Antiparasitic Chemotherapy for Human and Veterinary Use 3rd COST Action CM1307 Conference ...

140 Pages·2016·1.28 MB·English

3rd COST ACTION CM1307 CONFERENCE ● SOCEPA ● SEFIG  

Antiparasitic Chemotherapy for  
Human and Veterinary Use 

3rd COST Action CM1307 Conference 
/ SOCEPA / SEFIG Joint Meeting 
& WG2 and WG3 Meeting 

October 24‐26, 2016 
Madrid, Spain

3rd COST Action CM1307 Conference ● SOCEPA ● SEFIG, Madrid, 2016

COST Action CM1307

Chemotherapy towards diseases caused by
endoparasites: Antiparasitic Chemotherapy for
Human and Veterinary Use

3rd COST Action CM1307 Conference
/ SOCEPA / SEFIG Joint Meeting
& WG2 and WG3 Meeting

October 24-26, 2016
Madrid, Spain

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The Joint COST Action CM1307 3rd Conference / Sociedad Española de
Parasitología (SOCEPA) / Sociedad Española de Farmacia Industrial y Galénica
(SEFIG)/ WG2 and WG3 Meeting has been organized by the UCM Research
Group ICPVet, Faculty of Veterinary Medicine, Universidad Complutense de
Madrid, Madrid, Spain. Conference and WG2 and WG3 will be held in the Hotel
Tryp Chamartín, Calle Mauricio Ravel 10, 28046 Madrid
(http://www.melia.com/en/hotels/spain/madrid/tryp-madrid-chamartin-
hotel/index.html).
This meeting is focused on different topics covering the scope of the COST
Action CM1307. Invited conferences and talks have been organized in several
sessions:

 Molecules and targets I
 Molecules and targets II
 Molecules and targets III
 Molecules and targets IV
 Natural products
 Drug delivery I
 Drug delivery II
 Drug delivery III
 Screening models
 Chemotherapy of parasitic diseases in human and veterinary medicine

The meeting also includes posters and a round table discussion at the end of
the 3rd Conference COST CM1307/SEFIG/SOCEPA meeting.
The meeting will be followed by the meetings of working groups WG2
(Medicinal Chemistry) and WG3 (Natural products) and the meeting of
Management Committee of the COST Action.

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Scientific Committee
Philippe M. Loiseau (University of Paris-SUD-CNRS, France)
R. Luise Krauth-Siegel (University of Heidelberg, Germany)
Harry P. de Koning (University of Glasgow, United Kingdom)
M. Paola Costi (University of Modena and Reggio Emilia, Italy)
Tomaž Šolmajer (University of Ljubljana, Slovenia)
Vassilios Roussis (National and Kapodistrian University of Athens, Greece)
Thomas J. Schmidt (University of Münster, Germany)
Francisco J. Otero-Espinar (University of Santiago de Compostela, Spain)
Fred Opperdoes (De Duve Institute, Belgium)
Ana Tomás (University of Porto, Portugal)
Juan M. Irache (University of Navarra, Spain)

Organizing Committee
María Jesús Corral (University Complutense of Madrid, Spain)
Ana Isabel Olías-Molero (University Complutense of Madrid, Spain)
M. Dolores Jiménez-Antón (University Complutense of Madrid, Spain)
Alberto Gutiérrez-Dionisio (University Complutense of Madrid, Spain)
José María Alunda (University Complutense of Madrid, Spain)
Philippe M. Loiseau (University of Paris-SUD-CNRS, France)

Sponsors
The meeting has been sponsored by the Universidad Complutense of Madrid,
SOCEPA and the Colegio de Veterinarios de Madrid (Colvema).

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Scientific Programme

October 23rd

18:30 Get-together meeting: cocktail –“vino español”

October 24th

OPENING OF THE CONFERENCE

9:00 Otero-Espinar F.J., President SEFIG
Valladares B., President SOCEPA
Loiseau P.M., Chair COST Action CM1307

OPENING LECTURE

9:20 Descoteaux A., INRS- Institut Armand-Frappier, Laval, Canada (COST invited
speaker)
Leishmania targets the host cell membrane fusion machinery to modulate
immune responses

MOLECULES AND TARGETS I
Chairpersons A. Descoteaux, A. Tomas

10:00 Loiseau P.M., University of Paris-Sud, France
Design of antileishmanial agents targeting host cell vesicular trafficking

10:20 Pomel S., University of Paris-Sud, France
GDP-mannose pyrophosphorylase: a therapeutic target for the selection of new
specific antileishmanial agents

10:40 Mangalagiu I.I., Alexandru Ioan Cuza University of Iasi, Romania
New azaheterocycles derivatives of potential interest in leishmaniasis

11:00 Stevanović S., University of Belgrade, Serbia
Design of novel NADH dehydrogenase inhibitors as antileishmanial agents

11:20-11:50 Coffee break and poster viewing

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MOLECULES AND TARGETS II
Chairpersons E. Davioud-Charvet, R. Leurs

11:50 Kivrak A., Yuzuncu Yil University, Turkey
Synthesis of novel thienocarbazole derivatives via intramolecular cyclization
reactions

12:10 Botta M., University of Siena, Italy
New promising targets vs neglected Tropical Diseases (Leishmaniasis and
Trypanosomiasis)

12:30 García-Sosa A.T., University of Tartu, Estonia
Designing inhibitors with pan-activity and poly-pharmacology for neglected
diseases and parasites

12:50-14:00 Lunch and poster viewing

MOLECULES AND TARGETS III
Chairpersons H. de Koning, F. Opperdoes

14:00 Krauth-Siegel R.L., Biochemie-Zentrum der Universität Heidelberg, Germany
Small redoxins as target molecules in antitrypanosomal drug development

14:20 Leurs R., VU University Amsterdam, The Netherlands
Phosphodiesterase inhibitors as a potential treatment for Neglected Parasitic
Diseases

14:40 Dardonville C., Instituto de Química Médica IQM-CSIC, Spain
Targeting trypanosome alternative oxidase (TAO) inhibitors to mitochondria:
original targeting for a unique target

15:00 de Koning H.P., University of Glasgow, United Kingdom
Trypanocydal action of bisphosphonium salts through a mitochondrial target in
bloodstream form of Trypanosoma brucei

15:20-16:00 Coffee break and poster viewing

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MOLECULES AND TARGETS IV
Chairpersons R.L. Krauth-Siegel, P. Loiseau

16:00 Mukherjee B., University of Geneva, Switzerland
Structure-function relationships of Toxoplasma gondii aspartyl protease 3

16:20 Doligalska M., University of Warsaw, Poland
On the way to find a cure for infection with Babesia microti

16:40 de Koning H.P., University of Glasgow, United Kingdom
Potential antischistosomal activity of PDE inhibitors using in vitro Schistosoma
mansoni worm killing

17:00 Leontovyč A., The Czech Academy of Sciences, Czech Republic
Secreted serine protease SmSP2 of the blood fluke Schistosoma mansoni:
biochemical characterization, localization and host protein processing

17:20 Cordeiro-da-Silva A., I3S, IBMC, University of Porto, Portugal
Trypanosomatid ribose 5-phosphate isomerase structures and fragment
screening revels novel lead compound series

17:40 Free time*

*18:00: Walking free tour: a visit to monumental Madrid

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October 25th

NATURAL PRODUCTS
Chairpersons T.J. Schmidt, V. Roussis

09:00 Schmidt T.J., University of Münster, Germany
European box tree (Buxus sempervirens L.) contains alkaloids with potent and
selective anti-protozoal activity

09:20 Biedermann D., The Czech Academy of Sciences, Czech Republic
The effect of flavonolignans on the Mesocestoides vogae (Cestoda) tetrathyridia

09:40 Gemma S., University of Siena, Italy
From the natural compound dihydroplakortin to synthetic bicyclic and bridged
endoperoxides active against chloroquine-sensitive and chloroquine-resistant
Plasmodium falciparum parasites

10:00 Ebiloma G.U., University of Glasgow, United Kingdom
Antiprotozoal compounds from Nigerian medicinal plants: identification and
mode-of-action studies

DRUG DELIVERY I
Chairpersons P. Couvreur, J.J. Torrado

10:20 Couvreur P., University of Paris-Sud, France (COST Invited speaker)
Nanotechnologies for the treatment of severe diseases

11:00-11:20 Coffee break and poster viewing

DRUG DELIVERY II
Chairpersons P. Couvreur, J.J. Torrado

11:20 Otero-Espinar F.J., University of Santiago de Compostela, Spain (SEFIG
sponsored speaker)
Development and in vivo efficacy of biocompatible drug-loaded microspheres
against Cryptosporidium parvum

11:40 Serrano D.R., University Complutense of Madrid, Spain
Is the oral delivery of Amphotericin B possible to treat parasitic diseases?

12:00 Lopes F., University of Lisbon, Portugal
Nanoencapsulation of tetraoxane-based double drugs with antileishmanial
activity

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