Activation and Desensitization of Transducing Pathways PDF
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NATO ASI Series Advanced Science Institutes Series A series presenting the results of activities sponsored by the NATO Science Committee, which aims at the dissemination of advanced scientific and technological knowledge, with a view to strengthening links between scientific communities. The Series is published by an international board of publishers in conjunction with the NATO Scientific Affairs Division A Life Sciences Plenum Publishing Corporation B Physics London and New York C Mathematical and Kluwer Academic Publishers Physical Sciences Dordrecht, Boston and London D Behavioural and Social Sciences E Applied Sciences F Computer and Springer-Verlag Systems Sciences Berlin Heidelberg New York G Ecological Sciences London Paris Tokyo Hong Kong H Cell Biology Series H: Cell Biology Vol. 44 The ASI Series Books Published as a Result of Activities of the Special Programme on CELL TO CELL SIGNALS IN PLANTS AND ANIMALS This book contains the proceedings of a NATO Advanched Research Workshop held within the activities of the NATO Special Programme on Cell to Cell Signals in Plants and Animals, running from 1984 to 1989 under the auspices of the NATO Science Committee. The books published as a result of the activities of the Special Programme are: Vol. 1: Biology and Molecular Biology of Plant-Pathogen Interactions. Edited by JA Bailey. 1986. Vol. 2: Glial-Neuronal Communication in Development and Regeneration. Edited by H.H. Althaus and W Seifert. 1987. Vol. 3: Nicotinic Acetylcholine Receptor: Structure and Function. Edited by A. Maelicke. 1986. Vol. 4: Recognition in Microbe-Plant Symbiotic and Pathogenic Interactions. Edited by B. Lugtenberg. 1986. Vol. 5: Mesenchymal-Epithelial Interactions in Neural Development. Edited byJ.R. Wolff, J. Sievers, and M. Berry. 1987. Vol. 6: Molecular Mechanisms of Desensitization to Signal Molecules. Edited byTM. Konjin, P.J.M. Van Haastert, H. Van der Starre, H. Van derWel, and MD. Houslay. 1987. Vol. 7: Gangliosides and Modulation of Neuronal Functions. Edited by H. Rahmann. 1987. Vol. 9: Modification of Cell to Cell Signals During Normal and Pathological Aging. Edited By S. Govoni and F. Battaini. 1987. Vol. 10: Plant Hormone Receptors. Edited by D. Klambt. 1987. Vol. 11: Host-Parasite Cellular and Molecular Interactions in Protozoal Infections. Edited by K.-P. Chang and D. Snary 1987. Vol. 12 The Cell Surface in Signal Transduction. Edited by E. Wagner, H. Greppin, and B. Millet. 1987. Vol. 19: Modulation of Synaptic Transmission and Plasticity in Nervous Systems. Edited by G. Hertting and H.-G. Spatz. 1988. Vol. 20: AminoAcid Availability and Brain Function in Health and Disease. Edited by G. Huether. 1988. Vol. 21: Cellular and Molecular Basis of Synaptic Transmission. Edited by H. Zimmermann. 1988. Vol. 23: The Semiotics of Cellular Communication in the Immune System. Edited by E.E. Sercarz, F. Celada, NA Mitchison, and T Tada. 1988. Vol. 24: Bacteria, Complement and the Phagocytic Cell. Edited by FC. Cabello and C. Pruzzo. 1988. Vol. 25: Nicotinic Acetylcholine Receptors in the Nervous System. Edited by F Celementi, C. Gotti, and E. Sher. 1988. Vol. 26: Cell to Cell Signals in Mammalian Development. Edited by SW. de Laat, J.G. Bluemink, and C.L. Mummery. 1989. Vol. 27: Phytotoxinsand Plant Pathogenesis. Edited by A. Graniti, R.D. Durbin, and A. Ballio. 1989. Vol. 31: Neurobiology of the Inner Retina. Edited by R. Weiler and N.N. Osborne. 1989. Vol. 32: Molecular Biology of Neuroreceptors and Ion Channels. Edited by A. Maelicke. 1989. Vol. 33: Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. Edited byF Battaini, S. Govoni, M.S. Magnoni, and M. Trabucchi.1989. Vol. 35: Cell Separation in Plants: Physiology, Biochemistry and Molecular Biology. Edited by D.J. Osborne and M.B. Jackson. 1989. Vol. 36: Signal Molecules in Plants and Plant-Microbe Interactions. Edited by B.J.J. Lugtenberg. 1989. Vol. 39: Chemosensory Information Processing. Edited by D. Schild. 1990. Vol. 41: Recognition and Response in Plant-Virus Interactions. Edited by R.S.S. Fraser. 1990. Vol. 43: Cellular and Molecular Biology of Myelination. Edited by G. Jeserich, H. H. Althaus, and T V. Waehneldt. 1990. Vol. 44: Activation and Desensitization ofTransducing Pathways. Edited by T M. Konijn, M. D. Houslay, and P J. M. Van Haastert. 1990. Activation and Desensitization of Transducing Pathways Edited by T. M. Konijn Zoblogisch Laboratorium, Kaiserstraat 63, POB 9516,2300 RA Leiden, The Netherlands M. D. Houslay Institute of Biochemistry, The University of Glasgow, Glasgow G12 800, Scotland P. J. M. Van Haastert Biochemisch Laboratorium, Nijenborgh 16, POB 9747 AG Groningen, The Netherlands Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Published in cooperation with NATO Scientific Affairs Division Proceedings of the NATO Advanced Research Workshop on Activation and Desensitization of Transducing Pathways held at Noordwijkerhout, The Netherlands, May 25-27,1989 ISBN-13: 978-3-642-83620-6 e-ISBN-13:978-3-642-83618-3 001: 10.1007/978-3-642-83618-3 Library of Congress Cataloging-in-Publication Data NATO Advanced Research Workshop on Activation and Desensitization of Transducing Pathways (1989: Noordwijkershout, Netherlands) Activation and desensitization of transducing pathways 1 edited by 1 M. Konijn, M. D. Houslay, P. J. M. van Haastert. p. cm.-(NATO ASI series. Series H, Cell biology; vol. 44) "Published in cooperation with NATO Scientific Affairs Division." "Proceedings of the NATO Advanced Research Workshop on Activation and Desensitization of Transducing Pathways held at Noordwijkershout, the Netherlands, May 25-27,1989"-Ip. verso. Includes bibliographical references. ISBN-13:978-3-642-83620-6 (U.S.: alk. paper) 1. Cellular signal transduction-Congresses. 2. Second messengers (Biochemistry)-Congresses. I. Konijn, 1 M. II. Houslay, Miles D. III. North Atlantic Treaty Organization. Scientific Affairs Division. IV. Haastert, P. J. M. van. V. Title. VI. Series. QP517.C45N37 1989 674.87'6-dc20 90-9800 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1990 Softcover reprint of the h<rdcover 1st edition 1990 2131/3140-543210 - Printed on acid-Iree-paper Contents PARTICIPANTS ix PREFACE xi CHEMOTAXIS AND CHEMOSENSING Activation and desensitization in bacterial chemotaxis M.I. SIMON 3 Discussion 18 Adaptation of chemoattractant elicited responses in Dictyostelium discoideum R. VAUGHAN, R. JOHNSON, M. CATERINA and P. DEVREOTES 23 Discussion 37 The inositolcycle of Dictyostelium discoideum P.J.M. VAN HAASTERT, A.A. BOMINAAR, J. VAN DER KAAY, R. DRAIJER, L.C. PENNING, E. ROOVERS, M.M. DE VRIES, A.A. VINK, F. KESBEKE, and B.E. SNAAR-JAGALSKA 41 Discussion 56 CYCLIC NUCLEOTIDE-COUPLED SYSTEMS Glucagon activates two distinct signal transduction systems in hepatocytes,which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of G-2 and the i phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase M.D. HOUSLAY, M. BUSHFIELD, E. KILGOUR, B. LAVAN, S. GRIFFITHS, N.J. PYNE, E.K.-Y. TANG and G.J. MURPHY 63 Discussion 79 Multiple pathways for glucagon-induced heterologous desensitization of liver adenylyl cyclase R.T. PREMONT and R. IYENGAR 85 Discussion 95 The mechanisms of luteinizing hormone-induced activation and desensitization of adenylate cyclase B.A. COOKE, D.R.E. ABAYASEKERA, and M.P. ROSE 99 Discussion 110 VI Role of protein kinases in the desensitization sensitization of ~-adrenergic receptor and prostaglandin receptor stimulation of adenylyl cyclase R.B. CLARK, M.W. KUNKEL, J.A. JOHNSON, R. GOLDSTEIN, and J. FRIEDMAN 115 Discussion 129 Direct involvement of the cyclic nucleotide binding sites in the cyclic-nucleotide-induced charge shift of protein kinases L.WOLFE, T.A. WOODFORD, S.H. FRANCIS, and J.D. CORBIN 133 Discussion 148 INOSITOL PHOSPHOLIPID-COUPLED SYSTEMS Heterogeneity amongst myo-inositol derivatives: metabolism of second messengers and synthesis of co-signals C.P. DOWNES, L.R. STEPHENS, and P.T. HAWKINS 153 Discussion 162 Role of glycosyl-phosphatidylinositols in insulin signalling I. VARELA, J.F. ALVAREZ, J. PUERTA, R. CLEMENTE, A. GUADANO, M. AVILA, F. ESTEVEZ, S. ALEMANY, and J .M. MATO 167 Discussion 177 Agonist and guanine nucleotide regulation of P2Y- purinergic receptor-linked phospholipase C J.L. BOYER, M.W. MARTIN, C.L. COOPER, G.L. WALDO, A.J. MORRIS, H.A. BROWN, R.A. JEFFS, J.R. HEPLER, C.P. DOWNES, and T.K. HARDEN 181 Discussion 194 G-PROTEIN ACTIVATION Mechanisms involved in G-protein activation by hormone receptors K.H.JAKOBS, T. WIELAND, and P. GIERSCHIK 199 Discussion 210 VISUAL TRANSDUCTION Regulation and rapid inactivation of the light induced cGMP phosphodiesterase activity in vertebrate retinal rods M. CHABRE, P. DETERRE, P. CATTY, and T.M. VUONG 215 Discussion 226 VII AUXIN-COUPLED SYSTEMS Characterization and modulation of the sensitivity of plant protoplasts to auxin H. BARBIER-BRYGOO, G. EPHRITIKHINE, W.H. SHEN, A. DELBARRE, D . KLAMBT, and J. GUERN 231 Discussion 243 The auxin-binding-protein from maize coleoptiles G. VIOLA, U. TILLMANN, T. HESSE, B. KNAUTH, K. PALME, M. L~BLER, and D. KLAMBT 245 Discussion 251 Is a GTP-binding protein involved in the auxin-mediated phosphoinositide response on plant cell membranes? B. ZBELL, H. HOHENADEL, I. SCHWENDEMANN, and C. WALTER- BACK 255 Discussion 264 ION CONDUCTANCE Regulation of the desensitization of the acetylcholine nicotinic receptor C. MULLE, P. BENOIT, F. REVAH, AND J.P. CHANGEUX 269 Discussion 280 CELLULAR SYSTEMS The control of human thyroid cell function, proliferation and differentiation S. REUSE, C. MAENHAUT, A. LEFORT, F. LIBERT, M. PARMENTIER, E. RASPE, P. ROGER, B. CORVILAIN, E. LAURENT, J. MOCKEL, F. LAMY, J. VAN SANDE, G. VASSART, and J.E. DUMONT 285 Discussion 304 Activation of the regulated secretory pathway in neuronal cells during in vitro differentiation E. SHER, S. DENIS-DONINI, A. ZANINI, C. BISIANI, E. BIANCARDI, and F. CLEMENTI 307 Discussion 319 Participants NATO Workshop on Activation and Desensitization of Transducing Pathways, held at Noordwijkerhout, The Netherlands, 24th-27th May, 1989. H. BARBIER-BRYGOO, Centre National de la Recherche Scientifique, Physiologie cellulaire vegetale, Batiment 15, Avenue de la Terrasse, F-91190 Gif-Sur-Yvette, France. J.L. BOYER, Dept. of Pharmacology, Univ. of North Carolina, School of Medicine, Chapel Hill, NC 27514, USA. M.G. CARON, Dept. of Physiology, Duke Univ. Med. Center, Durham, NC 27710, USA. M. CHABRE, CNRS - Institut de Pharmacologie, Route des Lucioles, Sophia Antipolis, F-06560 Valbonne, France. R.B. CLARK, Graduate School of Biomedical Sciences, Univ. of Texas Health Science Center, POB 20334, Houston, TX 77225, USA. F. CLEMENTI, Dipartimento di Farmacologia, Universita di Milano, Via Vanvitelli 32, 1-20129 Milano, Italy. B. COOKE, Dept. of Biochemistry, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, England. J.D. CORBIN, Howard Hughes Medical Institute, Dept. of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, TN 37232, USA. P.N. DEVREOTES, The Johns Hopkins University, School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA. C.P. DOWNES, Smith, Kline & French Research Ltd, The Fryt he, Welwyn, Hertfordshire, England AL6 9AR. J.E. DUMONT, Faculte de Medicine, Campus Hopital Erasme, Route de Lennik 808, B-1070 Bruxelles, Belgium. x G. EPHRITIKHINE, Centre National de la Recherche Scientifique, Physiologie cellulaire vegetale, Batiment 15, Avenue de la Terrasse, F-91190 Gif-Sur-Yvette, France M.D. HOUSLAY, Inst. of Biochemistry, The Univ. of Glasgow, Glasgow G12 8QQ, Scotland. R. IYENGAR, Dept. of Pharmacology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. K.H. JAKOBS, Pharmakologisches Inst. der Univ. Heidelberg, Im Neuenheimer Feld 366, 0-6900 Heidelberg, FRG. D. KLAMBT, Botanisches Institut der Univ. Bonn, Meckenheimer Allee 170, 0-5300 Bonn 1, FRG. T.M. KONIJN, Zoologisch Laboratorium, Kaiserstraat 63, POB 9516, 2300 RA Leiden, The Netherlands. K.R. LIBBENGA, Botanisch Laboratorium, Nonnenstreeg 3, POB 9516, 2300 RA Leiden, The Netherlands. J. MATO, Metabolismo Nutrici6n y Hormonas, Fundaci6n Jimenes Diaz, Avda de los Reyes Cat61icos 2, 28040 Madrid 3, Spain. C. MULLE, Molecular Neurobiology, Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris Cedex 15, France. R. PREMONT, Dept. of Pharmacology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA. P. SCHAAP, Zoologisch Laboratorium, Kaiserstraat 63, POB 9516, 2300 RA Leiden, The Netherlands. M.I. SIMON, Calif. Inst. of Technology, Division of Biology 147-75, Pasadena, CA 91125, USA B.E. SNAAR-JAGALSKA, Zoologisch Laboratorium, Kaiserstraat 63, POB 9516, 2300 RA Leiden, The Netherlands. P.J.M. VAN HAASTERT, Biochemisch Laboratorium, Nijenborgh 16, 9747 AG Groningen, The Netherlands. B. ZBELL, Botanisches Institut der Universitat, Im Neuenheimer Feld 360, 0-6900 Heidelberg, FRG. Hostess: Eva Luderus Projection: Cor Schoen Recording discussions: Bert Van Duijn, Fanja Kesbeke and Ton Bominaar Mieke Rozenboom Secreta~: Preface This book reports the proceedings of a small NATO-supported workshop held at Noordwijkerhout, in the Netherlands, during 25-27th. May 1989. The aim of this workshop was for a panel of experts to present data and analyse future developments in the rapidly expanding field of signal transduction processes in biological systems. This field will have considerable importance for the burgeoning biotechnology and biomedical/ health-care areas, well into the 21st century. Its pervasive nature was explored in the various representatives of the workshop, who were involved in investigating a diverse array of creatures from micro-organisms and slime moulds through to plants and animal cells. In all such creatures we find that cellular signalling systems are of crucial importance in allowing such creatures to survive, adapt, grow and differentiate. Intriguingly, the fundamental components of the signalling systems employed show a high degree of conservation, although their usage is clearly individually tailored to particular creatures and Situations. One clear observation, has been the major impact that molecular biology has made to this field over the past few years. This has provided the nascent beginnings of relating the fine structure of components of signal transduction systems to their particular functions. The proteins involved in signal transduction processes are normally found in vanishingly small quantities, which makes for distinct difficulties in their analysis. However, molecular biological techniques coupled with new developments in dealing with membrane proteins should, in the future, allow us to look forward to producing considerable quantities of these proteins for X-ray crystallographic analysis. We have known for some time that a diverse array ofp roteins was involved in the various signal transduction processes. However, molecular biological analyses have indicated that the true diversity of such systems is far greater than we ever envisaged. The functional significance of these observations and the mechanisms whereby signal transduction systems interact together, to form networked arrays, will provide a conSiderable challenge for the future. The Editors May 1989
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