials
effect on fluorescein uptake in effect on primaquine metabolism by
renal tubules 2213 human liver microsomes 587
Aminopeptidases N, A and W Antimony
kidney, inhibition of 1725 biliary excretion, role of glutathione
Aminopeptidase P 1275
platelets 4/79 Antioxidants
Aminophospholipid — acid-glutathione interaction
asymmetry in synaptosomes, effect of 05
phospholipase A2 toxins and boldine 1765
enzymes 1073 coumarins 205
4-Aminopyridine dihydrolipoic acid 1637
effect on GABA release from synapt- ebselen 39
osomes 301 in heart, effect of ethanol 1495
BIOCHEMICAL PHARMACOLOGY
Antioxidants(contd. ) eocenes acid 2-0-a-glucoside(contd. )
inhibition of porcine 5-lipoxygenase 2191
157 Ascorbyl radical
effect on synaptosomal amine uptake reduction by dihydrolipoic acid 1637
2395 Asialoglycoprotein receptor
«l-Antiproteinase liver, drug targeting 2117
inactivation by phenylbutazone + haem Asparaginase
proteins 981 induced histamine release from
Antitumor drugs mast cells 533
effect on membrane phospholipid Atherogenesis
homeostasis 1139 effect of dihydropyridine calcium
Antitumor ether lipids 819 channel blockers 2379
Aorta Atrial muscle
effect of cyclic AMP phosphodiester- effect of TMB8 425
ase inhibitors on DNA synthesis Atrial natriuretic factor
in smooth muscle cells 85/7 pharmacokinetics in anaesthetized
endothelin release from endothelial rats 1013
cells 851 Audiogenic seizures
Al2-PGJ2-induced protein synthesis effect on tribulin in brain 1209
in endothelial cells, effect of Auranofin
glutathione 1597 effect on PMN activation 1091
Apoptosis Aurocyanide
in thymocytes from dexamethasone- .
effect on PMN activation 1091
treated rats 2131 Aurothiomalate
1-B-D-Arabinosylcytosine
effect on PMN activation 1091
effect on polyamines in male access- Azapurine ribonucleosides
ory organs 593 inhibition of adenosine deaminase
Arachidonic acid 1697
Ca2+-dependent release from neutro- 3'-Azido-3'-deoxythymidine
phils 2055 effect on erythropoietin receptor
effect on GABA, receptor ligand 1009
binding 11 glucuronidation in liver, effect of
liberation in mast cells, effect of malaria infection 1879
biscloclaurine alkaloids 45 3'-Azido-2' ,3'-dideoxyuridine
metabolism in platelets, effect of a disposition in hepatocytes
hypoglycaemic agents 68/7
PGE2-induced release from cultured Azidopine
chromaffin cells 2315 labeling of P-glycoprotein in
in thrombocytes from schizophrenic P388/ADR plasma membranes’ 1707
patients, effect of neuroleptics Aziridinylalkylamines
317 inhibition of diamine oxidase 1229
Arachidonic acid cascade 5-(Aziridinyl-1l-yl)-2,4-dinitrobenz-
PAF formation 1001 amide
Argatroban bioactivation 2289, 2297
effect on thrombin-induced responses potentiation of cytotoxicity by
in endothelial cells 2409 reduced pyridine nucleotides 1739
Aristolochic acid reduction by DT diaphorase
effect on lysoPAF production and NAD* as cofactor 631
arachidonic acid release 2055 novel co-factors 25
Aroclor 1254 2,2'-Azobis(2-amidopropane)
induction of cyt P450 activities in inactivation of yeast alcohol
hepatocytes 455 dehydrogenase 1443
Arteparon Azole antifungal agent AFK-108
effect on metalloproteinases 1549 inhibition of lanosterol 14&-demethyl-
Arthritis ase in yeast 1/701
tetracyclines and phospholipase A2
1165
treatment with fluoromethyl ketones Barbital
1201 induction of hepatic drug-metabolizing
2-Arylpropionyl-coenzyme A thioesters enzymes 1651
Co-A ligase catalysing formation of Barbiturates
2415 protection against alloxan toxicity
Ascorbic acid
glutathione interaction 1905 Bay K8644
induced decrease in synaptosomal effect on calcium uptake by liver
amine uptake, effect of antioxid- plasma membrane vesicles 1214
ants 2395 inhibition of PN200-110 binding in
prooxidant action in fibroblasts heart, effect of GTP-%-S 1680
2191 BAY U 3405
effect on prooxidant effect of binding to platelets 495
phenylbutazone 981 Benf luorex
Ascorbic acid 2-Q-a#-glucoside — on glucose metabolism in rats
cytotoxicity to cultured fibroblasts
BIOCHEMICAL PHARMACOLOGY 5
Benoxaprofen 2',7'-Bis(2-carboxye)t-5h(y6l)-
effect on peroxisomal palmitoyl-CoA carboxyfluorescein
ligase 261 polarized efflux from cultured
Benz(a)anthracene quinone epithelial cells 417
reduction by liver dihydrodiol 4-(Bis(2-chloroethyl)amino)benzoic acid
dehydrogenase 341 cytotoxicity, DNA crosslinking and
Benzoate DNA sequence selectivity of 59
effect on chiral inversion of ibupro- Biscoclaurine alkaloids
fen in hepatocytes 1468 inhibition of mast cell phospho-
Benzodiazepine receptors lipase A2 45
in brain 1,3-Bis-(3,4-dichlorophenyl )-2-thiourea
effect of ethanol 1335 oxidation in mammalian tissues 2029
imidazo(1,2-b)pyridazines as Bismuth
ligands 1555 biliary excretion, role of glutathione
in liver mitochondria, effect of 1275
protoporphyria 1159 Bleomycin
peripheral type genotoxicity in hepatocytes 1255
human lymphocytes and lymphoma induced DNA damage, inhibition of
cells 269 repair by 2'-deoxycoformycin 2229
imidazo(1,2-b)pyridazines as Blood
ligands 1555 NAD(P)H metabolism 631
Benzoic acids Blood flow
quantitative structure-metabolism heart, effect of furoxans 1149
relationships 1935 Blood pressure
Benzo(a)pyrene effect of cadmium 187
metabolism in cryopreserved liver Boldine
parenchymal cells 309 antioxidant activity in liver 1765
microsomal biotransformation in rat Bone marrow progenitor cells
tissues, effect of ethanol 1977 cytotoxicity of 2',3'-dideoxy-3'-
Benzo(a)pyrene quinone thiacytidine enantiomers 1921
reduction by liver dihydrodiol effect of zidovudine on erythro-
dehydrogenase 341 poietin receptor 1009
1,4-Benzoquinone BQ-123
reduction by liver dihydrodiol suppressive effect on ET-1l-induced
dehydrogenase 341 reduction of lipoprotein lipase
Benzphetamine N-demethylase in adipocytes 143]
in hepatocytes, effect of serum-free Bradykinin
medium 1461 cleavage of Arg!-Pro2 bond by
in liver aminopeptidase P in human platelets
effect clotrimazole 2266 479
effect ethylbenzene 1171 Brain
effect exercise 121 effect of antidepressants on
effect interleukin-1 1669 adrenergic transmission 1067
Bepridil clonidine-displacing substance in
effect on Nat,K*-ATPase and sodium 733
pump 1529 cyt P450 in microsomes 1223
Berbamine 4-DAMP mustard inactivates muscarinic
effect on arachidonic acid liberation receptors 285
in mast cells 45 effect of (-)deprenyl infusion on
Berbamine compound E6 superoxide dismutase and catalase
interaction with calmodulin-dependent 2185
myosin light-chain kinase 1543 effect of ethanol on benzodiazepine
Berenil receptors 1335
inhibition of enzymes of polyamine 5-fluoro-DOPA and 6-fluoro-DOPA
back-conversion 830 metabolism in cultured fetal cells
Bestatin 99
inhibition of zinc aminopeptidases GABAergic system and propranolol
1725 hypotension 465
Bile haloperidol reductase in 867
antimony and bismuth excretion 1275 histamine H3 receptors 1261
lipid and protein secretion, effect methionine synthase and AdoMet/AdoHcy
of cyclosporin A 1105 ratio, effect of nitrous oxide
taurocholate-stimulated excretion of 1349
horseradish peroxidase, effect of effect of methylparaben on cyclic
lysosomotropic agents 1683 nucleotides 1053
transport of steroidal muscle polyamine function 401
relaxants 1453 L-tryptophan and 6-fluoro-DL-
Bile acid tryptophan uptake 2082
effect of cyclosporin A on secretion Breast cancer cells
1105 MCF-7
glutathione and synthesis of 1475 diaziquone metabolism 1625
Bile salts drug resistance reversion by
effect on cation uptake in liver 2323 doxorubicin-nanospheres 509
RD AA Tndex-R
BIOCHEMICAL PHARMACOLOGY
Breast cancer cells C5a
MCF-7(contd. ) induced superoxide anion production,
effect of vitamin D analogues on effect of molsidomine 637
proliferation 693, 2273 Cadaverine
MDA468, T47D and ZR75, DT-diaphorase aziridinyl derivatives, inhibition
levels and sensitivity to quinone- of diamine oxidase 1229
based drugs 409 Cadmium
BRL 37,344 decreased glucuronidation in rat 2139
characterization in liver plasma induction of renal and hepatic
membranes 2333 ornithine decarboxylase /721
S-p-Bromobenzylglutathione diethyl ester effect on renin angiotensin system
effect on leukemia HL-60 cells 2357 in rats 187
2-Bromocarboxylic acids Caffeine
conjugation by glutathione S-trans- effect on alloxan toxicity 2111
ferases 1249 fluorescence quenching of HSA 824
p-Bromophenacyl bromide Calcipotriol
~ effect on lysoPAF production and effect on breast cancer cell prolif-
arachidonic acid release 2055 eration 693
effect on PGE2-induced catecholamine Calcium
release from chromaffin cells 2315 effect of altered homeostasis on
3-(3-Bromopheny]1 )-2-hydroxy-1(1-(4- glutathione S-transferase iso-
phenylpiperidinyl))propane enzymes in hepatocytes 2099
Ca2+ channel blocking activity 2039 effect on CGS 21680 binding to
Bronchospasm adenosine A2 receptor in striatum
effect of alkylbenzoylacrylic acids 2365
805 dependent arachidonic acid release
Bufurolol monooxygenase from neutrophils 2055
in liver microsomes, effect of S-(1,2-dichlorovinyl )-L-cysteine-
interleukin-lex 1669 induced release from kidney
B-Bungarotoxin mitochondria 1131
effect on aminophospholipid asymmetry in endothelial cells, effect of
1073 thrombin 2409
Butein homeostasis in brain, effect of
effect on lipolysis in adipocytes polyamines 401
1307 human phospholipase A2 responses to
Buthionine sulfoximine 1849
effect on enalapril hepatotoxicity independent and dependent release of
1803 GABA, effect of depolarizing
glutathione-ascorbic acid interaction agents 301
1905 influence on activation of glycogen-
glutathione depletion in melanoma olysis by methotrexate /76l
cells 1383 metabolism in vivo, effect of
effect on heat and oxidative stress vitamin D analogues 693
in human tumor cells 2126 mitochondrial
effect on mutagenicity of RSU-1069 and role in prooxidant induced cell
RSU-1131 in V79-4 cells 1341 injury 1995
effect on Al2-PGJ2-induced protein effect of trifluoperazine on
synthesis in aortic endothelial prooxidant induced damage 1/795
cells 1597 in N1IE-115 cells, effect of ATP 1479
Butylated hydroxyanisole release from parotid cells, effect of
dietary, induction of rat hepatic and monensin 1395
intestinal glutathione S-transfer- transport in mammary tissue, effect
ases 596 of salicylate 645
inhibition of porcine 5-lipoxygenase uptake by kidney microsomes, effect
157 of ochratoxin A 1401
Butylated hydroxytoluene uptake by liver plasma membrane
inhibition of porcine 5-lipoxygenase vesicles, effect of 1,4-dihydro-
157 pyridines 1214
t-Butylbicyclophosphorothionate Calcium antagonists
binding in brain, effect of free effect on Na*+,K*t-ATPase in kidney
fatty acids 11 1529
t-Butyl hydroperoxide protection against hypoxic liver
effect on glutathione S-transferase injury 2207
isoenzymes in hepatocytes 2099 protection against oxidized LDL in
induced cell injury, effect of lymphoid cells 2379
cyclosporin A 1995 Calcium channels
effect on protein S-thiolation in in heart, effect of G proteins 1680
endothelial cells 1757 Calcium/sodium exchange
toxicity in hepatocytes, effect of in atrial muscle, effect of TMB8 425
iron 1367 Calmodulin
BW348U87 dependent myosin light chain kinase,
binding to HSA 1417 interaction with berbamine
compound E6 1543
BIOCHEMICAL PHARMACOLOGY
Calmodulin binding protein Cepharanthine
synthesis in adrenocortical cells in effect on arachidonic acid liberat-
substance P-induced steroido- ion in mast cells 45
genesis 1357 Cerium
Candoxatrilat effect on cyt P4502a-4/5 expression
effect on clearance of atrial natri- in liver and kidney 1269
uretic factor in rats 1013 CGP 12,177A
Capsaicin characterization in liver plasma
neuropharmacology 611 membranes 2333
Capsazepine 611 CGP 20712A
Captan effect on iodocyanopindolol binding
inhibition of RNA polymerase 2251 in adipose tissue 681
Captopril CGS 21680
effect on zinc aminopeptidases 1725 binding to adenosine A2 receptors in
Carbachol striatum, ion effects 2365
induced catecholamine secretion, Chalcone
effect of sea urchin toxin 1/779 inhibition of glutathione reductase
Carbamazepine 1603
cyt P450 3A-mediated bioactivation Chelators
2307 in vivo iron mobilization 1023
p-Carbolines Chemoattractants
inhibition of histamine-N-methyltrans- induced respiratory burst in neutro-
ferase 989 phils, effect of sydonimines 637
Carbonyl reduction Chinese hamster lung cells
in continuous cell lines 2005 adriamycin resistant and radiation-
Carboplatin sensitive lines 1859, 1869
induced histamine release from mast 5,11-dimethy1l-5H-indolo(2,3-b)-
cells 533 quinoline toxicity 2149
Carboxylesterase effect of Servier 9788 1707
in rat and guinea pig tissues, mono- Chinese hamster ovary cells LR73MDR
clonal antibodies to isoenzymes 509
171 Chlorambucil
in rat liver cells 827 cytotoxicity, DNA crosslinking and
Cardiac glycosides DNA sequence selectivity 59
effect on cation uptake in liver 2323 DNA adducts 571
Carnitine 1-Chloro-2,4-dinitrobenzene
in rat organs, effect of pivampicillin conjugation by glutathione S-trans-
1226 ferase, effect of dicumarol 921
Cassigarol A 8-(4-Chlorophenyl)thio-cyclic AMP
inhibition of gastric H*+,K*t-ATPase inhibition of phosphodiesterase Va
and acid secretion 33 2303
Catalase Chloroquine
in Acanthocheilonema viteae and its accumulation in Plasmodium falciparum
host tissue, effect of compound 1317
82/437 727 effect on taurocholate-stimulated
in brain and liver, effect of biliary excretion of horseradish
(-)-deprenyl infusion 2185 peroxidase 1683
mediated ethanol metabolism in brain Chlorpromazine
93 effect on cyt P450s in liver 1219
Catechin effect on platelet phosphoinositide
effect on cyclic AMP phosphodiesterase metabolism 2013
in adipocytes 1307 Cholesterol
inhibition of glutathione reductase biliary secretion, effect of
1603 cyclosporin A 1105
effect on lysosomes subjected to effect on membrane actions of
stress 1243 ethanol 769
Catecholamines Cholesterol 7&«-hydroxylase mRNA
PGE2-induced release from cultured in Hep G2 cells, effect of glutath-
chromaffin cells 2315 ione 1475
secretion and synthesis in adrenal Chondrocytes
medullary cells, effect of sea binding of oxime acetylcholinester-
urchin toxin 1779 ase reactivators to proteoglycans
Cathepsin B 1927
in liver and kidney, inhibition by Chondroprotective drugs
peptidyl fluoromethyl ketones effect on metalloproteinases 1549
1201 Chromaffin cells
Cations catecholamine release by PGE2 2315
effect on adenosine A2 receptors 2365 cyclic AMP metabolism in 2105
multispecific uptake system in liver Chromanoxyl radical
2323 reduction by dihydrolipoic acid 1637
transport in mammary tissue, effect Chrysene quinone
of salicylate 645 reduction by liver dihydrodiol
Cepharanthine dehydrogenase 341
BIOCHEMICAL PHARMACOLOGY
CI-921 Concanavalin A(contd.)
oxidation by myeloperoxidase 1731 effect of staurosporine 1563
CI-972 Corn oil
in_vitro and in vivo activities 996 effect on UDP-glucuronosyltransferase
Cicloprofen in liver 335
effect on peroxisomal palmitoyl-CoA Cortisol
ligase 261 substance P-induced secretion 1357
Cinnarizine COS-1 cells
oxidative metabolism in liver micro- folate receptor characteristics 1898
somes 1471 Coumarin
Ciprofibrate interaction with reactive oxygen
effect on peroxisomal palmitoyl-CoA species 205
ligase 261 toxicity in hepatocytes, effect of
Cisplatin serum-free medium 1461
effect on gene expression in CV-1 Coumarin 7-hydroxylase
cells 107 in liver
nephrotoxicity, role in lipid effect of cerium 1269
peroxidation 1193 hamster, effect of clotrimazole
resistant lung squamous carcinoma 2266
cell line, reduced drug accumulat- Cryopreserved liver cells
ion in 394 metabolism in 309
toxicity in LLC-PK) cells, effect of Cumeme hydroperoxide
ebselen 382 induced cell injury, effect of
Citralopram cyclosporin A_ 1995
effect on central adrenergic trans- reduction by glutathione peroxidase,
mission 1067 effect of dicumarol 921
Clonidine-displacing substances CV-1 cells
in peripheral tissues and serum /733 cisplatin and gene expression 107
Clopidogrel a-Cyano-4-hydroxycinnamate
hepatic metabolism 52/7 effect on fluorescein uptake in
Clotrimazole renal tubules 2213
modulation of hepatic cyt P450s in Cyclic nucleotide phosphodiesterases
Syrian and Chinese hamsters 2266 in adrenal medullary cells, regulation
c-myc RNA of cyclic AMP metabolism 2105
in HL-60 cells, effect of 3-deaze-(*)- in aortic smooth muscle, regulation
aristomycin 1283 of DNA synthesis 857
CoA in brain, effect of methylparaben
in liver mitochondria, effect of 1053
ibuprofen enantiomers 1291 inhibition by 8-(4-chlorophenyl)thio-
CoA ligase cyclic AMP 2303
in liver microsomes, formation of in pancreatic islets, effect of
2-arylpropionyl-CoA thioesters cyclosporin A 359
2415 Cyclic nucleotide phosphodiesterase
Cobalt protoporphyrin inhibitors
effect on enalapril hepatotoxicity inhibition of smooth muscle cell
1803 proliferation 85/7
Coformycin Cycloheximide
inhibition of adenosine deaminase inhibition of cyclooxygenase product
1697 formation 955
Colchicine inhibition of mast cell 5-HT release
effect on dopamine synthesis in 659
kidney 1883 Cyclooxygenase
Collagenase in monocytes, regulation via protein
effect of chrondroprotective drugs synthesis 955
1549 Cyclophosphamide
Colon effect on glucuronidation and lipid
phenylethanolaminotetralines compete peroxidation in liver 747
with dihydroalprenolol binding 665 Cyclosporin A
Colon tumor cells effect on cyclic AMP system in
aniline mustard toxicity 59 pancreatic islets 359
DT-diaphorase levels and sensitivity inhibition of biliary lipid and
to quinone-based drugs 409 protein secretion 1105
effect of fatty acid conjugates of prevention of hepatotoxic effects of
2'-deoxy-5-fluorouridine 149 l-methyl-4-phenylpyridinium 833
effect of Servier 9788 1707 protection against prooxidant-induced
effect of SRI 62-834 819 cell killing 1995
effect of woodfruticosin 1961 Cypla-l gene expression
Compound 48/80 n cultured mouse hepatocytes 51
induced arachidonic acid liberation Cysteine
in mast cells, effect of bisco- effect on glutathione and adenosine
claurine alkaloids 45 3'-phosphate 5'-phosphosulfate
Concanavalin A syntheses in hepatocytes 447
induced thymocyte proliferation, induced generation of nitric oxide
BIOCHEMICAL PHARMACOLOGY
Cysteine(contd. ) Cytochrome P450 3A
from furoxans 1149 in liver
in kidney, depletion by acetaminophen human, effect of age and gender
during aging 129 275
Cytarabine mediated bioactivation of
induced hiatamine release from mast carbamazepine 2307
cells 533 phenobarbital induction, strain
Cytochalasin B and species differences 1651
effect on dopamine synthesis in substrate structure-activity relation-
kidney 1883 ship 2089
Cytochrome b5 Cytochrome P450 4A mRNA
in liver microsomes, effect of in liver, suppression mediated by
perfluoro fatty acids 1183 interferon inducer 604
Cytochrome P450 Cytochrome P450 cl/7
in brain microsomes, human, regional in testes microsomes, inhibition by
differences 1223 ketoconazole 2371
enalapril bioactivation 1803 Cytochrome P45014pm
estradiol metabolism in human liver in yeast, interaction with AFK-108
1745 1701
in hepatocytes, effect of serum-free Cytochrome P450 reductase
medium 1461 in liver microsomes, SR 4233 bioact-
in liver microsomes ivation 251]
6-aminochrysene activation 913 Cytokines
cinnarizine metabolism 14/71 production in HL-60 cells, effect of
effect of ethylbenzene 1171 diethyldithiocarbamate 365
hamster, effect of clotrimazole Cytoskeleton disrupter compounds
2266 effect on dopamine synthesis in
effect of interleukin-6 137 kidney 1883
effect of perfluoro fatty acids
1183
effect of phenothiazines 1219 Dansylsarcosine
SR 4233 bioactivation 25] binding sites on albumins 873
liver parenchymal cells, effect Dapsone
of cryopreservation 309 peroxidase inhibition 553
lung Daunomycin
human, monoclonal antibodies 183 redox activation in erythrocytes
effect of liposome-associated 1535
&-tocopherol on paraquat-induced 3-Deaza-(+)-aristeromycin
changes 1811 effect on steady state levels of
Cytochrome P450 1Al c-myc RNA in HL-60 cells 1283
in hepatocytes, effect of PCBs 455 9-Deazaguanine analogues
in liver microsomes, suicide inhibitors of purine nucleoside
inhibitors /78/7 phosphorylase, in vitro and
Cytochrome P450 2a-4/5 in vivo activities 996
expression in liver and kidney, Debrisoquine 4-hydroxylase cyt P450
effect of cerium 1269 human, in yeast 61/7
Cytochrome P450 2B Debrisoquine monooxygenase
in liver microsomes in liver, effect of interleukin le
inhibition and induction by 1669
promazine and chlorpromazine 1219 Delphinidin chloride
phenobarbital induction, strain inhibition of glutathione reductase
and species differences 1651 1603
suicide inhibitors 78/7 Deltorphin
Cytochrome P450 2B RNA g-opioid receptor binding 1687
expression in lung and liver, effect 4-Demethoxy-daunorubicin
of ethanol during pregnancy 797 interaction with BSA, effect of pH
Cytochrome P450 2Cl1l 2347
in liver microsomes, benzo(a)pyrene 2'-Deoxyadenosine
biotransformation 1977 inhibition of MOLT-4 cell growth,
Cytochrome P450 2D effect of adenosine deaminase
in liver microsomes, effect of inhibitors 1697
interleukin-l« on activity and 2'-Deoxyasenosine-5'-triphosphate
gene expression 1669 analogues
substrate structure-activity relation- inhibition of FIV reverse trans-
ship 2089 criptase 13/75
Cytochrome P450 2D6 2'-Deoxycoformycin/deoxyadenosine
human, in yeast 617 inhibition of repair of bleomycin-
Cytochrome P450 2El induced DNA damage 2229
2,2,2-trifluoroethanol metabolism in Deoxycytidylate deaminase
liver 1829 in leukemia cells, modulation 1819
Cytochrome P450 2E RNA 3'-Deoxy-2',3'-didehydrothymidine
expression in lung and liver, effect cleavage by E.coli thymidine
of ethanol during pregnancy 797 phosphorylase 199
10 BIOCHEMICAL PHARMACOLOGY
2'-Deoxy-5-fluorouridine Dexamethasone(contd. )
fatty acid conjugates, as antitumor in liver microsomes 2307
drugs 149 inhibition of EGR-1 and NF-;,B gene
5'-Deoxy-5'-((2-hydrazin)o-emtethhyyll- expression 1569 235
amino) adenosine effect on testosterone metabolism in
inhibition of S-adenosylmethionine cultured hepatocytes 1523
decarboxylase in Trypanosoma Diabetes
brucei brucei 905 alloxan induced, protection against
Deoxyribonucleic acid 2111
bleomycin-induced damage 1255 effect of molybdate + H209 or
inhibition of repair by 2'-deoxy- tungstate + H709 on glucose trans-
coformycin 2229 port in adipocytes 1/74
chlorambucil adducts 5/71 effect of oral hypoglycaemic agents
crosslinking ability of aniline on platelet functions 68/7
mustards 59 Diamide
GR63178A binding 433 effect on protein S-thiolation in
H909-histidine induced damage, effect endothelial cells 1/757
of glutamine 2418 Diamine oxidase
polyamidine binding 1985 inhibition by aziridinylalkylamines
quinone induced single strand breaks 1229
215 1,3-Diaminopropane
synthesis in aortic smooth muscle, aziridinyl derivatives, inhibition
inhibition by cyclic AMP phospho- of diamine oxidase 1229
diesterase inhibitors 85/7 cis-Diamminedichloroplatinum(I1)
synthesis in hepatocytes, effect of effect on gene expression in CV-l
hepatocyte growth factor 1037 cells 107
synthesis inhibition by purine and resistant lung squamous-carcinoma
pyrimidine monoadducts 1123 cell line, reduced drug accumul-
synthesis in lung, effect of difluoro- ation 394
methylornithine 965 toxicity in LLC-PK] cells, effect
Deoxyribonucleic acid polymerases of ebselen 382
synthesis of DNA containing mono- Diarylsulfonylureas
adducted purines and pyrimidines effect on mitochondria 2387
1123 Diazepam
Deoxyribonucleic acid topoisomerase II binding in brain, effect of imidazo
5,11-dimethy1-5H-indolo(2,3-b)- (1,2-b)pyridazines 1555
quinoline as a targeting agent binding to HSA variants 1515
2149 effect on drug binding to albumins
effect of GR63178A 433 873
inhibition by woodfruticosin 1961 effect on Pk 11195 binding in
in mitoxantrone resistant leukemia lymphocytes and lymphoma cells
P388 cells 937 269
Deoxyribonucleic acid topoisomerase II Diazinon
inhibitors altered L-tryptophan metabolism in
antitumor activity 1961 mice 2243
Deoxythymodine analogues Diaziquone
inhibition of poly(ADP-ribose) diaphorase-induced alkylating
polymerase 947 activity 1625
Deoxyuridine analogues 1,1-Dibenzyl-3-phenyl-2-thiourea
inhibition of poly(ADP-ribose) oxidation in mammalian tissues 2029
polymerase 94/7 2,2'-Dicarbomethoxylamino-5,5'-dibenz-
(-)Deprenyl imidazoyl ketone
effect on superoxide dismutase and effect on antioxidant defenses in
catalase in brain and liver 2185 A.viteae and mastomys tissues 72/7
Desferrioxamine N-(3,4-Dichlorob) aemnilzoryilde
effect on ethoxyresorufin Q-deethyl- effect on atrial muscle 425
ase induction by Aroclor 1254 in Dichloromethane diphosphonate
hepatocytes 455 cytotoxicity in Dictyostelium 2157
in vivo iron mobilization 1023 S-(1,2-Dichlorovinyl )-L-cysteine
Desipramine induced release of mitochondrial Ca2+
effect on central adrenergic trans- and cytotoxicity in renal cells
mission 1067 1131
Deuterium isotope effects Dictyostelium discoideum
microsomal demethylation of N,N- cytotoxicity of pyrophosphate
dimethylbenzamides 651 analogues 2157
Development Dicumarol
epoxide hydrolase in liver 815 inhibition of glutathione transfer-
effect of fasting on glutathione in ases and glutathione peroxidase II
liver and lung 1489 921
Dexamethasone N,N'-Dicyclohexyl carbodiimide
effect on apoptosis in thymocytes effect on SCH23390 binding in
2131 brain 325
effect on carbamazepine metabolism Didanosine