Table Of Content

Contents Preface Humanitarian and Scientific Awards Opening Address M. Nicolini An historical and up-to-date contribution of italian scientists to the understanding of pathology of Alzheimer’s disease (AD) G. Macchi Alzheimer’s disease: is it a disease? L. Amaducci DIAGNOSIS AND CLINICAL EVALUATION Changes of hexokinase activity with age: relevance to Alzheimer disease P. Antuono, J. Ravanelli-Meyer, K. Nicholson, N. Pomara, D. Deptula, R. Singh and T. Cooper A statistical procedure applied to positron emission tomographic (PET) data for the early detection of Alzheimer’s disease (AD) N.P. Azari, K.D. Pettigrew, M.B. Schapiro, J.V. Haxby, C.L. Grady, P. Pietrini, J.A. Salerno, L.L. Heston, S.I. Rapoport and B. Horwitz Alzheimer disease and driving: the role of the health care professional and caregiver J. Beyer, S. Moser and P. Antuono Vision in Alzheimer’s disease and in normal aging as assessed by illusory contour perception B. Contant, G. Leuba, P. Schwed and J. Wertheimer VII Vill Contents Predominant left-sided cognitive decline in early Alzheimer’s disease (AD): reality or fiction? Evidence from a syntactic task L.P. De Vreese, M. Neri and G. Salvioli Spectrum of vascular dementia and the interface with Alzheimer’s disease V.O.B. Emery, E. Gillie and P. Ramdev A short human figure drawing scale for the assessment of cognitive dysfunction in old age K. Ericsson, A. Falkehed, L.G. Forssell, K. Holmén, L. R6nnberg and B. Winblad The formal organizations and the care of persons with Alzheimer’s disease K. Ericsson and B. Winblad Different profiles of memory impairment in Alzheimer’s disease and vascular dementia G. Finali, M. Piccirilli and G.L. Piccinin Cortical D2 dopaminergic receptors in Alzheimer’s disease and dementia of frontal type G.B. Frisoni, G. Pizzolato, A. Bianchetti, G. Ferlin, L. Battistin and M. Trabucchi Corticobasal degeneration: dopamine D2 receptor SPECT analysis G.B. Frisoni, G. Pizzolato, O. Zanetti, A. Bianchetti, G. Ferlin and M. Trabucchi Visuo-spatial language function in the patients with Alzheimer’s disease M. Fujii, S. Murakami, R. Fukatsu, N. Nakano, N. Takahata and M. Yamada Membranous lipodystrophy (Nasu-Hakola disease) with Alzheimer’s senile change R. Fukatsu, T. Yokoo, Y. Takamaru, K. Tsuzuki, K. Oguma, N. Itoh and N. Takahata Contents linical differentiation of Alzheimer type dementia and comparative effects of therapy S. Gavrilova, N.Seleznyova, A. Iznak, N.Mikhailova, N. Dybovskaya and I. Kolykhalov Differential expression of al-antichymotrypsin in the Alzheimer brains K. Ishiguro, M. Shoji, H. Yamaguchi, K. Okamoto, S. Hirai and M. Takatama Three dimensional surface display of cerebral blood flow in Alzheimer’s and Binswanger’s disease K. Kawabata, H. Tachibana, B. Okuda and M. Sugita Dementia in Parkinson’s disease compared with Alzheimer’s type dementia. A °°T CHMPAO SPECT study M.A. Kuiper, Ph. Scheltens, H.C. Weinstein and E.Ch. Wolters Correlation between dementia and visual or hearing deficit M.C. Mizzoni, G. Neroni-Mercati, G. Tatangelo, E. Giannandrea and S. Bonaiuto Disorganized eye movement during copying in Alzheimer’s disease related to head position S. Murakami, M. Fujii, R. Fukatsu, J. Miyazawa, N. Nakano, K. Utumi, S. Hayashi, N. Takahata, M. Yamada, K. Uomori, H. Hongo, M. Yoshimatsu, K. Ueno and T. Fukuda The italian version of the Camdex: a validation study M. Neri, E. Andermarcher, V. Puviani, S. Rubichi, A. Spano, G. Salvioli and C. Cipolli Neurophysiological assessment of Alzheimer’s disease M. Onofrj, T. Fulgente, F. Ferracci and D. Gambi Deficit awareness in dementia: relevance to the clinical diagnosis of Alzheimer’s disease B.R. Ott, J. Tornabene and B.S. Fogel Magnetic resonance-based hippocampal volumetry in Alzheimer’s disease and normal aging R.C. Petersen, C.R. Jack, Jr. and G.E. Smith xX Contents A longitudinal positron emission tomography study of cerebral glucose metabolism in patients with Alzheimer’s disease and prominent visual impairment P. Pietrini, U. Freo, C.L. Grady, J.V. Haxby, J.A. Salerno, A.Gonzales—Aviles and M.B. Schapiro SPECT imaging of the brain in dementia: follow-up evaluation G. Pizzolato, C. Briani, A. Rossato, I. Ponza, M. Dam, F. Chierichetti, N. Borsato, G. Ferlin and L. Battistin The contribution of neuroimaging to the differential diagnosis of early dementia in a memory clinic A. Spano, H. Forstl, O.P. Almeida and R. Levy Disorganized eye and head coordination system in the patients with Alzheimer’s disease K. Utsumi, S. Murakami, M. Fujii, R. Fukatsu, J. Miyazawa, N. Takahata, H. Hongo, M. Yamada, K. Uomori, H. Yoshimatsu and K. Ueno Shortened stroop color-word test: its application in Alzheimer’s disease A. Venneri, M.A. Molinari, R. Pentore, B. Cotticelli, P. Nichelli and P. Caffarra Depression and insight in Alzheimer’s disease and vascular dementia F.R.J. Verhey, N. Rozendaal, R.W.H.M. Ponds and J. Jolles BIOMARKERS A rational approach to the study of biochemical diagnostic maixers of Alzheimer’s disease K. Blennow and A. Wallin CSF amino-acids pattern in some neurodegenerative disorders F. Dagani, L. Canevari, R. Maserati, G. Bono and P. Tosca Contents Increased beta2-microglobulin (§2-M) and interleukin-6 (IL-6) in sera from elder persons with Down syndrome P.D. Mehta, A.J. Dalton, S.P. Mehta, M.E. Percy and H.M. Wisniewski CSF biopterin and neopterin levels in Alzheimer’s and Parkinson’s disease patients M.A. Kuiper, T. Teerlink, P.L.M. Bergmans, Ph. Scheltens, W. van Pelt and E.Ch. Wolters Detection of the prion protein in peripheral tissues of libyan Jews with Creutzfeldt-Jakob disease Z. Meiner, M. Halimi, R.D. Polakiewicz, S.B. Prusiner and R. Gabizon Rheological measurements of whole blood from Alzheimer’s disease, dialysis, and multi infarctual dementia patients P.F. Zatta, A.M. Tollardo, M. Favarato, G. Bazzato, P. Morachiello and M. Nicolini STRUCTURAL AND BIOCHEMICAL PATHOLOGY A morphometric analysis of cerebral cortical neurons in progressive supranuclear palsy J.G. Bautista, M. Sato and K. Miyoshi Dual modulation of protein kinase C activity by amyloid beta-protein A. Chauhan, Ved P.S. Chauhan, H. Brockerhoff and H.M. Wisniewski Regional immunocytochemical studies of brains of prospectively studied demented and nondemented normal elderly humans D.W. Dickson, G. Singer, P. Davies, S.H. Yen and H.A. Crystal The centenarians’ brain J.J. Hauw, P. Delaére, Y. He, P.Y. Nakache, G. Fayet, C. Costa, A. Sachet, F. Piette, R. Moulias and C. Duyckaerts XII Contents Neuropathological evaluation of 923 patients from a geriatric hospital P. Giannakopoulos, C. Bouras, P.R. Hof and J.P. Michel Expression of Alz-50 immunoreactivity in primate hypothalamus and spinal cord P. Liberini, P. Piccardo and A.C. Cuello Comparative study of granulovacuolar degeneration in neurodegenerative diseases U. Liibke, M. Mercken, M. Vandermeeren, C. Ceuterick—de—Groote, E. Vanmechelen, J.-J. Martin and P. Cras Immunohistochemical and ultrastructural studies of granulovacuolar degeneration K. Okamoto, S. Hirai, H. Yamaguchi, K. Ishiguro and M. Takatama Origin of neuritic plaques in Alzheimer disease G. Perry, M. Kawai, R.N. Kalaria, M. Tabaton and P. Cras Novel protein component of SP-40,40 exists in senile plaque amyloid Y.Takamaru, R. Fukatsu, K. Tsuzuki, S. Nagasawa, Y. Aizawa, K. Oguma, N. Takahata and T. Ueno Rimmed vacuoles in oculopharyngeal muscular dystrophy contain amyloid precursor protein M. Villanova, U. Liibke, M. Vandermeeren, M.Mercken, G.C. Guazzi, J.-J. Martin, G. Perry and P. Cras Glycosylation study of Alzheimer’s disease patients cerebral cortex S. Zanoni, P.F. Zatta, C. Bordin, R. Giordano and M. Favarato Synaptophysin expressivity of the cortical neuropil in primary neurodegenerative and vascular dementia S.-S.Zhan, K. Beyreuther and H.P. Schmitt Contents NEURONAL DYSFUNCTION Superoxide dismutase in aging brain and related degenerative diseases F. Bracco, A.P. Burlina, M. Scarpa, A. Rigo and L. Battistin Changes in structure and function of neuronal membrane proteins of the anion exchange family in Alzheimer’s disease G.J.C.G.M. Bosmann, A.P. Stoffels, 1.G.P. Bartholomeus, F.P.A. Van Workum, K. Renkawek and W.J. De Grip NGF-Induced activation of immediate early genes in primary cultures of Ts 16 basal forebrain cholinergic neurons P. Corsi, S.M. Cozza and J.T. Coyle Glutamatergic neurotransmission in rat brain synaptosomes: effect of aging and inhibition of energy metabolism F. Dagani, R. Ferrari and L. Canevari Lesions in the pulvinar of patients with Alzheimer’s disease R.O. Kuljis Excitoprotective and calcium-regulation functions of secreted forms of B-amyloid precursor protein: implications for the pathogenesis of Alzheimer’s disease M.P. Mattson, B. Cheng, V.L. Smith—Swintosky, I. Lieberburg and R.E. Rydel Morphological observation of effects of Cerebrolysin on cultured neural cells T. Satou, M. Imano, F. Akai, S. Hashimoto, T. Itoh and M. Fujimoto CYTOSKELETAL PROTEIN ALTERATIONS Tau protein phosphorylation by protein kinase C and proline- directed protein kinases: implications in Alzheimer’s disease I. Correas, J. Diaz—Nido, M.D. Ledesma and J. Avila XIV Contents Leukocyte hexokinase activity in Alzheimer’s disease N. Pomara, D. Deptula, P. Antuono, R. Singh, J. Ravanelli-Meyer, T. Cooper and F. Leviste APP Intra-amyloid secretory cleavage activity: phylogenetic conservation T.V. Ramabhadran, S.E. Gandy and P. Greengard Aberrant accumulation of phospholipase C in Alzheimer’s brains S. Shimohama, Y. Homma, S. Fujimoto, T. Suenaga, T. Taniguchi, W. Araki, Y. Yamaoka, H. Matsushima, T. Takenawa and J. Kimura Phosphorylation of tau protein by cAMP-dependent protein kinase: identification of phosphorylation sites and effect on tau function C.W. Scott, R.C. Spreen, J.L. Hermann, F.P. Chow and C.B. Caputo 6-AMYLOIDOSIS Bulbus oculi with amyloid deposits in old age and in patients with senile dementia of Alzheimer type J. Bohl and E. Fontanji Alzheimer’s disease: binding of vascular and neuroblastoma heparan sulfate proteoglycans to amyloid 6 protein A4 L. Buée, W. Ding, P.R. Hof, N.J. Boyle, J.P. Anderson, J.H. Morrison, N.K. Robakis, A. Delacourte and H.M. Fillit BA4 Amyloidosis in familial Alzheimer’s disease with the mutation in Codon 717 of the BA4 amyloid precursor protein gene N.J. Cairns Identification of adrelase-A serine hydrolase intrinsic to the Alzheimer amyloid precursor protein U.S. Kayyali, B. Greenberg, D. Dressler and H. Potter Contents Differential expression of the gene promoter enconding beta- amyloid protein precursor in presence of phorbol esters D.K. Lahiri Amyloid precursor-like protein: a member of the highly conserved APP gene family W. Wasco, B.T. Hyman and R.E. Tanzi Ultrastructural localization of APP in normal and Alzheimer brains H. Yamaguchi, T. Yamazaki, K. Ishiguro, K. Okamoto, S. Hirai and M. Takatama ENVIRONMENTAL TOXINS Interaction of aluminium with the mammalian mitochondrial outer membrane C. Ballarin, T. Mirzabekov, M. Nicolini, P.F. Zatta and M.C. Sorgato Possible role for aluminum and serine protease interactions in amyloidogenesis of Alzheimer’s disease M. Clauberg and J.G. Joshi Alzheimer brain pathology and chronic administration of drugs: the neuroleptics J. Constantinidis Ferritin H-chain mRNA in aging and Alzheimer’s disease M. Dhar and J.G. Joshi Aluminum and Alzheimer’s disease: intracellular distribution of aluminium as revealed by “Al-binding C.B. Dobson, J. Templar, J.P. Day and R.F. Itzhaki Natural models of aluminium toxicity in fish from acid-rain lakes T.P. Flaten, I. Wakayama, M.J. Sturm, W. Kretser, S. Capone, T. Dudones, D.W. Bath, J. Gallagher, W. Moore and R.M. Garruto XVI Contents Aluminum in neocortical nuclei. Removal by shuttle chelation and relevance to Alzheimer’s disease pharmacotherapy T.P.A. Kruck, D.R.C. McLachlan, C. Bergeron and W.J. Lukiw Prediction of side effects in Alzheimer’s disease patients on longterm deferoxamine-mesylate treatment T.P.A. Kruck, E.A. Fisher and D.R.C. McLachlin The interaction of aluminum with fundamental levels of genetic organization in Alzheimer’s disease: the human neurofilament light (HNF-—L) chain gene locus W.J. Lukiw, B. Krishnan, C. Bergeron, T.P.A. Kruck, L. Wong and D.R.C. McLachlan Environmental exposure to aluminum in the presence of normal renal function D.R.C. McLachlan Short exposure to aluminum induces neurofilament phosphorylation in in vitro rat brain neuronal cultures M. Pakaski, I. Hlavati and P. Kasa Modelling the interaction of membrane phospholipid components with AI(III) in water and protic solvents: a NMR approach F. Tisato, P. Zambenedetti, B. Corain and P.F. Zatta BLOOD BRAIN BARRIER AND IMMUNOLOGICAL FACTORS Amyloid precursor protein (APP) is rapidly expressed in glia associated with reactive neurons. Early and rapid de novo- sinthesis of APP in activated microglia R.B. Banati, J. Gehrmann, C. Czech, U. Monning, L.L. Jones, G. Konig, K. Beyreuther and G.W. Kreutzberg Glycosylation and membrane interaction of normal and scrapie prion proteins and the role in scrapie infectivity M. Ceroni, J. Safar, P. Pergami, C. Camana and C.J. Gibbs Jr.