Apoptosis in Cardiac Biology PDF
Preview Apoptosis in Cardiac Biology
Erratum The publisher regrets the incomplete address of the editors of this book. APOPTOSIS IN CARDIAC BIOLOGY Edited by: Heribert Schunkert G.A.J . Riegger University of Regensburg Germany Kluwer Academic Publishers Boston-Dordrecht-London APOPTOSIS IN CARDIAC BIOLOGY Edited by: Heribert Schunkert Klinik und bliklinik fur Innere Germany Kluwer Academic Publishers Boston-Doredrecht-London Distributors for North, Central and South America: Kluwer Academic Publishers 10 1 Philip Drive Assinippi Park Norwell, Massachusetts 02061 USA Telephone (78 1) 87 1-6600 Fax (78 1) 68 1-9045 E-Mail <kluwer@w kap.corn> Distributors for all other countries: Kluwer Academic Publishers Group Disttibution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS Telephone 31 78 6392 392 Fax 3 1 78 6546 474 E-Mail <services @ wkap.n1> gLAvI Electronic Services <http://www.wkap.nl> Library of Congress Cataloging-in-PublicationD ata A C.I.P. Catalogue record for this book is available from the Library of Congress. Copyright 2000 by Kluwer Academic Publishers @ All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo- copying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061. Printed on acid-free paper. Printed in the United States of America Contents List of Contributors ................................................................................ vii ... Introduction.. .........................,...........................,...... ..... .............................X M PART ONE: BASIC MECHANISMS OF APOPTOSlS The initiation of apoptosis Death receptors and their ligands ................................................................5. Jurgen Holh, Dorothea Darner Regulation of apoptosis by CD 137 ...........................................................2 9 Henbert Schwan Reactive oxygen species and apoptosis ................................ .. ...............3 9 Riidiger von Harsdorf The mediators of apoptosis Oncogenes and p53 .................................................................... ...............6 1 Franz Kohlhuber, Dirk Eick BCL-2 family members and mitochondria. .................................................7. 1 Klaus Schloltmann, Jiirgen Schdlmerich Inhibition of cardiac myocyte apoptosis by gpl30-dependent cytokines .... 91 Kai C. Wollert Cell cycle regulation and apoptotic cell death .........................................I.0. 1 Lothar Jahn, Hamid Bar The execution of apoptosis Caspase cascades and caspase targets .................................................1. 11 Thomas Rude/ Apoptosis: a distinctive form of cell death ...............................................1..2 3 L.B. Jordan, D.J . Harrison PART TWO: CELLULAR TARGETS IN THE CARDIOVASCULAR SYSTEM Blood vessels Apoptosis and cell cycle in endothelial cells ........................................... 141 loakim Spyridopoulos APOPTOSIS IN CARDIAC BIOLOGY 11.2 Myocardium 11.2.1 Endurance under stress and cardioprotective functions by cardiac fibroblasts .................................................................................I..5. 9 Mahboubeh Eghbali- Webb 11.2.2 Cardiac myocytes ............................ .. ...................................................I.7. 5 Armin Haunstetter, Markus Haass, Seigo lzurno 11.2.3 Cardiac myocytes and fibroblasts exhibit differential sensitivity to apoptosis-inducing stimuli .................... . ......................................... 189 Edward G. Lakatta, Xilin Long, Alan Chesley, Michael Crow PART THREE: APOPTOSIS IN CARDIAC DISORDERS 111.1 Vascular disease Ill.1 . I Hypertension as a cardiovascular proliverative disorder .........................2. 1 3 Denis deBlois, Sergei Orlov, Pave1 Hamet 111.1.2 Apoptosis in human atherosclerosis... ....................................................2..2 3 Gerhard Bauriedel, Randolph Hutter, Ulrich Welsch, Bemdt Luderitz 111.2 Cardiac disease 111.2.1 Apoptosis in myocardial infarction ........................................................ 239 Andreas V. Sigel, Gunter A. J. Riegger 111.2.2 Pro-inflammatory and pro-apoptotic factors in heart failure ....................2..6 1 Laura Agnoletti, Laura Comini, Guiseppina Gaia, Salvatore Curello, Roberto Ferari 111.2.3 Molecular mechanisms of cardiac myocardial remodeling during aging. Role of apoptosis .........................................................................2..7 3 Ziad MaNat, Bernard Swynghedauw 111.2.4 Apoptosis during cardiac surgery ...................................... .... ....................2. 87 Hemann Aebert, Joachim P. Schmitt, Heribert Schunkert PART FOUR: THERAPEUTICAL OPTIONS IV.1 New opportunities for heart disease therapeutics. ...................................2. 99 Giora Z. Feuerstein 1V.2 Beta blocker therapy and prevention of apoptosis ............... .. .............3 09 Andreas V. Sigel, Heribert Schunkert lV.3 Apoptosis in cardiac myocytes - Role of the renin-angiotensin-system ... 317 Daniela Grimm, Gilbert Schonfelder, Martin Paul IV.4 Estrogens and the prevention of cardiac apoptosis .................................3. 29 Christian Grohe, Rainer Meyer, Hans Vetter IV.5 Open questions on apoptosis in cardiac biology .................................. 337 Heriben' Schunkert Index ........................................................................................................-. 343 List of Contributors Privatdozent Dr. rned. Hermann Aebert Laura Comini, M.D. Klinik und Poliklinik fur Herz-, Thorax- Cardiovascular Research Center und herznahe Gefilnchirurgie ,,Salvatore Maugeri" Foundation University of Regensburg Via Pinidolo, 23 Franz-Josef-Straui3-Allee 11 1-25064 Gussago (Brescia) 0-93053 Regensburg ltaly Germany Laura Agnoletti, M.D. Michael T. Crow, Ph.D. Cardiovascular Research Center Laboratory of Cardiovascular Sciences ,,Salvatore Maugeri" Foundation Gerontology Research Center Via Pinidolo, 23 National Institute on Aging, National Institutes 1-25064 Gussago (Brescia) of Health Italy 5600 Nathan Shock Drive Baltimore, MD 21 224 USA Dr. med. Harald Bar Salvatore Curello, M.D. Department of Internal Medicine Chair of Cardiology University of Heidelberg Spedali Civili Bergheimer Strafie 58 P.le Spedali Civili D-69115 Heidelberg 1-2512 3 Brescia Germany ltaly Prof. Dr. med. Gerhard Bauriedel, Dr. rer. nat. Dorothea Darmer FACC, FESC Martin-Luther Universitat Halle-Wittenberg Associate Professor, Department of Internal lnstitut fur Pathophysiologie Medicine II/Cardiology Magdeburger Strafie 18 University of Bonn D-06097 Halle Sigmund-Freud-Strai3e2 5 Germany D-53105 Bonn Germany Alan Chesley, Ph.D. Denis deBlois, Ph.D. Laboratory of Cardiovascular Sciences CHUM Research Center Gerontology Research Center 3840 St-Urbain National lnstitute on Aging, National Institutes Montreal, Quebec of Health H2W IT8 5600 Nathan Shock Drive Canada Baltimore, MD 21 224 USA APOPTOSIS IN CARDIAC BIOLOGY Mahboubeh Eghbali-Webb, Ph.D. Privatdozent Dr. med. Christian Grohb Department of Anesthesiology Rheinische Friedrich-Wilhelms-UniversitPt Yale School of Medicine Medizinische Univ.-Poliklinik 333 Cedar Street Wilhelmstral3e 35-37 New Haven, CT 065/0 D-53111 Bonn USA Germany Dr. rer. nat. Dirk Eick Dr. med. Markus Haass lnstitut fur Klinische Molekularbiologie Department of Cardiology und Tumorgenetik University of Heidelberg GSF-Forschungszentrum fur Umwelt und Bergheimer StraRe 58 Gesundheit D-69115 Heidelberg MarchioninistraRe 25 Germany 0-813 77 Munchen Germany Roberto Ferrari, M.D. Pave! Hamet, M.D., Ph.D. Chair of Cardiology Professor of Internal Medicine University of Ferrara CHUM Research Center "Salvatore Maugeri" Foundation 3840 St-Urbain Via Pinidolo, 23 Montreal, Quebec 1-25064 Gussago (Brescia) H2W IT8 ltaly Canada Giora 2. Feuerstein, M.D. David J. Harrison, M.D. Senior Director, Cardiovascular Sciences Professor of Pathology DuPont Pharmaceuticals Corporation Department of Pathology E40013255 The University of Edinburgh Route 141 & Henry Clay Road Medical School Wilmington, DE 19880-0400 Teviot Place USA Edinburgh EH8 9AG. United Kingdom Guiseppina Gaia, M.D. Dr. med. RSjdiger von Harsdorf Cardiovascular Research Center Franz-Valhard-Klinik ,,Salvatore Maugeri" Foundation Humboldt-UniversitPt Via Pinidolo, 23 UniversitiitsklinikumC harit4 1-25064 Gussago (Brescia) Wiltbergstral3e 50 ltaly 0-13 12 5 Berllin Germany Dr. med. Daniela Grimm Dr. med. Armin Haunstetter Institute of Clinical Pharmacology and Department of Cardiology Toxicology University of Heidelberg Benjamin Franklin Medical Center Bergheimer StraQe 58 FU-Berlin 0-6911 5 Heidelberg GarystralSe 5 Germany D-14195 Berlin Germany viii LIST OF CONTRIBUTORS Prof. Dr. rned. Jiirgen Holtz Edward G. Lakatta, M.D., Ph.D. Professor of Physiology Laboratory of Cardiovascular Sciences Martin-Luther Universitlt Halte-Wittenberg Gerontology Research Center Institut fur Pathophysiologie National Institute on Aging, National Institutes Magdeburger Strafie 18 af Health D-06097 Halle 5600 Nathan Shock Drive Germany Baltimore, MD 21 224 USA Dr. med. Randolph Hutter Xilin Long, M.D. Department of Internal Medicine IIICardiology Laboratory of Cardiovascular Sciences University of Bonn Gerontology Research Center Sigmund-Freud-StralJe 25 National lnstitute on Aging, National lnstitutes D-53105 Bonn of Health Germany 5600 Nathan Shock Drive Baltimore, MD 21224 USA Seigo Izumo, M.D. Prof. Dr. med. Berndt LUderik, Cardiovascular Division FACC, FESC Beth Israel Deaconess Medical Center Professor of lnternal Medicine Harvard Medical School Department of Internal Medicine ll/Cardiology 330 Brookline Ave. University of Bonn Boston, MA 0221 5 Sigmund-Freud-Srafie 25 USA 0-53105 Bonn Germany Privatdozent Dr. med. Lothar Jahn Ziad Mallat, M.D. Department of Internal Medicine U141-INSERM-Hospital tariboisiere University of Heidelberg 41 Bd de la Chapelle Bergheimer Straf3e 58 F-75475 Paris Cedex 0-691 15 Heidelberg France Germany Lee Baines Jordan, S.Sc.(Hons), Privatdozent Dr. rer. nat. Rainer Meyer M.B., Ch.B. Rheinische Friedrich-Wiihelms-Universitiit Department of Pathology Physiologisches lnstitut The University of Edinburgh Wilhelmstral3e 31 Medical School D-53111 Bonn Teviot Place Germany Edinburgh EH8 9AG. United Kingdom Dr. rer. nat. Franz Kohlhuber Sergei Qrlov, Ph.D. lnstitut for Kiinische Molekularbiologie CHUM Research Center und Tumorgenetik 3840 St-Urbain GSF-Forschungszentrum fiir Umwelt und Montreal, Quebec Gesundheit H2W IT8 Marchioninistraae2 5 Canada D-81377 Mtinchen Germany APOPTOSIS IN CARDIAC BIOLOGY Prof. Dr. med. Martin Paul Dr. med. Gilbert Schiinfelder Professor of Pharmacology and Toxicology Institute of Clinical Pharmacology and Institute of Clinical Pharmacology and Toxicology Toxicology Benjamin Franklin Medical Center Benjamin Franklin Medical Center FU-Berlin FU-Berlin Garystral3e 5 Garystraae 5 D-14195 Berlin D-14195 Berlin Germany Germany Prof. Dr. med. Giinter A.J. Riegger Prof. Dr. med. Heribert Schunkert Professor of lnternal Medicine Professor of Clinical and Molecular Cardiology University of Regensburg University of Regensburg Franz-Josef-Straul3-Atlee 11 Franz-Josef-Straun-Allee 11 D-93053 Regensburg D-93053 Regensburg Germany Germany Dr. rer. nat. Thomas Rudei Dr. rer. nat. Herbert Schwarz Max-Planck-Institutef or Infection Biology Department of Pathology Department of Molecular Biology University of Regensburg Monbijoustraae 2 Franz-Josef-StraulJ-Allee 11 D-10117 Berlin D-93053 Regensburg Germany Germany Dr. med. Klaus Schlottmann Dr. med. Andreas V. Sigel Department of lnternal Medicine Department of lnternal Medicine University of Regensburg University of Regensburg Franz-Josef-StrauO-Allee 11 Franz-Josef-Straul3-AIlee 11 D-93053 Regensburg D-93053 Regensburg Germany Germany Dr. med. Joachim P. Schmitt loakim Spyridopoulos, M.D. Klinik und Poliklinik fur Herz-, Thorax- Department of Cardiology and Cardiovascular und herznahe GefPGchirurgie Research University of Regensburg Medizinische Klinik Tubingen Franz-Josef-StraulJ-Allee 11 Otfried-MLiller-Stra13e 10 D-93053 Regensburg D-72076 Tubingen Germany Germany Prof. Dr. med. JQrgen Schiilmerich Bernard Swynghedauw, M.D. Professor of lnternal Medicine Professor of Physiology University of Regensburg U127-INSERM-Hospital Lariboisierf Franz-Josef-StrauO-Allee 1 1 41 Bd de la Chapelle 0-93053 Regensburg F-75475 Paris Cedex Germany France LIST OF CONTRIBUTORS Prof. Dr. med. Hans Vetter Rheinische Friedrich-Wilhelms-Universitat Medizinische Univ.-Poliklinik Wilhelmstrafie 35-37 D-53111 Bonn Germany Dr. med. Ulrich Welsch Department of Anatomy Ill University of Munich Pettenkoferstrafie 11 D-80336 Miinchen Germany Dr. med. Kai C. Wollert Department of Cardiology and Angiology Medizinische Hochschule Hannover Carl-Neuberg-Straae 1 D-30625 Hannover Germany
The list of books you might like
