Apoptosis : physiology and pathology PDF
Preview Apoptosis : physiology and pathology
APOPTOSIS Apoptosis,orcelldeath,canbepathological,asignofdiseaseanddamage,orphysiologic,a processessentialfornormalhealth.Thispathologicaldysregulationofcelldeathcanbecharac- terizedbyeithertoomuchlossofessentialcellsintheheart,brain,andothertissueswithlittle regenerativecapacityortoolittlecellturnoverinself-renewingtissues,givingrisetocancer andothermaladies.Thisisaprocessoffundamentalimportancefordevelopmentandnormal health,whichisalteredinmanydiseaseconditions.Thisbook,withcontributionsfromexperts inthefield,providesatimelycompilationofreviewsofmechanismsofapoptosis.Thebookis organizedintothreeconvenientsections.Thefirstsectionexploresthedifferentprocessesof cell death and how they relate to each other. The second section focuses on organ-specific apoptosis-relateddiseases.Thethirdsectionexplorescelldeathinnonmammalianorganisms thathaveservedaspopularmodelsforresearch.Thiscomprehensivetextisamust-readforall researchersandscholarsinterestedinapoptosisandcelldeath. JohnC.ReedisChiefExecutiveOfficeroftheSanford-BurnhamMedicalResearchInstitute. Dr.ReedisalsoProfessorandDonaldBrenExecutiveChairatSanford-Burnham,withadjunct professor appointments at several universities. Dr. Reed and his research team have con- tributedmorethan800researchpublicationstotheliterature.Theirworkisamongthemost highly cited in all of science worldwide. Dr. Reed is the recipient of numerous awards and honorsandhasbeenawardedmorethaneightyresearchgrantsforhiswork.Heisanamed inventorfornearly100patentsandthefounderorcofounderoffourbiotechnologycompanies. Dr.Reedhasservedontheeditorialboardsofnumerousjournals;asanadvisortonumerous public,private,andgovernmentalorganizations;andontheboardsofdirectorsofseveralpub- licandprivatebiotechnologycompaniesandlife-sciencesorganizations. DouglasR.GreenisChairoftheDepartmentofImmunologyatSt.JudeChildren’sResearch Hospital,wherehealsoholdsthePeterDohertyEndowedChair.Dr.GreencametoSt.Judein 2005,priortowhichhewasHeadoftheDivisionofCellularImmunologyattheLaJollaInstitute ofAllergyandImmunology.Dr.Greenservesasaneditorforanumberofleadingjournalsand isEditor-in-ChiefofthejournalOncogene. A P O P TO S I S PHYSIOLOGY AND PATHOLOGY Editedby JOHNC.REED Sanford-BurnhamMedicalResearchInstitute DOUGLASR.GREEN St.JudeChildren’sResearchHospital cambridgeuniversitypress Cambridge,NewYork,Melbourne,Madrid,CapeTown, Singapore,Sa˜oPaulo,Delhi,Tokyo,MexicoCity CambridgeUniversityPress 32AvenueoftheAmericas,NewYork,NY10013-2473,USA www.cambridge.org Informationonthistitle:www.cambridge.org/9780521886567 (cid:2)C CambridgeUniversityPress2011 Thispublicationisincopyright.Subjecttostatutoryexception andtotheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithoutthewritten permissionofCambridgeUniversityPress. Firstpublished2011 PrintedintheUnitedStatesofAmerica AcatalogrecordforthispublicationisavailablefromtheBritishLibrary. LibraryofCongressCataloginginPublicationdata Apoptosis:physiologyandpathology/[editedby]JohnC.Reed, DouglasR.Green. p.;cm. Includesbibliographicalreferences. ISBN978-0-521-88656-7(hardback) 1.Apoptosis. I.Reed,JohnC.,1958–editor. II.Green,DouglasR., 1955–editor. III.Title. [DNLM:1.Apoptosis. 2.Apoptosis–physiology. 3.CellDeath.QU375] QH671.A6594 2011 611(cid:3).01815–dc22 2010045696 ISBN978-0-521-88656-7Hardback CambridgeUniversityPresshasnoresponsibilityforthepersistenceor accuracyofURLsforexternalorthird-partyInternetWebsitesreferredtoin thispublicationanddoesnotguaranteethatanycontentonsuchWebsites is,orwillremain,accurateorappropriate. Contents Contributors pageix I. GENERALPRINCIPLESOFCELLDEATH 1 HumanCaspases–ApoptosisandInflammationSignalingProteases.............1 GuyS.Salvesen 2 InhibitorofApoptosisProteins............................................. 11 JasonB.Garrison,AndreasKrieg,KateWelsh,YunfeiWen,andJohnC.Reed 3 DeathDomain–ContainingReceptors–DecisionsbetweenSuicideandFire ..... 23 HenningWalczakandChahrazadeKantari 4 MitochondriaandCellDeath..............................................37 GavinP.McStayandDouglasR.Green 5 TheControlofMitochondrialApoptosisbytheBCL-2Family.................. 44 AnthonyLetai 6 EndoplasmicReticulumStressResponseinCellDeathandCellSurvival.........51 MichaelBoyce,MartaM.Lipinski,Be´ne´dicteF.Py,andJunyingYuan 7 Autophagy–TheLiaisonbetweentheLysosomalSystemandCellDeath......... 63 HiroshiKogaandAnaMariaCuervo 8 CellDeathinResponsetoGenotoxicStressandDNADamage.................. 74 PabloLopez-BergamiandZe’evRonai 9 CeramideandLipidMediatorsinApoptosis ................................. 88 ThomasD.Mullen,RussellW.Jenkins,LinaM.Obeid,andYusufA.Hannun 10 CytotoxicGranulesHousePotentProapoptoticToxinsCriticalfor AntiviralResponsesandImmuneHomeostasis.............................. 106 KatherineBaran,IliaVoskoboinik,NigelJ.Waterhouse,VivienR.Sutton, andJosephA.Trapani II. CELLDEATHINTISSUESANDORGANS 11 CellDeathinNervousSystemDevelopmentandNeurologicalDisease.........123 JuyingLiandJunyingYuan 12 RoleofProgrammedCellDeathinNeurodegenerativeDisease................135 DaleE.Bredesen v vi CONTENTS 13 ImplicationsofNitrosativeStress-InducedProteinMisfolding inNeurodegeneration................................................... 145 TomohiroNakamuraandStuartA.Lipton 14 MitochondrialMechanismsofNeuralCellDeathinCerebralIschemia.........153 LucianSoane,BrianM.Polster,andGaryFiskum 15 CellDeathinSpinalCordInjury–AnEvolvingTaxonomywith TherapeuticPromise .................................................... 164 RajivR.RatanandMosesV.Chao 16 ApoptosisandHomeostasisintheEye.....................................176 JerryY.Niederkorn 17 CellDeathintheInnerEar ............................................... 182 LisaL.CunninghamandJustinTan 18 CellDeathintheOlfactorySystem......................................... 194 PawelKermer 19 ContributionofApoptosistoPhysiologicRemodelingoftheEndocrine PancreasandPathophysiologyofDiabetes ................................. 201 NikaN.Danial 20 ApoptosisinthePhysiologyandDiseasesoftheRespiratoryTract ............. 221 ChristianTaubeandMartinSchuler 21 RegulationofCellDeathintheGastrointestinalTract........................231 MariaEugeniaGuicciardiandGregoryJ.Gores 22 ApoptosisintheKidney..................................................240 JuanAntonioMoreno,AdrianMarioRamos,andAlbertoOrtiz 23 PhysiologicandPathologicalCellDeathintheMammaryGland............... 250 ArmelleMeletandRoyaKhosravi-Far 24 TherapeuticTargetingApoptosisinFemaleReproductiveBiology.............. 273 KaisaSelesniemiandJonathanL.Tilly 25 ApoptoticSignalinginMaleGermCells....................................283 AmiyaP.SinhaHikim,YueJia,Yan-HeLue,ChristinaWang,andRonaldS.Swerdloff 26 CellDeathintheCardiovascularSystem.................................... 295 VladimirKaplinskiy,MartinR.Bennett,andRichardN.Kitsis 27 CellDeathRegulationinMuscle........................................... 313 AyeshaSaleem,LawrenceKazak,MichaelO’Leary,andDavidA.Hood 28 CellDeathintheSkin....................................................323 SaskiaLippens,EstherHoste,PeterVandenabeele,andWimDeclercq 29 ApoptosisandCellSurvivalintheImmuneSystem .......................... 333 DelphineMe´rinoandPhilippeBouillet 30 CellDeathRegulationintheHematopoieticSystem.......................... 350 PaulA.Ney 31 ApoptoticCellDeathinSepsis............................................363 PavanBrahmamdam,JaredT.Muenzer,RichardS.Hotchkiss,andJonathanE.McDunn 32 Host–PathogenInteractions..............................................372 MayaSaleh CONTENTS vii III. CELLDEATHINNONMAMMALIANORGANISMS 33 ProgrammedCellDeathintheYeastSaccharomycescerevisiae................. 389 ValterD.LongoandCristinaMazzoni 34 CaenorhabditiselegansandApoptosis ..................................... 397 BrianL.HarryandDingXue 35 ApoptoticCellDeathinDrosophila........................................407 KathleenGalindoandJohnM.Abrams 36 AnalysisofCellDeathinZebrafish......................................... 412 UjwalJ.PyatiandA.ThomasLook Color plates follow page 226 . Contributors JohnM.Abrams MosesV.Chao GeneticsandDevelopmentGraduateProgram MolecularNeurobiologyProgram DepartmentofCellBiology SkirballInstituteofBiomolecularMedicine UTSouthwesternMedicalCenter NewYorkUniversityLangoneSchoolofMedicine Dallas,TX NewYork,NY KatherineBaran AnaMariaCuervo CancerImmunologyProgram DepartmentofDevelopmentalandMolecularBiology ResearchDivision MarionBessinLiverResearchCenter PeterMacCallumCancerCentre InstituteforAgingResearch Victoria AlbertEinsteinCollegeofMedicine Australia Bronx,NY MartinR.Bennett LisaL.Cunningham DivisionofCardiovascularMedicine SectiononSensoryCellBiology UniversityofCambridgeandAddenbrooke’sCentrefor NationalInstituteonDeafnessandOther ClinicalInvestigation CommunicationDisorders Addenbrooke’sHospital NationalInstitutesofHealth Cambridge Rockville,MD UnitedKingdom NikaN.Danial PhilippeBouillet DepartmentofPathology TheWalterandElizaHallInstituteofMedicalResearch HarvardMedicalSchool Melbourne DepartmentofCancerBiology Australia Dana-FarberCancerInstitute MichaelBoyce Boston,MA DepartmentofCellBiology WimDeclercq HarvardMedicalSchool MolecularSignalingandCellDeathUnit Boston,MA DepartmentforMolecularBiomedicalResearch PavanBrahmamdam VIB-GhentUniversity DepartmentofSurgery Ghent WashingtonUniversitySchoolofMedicine Belgium St.Louis,MO GaryFiskum DaleE.Bredesen DepartmentofAnesthesiology BuckInstituteforResearchonAging Shock,Trauma,andAnesthesiologyResearchCenter UniversityofCalifornia–SanFrancisco UniversityofMarylandSchoolofMedicine SanFrancisco,CA Baltimore,MD ix x CONTRIBUTORS KathleenGalindo YueJia DepartmentofCellBiology DepartmentofMedicine UTSouthwesternMedicalCenter Harbor-UCLAMedicalCenter Dallas,TX LosAngelesBiomedicalResearchInstitute DavidGeffenSchoolofMedicineatUCLA JasonB.Garrison Torrance,CA ApoptosisandCellDeathResearchProgram Sanford-BurnhamMedicalResearchInstitute ChahrazadeKantari LaJolla,CA TumourImmunologyUnit,DepartmentofMedicine ImperialCollegeLondon GregoryJ.Gores London MilesandShirleyFitermanCenterforDigestiveDiseases UnitedKingdom DivisionofGastroenterologyandHepatology VladimirKaplinskiy MayoClinicCollegeofMedicine WilfFamilyCardiovascularResearchInstituteand Rochester,MN DepartmentofMedicineandCellBiology DouglasR.Green AlbertEinsteinCollegeofMedicine DepartmentofImmunology Bronx,NY St.JudeChildren’sResearchHospital LawrenceKazak Memphis,TN SchoolofKinesiologyandHealthScience YorkUniversity MariaEugeniaGuicciardi Toronto,Ontario MilesandShirleyFitermanCenterforDigestiveDiseases Canada DivisionofGastroenterologyandHepatology MayoClinicCollegeofMedicine PawelKermer Rochester,MN DepartmentofNeurology UniversityMedicalCenter YusufA.Hannun DFGResearchCenter“MolecularPhysiologyofthe BiochemistryandMolecularBiology Brain”(CMPB) MedicalUniversityofSouthCarolina Go¨ttingen Charleston,SC Germany BrianL.Harry RoyaKhosravi-Far DepartmentofMCDBiology DepartmentofPathology UniversityofColorado BethIsraelDeaconessMedicalCenter Boulder,CO HarvardMedicalSchool Boston,MA DavidA.Hood SchoolofKinesiologyandHealthScience RichardN.Kitsis YorkUniversity WilfFamilyCardiovascularResearchInstitute Toronto,Ontario DepartmentofMedicineandCellBiology Canada AlbertEinsteinCollegeofMedicine Bronx,NY EstherHoste HiroshiKoga MolecularSignalingandCellDeathUnit DepartmentofDevelopmentalandMolecularBiology DepartmentforMolecularBiomedicalResearch MarionBessinLiverResearchCenter VIB-GhentUniversity InstituteforAgingResearch Ghent AlbertEinsteinCollegeofMedicine Belgium Bronx,NY RichardS.Hotchkiss AndreasKrieg DepartmentofPediatrics ApoptosisandCellDeathResearchProgram WashingtonUniversitySchoolofMedicine Sanford-BurnhamMedicalResearchInstitute St.Louis,MO LaJolla,CA RussellW.Jenkins AnthonyLetai BiochemistryandMolecularBiology DepartmentofMedicalOncology MedicalUniversityofSouthCarolina Dana-FarberCancerInstitute Charleston,SC Boston,MA CONTRIBUTORS xi JuyingLi ArmelleMelet DepartmentofCellBiology UMR8601 HarvardMedicalSchool UniversityParisDescartes Boston,MA Paris France MartaM.Lipinski DepartmentofCellBiology DelphineMe´rino HarvardMedicalSchool TheWalterandElizaHallInstituteofMedical Boston,MA Research SaskiaLippens Melbourne MolecularSignalingandCellDeathUnit Australia DepartmentforMolecularBiomedicalResearch JuanAntonioMoreno VIB-GhentUniversity FundacionJimenezDiaz Ghent UniversidadAutonomadeMadrid Belgium Madrid StuartA.Lipton Spain DelE.WebCenterforNeuroscience AgingandStemCellResearchProgram JaredT.Muenzer Sanford-BurnhamMedicalResearchInstitute DepartmentofPediatrics LaJolla,CA WashingtonUniversitySchoolofMedicine St.Louis,MO ValterD.Longo DivisionofBiogerontology ThomasD.Mullen AndrusGerontologyCenter BiochemistryandMolecularBiology UniversityofSouthernCalifornia MedicalUniversityofSouthCarolina LosAngeles,CA Charleston,SC A.ThomasLook TomohiroNakamura DepartmentofPediatricOncology DelE.WebCenterforNeuroscience Dana-FarberCancerInstitute AgingandStemCellResearch HarvardMedicalSchool Sanford-BurnhamInstituteforMedicalResearch Boston,MA LaJolla,CA PabloLopez-Bergami InstitutodeBiologiayMedicinaExperimental PaulA.Ney BuenosAires DepartmentofBiochemistry Argentina St.JudeChildren’sResearchHospital Memphis,TN Yan-HeLue DepartmentofMedicine JerryY.Niederkorn Harbor-UCLAMedicalCenter DepartmentofOphthalmology LosAngelesBiomedicalResearchInstitute UTSouthwesternMedicalCenter DavidGeffenSchoolofMedicineatUCLA Dallas,TX Torrance,CA LinaM.Obeid CristinaMazzoni BiochemistryandMolecularBiology PasteurInstitute-CenciBolognettiFoundation MedicalUniversityofSouthCarolina DepartmentofCellandDevelopmentalBiology Charleston,SC UniversityofRome Rome MichaelO’Leary Italy SchoolofKinesiologyandHealthScience JonathanE.McDunn YorkUniversity DepartmentofAnesthesiologyResearchUnit Toronto,Ontario WashingtonUniversitySchoolofMedicine Canada St.Louis,MO AlbertoOrtiz GavinP.McStay FundacionJimenezDiaz DepartmentofBiologicalSciences UniversidadAutonomadeMadrid ColumbiaUniversity Madrid NewYork,NY Spain
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