Atrial Fibrillation - Mechanisms and Treatment

246 Pages·2016·10.76 MB·English

by  Tong Liu.

ATRIAL FIBRILLATION
MECHANISMS AND
TREATMENT
Edited by Tong Liu
ATRIAL FIBRILLATION -
MECHANISMS AND
TREATMENT
Edited by Tong Liu
Atrial Fibrillation - Mechanisms and Treatment
http://dx.doi.org/10.5772/46219
Edited by Tong Liu
Contributors
José Joaquín Rieta, Raúl Alcaraz, Atilla Bitigen, Vecih Oduncu, Tong Liu, Panagiotis Korantzopoulos, Guangping Li,
Anna Chernova, Svetlana Nicoulina, Vladimir Abramovich Shulman, Dudkina Ksenya, Oksana Gavrilyuk, Hongtao
Wang, Lucía Cid Conde, José López Castro, Stefano Perlini, Fabio Belluzzi, Francesco Salinaro, Francesco Musca, Hanan
Ahmed Galal Azzam, Paul Wolkowicz, Patrick Umeda, OLeg Sharifov, Ferdinand Urthaler
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First published February, 2013
Printed in Croatia
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Atrial Fibrillation - Mechanisms and Treatment, Edited by Tong Liu
p. cm.
ISBN 978-953-51-1023-1

Contents
Preface VII
Section 1 Pharmacological Management 1
Chapter 1 Atrial Fibrillation and the
Renin-Angiotensin-Aldosterone System 3
Stefano Perlini, Fabio Belluzzi, Francesco Salinaro and Francesco
Musca
Chapter 2 Antioxidant Therapies in the Prevention and Treatment of
Atrial Fibrillation 29
Tong Liu, Panagiotis Korantzopoulos and Guangping Li
Chapter 3 Effect of CD3+ T-Lymphocyte and n-3 Polyunsaturated Fatty
Acids on the Diagnosis or Treatment of Atrial Fibrillation 45
Qiang-Sun Zheng, Hong-Tao Wang, Zhong Zhang, Jun Li, Li Liu and
Bo-yuan Fan
Section 2 Mechanisms 57
Chapter 4 New Candidate Genes in Atrial Fibrillation Polymorphisms of
the Alpha 2-Beta-Adrenoceptor and the Endothelial NO
Synthase Genes in Atrial Fibrillation of Different
Etiological Origins 59
Svetlana Nikulina, Vladimir Shulman, Ksenya Dudkina, Anna
Chernova and Oksana Gavrilyuk
Chapter 5 Voltage-Independent Calcium Channels, Molecular Sources of
Supraventricular Arrhythmia 79
Paul E. Wolkowicz, Patrick K. Umeda, Ferdinand Urthaler and Oleg
F. Sharifov
VI Contents
Chapter 6 Thrombogenesis in Atrial Fibrillation 127
Hanan Ahmed GalalAzzam
Section 3 Signal Analysis 153
Chapter 7 Applications of Signal Analysis to Atrial Fibrillation 155
José Joaquín Rieta and Raúl Alcaraz
Chapter 8 The Contribution of Nonlinear Methods in the Understanding
of Atrial Fibrillation 181
Raúl Alcaraz and José Joaquín Rieta
Section 4 Anticoagulation Therapy 205
Chapter 9 New Oral Anticoagulants in Atrial Fibrillation 207
Lucía Cid-Conde and José López-Castro
Chapter 10 Anticoagulant Therapy in Patients with Atrial Fibrillation and
Coronary Artery Disease 229
Atila Bitigen and Vecih Oduncu
Preface
Atrial fibrillation is a rapidly evolving epidemic associated with increased cardiovascular
morbidity and mortality, and its prevalence has increased during the past few decades. In
the past few years, the recent understanding of the diverse mechanisms of this arrhythmia
has led to the improvement of our therapeutic strategies. However, many clinicians have
still felt the frustration in management of this commonly encountered arrhythmia.
This book contains a spectrum of different topics from bench to bedside in atrial fibrillation. We
try to introduce the most recent advancement of mechanisms and treatment of AF including
genetics, calcium signaling, thrombogenesis, signal analysis, upstream therapies focus on re‐
nin-angiotensin-aldosterone system inhibitors, antioxidants and n-3 polyunsaturated fatty
acids, and anticoagulation issues. I strongly believe that scientists, cardiologists and electro‐
physiologists will find this book very informative and useful. The references cited in each
chapter will definitely act as additional source of information for readers.
I am grateful to the all the authors who contributed to this book with their valuable experi‐
ence. I also appreciate the great help from InTech editorial office, Ms. Mirna Cvijic and Mr.
Dejan Grgur, who guided me through the publication process step by step. I would also like
to thank for the important contributions from the co-editors of this book – Prof. Guangping
Li, my mentor, and Dr. Panagiotis Korantzopoulos, my best friend who guided me to ex‐
plore the wonderful world of arrhythmia. Finally, special thanks to my family – wife, Lijian,
and son, Yujie, who provided continuous inspiration and support to my work.
Tong Liu, MD, PhD
Department of Cardiology, Tianjin Institute of Cardiology
Second Hospital of Tianjin Medical University, Tianjin
People’s Republic of China

Section 1
Pharmacological Management