Applications in Plant Biotechnology: Focus on Plant Secondary Metabolism and Plant Molecular Pharming PDF
Preview Applications in Plant Biotechnology: Focus on Plant Secondary Metabolism and Plant Molecular Pharming
Applications in Plant Biotechnology Focus on Plant Secondary Metabolism and Plant Molecular Pharming Editors: Abdullah Makhzoum Department of Biological Sciences and Biotechnology Botswana International University of Science and Technology Palapye, Botswana Kathleen Hefferon Department of Microbiology Cornell University, Ithaca, NY, USA p, p, A SCIENCE PUBLISHERS BOOK A SCIENCE PUBLISHERS BOOK First edition published 2023 by CRC Press 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 and by CRC Press 4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN © 2023 Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, LLC Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, access www.copyright.com or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. For works that are not available on CCC please contact [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging‑in‑Publication Data (applied for) ISBN: 978-0-367-34446-7 (hbk) ISBN: 978-1-032-39824-2 (pbk) ISBN: 978-1-003-00886-6 (ebk) DOI: 10.1201/9781003008866 Typeset in Times New Roman by Radiant Productions Preface This book is the fruition of three years of effort made by all co-authors and editors. It summarizes recent innovative applications in plant biotechnology in two important areas: plant secondary metabolism and plant molecular pharming. In the section on plant secondary metabolism, the first chapter focuses on recent innovations and discoveries using the medicinal plant species Withania somnifera as a pharma factory and its tremendous potential in the medical and pharmaceutical industries. The second chapter highlights several very promising biotechnological approaches and applications used to produce a number of important tropane alkaloids. The third chapter illustrates the applications and mechanisms of specific plant secondary metabolites as anticancer drugs and bioactive compounds, and their mode of action. The fourth chapter describes the in silico and computational analysis of African medicinal plants and reports the content of some databases and libraries as CamMedNP, ConMedNP, NANPDB, p-ANAPL, AfroDb, AfroCancer, AfroMalariaDb, Afrotryp, Ethiopia (ETM DB), and South Africa (SANCDB). The fifth chapter discusses the ethno botanical uses of the Strychnos species found in the Southern African region and explores a variety of chemical compounds extracted from different Strychnos species, while addressing the antimicrobial activity and toxicity of these compounds. The sixth chapter explains the role of Agrobacterium rhizogenes as a vector in transforming medicinal plants and for inducing hairy roots. Hairy roots are a profound tool used in plant metabolic engineering to enhance secondary metabolite production and accumulation. The second section of the book deals with plant molecular pharming and its applications. This section initiates from the seventh chapter, and explains different methods and tools used in plant molecular pharming as well the challenges ahead for the production of recombinant proteins, and potential solutions. The eighth chapter highlights some important livestock diseases and the potential of plant-based vaccines to protect against them. The go-to-market potential in addition to cost-effectiveness and other advantages of plant-based vaccines are presented in relation to a number of United Nations Sustainable Development Goals (SDGs). The ninth chapter considers recent advancements in engineering of chloroplasts, which can serve as a target organelle for the production of biomolecules or the improvement of agronomic traits. The chloroplast has been extensively explored and engineered to produce valued molecules such as enzymes, secondary metabolites, protein drugs, vaccines, anti-microbial peptides, and interfering RNAs for over 30 years. Chapter ten addresses the applications of plant viruses for the expression and synthesis of vaccines against several infectious human diseases and cancers as well as other therapeutic proteins. This chapter also discusses various investigative reports using well-known and important plant viruses such as the Tobacco mosaic virus, Cowpea mosaic virus and Potato virus X, which have been employed for iv Applications in Plant Biotechnology biotechnological, prophylactic and therapeutic purposes. The eleventh chapter discusses the use of plant molecular pharming to manufacture biologics against HIV. It addresses progress in the development of plant-derived HIV vaccines, the risks and challenges associated with vaccine production in plants, as well as the benefits of vaccine production in plants compared to other expression systems. In summary, this book covers two increasingly growing fields of plant biotechnology, by drawing on some of the most prominent research groups in their respective fields as co authors. The research described in this book should be helpful for any who are interested in both current and future aspects of plant biotechnology for many years to come. Contents Preface iii Acknowledgment of Reviewers vii I-Plant Secondary Metabolism 1. Withania somnifera: A Future Pharma Factory 3 Tarun Halder, Subrata Kundu and Biswajit Ghosh 2. Biotechnological Approaches for Tropane Alkaloids Production 45 Ryad Amdoun, Boualem Harfi, Asma Moussous, Abdullah Makhzoum and Lakhdar Khelifi 3. Anticancer Mechanisms of Plant Secondary Metabolism 61 David O Nkwe 4. In silico and Computational Analysis of Plant Secondary Metabolites 74 from African Medicinal Plants Smith B Babiaka, Pascal Amoa Onguéné, Boris Davy Bekono and Fidele Ntie‑Kang 5. Botany, Phytochemistry, Pharmacology, and Toxicity of the 91 Southern African Strychnos Species Willie Marenga, Abdullah Makhzoum and Gaolathe Rantong 6. Preference of Agrobacterium rhizogenes Mediated 119 Transformation of Angiosperms Kamogelo M Mmereke, Aaqib Javid, Sukanya Majumdar, Ipshita Ghosh, Sonia Malik, Abdullah Makhzoum and Sumita Jha II-Plant Molecular Pharming 7. Plant Molecular Pharming: Methods, Tools, Challenges Ahead for 165 Production of Recombinant Proteins, and Potential Solutions Shahram Shokrian Hajibehzad, Azadeh Mohseni, Mohammad Dolati, Saeid Malekzadeh Shafaroudi, Kathleen Hefferon and Abdullah Makhzoum 8. Plant-based Vaccines against Livestock Diseases: Way to Achieve 204 Several Sustainable Development Goals Mohammad Tahir Waheed, Muhammad Suleman Malik, Kiran Saba, Iqra Younus, Niaz Ahmad, Bushra Mirza and Andreas Günter Lössl vi Applications in Plant Biotechnology 9. Chloroplast Biotechnology Tools for Industrial and 239 Clinical Applications Kwang‑Chul Kwon 10. Plant Virus-Based Expression Vectors and their Applications 276 in Foreign Protein/Antigen Expression Srividhya Venkataraman, Erum Shoaeb and Kathleen Hefferon 11. Plant Molecular Pharming of Biologics to Combat HIV 296 Goabaone Gaobotse, Jocelyne Trémouillaux‑Guiller, Srividhya Venkataraman, Mohammed Kamil Sherif, Abdullah Makhzoum and Kathleen Hefferon Index 349 About the Editors 355 Acknowledgment of Reviewers Reviewers Dr. Marina Clemente Instituto Tecnológico de Chascomús (INTECH) CONICET-UNSAM Intendente Marino Km 8,2; CC 164 (B7130IWA) Chascomús; Provincia de Buenos Aires; Argentina Tel:+54-2241-430323; FAX:+54-2241-424048 E-mail: [email protected] https://intech.conicet.gov.ar/ www.iib.unsam.edu.ar/iib-unsam/investigacion.html Professor Sumita Jha Department of Botany, University of Calcutta’35 Ballygunge Circular Road, Kolkata 700019, India Professor Sergio Rosales Mendoza Faculty of Chemical Sciences Center for Research in Biomedicine and Health Office Address: Manuel Nava 6 CP. 78210 San Luis Potosi Telephone: (+52) 4448262440 Email: [email protected] Website: https://www.researchgate.net/profile/Sergio_Rosales-Mendoza ORCID: 00-0003-2569-7329 Dr. Mohammad Tahir Waheed Assistant Professor Course Coordinator Department of Biochemistry Quaid-i-Azam University 45320, Islamabad, Pakistan Member: International Society of Plant Molecular Farming (ISPMF) Member: European Plant Science Organization (EPSO) Member: Asian Council of Science Editors (ACSE) Associate Editor: 1. BMC Plant Biology 2. BMC Developmental Biology 3. American Journal of Biochemistry and Biotechnology Tel: 0092-51-90643207 viii Applications in Plant Biotechnology Cell: 0092-333-9964114 https://scholar.google.com.pk/citations?user=5cYbyykAAAAJ&hl=en&oi=ao https://www.researchgate.net/profile/Mohammad_Waheed2 https://bmcplantbiol.biomedcentral.com/about/editorial-board https://bmcdevbiol.biomedcentral.com/about/editorial-board https://thescipub.com/journals/ajbb/editors Dr. Mohamed Elhiti Associate Professor Department of Botany, Faculty of Science, Tanta University, Tanta, 31527, Egypt Professor Ed Rybicki Director, Biopharming Research Unit Molecular & Cell Biology Department University of Cape Town Dr. Sarah Bushra Nasir Abdus Salam School of Sciences, Department of Life Sciences, Nusrat Jahan College, Chenab Nagar, Pakistan. Abdulbaset Azizi Department of Plant Protection University of Kurdistan, Sanandaj, Iran Dr. Emmanuel Margolin Postdoctoral Scientist Bioharming research Unit (Department of Molecular and Cell Biology), University of Cape Town And Viral Vaccine Development Group and Human Papillomavirus Research Group (Department of Pathology), Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Scienc-es, University of Cape Town Dr. Mohammed Kamil Sherif Central Medical Centre Palapye, Botswana E-mail: [email protected] I-Plant Secondary Metabolism
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