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An Introduction to Neuroendocrinology - R. Brown (Cambridge, 1994) WW PDF

431 Pages·1994·13.33 MB·English
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This book is designed as an introductory text in neuroendocrinology - the study of the interaction between the brain and endocrine system and the influence of this on behavior. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones are examined. The function of neuro- peptides is discussed with respect to the neuroendocrine system and behavior. The neuroimmune system and cytokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behav- ior are outlined. Each chapter has review questions designed for introduc- tory students, and essay questions for more advanced honours or gradu- ate students. This book is written for undergraduates and graduates in biology, neuroscience, psychology and physiology, and will be of interest to those in related disciplines. AN INTRODUCTION TO NEUROENDOCRINOLOGY An introduction to neuroendocrinology RICHARD E. BROWN Professor of Psychology, Dalhousie University Halifax, Nova Scotia, Canada CAMBRIDGE UNIVERSITY PRESS CAMBRIDGE UNIVERSITY PRESS Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, Sao Paulo Cambridge University Press The Edinburgh Building, Cambridge CB2 2RU, UK Published in the United States of America by Cambridge University Press, New York www. Cambridge. org Information on this title: www.cambridge.org/9780521416450 © Cambridge University Press 1994 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 1994 Reprinted 1994,1997, 1998,2000, 2002 A catalogue record for this publication is available from the British Library Library of Congress Cataloguing in Publication data Brown, Richard E. An introduction to neuroendocrinology / Richard E. Brown. p. cm. ISBN 0 521 41645 0 (hardback) ISBN 0 521 42665 0 (pbk.) 1. Neuroendocrinology. I. Title. [DNLM: 1. Neuroendocrinology. WL102B879i 1993] QP356.4.B76 1993 612.8-dc20 DNLM/DLC for Library of Congress 93-14802 CIP ISBN-13 978-0-521-41645-0 hardback ISBN-10 0-521-41645-0 hardback ISBN-13 978-0-521-42665-7 paperback ISBN-10 0-521-42665-0 paperback Transferred to digital printing 2005 Every effort has been made in preparing this publication to provide accurate and up-to-date information which is in accord with accepted standards and practice at the time of publication. Although case histories are drawn from actual cases, every effort has been made to disguise the identities of the individuals involved. Nevertheless, the authors, editors and publishers can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors editors and publishers therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this publication. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use. This book is dedicated to the more than 2000 Dalhousie University students who have taken Hormones and Behaviour over the last 14 years and who have encouraged me to write this book, especially those who gave critical comments on the first three drafts of the book. Contents Preface page xiii Acknowledgements xv Illustration credits xvi List of abbreviations xix 1 Classification of chemical messengers 1 1.1 Hormones, the brain and behavior 1 1.2 The body's three communication systems 3 1.3 Methods of communication between cells 5 1.4 Types of chemical messenger 6 1.5 Neuroregulators: neuromodulators and neuropeptides 13 1.6 Summary 15 2 The endocrine glands and their hormones 19 2.1 The endocrine glands 19 2.2 The hormones of the endocrine glands 20 2.3 Summary 27 3 The pituitary gland and its hormones 30 3.1 The pituitary gland 3 0 3.2 The hormones of the pituitary gland 3 3 3.3 The endorphins 3 6 3.4 Pituitary hormones in the brain 3 7 3.5 Summary 37 4 The hypothalamic hormones 40 4.1 The functions of the hypothalamus 40 4.2 Hypothalamic neurosecretory cells 41 4.3 The neuroendocrine transducer concept 44 4.4 The hypothalamic hypophysiotropic hormones 4 5 4.5 Complexities of hypothalamic-pituitary interactions 50 4.6 Summary 52 5 Neurotransmitters 56 5.1 Categories of neurotransmitters 57 5.2 The nerve cell and the synapse 60 5.3 Neurotransmitter biosynthesis and storage 61 5.4 The release of neurotransmitters and their action at receptors 65 5.5 Receptors for neurotransmitters 6 5 5.6 Deactivation of neurotransmitters 6 9 IX

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Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.